As a preliminary step in the nonlinear design of shape memory alloy(SMA) composite structures,the force-displacement characteristics of the SMA layer are studied.The bilinear hysteretic model is adopted to describe ...As a preliminary step in the nonlinear design of shape memory alloy(SMA) composite structures,the force-displacement characteristics of the SMA layer are studied.The bilinear hysteretic model is adopted to describe the constitutive relationship of SMA material.Under the assumption that there is no point of SMA layer finishing martensitic phase transformation during the loading and unloading process,the generalized restoring force generated by SMA layer is deduced for the case that the simply supported beam vibrates in its first mode.The generalized force is expressed as piecewise-nonlinear hysteretic function of the beam transverse displacement.Furthermore the energy dissipated by SMA layer during one period is obtained by integration,then its dependencies are discussed on the vibration amplitude and the SMA's strain(Ms-Strain) value at the beginning of martensitic phase transformation.It is shown that SMA's energy dissipating capacity is proportional to the stiffness difference of bilinear model and nonlinearly dependent on Ms-Strain.The increasing rate of the dissipating capacity gradually reduces with the amplitude increasing.The condition corresponding to the maximum dissipating capacity is deduced for given value of the vibration amplitude.The obtained results are helpful for designing beams laminated with shape memory alloys.展开更多
The existence of rolling deformation area in the rolling mill system is the main characteristic which dis- tinguishes the other machinery. In order to analyze the dynamic property of roll system's flexural deformatio...The existence of rolling deformation area in the rolling mill system is the main characteristic which dis- tinguishes the other machinery. In order to analyze the dynamic property of roll system's flexural deformation, it is necessary to consider the transverse periodic movement of stock in the rolling deformation area which is caused by the flexural deformation movement of roll system simul- taneously. Therefore, the displacement field of roll system and flow of metal in the deformation area is described by kinematic analysis in the dynamic system. Through intro- ducing the lateral displacement function of metal in the deformation area, the dynamic variation of per unit width rolling force can be determined at the same time. Then the coupling law caused by the co-effect of rigid movement and flexural deformation of the system structural elements is determined. Furthermore, a multi-parameter coupling dynamic model of the roll system and stock is established by the principle of virtual work. More explicitly, the cou- pled motion modal analysis was made for the roll system. Meanwhile, the analytical solutions for the flexural defor- mation movement's mode shape functions of rolls are discussed. In addition, the dynamic characteristic of the lateral flow of metal in the rolling deformation area has been analyzed at the same time. The establishment ofdynamic lateral displacement function of metal in the deformation area makes the foundation for analyzing the coupling law between roll system and rolling deformation area, and provides a theoretical basis for the realization of the dynamic shape control of steel strip.展开更多
Broadband response metamaterial absorber(MMA)remains a challenge among researchers.A nanostructured new zero-indexed metamaterial(ZIM)absorber is presented in this study,constructed with a hexagonal shape resonator fo...Broadband response metamaterial absorber(MMA)remains a challenge among researchers.A nanostructured new zero-indexed metamaterial(ZIM)absorber is presented in this study,constructed with a hexagonal shape resonator for optical region applications.The design consists of a resonator and dielectric layers made with tungsten and quartz(Fused).The proposed absorbent exhibits average absorption of more than 0.8972(89.72%)within the visible wavelength of 450–600 nm and nearly perfect absorption of 0.99(99%)at 461.61 nm.Based on computational analysis,the proposed absorber can be characterized as ZIM.The developments of ZIM absorbers have demonstrated plasmonic resonance characteristics and a perfect impedance match.The incidence obliquity in typically the range of 0◦–90◦both in TE and TM mode with maximum absorbance is more than 0.8972(∼89.72%),and up to 45◦angular stability is suitable for solar cell applications,like exploiting solar energy.The proposed structure prototype is designed and simulated by studying microwave technology numerical computer simulation(CST)tools.The finite integration technique(FIT)based simulator CST and finite element method(FEM)based simulator HFSS also helps validate the numerical data of the proposed ZIM absorber.The proposed MMA design is appropriate for substantial absorption,wide-angle stability,absolute invisible layers,magnetic resonance imaging(MRI),color images,and thermal imaging applications.展开更多
