COVID-19 pandemic restrictions limited all social activities to curtail the spread of the virus.The foremost and most prime sector among those affected were schools,colleges,and universities.The education system of en...COVID-19 pandemic restrictions limited all social activities to curtail the spread of the virus.The foremost and most prime sector among those affected were schools,colleges,and universities.The education system of entire nations had shifted to online education during this time.Many shortcomings of Learning Management Systems(LMSs)were detected to support education in an online mode that spawned the research in Artificial Intelligence(AI)based tools that are being developed by the research community to improve the effectiveness of LMSs.This paper presents a detailed survey of the different enhancements to LMSs,which are led by key advances in the area of AI to enhance the real-time and non-real-time user experience.The AI-based enhancements proposed to the LMSs start from the Application layer and Presentation layer in the form of flipped classroom models for the efficient learning environment and appropriately designed UI/UX for efficient utilization of LMS utilities and resources,including AI-based chatbots.Session layer enhancements are also required,such as AI-based online proctoring and user authentication using Biometrics.These extend to the Transport layer to support real-time and rate adaptive encrypted video transmission for user security/privacy and satisfactory working of AI-algorithms.It also needs the support of the Networking layer for IP-based geolocation features,the Virtual Private Network(VPN)feature,and the support of Software-Defined Networks(SDN)for optimum Quality of Service(QoS).Finally,in addition to these,non-real-time user experience is enhanced by other AI-based enhancements such as Plagiarism detection algorithms and Data Analytics.展开更多
Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reli...Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reliability and accuracy but still faces challenges such as optimization of the multi-clock source selection and the clock source weight calculation at different timescales,and the coupling of synchronization latency jitter and pulse phase difference.In this paper,the multi-timescale MTS model is conducted,and the reinforcement learning(RL)and analytic hierarchy process(AHP)-based multi-timescale MTS algorithm is designed to improve the weighted summation of synchronization latency jitter standard deviation and average pulse phase difference.Specifically,the multi-clock source selection is optimized based on Softmax in the large timescale,and the clock source weight calculation is optimized based on lower confidence bound-assisted AHP in the small timescale.Simulation shows that the proposed algorithm can effectively reduce time synchronization delay standard deviation and average pulse phase difference.展开更多
Effective control of time-sensitive industrial applications depends on the real-time transmission of data from underlying sensors.Quantifying the data freshness through age of information(AoI),in this paper,we jointly...Effective control of time-sensitive industrial applications depends on the real-time transmission of data from underlying sensors.Quantifying the data freshness through age of information(AoI),in this paper,we jointly design sampling and non-slot based scheduling policies to minimize the maximum time-average age of information(MAoI)among sensors with the constraints of average energy cost and finite queue stability.To overcome the intractability involving high couplings of such a complex stochastic process,we first focus on the single-sensor time-average AoI optimization problem and convert the constrained Markov decision process(CMDP)into an unconstrained Markov decision process(MDP)by the Lagrangian method.With the infinite-time average energy and AoI expression expended as the Bellman equation,the singlesensor time-average AoI optimization problem can be approached through the steady-state distribution probability.Further,we propose a low-complexity sub-optimal sampling and semi-distributed scheduling scheme for the multi-sensor scenario.The simulation results show that the proposed scheme reduces the MAoI significantly while achieving a balance between the sampling rate and service rate for multiple sensors.展开更多
The existing systems sustained with the investments made require more automation and digital transformation with the continuous advancement of tech-nology.The aviation industry is a sector that is open to more automat...The existing systems sustained with the investments made require more automation and digital transformation with the continuous advancement of tech-nology.The aviation industry is a sector that is open to more automation and digi-tal transformation,mainly because of the intense competition and the analysis of a large variety of data.The long duration of operations in current airline processes and some processflows cause customer dissatisfaction and cost increase.In this study,the boarding process,which is one of the operational processes of airline transportation and is open to improvement,was discussed.The classical boarding process has been redesigned using Internet of