Regulations for the Manufacture and Control of Live Poliovirus Vaccine: International Experience and China’s Path

The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine.

Modified Two-Degrees-of-Freedom Internal Model Control for Non-Square Systems with Multiple Time Delays

A modified two-degrees-of-freedom( M-TDOF) internal model control( IMC) method is proposed for non-square systems with multiple time delays and right-half-plane( RHP) zeros. In this method,pseudo-inverse is introduced to design the internal model controller,and a desired closed-loop transfer function is designed to eliminate the unrealizable factors of the derived controller. In addition,set-point tracking and load-disturbance rejection of each process are separately controlled by two controllers. The simulation results show that in addition to high decoupling performance and robustness,the proposed control method also effectively improves loaddisturbance rejection and simultaneously optimizes the input tracking performance and disturbance rejection performance by selecting the parameters of controllers. Furthermore,the higher tolerance of model mismatch is achieved in this paper.

Multi-loop Internal Model Controller Design Based on a Dynamic PLS Framework

In this paper,a multi-loop internal model control(IMC) scheme in conjunction with feed-forward strategy based on the dynamic partial least squares(DyPLS) framework is proposed.Unlike the traditional methods to decouple multi-input multi-output(MIMO) systems,the DyPLS framework automatically decomposes the MIMO process into a multi-loop system in the PLS subspace in the modeling stage.The dynamic filters with identical structure are used to build the dynamic PLS model,which retains the orthogonality among the latent variables.To address the model mismatch problem,an off-line least squares method is applied to obtain a set of optimal filter parameters in each latent space.Without losing the merits of model-based control,a simple and easy-tuned IMC structure is readily carried over to the dynamic PLS control framework.In addition,by projecting the measurable disturbance into the latent subspace,a multi-loop feed-forward control is yielded to achieve better performance for disturbance rejection.Simulation results of a distillation column are used to further demonstrate this new strategy outperforms conventional control schemes in servo behavior and disturbance rejection.

Design of active disturbance rejection internal model control strategy for SISO system with time delay process

A novel control scheme of active disturbance rejection internal model control(ADRIMC) is proposed to improve the anti-interference ability and robustness for the dead-time process. The active anti-interference concept is introduced into the internal model control(IMC) by analyzing the relationship between IMC and disturbance observer control(DOB). Further, a design process of disturbance filter is presented to realize the active anti-interference ability for ADRIMC scheme. The disturbance filter is used to estimate an equivalent disturbance consisting of both external disturbances and internal disturbances caused by model mismatches.Simulation results demonstrate that the proposed method possesses a good disturbance rejection performance, though losing some partial dynamic performance. In other words, the proposed method shows a tradeoff between the dynamic performance and the system robust.

Vehicle Active Steering Control Research Based on Two-DOF Robust Internal Model Control

Because of vehicle＇s external disturbances and model uncertainties,robust control algorithms have obtained popularity in vehicle stability control.The robust control usually gives up performance in order to guarantee the robustness of the control algorithm,therefore an improved robust internal model control（IMC） algorithm blending model tracking and internal model control is put forward for active steering system in order to reach high performance of yaw rate tracking with certain robustness.The proposed algorithm inherits the good model tracking ability of the IMC control and guarantees robustness to model uncertainties.In order to separate the design process of model tracking from the robustness design process,the improved 2 degree of freedom（DOF） robust internal model controller structure is given from the standard Youla parameterization.Simulations of double lane change maneuver and those of crosswind disturbances are conducted for evaluating the robust control algorithm,on the basis of a nonlinear vehicle simulation model with a magic tyre model.Results show that the established 2-DOF robust IMC method has better model tracking ability and a guaranteed level of robustness and robust performance,which can enhance the vehicle stability and handling,regardless of variations of the vehicle model parameters and the external crosswind interferences.Contradiction between performance and robustness of active steering control algorithm is solved and higher control performance with certain robustness to model uncertainties is obtained.

Generalized Internal Model Robust Control for Active Front Steering Intervention

Because of the tire nonlinearity and vehicle＇s parameters＇uncertainties,robust control methods based on the worst cases,such as H_∞,μsynthesis,have been widely used in active front steering control,however,in order to guarantee the stability of active front steering system（AFS）controller,the robust control is at the cost of performance so that the robust controller is a little conservative and has low performance for AFS control.In this paper,a generalized internal model robust control（GIMC）that can overcome the contradiction between performance and stability is used in the AFS control.In GIMC,the Youla parameterization is used in an improved way.And GIMC controller includes two sections：a high performance controller designed for the nominal vehicle model and a robust controller compensating the vehicle parameters＇uncertainties and some external disturbances.Simulations of double lane change（DLC）maneuver and that of braking on split-μroad are conducted to compare the performance and stability of the GIMC control,the nominal performance PID controller and the H_∞controller.Simulation results show that the high nominal performance PID controller will be unstable under some extreme situations because of large vehicle＇s parameters variations,H_∞controller is conservative so that the performance is a little low,and only the GIMC controller overcomes the contradiction between performance and robustness,which can both ensure the stability of the AFS controller and guarantee the high performance of the AFS controller.Therefore,the GIMC method proposed for AFS can overcome some disadvantages of control methods used by current AFS system,that is,can solve the instability of PID or LQP control methods and the low performance of the standard H_∞controller.