Based on field geological survey, interpretation of seismic reflection profile and thermochronology dating, this paper systematically studied the structural deformation of the Yuqia-Jiulongshan region in northern Qaid...Based on field geological survey, interpretation of seismic reflection profile and thermochronology dating, this paper systematically studied the structural deformation of the Yuqia-Jiulongshan region in northern Qaidam Basin during the Cenozoic. The results show that the area is primarily dominated by a large box-shaped anticline, with steep limbs and a wide and gently-deformed core. The Mahaigaxiu and Jiulongshan anticlines are secondary folds controlled by secondary faults in the limbs of the box-shaped anticline. Whereas the Yuqia and the Northern Yuqia anticlines are secondary folds within the wide core of the box-shaped anticline. The geometry of the box-shaped anticline is mainly controlled by some high-angle reverse faults with certain right-lateral strike-slip components, displaying distinct positive flower structures in section view. Combining the sedimentary correlation and detrital apatite fission track analysis, we believe that the Yuqia-Jiulongshan region was a paleo-uplift that developed slightly in the early Cenozoic, resulting in the relatively thin Cenozoic strata. The intense deformation that shaped the present-day structural framework occurred in or after the sedimentary period of Shizigou Formation. The Yuqia – Jiulongshan paleo-uplift is adjacent to the Sainan depression that is rich in Lower-Middle Jurassic source rocks, and thus has high potential for future hydrocarbon exploration.展开更多
Shape coefficient is a significant factor accounting for building energy consumption. In order to decrease the building energy consumption of rural residence in severe cold regions,this paper from the perspective of r...Shape coefficient is a significant factor accounting for building energy consumption. In order to decrease the building energy consumption of rural residence in severe cold regions,this paper from the perspective of regulating the shape coefficient limit value,applies the field survey method to statistic and analyze the shape,width and depth of rural residence in severe cold regions and concludes the distribution characteristics and scope of building area. On this basis,though calculating and analyzing the relations between shape coefficient and length-width ratio under different building areas,meanwhile comprehensive considering the building function,farmers' living mode and requirements etc,it put forward that the shape coefficient of rural residence in severe cold regions should below 0. 8. It has important significance for guiding the rural energy-saving house design and construction of severe cold regions.展开更多
Salmonella is one of the major pathogenic bacteria present in contaminated water. 16-23S rRNA spacer region has been reported to be polymorphic at serovar level in Salmonella. Salmonella isolates obtained from Ganges ...Salmonella is one of the major pathogenic bacteria present in contaminated water. 16-23S rRNA spacer region has been reported to be polymorphic at serovar level in Salmonella. Salmonella isolates obtained from Ganges river water were studied for 16-23S rRNA spacer region polymorphism. Thirty three isolates belonging to eight serovars (S. Typhimurium, S. Abuja, S. Pantypridd, S. Lagos, S. Chinkual, S. Zwickau, S. Goldenberg and S. Oritamerin) were studied for the polymorphism. Out of 33 isolates, 15 different profiles were observed no serovar specific profile. Our findings indicate that 16-23S rRNA spacer region is not specific at serovar level, but can be used for differentiation of different Salmonella isolates.展开更多
A numerical study is presented,using a homogenization technique to consider the plain strain problem of visco-plastic porous medium shaped by regularly distributed circular particles. Based on a rigid plastic material...A numerical study is presented,using a homogenization technique to consider the plain strain problem of visco-plastic porous medium shaped by regularly distributed circular particles. Based on a rigid plastic material,the paper derives the macroscopic constitutive laws for homogenous equivalent medium. By changing the shape parameter of circular particles,the effect of pore shape on macroscopic constitutive laws is explored. Yield surfaces with different pore shapes are obtained. About voids,a two-scale conception is introduced,which regards main void as macroscopic scale and secondary cavities as microscopic scale. The macroscopic potential involving main and secondary voids is achieved. The proposed macroscopic constitutive law taking microscopic features as influence factors is helpful for exploring the macroscopic mechanical properties of porous medium when numerical simulation is required.展开更多
With the objective of studying the relationships between high-velocity gas and water maser emissions the results of a search from 95 IRAS sources for high-velocity gas associated with star forming molecular clouds are...With the objective of studying the relationships between high-velocity gas and water maser emissions the results of a search from 95 IRAS sources for high-velocity gas associated with star forming molecular clouds are reported. 21 sources have been identified as molecular outflow candidates.展开更多