Things technology a model called Boarding 4.0 was created.With Boarding 4.0,it is aimed to design a process where passengers can take their time before boarding more efficiently.In the study,the sub-processes of the Boarding 4.0 model,other processes that the sub-processes interact with,their activities,and data exchange passenger move-ments during the activities are explained in detail.Compared to the classical boarding process and Boarding 4.0 with the fuzzy ahp technique,it has been shown that boarding 4.0 is more advantageous and passenger movement times can be reduced during boarding.As a result of the evaluation made with the fuzzy ahp,it was determined that boarding 4.0 is more advantageous than the classical boarding process.In addition,when the total time of the sub-activities in the board-ing process is calculated,boarding activities for a passenger take 50 min with the classic boarding process and 20 min with Boarding 4.0.Thus,when Boarding 4.0 is used,the passenger gains 30 min.Furthermore,when the calculation is made concerning the airport’s current capacity,two passengers are hosted with the clas-sical boarding process,whilefive passengers are hosted with Boarding 4.0.This acquisition is significant for airports in terms of efficient use of resources.展开更多
The use of Internet of Things(IoT)applications become dominant in many systems.Its on-chip data processing and computations are also increasing consistently.The battery enabled and low leakage memory system at subthre...The use of Internet of Things(IoT)applications become dominant in many systems.Its on-chip data processing and computations are also increasing consistently.The battery enabled and low leakage memory system at subthreshold regime is a critical requirement for these IoT applications.The cache memory designed on Static Random-Access Memory(SRAM)cell with features such as low power,high speed,and process tolerance are highly important for the IoT memory system.Therefore,a process tolerant SRAM cell with low power,improved delay and better stability is presented in this research paper.The proposed cell comprises 11 transistors designed with symmetric approach for write operations and single ended circuit for read operations that exhibits an average dynamic power saving of 43.55%and 47.75%for write and 35.59%and 36.56%for read operations compared to 6 T and 8 T SRAM cells.The cell shows an improved write delay of 26.46%and 37.16%over 6 T and 8T and read delay is lowered by 50.64%and 72.90%against 6 T and 10 T cells.The symmetric design used in core latch to improve the write noise margin(WNM)by 17.78%and 6.67%whereas the single ended separate read circuit improves the Read Static Noise Margin(RSNM)by 1.88x and 0.33x compared to 6 T and 8T cells.The read power delay product and write power delay product are lower by 1.94x,1.39x and 0.17x,2.02x than 6 T and 8 T cells respectively.The lower variability from 5000 samples validates the robustness of the proposed cell.The simulations are carried out in Cadence virtuoso simulator tool with Generic Process Design Kit(GPDK)45 nm technology file in this work.展开更多
According to many years of experimental summary, the technical demands, process control, seed test, seed quality and work record (ledger management) of cleaning processing of feeding millet seeds in Hebei Province w...According to many years of experimental summary, the technical demands, process control, seed test, seed quality and work record (ledger management) of cleaning processing of feeding millet seeds in Hebei Province were studied, and specific measures and technical indicators of the technical regulations were analyzed to provide normalized, standardized, industrial and marketization technical support for the cleaning processing of feeding millet seeds.展开更多
The power of financial innovations to affect societies on global and intergenerational levels compels us to ask how we can ensure their responsible emergence in society.This requires an understanding of how innovation...The power of financial innovations to affect societies on global and intergenerational levels compels us to ask how we can ensure their responsible emergence in society.This requires an understanding of how innovation occurs and how it is governed in practice.Despite this,there is little research on the process and governance of financial innovation.The few studies conducted in this area have focused on the‘backend’of the innovation process.Therefore,using data from secondary sources,this study investigates how two major financial innovations occurred and were governed,and it discusses the findings in relation to those in the literature.This approach revealed that innovation processes fall within a continuum ranging from structured to unstructured.Moreover,lead times are potentially longer for innovations that are significantly disruptive,new to the market,and technological in nature.Finally,innovation processes can involve multiple stakeholders who use both statutory regulation and self-regulation for innovation governance.This paper concludes that innovation processes and their governance can vary significantly according to different areas of the financial landscape and associated innovation contexts.Thus,there is a need for more empirical work to understand such variability and practices in the sector as a whole.展开更多
