The pharmacokinetics of a sustained- release formulation and an enteric- coated tablet of diclofenac sodium were studied on 8 healthy male volunteers in an open,randomized crossover study.Drug level in serum was assay...The pharmacokinetics of a sustained- release formulation and an enteric- coated tablet of diclofenac sodium were studied on 8 healthy male volunteers in an open,randomized crossover study.Drug level in serum was assayed by HPLC method.The changes in serum concentration were conformed to a l-compartment open model.The t_1/2 (Ke)averaged 2.15±0.17 and ll.60 ± l.95 h,and the areas under the drug concentration curves were 5.87 ± 0.67 and 5.55 ± 0.57μgh/ml for enteric-coated and sustained-release tablet of diclofenac sodium,respectively. The mean relative bioavailability of sustained-release tablet was 0.95 to that of enteric-coated tablet.展开更多
According to the question of how to transfer data between Pro/E and ADAMS correctly, the paper gives an improved importing solution, which combines the interface and the Standard Data Format（SDF） files. It settles t...According to the question of how to transfer data between Pro/E and ADAMS correctly, the paper gives an improved importing solution, which combines the interface and the Standard Data Format（SDF） files. It settles the problems caused by improper geometry during the import conducted by the interface software. With the solution ,fea- ture points can be conveniently picked to build kinematic constraints are the preparation of the model will be simpli- fied. An example is given for the method, and corresponding simulations are conducted. The results of the simula- tions verify the validity of the solution.展开更多
文摘The pharmacokinetics of a sustained- release formulation and an enteric- coated tablet of diclofenac sodium were studied on 8 healthy male volunteers in an open,randomized crossover study.Drug level in serum was assayed by HPLC method.The changes in serum concentration were conformed to a l-compartment open model.The t_1/2 (Ke)averaged 2.15±0.17 and ll.60 ± l.95 h,and the areas under the drug concentration curves were 5.87 ± 0.67 and 5.55 ± 0.57μgh/ml for enteric-coated and sustained-release tablet of diclofenac sodium,respectively. The mean relative bioavailability of sustained-release tablet was 0.95 to that of enteric-coated tablet.
文摘According to the question of how to transfer data between Pro/E and ADAMS correctly, the paper gives an improved importing solution, which combines the interface and the Standard Data Format（SDF） files. It settles the problems caused by improper geometry during the import conducted by the interface software. With the solution ,fea- ture points can be conveniently picked to build kinematic constraints are the preparation of the model will be simpli- fied. An example is given for the method, and corresponding simulations are conducted. The results of the simula- tions verify the validity of the solution.