Two forms of A. halimus shrubs: erect habit (A. halimus) and bushy habit shrub (A. schweinfurthii) are used naturally isolated by a considerable distance from each other and occupy the same area. To explore the effect...Two forms of A. halimus shrubs: erect habit (A. halimus) and bushy habit shrub (A. schweinfurthii) are used naturally isolated by a considerable distance from each other and occupy the same area. To explore the effect of natural isolation on the genetic basis of the two forms, Start Codon Targeted (SCoT) and the phylogenetic relationships of A. halimus by sequencing ITS1-5.8S-ITS2 regions of the ribosomal DNA are used. Significant isolation-by-distance relationship was found (r = 0.62, P = 0.001). Soil factors did not influence molecular variations. The natural isolation of A. halimus habitats restricts gene flow among the populations and the observed high within-population genetic diversity (74.19%) in this species is best explained by its outcrossing behaviour, long-lived individuals and overlapping generations. The UPGMA analysis of the SCoT results showed that all the studied populations were divided into two discrete genetic groups with significant separation of the two forms in Burg El-Arab area (Populations 1 and 2) and insignificant separation between two forms in El-Hammam area (population 5 and 6). The sequencing of the ITS1-5.8S-ITS2 rDNA regions also showed the insignificant separation of the two A. halimus forms. We conclude that gene flow depending on habitat fragmentation was the main factor affecting the population genetic differentiation. We suggest that the two forms do not merit specific rank in presence of interference between the two forms and absence of a breeding barrier fail to separate the different populations when they become sympatric.展开更多
The first mapping observations of the bipolar HII region S106 in HCN J = 3 - 2 line were made by KOSMA submillimeter telescope in April, 2004. The results show that there is a bipolar outflow centered on the high-mass...The first mapping observations of the bipolar HII region S106 in HCN J = 3 - 2 line were made by KOSMA submillimeter telescope in April, 2004. The results show that there is a bipolar outflow centered on the high-mass star S106 IRS4 and that the flat structure of molecular cloud core is perpendicular to the axis of the outflow. This image roughly corresponds to the optical image where a dark lane bisects the bipolar HII region. Together with the optical, infrared and radio data, we conclude that the central UC HII region and molecular outflow formed before the two lobes of the bipolar HII region, and that a neutral disk is responsible for the bipolar HII region and the outflow.展开更多
Based on a multiwavelength study, the interstellar medium and young stel- lar objects (YSOs) around the H II region Sh2-82 have been analyzed. Two molecular clumps were found from the archival data of the Galactic R...Based on a multiwavelength study, the interstellar medium and young stel- lar objects (YSOs) around the H II region Sh2-82 have been analyzed. Two molecular clumps were found from the archival data of the Galactic Ring Survey, and using the Two Micron All-Sky Survey catalog, we found two corresponding young clusters embedded in the molecular clumps. The very good relations between CO emission, infrared shells and YSOs suggest that it is probably a triggered star formation region from the expansion of Sh2-82. We further used the data from the Galactic Legacy Infrared Mid-Plane Survey Extraordinaire from Spitzer to study the YSOs within the two clumps, confirming star formation in this region. By spectral energy distribution fits to each YSO candidate with infrared excess, we derived the slope of the initial mass function. Finally, comparing the H II region's dynamical age and the fragmenta- tion time of the molecular shell, we discard the "collect and collapse" process as being the triggering mechanism for YSO formation. Sh2-82 can be a mixture of other pro- cesses such as radiative-driven implosion and/or collisions with pre-existing clumps.展开更多
Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation(HCN)channels alters neuronal excitability.However,the role of HCN channels in status epilepticus is not fully understood.In this study,we est...Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation(HCN)channels alters neuronal excitability.However,the role of HCN channels in status epilepticus is not fully understood.In this study,we established rat models of pentylenetetrazole-induced status epilepticus.We performed western blot assays and immunofluorescence staining.Our results showed that HCN1 channel protein expression,particularly HCN1 surface protein,was significantly decreased in the hippocampal CA1 region,whereas the expression of HCN2 channel protein was unchanged.Moreover,metabolic glutamate receptor 1(mGluR1)protein expression was increased after status epilepticus.The mGluR1 agonist(RS)-3,5-dihydroxyphenylglycine injected intracerebroventricularly increased the sensitivity and severity of pentylenetetrazole-induced status epilepticus,whereas application of the mGluR1 antagonist(+)-2-methyl-4-carboxyphenylglycine(LY367385)alleviated the severity of pentylenetetrazole-induced status epilepticus.The results from double immunofluorescence labeling revealed that mGluR1 and HCN1 were co-localized in the CA1 region.Subsequently,a protein kinase A inhibitor(H89)administered intraperitoneally successfully reversed HCN1 channel inhibition,thereby suppressing the severity and prolonging the latency of pentylenetetrazole-induced status epilepticus.Furthermore,H89 reduced the level of mGluR1,downregulated cyclic adenosine monophosphate(cAMP)/protein kinase A expression,significantly increased tetratricopeptide repeat-containing Rab8b-interacting protein(TRIP8b)(1a-4)expression,and restored TRIP8b(1b-2)levels.TRIP8b(1a-4)and TRIP8b(1b-2)are subunits of Rab8b interacting protein that regulate HCN1 surface protein.展开更多