Design and implementation of Internet of Things (IoT) systems require platforms with smart things and components. Two dominant architectural approaches for developing IoT systems are mashup-based and model-based appro...Design and implementation of Internet of Things (IoT) systems require platforms with smart things and components. Two dominant architectural approaches for developing IoT systems are mashup-based and model-based approaches. Mashup approaches use existing services and are mainly suitable for less critical, personalized applications. Web development tools are widely used in mashup approaches. Model-based techniques describe a system on a higher level of abstraction, resulting in very expressive modelling of systems. The article uses Cisco packet tracer 7.2 version, which consists of four subcategories of smart things—home, smart city, industrial and power grid, to design an IoT based control system for a fertilizer manufacturing plant. The packet tracer also consists of boards—microcontrollers (MCU-PT), and single boarded computers (SBC-PT), as well as actuators and sensors. The model facilitates flexible communication opportunities among things—machines, databases, and Human Machine Interfaces (HMIs). Implementation of the IoT system brings finer process control as the operating conditions are monitored online and are broadcasted to all stakeholders in real-time for quicker action on deviations. The model developed focuses on three process plants;steam raising, nitric acid, and ammonium nitrate plants. Key process parameters are saturated steam temperature, fuel flowrates, CO and SO<sub>x</sub> emissions, converter head temperature, NO<sub>x</sub> emissions, neutralisation temperature, solution temperature, and evaporator steam pressure. The parameters need to be monitored in order to ensure quality, safety, and efficiency. Through the Cisco packet tracer platform, a use case, physical layout, network layout, IoT layout, configuration, and simulation interface were developed.展开更多
Computer aided process planning(CAPP) is an important content of computer integrated manufacturing, and intelligentizing is the orientation of development of CAPP. Process planning has characters of empirical and ti...Computer aided process planning(CAPP) is an important content of computer integrated manufacturing, and intelligentizing is the orientation of development of CAPP. Process planning has characters of empirical and time-consuming to finalize, and the same technical aim always can be achieved by different process schemes, so intelligentizing of process decision making always be a difficult point of CAPP and computer integrated manufacturing (CIM). For the purpose of intelligent aided process decision making and reuse of process resource, this paper proposed a decision making method based on rough sets(RS) and regular distance computing. The main contents and methods of process planning decision making are analyzed under agile response manufacturing environment, the concept of process knowledge granule is represented, and the methods of process knowledge granule partitioning and granularity analysis are put forward. Based on the theory of RS and combined the method of process attributes importance identification, the paper brought forward a computing model for process scheme regulation distance under the same attribute conditions, and conflict resolution strategy was introduced to acquire process scheme fit for actual situation of enterprise's manufacturing resources, so as to realize process resources' conflict resolution and quick excavate and reuse of enterprises' existing process knowledge, to advance measures of process decision making and improve the rationality and capability of agile response of process planning.展开更多
This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled triblock copolymer envelop, may be cons...This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled triblock copolymer envelop, may be constructed using dendrimers as the crosslinking junctions. Replacing the branched low molecular weight PEI with polyamidoamine(PAMAM) dendrimer in the zeta potential regulated polymerization resulted in the similar network structured cationic polymer with electron microscopically visible crosslinking junctions. This visibility may offer a convenient way to characterize the molecular structure of the rationally designed networked siRNA-packing cationic polymer without altering its chemical properties and biologic functions. A series of physical-chemical characterizations and biological assays, comprising size, zeta potential, pre-phagocytic siRNA leaking and degradation, and silencing of functional genes, confirmed that the advanced properties of polywraplexes remained with the dendrimer junctions. Although sixth generation PAMAM dendrimer was used as the crosslinking junctions in the size-customizable polymerization for electron microscopic observation, lower generation dendrimer should also work in case more practical and structurally defined cationic polymer is needed.展开更多
