The aim of the investigation is to reveal possible causes of isolation and co-occurrence of the economically significant concentrations of gold and tin. Comparative analysis of the different-rank factors that influenc...The aim of the investigation is to reveal possible causes of isolation and co-occurrence of the economically significant concentrations of gold and tin. Comparative analysis of the different-rank factors that influenced migration and concentration of these elements show that different geochemical properties of Au and Sn are responsible for isolation of their big concentrations giving rise to independent metallogenic provinces, zones, and ore nodes. These differences resulted in individualization of the element migration ways to the level of ore concentration within the fluid-magmatie columns. Three main factors influenced the Au and Sn migration activity： different patterns of metal connection with the meh structure, different relation with oxygen, and different relation with other strong oxidizers. By the moment when ore-bearing fluid became isolated from magmas, the metallogenic signature of the melts, contrasting in redox-potential, had already been defined that was confirmed by the fact that tin ores associate predominantly with the granitoids of ilmenite series and gold ores - with those of magnetite series. The fluid-magmatic systems with an intermediate degree of the melt reduction-oxidation may be considered the potential producers of the combined metal concentrations. In these cases, the combined con- centrating of tin and gold is plagued by an opposite direction of the oxidation-reduction reactions when their most common minerals are formed： the main migration form of Sn^＋2 must be oxidized （with cassiterite portioning） , and the forms of Au^＋ or Au^＋3 must be reduced （with native gold portioning）. Probably, because of this the combined tin and gold concentrations are dominated by one of the metals with a tendency of accumulation in different-stage mineral complexes.展开更多
Continuous treatment with organic nitrates causes nitrate tolerance and provides evidence for a relationship between mitochondrial complex 1 activity and mitochondrial aldehyde dehydrogenase-2 (ALDH-2) with disturbanc...Continuous treatment with organic nitrates causes nitrate tolerance and provides evidence for a relationship between mitochondrial complex 1 activity and mitochondrial aldehyde dehydrogenase-2 (ALDH-2) with disturbances of the hemodynamics reaction during nitroglycerin (NTG) tolerance (NTGT). The purpose of this study was the evaluation of efficacy of original oxidized form NAD-containing drug, NADCIN<sup>®</sup>, on hemodynamic reactions, baroreflex sensitivity (BRS) and reflex control of splanchnic sympathetic nerve activity (SSNA), level of redox-potential, activity of ALDH-2 and superoxide anion generation in aortic tissue in rat model of NTGT. Five groups (7 - 9 each) of male Wistar rats, including control, acute i.v. NTG (150 mcg/kg) administration, NTG tolerance NTGT treatment with NADCIN<sup>®</sup> 8 mg/kg and methylene blue (MB, 2.5 mg/kg) were used. NTGT in rats was accompanied with the greatly attenuation of hemodynamics reaction, BRS, the decreasing of the ability to reflex control of SSNA without pronounce overexpression of endothelin-1 in vessels (aorta). In NTGT rats i.v. NTG along induced less hypotensive reactions and alterations in heart period vs single NTG treated group, more expressively decreased BRS (-34%) and reflex control of SSNA (-18%). NADCIN<sup>®</sup> significantly inhibits tolerance-inducing properties of the prolonged nitroglycerin infusion (max decrease of blood pressure response to nitroglycerin injection, % of normal controls: NTGT 51.2%, NADCIN<sup>®</sup> 91.6%, MB 55.8%). NADCIN<sup>®</sup> in NTGT rats after NTG i.v. administration increased reduced BRS (+37.8%, p < 0,05), reflex control of SSNA (+29.4%, p < 0.05) and reversed the decreasing of NAD/NADH ratio, ALDH-2 activity and decreasing in superoxide generation in thoracic aortic tissue. Thus, course treatment with NADCIN<sup>®</sup> of NTGT rats restores hemodynamics changes, BRS and SSNA throughout the increasing of redox-potential NAD/NADH and cessates the NTGT developing.展开更多
文摘The aim of the investigation is to reveal possible causes of isolation and co-occurrence of the economically significant concentrations of gold and tin. Comparative analysis of the different-rank factors that influenced migration and concentration of these elements show that different geochemical properties of Au and Sn are responsible for isolation of their big concentrations giving rise to independent metallogenic provinces, zones, and ore nodes. These differences resulted in individualization of the element migration ways to the level of ore concentration within the fluid-magmatie columns. Three main factors influenced the Au and Sn migration activity： different patterns of metal connection with the meh structure, different relation with oxygen, and different relation with other strong oxidizers. By the moment when ore-bearing fluid became isolated from magmas, the metallogenic signature of the melts, contrasting in redox-potential, had already been defined that was confirmed by the fact that tin ores associate predominantly with the granitoids of ilmenite series and gold ores - with those of magnetite series. The fluid-magmatic systems with an intermediate degree of the melt reduction-oxidation may be considered the potential producers of the combined metal concentrations. In these cases, the combined con- centrating of tin and gold is plagued by an opposite direction of the oxidation-reduction reactions when their most common minerals are formed： the main migration form of Sn^＋2 must be oxidized （with cassiterite portioning） , and the forms of Au^＋ or Au^＋3 must be reduced （with native gold portioning）. Probably, because of this the combined tin and gold concentrations are dominated by one of the metals with a tendency of accumulation in different-stage mineral complexes.
文摘Continuous treatment with organic nitrates causes nitrate tolerance and provides evidence for a relationship between mitochondrial complex 1 activity and mitochondrial aldehyde dehydrogenase-2 (ALDH-2) with disturbances of the hemodynamics reaction during nitroglycerin (NTG) tolerance (NTGT). The purpose of this study was the evaluation of efficacy of original oxidized form NAD-containing drug, NADCIN<sup>®</sup>, on hemodynamic reactions, baroreflex sensitivity (BRS) and reflex control of splanchnic sympathetic nerve activity (SSNA), level of redox-potential, activity of ALDH-2 and superoxide anion generation in aortic tissue in rat model of NTGT. Five groups (7 - 9 each) of male Wistar rats, including control, acute i.v. NTG (150 mcg/kg) administration, NTG tolerance NTGT treatment with NADCIN<sup>®</sup> 8 mg/kg and methylene blue (MB, 2.5 mg/kg) were used. NTGT in rats was accompanied with the greatly attenuation of hemodynamics reaction, BRS, the decreasing of the ability to reflex control of SSNA without pronounce overexpression of endothelin-1 in vessels (aorta). In NTGT rats i.v. NTG along induced less hypotensive reactions and alterations in heart period vs single NTG treated group, more expressively decreased BRS (-34%) and reflex control of SSNA (-18%). NADCIN<sup>®</sup> significantly inhibits tolerance-inducing properties of the prolonged nitroglycerin infusion (max decrease of blood pressure response to nitroglycerin injection, % of normal controls: NTGT 51.2%, NADCIN<sup>®</sup> 91.6%, MB 55.8%). NADCIN<sup>®</sup> in NTGT rats after NTG i.v. administration increased reduced BRS (+37.8%, p < 0,05), reflex control of SSNA (+29.4%, p < 0.05) and reversed the decreasing of NAD/NADH ratio, ALDH-2 activity and decreasing in superoxide generation in thoracic aortic tissue. Thus, course treatment with NADCIN<sup>®</sup> of NTGT rats restores hemodynamics changes, BRS and SSNA throughout the increasing of redox-potential NAD/NADH and cessates the NTGT developing.