基金supported by the National Natural Science Foundation of China (10872142 and 10632040)New Century Excellent Talents in University of China (NCET-05-0247)the Key Program of the Natural Science Foundation of Tianjin (09JCZDJ26800)
文摘As a preliminary step in the nonlinear design of shape memory alloy(SMA) composite structures,the force-displacement characteristics of the SMA layer are studied.The bilinear hysteretic model is adopted to describe the constitutive relationship of SMA material.Under the assumption that there is no point of SMA layer finishing martensitic phase transformation during the loading and unloading process,the generalized restoring force generated by SMA layer is deduced for the case that the simply supported beam vibrates in its first mode.The generalized force is expressed as piecewise-nonlinear hysteretic function of the beam transverse displacement.Furthermore the energy dissipated by SMA layer during one period is obtained by integration,then its dependencies are discussed on the vibration amplitude and the SMA's strain(Ms-Strain) value at the beginning of martensitic phase transformation.It is shown that SMA's energy dissipating capacity is proportional to the stiffness difference of bilinear model and nonlinearly dependent on Ms-Strain.The increasing rate of the dissipating capacity gradually reduces with the amplitude increasing.The condition corresponding to the maximum dissipating capacity is deduced for given value of the vibration amplitude.The obtained results are helpful for designing beams laminated with shape memory alloys.
基金Supported by National Natural Science Foundation of China(Grant No.51375424)
文摘The existence of rolling deformation area in the rolling mill system is the main characteristic which dis- tinguishes the other machinery. In order to analyze the dynamic property of roll system's flexural deformation, it is necessary to consider the transverse periodic movement of stock in the rolling deformation area which is caused by the flexural deformation movement of roll system simul- taneously. Therefore, the displacement field of roll system and flow of metal in the deformation area is described by kinematic analysis in the dynamic system. Through intro- ducing the lateral displacement function of metal in the deformation area, the dynamic variation of per unit width rolling force can be determined at the same time. Then the coupling law caused by the co-effect of rigid movement and flexural deformation of the system structural elements is determined. Furthermore, a multi-parameter coupling dynamic model of the roll system and stock is established by the principle of virtual work. More explicitly, the cou- pled motion modal analysis was made for the roll system. Meanwhile, the analytical solutions for the flexural defor- mation movement's mode shape functions of rolls are discussed. In addition, the dynamic characteristic of the lateral flow of metal in the rolling deformation area has been analyzed at the same time. The establishment ofdynamic lateral displacement function of metal in the deformation area makes the foundation for analyzing the coupling law between roll system and rolling deformation area, and provides a theoretical basis for the realization of the dynamic shape control of steel strip.
基金This work is supported by the Universiti Kebangsaan Malaysia research grant GUP-2020-074.
文摘Broadband response metamaterial absorber(MMA)remains a challenge among researchers.A nanostructured new zero-indexed metamaterial(ZIM)absorber is presented in this study,constructed with a hexagonal shape resonator for optical region applications.The design consists of a resonator and dielectric layers made with tungsten and quartz(Fused).The proposed absorbent exhibits average absorption of more than 0.8972(89.72%)within the visible wavelength of 450–600 nm and nearly perfect absorption of 0.99(99%)at 461.61 nm.Based on computational analysis,the proposed absorber can be characterized as ZIM.The developments of ZIM absorbers have demonstrated plasmonic resonance characteristics and a perfect impedance match.The incidence obliquity in typically the range of 0◦–90◦both in TE and TM mode with maximum absorbance is more than 0.8972(∼89.72%),and up to 45◦angular stability is suitable for solar cell applications,like exploiting solar energy.The proposed structure prototype is designed and simulated by studying microwave technology numerical computer simulation(CST)tools.The finite integration technique(FIT)based simulator CST and finite element method(FEM)based simulator HFSS also helps validate the numerical data of the proposed ZIM absorber.The proposed MMA design is appropriate for substantial absorption,wide-angle stability,absolute invisible layers,magnetic resonance imaging(MRI),color images,and thermal imaging applications.