Based on analysis of the present situation and problems of course project of the Internet of Things engineering,we propose a relational integrated course project pattern around three levels of perception layer,network...Based on analysis of the present situation and problems of course project of the Internet of Things engineering,we propose a relational integrated course project pattern around three levels of perception layer,network layer,application layer of the Internet of Things system.The realization of a complete Internet of Things system is divided into three course projects to complete three key points,which may eventually make a complete system of things.Through the link among the three integrated course projects,knowledge of four years will be connected together and form an organic whole.We use a team performance and examination methods of the process-oriented examination,project paper and oral examination for the integrated course project in order to improve students’cooperation ability,expression ability,communication ability and other integrated quality.展开更多
This process does not use general electroless plating solution containing formaldehyde(carcinogen) and phosphate(the object of waste water regulation). Furthermore, we succeeded in developing a new electroless copper ...This process does not use general electroless plating solution containing formaldehyde(carcinogen) and phosphate(the object of waste water regulation). Furthermore, we succeeded in developing a new electroless copper plating solution which is usable semi-permanently by using the special reducing agent. The electroless deposition forms a very thin conductive film on substrate. Therefore, it can prevent some appearance defects (e.g. pits, pin-holes, laminations and inclusions) that occur in the conventional ones. In addition, it is possible to eliminate electroplating of copper from the process by applying the exclusive nickel solution in electroplating. Therefore, the obtained metal parts can be recycled as high quality stainless steel. Given this copper electroplating-free process, 25 u m-thick nickel deposition at the stage of electroplating, at least, enables the metal layers to show properties as versatile as those of the conventional(its total thickness is 25 n m in the comparative conventional process).展开更多
In terms of second language acquisition or learning, research on anxiety has primarily focused on foreign language classroom anxiety or test anxiety, with little attention paid to anxiety in the process of writing aca...In terms of second language acquisition or learning, research on anxiety has primarily focused on foreign language classroom anxiety or test anxiety, with little attention paid to anxiety in the process of writing academic theses. This study aims to explore to what extent anxiety affects the whole process of three English majors writing their M.A. theses, as well as testing the relationships between anxiety and self-regulation in the whole process. The findings indicate that anxiety appears with high degree atthe preparation stage, slumps at the writing stage and reaches another high level at the revision stage. Anxiety also exists when negotiating with supervisors. What’s more, self-regulation has been proved to alleviate anxiety in the process of writing. This studycontributes new knowledge to the field by relating anxiety to self-regulation in the process of writing M.A. theses, yielding a deepened understanding of self-regulation that reduces anxiety in terms of the progress gradually achieved in the writing process. It alsohas implications for supervisors to pay attention to the way of negotiating with students that may cause anxiety during the academictheses writing process.展开更多
文摘COVID-19 pandemic restrictions limited all social activities to curtail the spread of the virus.The foremost and most prime sector among those affected were schools,colleges,and universities.The education system of entire nations had shifted to online education during this time.Many shortcomings of Learning Management Systems(LMSs)were detected to support education in an online mode that spawned the research in Artificial Intelligence(AI)based tools that are being developed by the research community to improve the effectiveness of LMSs.This paper presents a detailed survey of the different enhancements to LMSs,which are led by key advances in the area of AI to enhance the real-time and non-real-time user experience.The AI-based enhancements proposed to the LMSs start from the Application layer and Presentation layer in the form of flipped classroom models for the efficient learning environment and appropriately designed UI/UX for efficient utilization of LMS utilities and resources,including AI-based chatbots.Session layer enhancements are also required,such as AI-based online proctoring and user authentication using Biometrics.These extend to the Transport layer to support real-time and rate adaptive encrypted video transmission for user security/privacy and satisfactory working of AI-algorithms.It also needs the support of the Networking layer for IP-based geolocation features,the Virtual Private Network(VPN)feature,and the support of Software-Defined Networks(SDN)for optimum Quality of Service(QoS).Finally,in addition to these,non-real-time user experience is enhanced by other AI-based enhancements such as Plagiarism detection algorithms and Data Analytics.
