Objective To investigate the expression of fractalkine(FKN) and its receptor CX3CR1 in cardiac allografts and the effect of Cyclosporin A(CsA). Methods Three groups of rats underwent heterotopic cardiac transplantatio...Objective To investigate the expression of fractalkine(FKN) and its receptor CX3CR1 in cardiac allografts and the effect of Cyclosporin A(CsA). Methods Three groups of rats underwent heterotopic cardiac transplantation, 45 cases in each group and 5 cases in control group:SD to SD regarded as isograft group (group A), Wistear to SD divided into CsA untreated allograft group(group B) and CsA treated allograft group (group C), normal SD rats as control group. The FKN mRNA expression was detected by one-step RT-PCR method and the expression of FKN and CX3CR1 protein was detected by standard ABC immunohistochemical technique. Results The expressin of FKN mRNA and protein was weak in both isografts and normal heart specimens. The changes of FKN mRNA expression were correkted with the process of acute allograft rejection. The peak of FKN mRNA expression(0.8 ±0.26) appeared on the seventh day after transplantation, which could be downregulated by CsA significantly ( t = 2.390, P 【 0.05). FKN protein was展开更多
Key facts Synonyms：dysfunction of renal transplant due to renal artery stenosis.Classic imaging appearance：narrowing of the transplant renal artery Renal artery stenosis most common vascular complication,.venous ste...Key facts Synonyms：dysfunction of renal transplant due to renal artery stenosis.Classic imaging appearance：narrowing of the transplant renal artery Renal artery stenosis most common vascular complication,.venous stenosis may also be responsible for renal dysfunction.展开更多
The main significance of witnesses＇ appearing in court to testify in criminal trials is that this practice guarantees the defendant＇s right to confrontation. The issue can thus be framed in another way, as the issue...The main significance of witnesses＇ appearing in court to testify in criminal trials is that this practice guarantees the defendant＇s right to confrontation. The issue can thus be framed in another way, as the issue of the appearance in court of the necessary witnesses. Here, the defendant＇s right to confront is the key point. Since neither China＇s criminal procedural law nor corresponding judicial interpretations have granted the defendant the right to confront, the rate of appearance of the necessary witnesses amounts in practice to only about twenty- five percent. Criminal trials conducted in the absence of the right to confrontation usually conform to the doctrine of positive substantive truth and manifest a lack of care in conviction and sentencing as well as reliance on a single source of legitimacy in reaching judgments. To correct this state of affairs, it is necessary to institute the right to confront and corresponding safeguards.展开更多
It is of great significance for witnesses to appear in court in criminal cases so as to safeguard the right of confrontation of the defendant and achieve judicial justice.However,the witnesses in criminal cases refuse...It is of great significance for witnesses to appear in court in criminal cases so as to safeguard the right of confrontation of the defendant and achieve judicial justice.However,the witnesses in criminal cases refuse to appear in court and only give written testimony,and this has become a long‑standing problem in the judicial practice of China.To solve this problem,the Criminal Procedure Law of China,amended and improved the system of the witness appearing in court in 2012.Nevertheless,if the underlying problems in the judicial system of China are not settled,the system of the witness appearing in court in criminal cases still cannot turn into practicable measures.展开更多
文摘Objective To investigate the expression of fractalkine(FKN) and its receptor CX3CR1 in cardiac allografts and the effect of Cyclosporin A(CsA). Methods Three groups of rats underwent heterotopic cardiac transplantation, 45 cases in each group and 5 cases in control group:SD to SD regarded as isograft group (group A), Wistear to SD divided into CsA untreated allograft group(group B) and CsA treated allograft group (group C), normal SD rats as control group. The FKN mRNA expression was detected by one-step RT-PCR method and the expression of FKN and CX3CR1 protein was detected by standard ABC immunohistochemical technique. Results The expressin of FKN mRNA and protein was weak in both isografts and normal heart specimens. The changes of FKN mRNA expression were correkted with the process of acute allograft rejection. The peak of FKN mRNA expression(0.8 ±0.26) appeared on the seventh day after transplantation, which could be downregulated by CsA significantly ( t = 2.390, P 【 0.05). FKN protein was
文摘Key facts Synonyms：dysfunction of renal transplant due to renal artery stenosis.Classic imaging appearance：narrowing of the transplant renal artery Renal artery stenosis most common vascular complication,.venous stenosis may also be responsible for renal dysfunction.
文摘The main significance of witnesses＇ appearing in court to testify in criminal trials is that this practice guarantees the defendant＇s right to confrontation. The issue can thus be framed in another way, as the issue of the appearance in court of the necessary witnesses. Here, the defendant＇s right to confront is the key point. Since neither China＇s criminal procedural law nor corresponding judicial interpretations have granted the defendant the right to confront, the rate of appearance of the necessary witnesses amounts in practice to only about twenty- five percent. Criminal trials conducted in the absence of the right to confrontation usually conform to the doctrine of positive substantive truth and manifest a lack of care in conviction and sentencing as well as reliance on a single source of legitimacy in reaching judgments. To correct this state of affairs, it is necessary to institute the right to confront and corresponding safeguards.
文摘It is of great significance for witnesses to appear in court in criminal cases so as to safeguard the right of confrontation of the defendant and achieve judicial justice.However,the witnesses in criminal cases refuse to appear in court and only give written testimony,and this has become a long‑standing problem in the judicial practice of China.To solve this problem,the Criminal Procedure Law of China,amended and improved the system of the witness appearing in court in 2012.Nevertheless,if the underlying problems in the judicial system of China are not settled,the system of the witness appearing in court in criminal cases still cannot turn into practicable measures.