基金Supported by the China National Science and Technology Major Project(2016ZX05003-001,2017ZX05008-001).
文摘Based on field geological survey, interpretation of seismic reflection profile and thermochronology dating, this paper systematically studied the structural deformation of the Yuqia-Jiulongshan region in northern Qaidam Basin during the Cenozoic. The results show that the area is primarily dominated by a large box-shaped anticline, with steep limbs and a wide and gently-deformed core. The Mahaigaxiu and Jiulongshan anticlines are secondary folds controlled by secondary faults in the limbs of the box-shaped anticline. Whereas the Yuqia and the Northern Yuqia anticlines are secondary folds within the wide core of the box-shaped anticline. The geometry of the box-shaped anticline is mainly controlled by some high-angle reverse faults with certain right-lateral strike-slip components, displaying distinct positive flower structures in section view. Combining the sedimentary correlation and detrital apatite fission track analysis, we believe that the Yuqia-Jiulongshan region was a paleo-uplift that developed slightly in the early Cenozoic, resulting in the relatively thin Cenozoic strata. The intense deformation that shaped the present-day structural framework occurred in or after the sedimentary period of Shizigou Formation. The Yuqia – Jiulongshan paleo-uplift is adjacent to the Sainan depression that is rich in Lower-Middle Jurassic source rocks, and thus has high potential for future hydrocarbon exploration.
基金Sponsored by the National Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China (Grant No.2011BAJ08B06)
文摘Shape coefficient is a significant factor accounting for building energy consumption. In order to decrease the building energy consumption of rural residence in severe cold regions,this paper from the perspective of regulating the shape coefficient limit value,applies the field survey method to statistic and analyze the shape,width and depth of rural residence in severe cold regions and concludes the distribution characteristics and scope of building area. On this basis,though calculating and analyzing the relations between shape coefficient and length-width ratio under different building areas,meanwhile comprehensive considering the building function,farmers' living mode and requirements etc,it put forward that the shape coefficient of rural residence in severe cold regions should below 0. 8. It has important significance for guiding the rural energy-saving house design and construction of severe cold regions.
文摘Salmonella is one of the major pathogenic bacteria present in contaminated water. 16-23S rRNA spacer region has been reported to be polymorphic at serovar level in Salmonella. Salmonella isolates obtained from Ganges river water were studied for 16-23S rRNA spacer region polymorphism. Thirty three isolates belonging to eight serovars (S. Typhimurium, S. Abuja, S. Pantypridd, S. Lagos, S. Chinkual, S. Zwickau, S. Goldenberg and S. Oritamerin) were studied for the polymorphism. Out of 33 isolates, 15 different profiles were observed no serovar specific profile. Our findings indicate that 16-23S rRNA spacer region is not specific at serovar level, but can be used for differentiation of different Salmonella isolates.
基金Sponsored by the National Natural Science Foundation of China(Grant No.10972162)
文摘A numerical study is presented,using a homogenization technique to consider the plain strain problem of visco-plastic porous medium shaped by regularly distributed circular particles. Based on a rigid plastic material,the paper derives the macroscopic constitutive laws for homogenous equivalent medium. By changing the shape parameter of circular particles,the effect of pore shape on macroscopic constitutive laws is explored. Yield surfaces with different pore shapes are obtained. About voids,a two-scale conception is introduced,which regards main void as macroscopic scale and secondary cavities as microscopic scale. The macroscopic potential involving main and secondary voids is achieved. The proposed macroscopic constitutive law taking microscopic features as influence factors is helpful for exploring the macroscopic mechanical properties of porous medium when numerical simulation is required.
文摘With the objective of studying the relationships between high-velocity gas and water maser emissions the results of a search from 95 IRAS sources for high-velocity gas associated with star forming molecular clouds are reported. 21 sources have been identified as molecular outflow candidates.