基金supported by Science and Technology Project of China Southern Power Grid Company Limited under Grant Number 036000KK52200058(GDKJXM20202001).
文摘Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reliability and accuracy but still faces challenges such as optimization of the multi-clock source selection and the clock source weight calculation at different timescales,and the coupling of synchronization latency jitter and pulse phase difference.In this paper,the multi-timescale MTS model is conducted,and the reinforcement learning(RL)and analytic hierarchy process(AHP)-based multi-timescale MTS algorithm is designed to improve the weighted summation of synchronization latency jitter standard deviation and average pulse phase difference.Specifically,the multi-clock source selection is optimized based on Softmax in the large timescale,and the clock source weight calculation is optimized based on lower confidence bound-assisted AHP in the small timescale.Simulation shows that the proposed algorithm can effectively reduce time synchronization delay standard deviation and average pulse phase difference.
基金supported in part by the National Key R&D Program of China(No.2021YFB3300100)the National Natural Science Foundation of China(No.62171062)。
文摘Effective control of time-sensitive industrial applications depends on the real-time transmission of data from underlying sensors.Quantifying the data freshness through age of information(AoI),in this paper,we jointly design sampling and non-slot based scheduling policies to minimize the maximum time-average age of information(MAoI)among sensors with the constraints of average energy cost and finite queue stability.To overcome the intractability involving high couplings of such a complex stochastic process,we first focus on the single-sensor time-average AoI optimization problem and convert the constrained Markov decision process(CMDP)into an unconstrained Markov decision process(MDP)by the Lagrangian method.With the infinite-time average energy and AoI expression expended as the Bellman equation,the singlesensor time-average AoI optimization problem can be approached through the steady-state distribution probability.Further,we propose a low-complexity sub-optimal sampling and semi-distributed scheduling scheme for the multi-sensor scenario.The simulation results show that the proposed scheme reduces the MAoI significantly while achieving a balance between the sampling rate and service rate for multiple sensors.
文摘The existing systems sustained with the investments made require more automation and digital transformation with the continuous advancement of tech-nology.The aviation industry is a sector that is open to more automation and digi-tal transformation,mainly because of the intense competition and the analysis of a large variety of data.The long duration of operations in current airline processes and some processflows cause customer dissatisfaction and cost increase.In this study,the boarding process,which is one of the operational processes of airline transportation and is open to improvement,was discussed.The classical boarding process has been redesigned using Internet of Things technology a model called Boarding 4.0 was created.With Boarding 4.0,it is aimed to design a process where passengers can take their time before boarding more efficiently.In the study,the sub-processes of the Boarding 4.0 model,other processes that the sub-processes interact with,their activities,and data exchange passenger move-ments during the activities are explained in detail.Compared to the classical boarding process and Boarding 4.0 with the fuzzy ahp technique,it has been shown that boarding 4.0 is more advantageous and passenger movement times can be reduced during boarding.As a result of the evaluation made with the fuzzy ahp,it was determined that boarding 4.0 is more advantageous than the classical boarding process.In addition,when the total time of the sub-activities in the board-ing process is calculated,boarding activities for a passenger take 50 min with the classic boarding process and 20 min with Boarding 4.0.Thus,when Boarding 4.0 is used,the passenger gains 30 min.Furthermore,when the calculation is made concerning the airport’s current capacity,two passengers are hosted with the clas-sical boarding process,whilefive passengers are hosted with Boarding 4.0.This acquisition is significant for airports in terms of efficient use of resources.