Improvement of precision for pendulous integrating gyro accelerometer via adaptive internal model control

An adaptive internal mode control is proposed to eliminate effectively periodic disturbance with uncertain frequency caused by input error angle of PIGA （Pendulous Integrating Gyro Accelerometer）. An adaptive algorithm with periodic disturbance frequency identification on line is applied and the internal model controller parameters are adjusted to eliminate disturbance. Then the convergence of this algorithm and the stability of the system are proved by the averaging method. Simulation results verify the proposed scheme can eliminate periodic disturbance and improve the test precision for PIGA effectively.

Support vector regression-based internal model control

This paper proposes a design of internal model control systems for process with delay by using support vector regression(SVR).The proposed system fully uses the excellent nonlinear estimation performance of SVR with the structural risk minimization principle.Closed-system stability and steady error are analyzed for the existence of modeling errors.The simulations show that the proposed control systems have the better control performance than that by neural networks in the cases of the training samples with small size and noises.

Hybrid internal model control and proportional control of chaotic dynamical systems

A new chaos control method is proposed to take advantage of chaos or avoid it. The hybrid Internal Model Control and Proportional Control learning scheme are introduced. In order to gain the desired robust performance and ensure the system's stability, Adaptive Momentum Algorithms are also developed. Through properly designing the neural network plant model and neural network controller, the chaotic dynamical systems are controlled while the parameters of the BP neural network are modified. Taking the Lorenz chaotic system as example, the results show that chaotic dynamical systems can be stabilized at the desired orbits by this control strategy.

SVM Approximate-based Internal Model Control Strategy

一台支持向量机器(SVM ) 近似底的内部模型控制(IMC ) 策略为同步发电机的蒸气 valving 控制被介绍。建议 SVM IMC 策略包括二主要部分：在内部模型结构的 SVM 近似反的控制器和无常赔偿。SVM 反的控制器经由泰勒扩大用一条输入产量近似途径直接被导出，并且没有进一步的联机训练，它通过非线性的系统鉴定被实现。而且，一个坚韧性过滤器在内部模型结构被用于无常赔偿。模拟为蒸气 valving 控制显示出 SVM IMC 策略的有效性。

Temperature Control Based on Fuzzy Logic Two-degree-of-freedom Smith Internal Model

According to the characteristics of the large time delay,nonlinearity and the great inertia of temperature control system in biomass pyrolysis reactor,a two-degree-of-freedom Smith internal model controller based on fuzzy control is proposed.Firstly,the mathematical model of the temperature control system is established by using the step response method,and then the two-degree-of-freedom Smith internal model controller is designed,and the good tracking performance and disturbance suppression performance can be obtained by designing the set value tracking controller and interference rejection capability.Secondly,the fuzzy control algorithm is used to realize the on-line tuning of the control parameters of the two-degree-of-freedom Smith internal model algorithm.The simulation results show that,compared with the traditional internal model control,fuzzy internal model PID control and two-degree-of-freedom Smith internal model control,the algorithm proposed in this paper improves the influence of lag time on the control system,realizes the separation control of set point tracking and anti-jamming performance and the self-tuning of control parameters,and improves the control performance of the system.

Model reduction and active control of flexible beam using internal balance technique

The internal balance technique is effective for the model reduction in flexible structures, especially the ones with dense frequencies. However, due to the difficulty in extracting the internal balance modal coordinates from the physical sensor readings, research on this topic has been mostly theoretical so far, and little has been done in experiments or engineering applications. This paper studies the internal balance method theoretically as well as experimentally and designs an active controller based on the reduction model. The research works on a digital signal processor （DSP） TMS320F2812- based experiment system with a flexible beam and proposes an approximate approach to access the internal balance modal coordinates. The simulation and test results have shown that the proposed approach is feasible and effective, and the designed controller is successful in restraining the beam vibration.