文摘Two forms of A. halimus shrubs: erect habit (A. halimus) and bushy habit shrub (A. schweinfurthii) are used naturally isolated by a considerable distance from each other and occupy the same area. To explore the effect of natural isolation on the genetic basis of the two forms, Start Codon Targeted (SCoT) and the phylogenetic relationships of A. halimus by sequencing ITS1-5.8S-ITS2 regions of the ribosomal DNA are used. Significant isolation-by-distance relationship was found (r = 0.62, P = 0.001). Soil factors did not influence molecular variations. The natural isolation of A. halimus habitats restricts gene flow among the populations and the observed high within-population genetic diversity (74.19%) in this species is best explained by its outcrossing behaviour, long-lived individuals and overlapping generations. The UPGMA analysis of the SCoT results showed that all the studied populations were divided into two discrete genetic groups with significant separation of the two forms in Burg El-Arab area (Populations 1 and 2) and insignificant separation between two forms in El-Hammam area (population 5 and 6). The sequencing of the ITS1-5.8S-ITS2 rDNA regions also showed the insignificant separation of the two A. halimus forms. We conclude that gene flow depending on habitat fragmentation was the main factor affecting the population genetic differentiation. We suggest that the two forms do not merit specific rank in presence of interference between the two forms and absence of a breeding barrier fail to separate the different populations when they become sympatric.
文摘The first mapping observations of the bipolar HII region S106 in HCN J = 3 - 2 line were made by KOSMA submillimeter telescope in April, 2004. The results show that there is a bipolar outflow centered on the high-mass star S106 IRS4 and that the flat structure of molecular cloud core is perpendicular to the axis of the outflow. This image roughly corresponds to the optical image where a dark lane bisects the bipolar HII region. Together with the optical, infrared and radio data, we conclude that the central UC HII region and molecular outflow formed before the two lobes of the bipolar HII region, and that a neutral disk is responsible for the bipolar HII region and the outflow.
基金funded by the National Science Foundation undergrants AST-9800334,AST-0098562,AST-0100793,AST-0228993,& AST-0507657
文摘Based on a multiwavelength study, the interstellar medium and young stel- lar objects (YSOs) around the H II region Sh2-82 have been analyzed. Two molecular clumps were found from the archival data of the Galactic Ring Survey, and using the Two Micron All-Sky Survey catalog, we found two corresponding young clusters embedded in the molecular clumps. The very good relations between CO emission, infrared shells and YSOs suggest that it is probably a triggered star formation region from the expansion of Sh2-82. We further used the data from the Galactic Legacy Infrared Mid-Plane Survey Extraordinaire from Spitzer to study the YSOs within the two clumps, confirming star formation in this region. By spectral energy distribution fits to each YSO candidate with infrared excess, we derived the slope of the initial mass function. Finally, comparing the H II region's dynamical age and the fragmenta- tion time of the molecular shell, we discard the "collect and collapse" process as being the triggering mechanism for YSO formation. Sh2-82 can be a mixture of other pro- cesses such as radiative-driven implosion and/or collisions with pre-existing clumps.
基金supported by the National Natural Science Foundation of China,No.81760242(to MGM).
文摘Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation(HCN)channels alters neuronal excitability.However,the role of HCN channels in status epilepticus is not fully understood.In this study,we established rat models of pentylenetetrazole-induced status epilepticus.We performed western blot assays and immunofluorescence staining.Our results showed that HCN1 channel protein expression,particularly HCN1 surface protein,was significantly decreased in the hippocampal CA1 region,whereas the expression of HCN2 channel protein was unchanged.Moreover,metabolic glutamate receptor 1(mGluR1)protein expression was increased after status epilepticus.The mGluR1 agonist(RS)-3,5-dihydroxyphenylglycine injected intracerebroventricularly increased the sensitivity and severity of pentylenetetrazole-induced status epilepticus,whereas application of the mGluR1 antagonist(+)-2-methyl-4-carboxyphenylglycine(LY367385)alleviated the severity of pentylenetetrazole-induced status epilepticus.The results from double immunofluorescence labeling revealed that mGluR1 and HCN1 were co-localized in the CA1 region.Subsequently,a protein kinase A inhibitor(H89)administered intraperitoneally successfully reversed HCN1 channel inhibition,thereby suppressing the severity and prolonging the latency of pentylenetetrazole-induced status epilepticus.Furthermore,H89 reduced the level of mGluR1,downregulated cyclic adenosine monophosphate(cAMP)/protein kinase A expression,significantly increased tetratricopeptide repeat-containing Rab8b-interacting protein(TRIP8b)(1a-4)expression,and restored TRIP8b(1b-2)levels.TRIP8b(1a-4)and TRIP8b(1b-2)are subunits of Rab8b interacting protein that regulate HCN1 surface protein.