文摘The use of Internet of Things(IoT)applications become dominant in many systems.Its on-chip data processing and computations are also increasing consistently.The battery enabled and low leakage memory system at subthreshold regime is a critical requirement for these IoT applications.The cache memory designed on Static Random-Access Memory(SRAM)cell with features such as low power,high speed,and process tolerance are highly important for the IoT memory system.Therefore,a process tolerant SRAM cell with low power,improved delay and better stability is presented in this research paper.The proposed cell comprises 11 transistors designed with symmetric approach for write operations and single ended circuit for read operations that exhibits an average dynamic power saving of 43.55%and 47.75%for write and 35.59%and 36.56%for read operations compared to 6 T and 8 T SRAM cells.The cell shows an improved write delay of 26.46%and 37.16%over 6 T and 8T and read delay is lowered by 50.64%and 72.90%against 6 T and 10 T cells.The symmetric design used in core latch to improve the write noise margin(WNM)by 17.78%and 6.67%whereas the single ended separate read circuit improves the Read Static Noise Margin(RSNM)by 1.88x and 0.33x compared to 6 T and 8T cells.The read power delay product and write power delay product are lower by 1.94x,1.39x and 0.17x,2.02x than 6 T and 8 T cells respectively.The lower variability from 5000 samples validates the robustness of the proposed cell.The simulations are carried out in Cadence virtuoso simulator tool with Generic Process Design Kit(GPDK)45 nm technology file in this work.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest(20120304201)~~
文摘According to many years of experimental summary, the technical demands, process control, seed test, seed quality and work record (ledger management) of cleaning processing of feeding millet seeds in Hebei Province were studied, and specific measures and technical indicators of the technical regulations were analyzed to provide normalized, standardized, industrial and marketization technical support for the cleaning processing of feeding millet seeds.
文摘The power of financial innovations to affect societies on global and intergenerational levels compels us to ask how we can ensure their responsible emergence in society.This requires an understanding of how innovation occurs and how it is governed in practice.Despite this,there is little research on the process and governance of financial innovation.The few studies conducted in this area have focused on the‘backend’of the innovation process.Therefore,using data from secondary sources,this study investigates how two major financial innovations occurred and were governed,and it discusses the findings in relation to those in the literature.This approach revealed that innovation processes fall within a continuum ranging from structured to unstructured.Moreover,lead times are potentially longer for innovations that are significantly disruptive,new to the market,and technological in nature.Finally,innovation processes can involve multiple stakeholders who use both statutory regulation and self-regulation for innovation governance.This paper concludes that innovation processes and their governance can vary significantly according to different areas of the financial landscape and associated innovation contexts.Thus,there is a need for more empirical work to understand such variability and practices in the sector as a whole.
文摘Design and implementation of Internet of Things (IoT) systems require platforms with smart things and components. Two dominant architectural approaches for developing IoT systems are mashup-based and model-based approaches. Mashup approaches use existing services and are mainly suitable for less critical, personalized applications. Web development tools are widely used in mashup approaches. Model-based techniques describe a system on a higher level of abstraction, resulting in very expressive modelling of systems. The article uses Cisco packet tracer 7.2 version, which consists of four subcategories of smart things—home, smart city, industrial and power grid, to design an IoT based control system for a fertilizer manufacturing plant. The packet tracer also consists of boards—microcontrollers (MCU-PT), and single boarded computers (SBC-PT), as well as actuators and sensors. The model facilitates flexible communication opportunities among things—machines, databases, and Human Machine Interfaces (HMIs). Implementation of the IoT system brings finer process control as the operating conditions are monitored online and are broadcasted to all stakeholders in real-time for quicker action on deviations. The model developed focuses on three process plants;steam raising, nitric acid, and ammonium nitrate plants. Key process parameters are saturated steam temperature, fuel flowrates, CO and SO<sub>x</sub> emissions, converter head temperature, NO<sub>x</sub> emissions, neutralisation temperature, solution temperature, and evaporator steam pressure. The parameters need to be monitored in order to ensure quality, safety, and efficiency. Through the Cisco packet tracer platform, a use case, physical layout, network layout, IoT layout, configuration, and simulation interface were developed.