Eigen-Space Decomposition(ESD)Method for the Design of Internal Model Controller(IMC)from Noisy Input and Output Plant Data

A novel approach to design Internal Model Controller(IMC)is proposed in this paper directly from measuredinput and output plant data,which are assumed to becontaminated by measurement noise.In order to avoidthe complicated structure-identification problem inmost cases,two Finite Impulse Response(FIR)modelsare taken to represent the plant model and the internalmodel controller respectively.Taking account of mea-surement noise both in the plant input and its output,anESD based Total Least Squares(TLS)solution is appliedfor the unbiased identification of the plant model and itsinverse model,the latter constitutes the internal modelcontroller according to the principle that the internalmodel controller approximates the inverse dynamics ofthe plant model.Simulations are given for a testifica-tion.

Synthetical Control of AGC/LPC System Based on Neural Networks Internal Model Control

One synthetical control method of AGC/LPC system based on intelligence control theory-neural networks internal model control method is presented. Genetic algorithm (GA) is applied to optimize the parameters of the neural networks. Simulation results prove that this method is effective.

Electrostatic Suspension System Nonlinear Character Analysis and Its Internal Model Control

Nonlinearity is an important characteristic in electrostatic suspension system (ESS). This paper concludes the nonlinear parts in ESS, which generally result from the relationships between rotor displacement and capacitance, rotor displacement and electrostatic force, and control voltage and electrostatic force. In terms of the nonlinearities, a new control method with modified internal model control (IMC) was proposed to analyze the ESS, deduce the transfer function of the modified IMC controller in ESS, and simulate this new application in ESS. Comparing with proportional integral derivative (PID) control, IMC has only a parameter, and has better performance. As a result, IMC solves nonlinearity error well in ESS with only one uncertain parameter, and performs well when the rotor has large displacement.

Adaptive Internal Model Control of a DC Motor Drive System Using Dynamic Neural Network

This work concerns the study of problems relating to the adaptive internal model control of DC motor in both cases conventional and neural. The most important aspects of design building blocks of adaptive internal model control are the choice of architectures, learning algorithms, and examples of learning. The choice of parametric adaptation algorithm for updating elements of the conventional adaptive internal model control shows limitations. To overcome these limitations, we chose the architectures of neural networks deduced from the conventional models and the Levenberg-marquardt during the adjustment of system parameters of the adaptive neural internal model control. The results of this latest control showed compensation for disturbance, good trajectory tracking performance and system stability.

Optimized Model Based Controller with Model Plant Mismatch for NMP Mitigation in Boost Converter

In this paper,an optimized Genetic Algorithm(GA)based internal model controller-proportional integral derivative(IMC-PID)controller has been designed for the control variable to output variable transfer function of dc-dc boost converter to mitigate the effect of non-minimum phase(NMP)behavior due to the presence of a right-half plane zero(RHPZ).This RHPZ limits the dynamic performance of the converter and leads to internal instability.The IMC PID is a streamlined counterpart of the standard feedback controller and easily achieves optimal set point and load change performance with a single filter tuning parameterλ.Also,this paper addresses the influences of the model-based controller with model plant mismatch on the closed-loop control.The conventional IMC PID design is realized as an optimization problem with a resilient controller being determined through a genetic algorithm.Computed results suggested that GA–IMC PID coheres to the optimum designs with a fast convergence rate and outperforms conventional IMC PID controllers.

Predictive Functional Controller with a Similar Proportional Integral Optimal Regulator Structure:Comparison with Traditional Predic-tive Functional Controller and Application to Heavy Oil Coking Equipment

By extending the system's state variables,a novel predictive functional controller has been developed.The structure of this controller is similar to that of classical proportional integral(PI)optimal controller and in-cludes a control block that can perform a feed-forward control of future P-step set points.It considers both the state variables and the output errors in its cost function,which results in enhanced control performance compared with traditional state space predictive functional control(TSSPFC)methods that consider only the predictive output er-rors.The predictive functional controller(PFC)has been compared with TSSPFC in terms of tracking ability,dis-turbance rejection,and also based on its application to heavy oil coking equipment.The results obtained show the effectiveness of the controller.

Event-triggered robust cooperative output regulation for a class of linear multi-agent systems with an unknown exosystem

This paper investigates the robust cooperative output regulation problem for a class of heterogeneousuncertain linear multi-agent systems with an unknown exosystem via event-triggered control (ETC). By utilizingthe internal model approach and the adaptive control technique, a distributed adaptive internal model isconstructed for each agent. Then, based on this internal model, a fully distributed ETC strategy composed ofa distributed event-triggered adaptive output feedback control law and a distributed dynamic event-triggeringmechanism is proposed, in which each agent updates its control input at its own triggering time instants. It isshown that under the proposed ETC strategy, the robust cooperative output regulation problem can be solvedwithout requiring either the global information associated with the communication topology or the bounds ofthe uncertain or unknown parameters in each agent and the exosystem. A numerical example is provided toillustrate the effectiveness of the proposed control strategy.

Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.