基金supported by National Key Technology R&D Program of China (Grant No. 2006BAF01A07)National Hi-tech Research and Development Program of China (863 Program, Grant No. 2007AA04Z190)
文摘Computer aided process planning(CAPP) is an important content of computer integrated manufacturing, and intelligentizing is the orientation of development of CAPP. Process planning has characters of empirical and time-consuming to finalize, and the same technical aim always can be achieved by different process schemes, so intelligentizing of process decision making always be a difficult point of CAPP and computer integrated manufacturing (CIM). For the purpose of intelligent aided process decision making and reuse of process resource, this paper proposed a decision making method based on rough sets(RS) and regular distance computing. The main contents and methods of process planning decision making are analyzed under agile response manufacturing environment, the concept of process knowledge granule is represented, and the methods of process knowledge granule partitioning and granularity analysis are put forward. Based on the theory of RS and combined the method of process attributes importance identification, the paper brought forward a computing model for process scheme regulation distance under the same attribute conditions, and conflict resolution strategy was introduced to acquire process scheme fit for actual situation of enterprise's manufacturing resources, so as to realize process resources' conflict resolution and quick excavate and reuse of enterprises' existing process knowledge, to advance measures of process decision making and improve the rationality and capability of agile response of process planning.
基金the grant of the Natural Science Foundation of China(Grant nos.81373352 and 81690262)。
文摘This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled triblock copolymer envelop, may be constructed using dendrimers as the crosslinking junctions. Replacing the branched low molecular weight PEI with polyamidoamine(PAMAM) dendrimer in the zeta potential regulated polymerization resulted in the similar network structured cationic polymer with electron microscopically visible crosslinking junctions. This visibility may offer a convenient way to characterize the molecular structure of the rationally designed networked siRNA-packing cationic polymer without altering its chemical properties and biologic functions. A series of physical-chemical characterizations and biological assays, comprising size, zeta potential, pre-phagocytic siRNA leaking and degradation, and silencing of functional genes, confirmed that the advanced properties of polywraplexes remained with the dendrimer junctions. Although sixth generation PAMAM dendrimer was used as the crosslinking junctions in the size-customizable polymerization for electron microscopic observation, lower generation dendrimer should also work in case more practical and structurally defined cationic polymer is needed.
文摘Based on analysis of the present situation and problems of course project of the Internet of Things engineering,we propose a relational integrated course project pattern around three levels of perception layer,network layer,application layer of the Internet of Things system.The realization of a complete Internet of Things system is divided into three course projects to complete three key points,which may eventually make a complete system of things.Through the link among the three integrated course projects,knowledge of four years will be connected together and form an organic whole.We use a team performance and examination methods of the process-oriented examination,project paper and oral examination for the integrated course project in order to improve students’cooperation ability,expression ability,communication ability and other integrated quality.
文摘This process does not use general electroless plating solution containing formaldehyde(carcinogen) and phosphate(the object of waste water regulation). Furthermore, we succeeded in developing a new electroless copper plating solution which is usable semi-permanently by using the special reducing agent. The electroless deposition forms a very thin conductive film on substrate. Therefore, it can prevent some appearance defects (e.g. pits, pin-holes, laminations and inclusions) that occur in the conventional ones. In addition, it is possible to eliminate electroplating of copper from the process by applying the exclusive nickel solution in electroplating. Therefore, the obtained metal parts can be recycled as high quality stainless steel. Given this copper electroplating-free process, 25 u m-thick nickel deposition at the stage of electroplating, at least, enables the metal layers to show properties as versatile as those of the conventional(its total thickness is 25 n m in the comparative conventional process).
文摘In terms of second language acquisition or learning, research on anxiety has primarily focused on foreign language classroom anxiety or test anxiety, with little attention paid to anxiety in the process of writing academic theses. This study aims to explore to what extent anxiety affects the whole process of three English majors writing their M.A. theses, as well as testing the relationships between anxiety and self-regulation in the whole process. The findings indicate that anxiety appears with high degree atthe preparation stage, slumps at the writing stage and reaches another high level at the revision stage. Anxiety also exists when negotiating with supervisors. What’s more, self-regulation has been proved to alleviate anxiety in the process of writing. This studycontributes new knowledge to the field by relating anxiety to self-regulation in the process of writing M.A. theses, yielding a deepened understanding of self-regulation that reduces anxiety in terms of the progress gradually achieved in the writing process. It alsohas implications for supervisors to pay attention to the way of negotiating with students that may cause anxiety during the academictheses writing process.