Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer's disease and related neurodegenerative conditions

Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.

Multiplet relative location approach and waveform correlation correction and their application

The theory and method of relative location technique were described in the paper. The travel-time difference equa-tions for five phases (Pg, Sg, P11, S11 and Pn) were given. By using the multiplet relative location approach and wave correlation correction, the aftershock cluster of the Shunyi earthquake occurred on December 16, 1996 was relocated. The depth calculation was constrained by using multiple seismic phases. The relocation results were compared with that from traditional absolute location techniques.

Research on the rheological properties of pesticide suspension concentrate

This study reports research on pesticide suspension rheology and a new rheological parameter, the relative value of approach, which has great advantage for judging the physical stability of a pesticide suspension concentrate. Experiments showed that the system can form stable dispersions when the value of the relative value of approach (Sr) is less than 0.1.

Optimal paths planning in dynamic transportation networks with random link travel times

A theoretical study was conducted on finding optimal paths in transportation networks where link travel times were stochastic and time-dependent(STD). The methodology of relative robust optimization was applied as measures for comparing time-varying, random path travel times for a priori optimization. In accordance with the situation in real world, a stochastic consistent condition was provided for the STD networks and under this condition, a mathematical proof was given that the STD robust optimal path problem can be simplified into a minimum problem in specific time-dependent networks. A label setting algorithm was designed and tested to find travelers' robust optimal path in a sampled STD network with computation complexity of O(n2+n·m). The validity of the robust approach and the designed algorithm were confirmed in the computational tests. Compared with conventional probability approach, the proposed approach is simple and efficient, and also has a good application prospect in navigation system.

Kuhnian Understanding of Incommensurability and Implications of Paradigmatic Conception of Knowledge in International Relations

In international relations theory （maybe more than in any other discipline of social sciences）, the paradigmatic construction of Thomas Kuhn and his model of incommensurability might be applied to the theoretical interpretation of phenomena; and it is one of the cornerstones of the methodological toolkit for the interpretation in this field. The paper explores the reason why Kuhn＇s understanding of incommensurability seems to be necessary for the conception of knowledge in international relations： the concept of incommensurability can be considered typical as it is meant to indicate a conflict, of one form or another, between theories. And the discipline of international relations is more than a perfect ground for considering this concept when one is having in mind the high degree of polarized debate among rivalry theoretical schools （for interpreting and describing the identical phenomena） that is present from the very beginning of the discipline. Recalling the Kuhnian conception of science in paradigmatic view with an aim for understanding--international relations theory, the paper analyzes furthermore his rejection of the traditional dichotomy between “objectivisn”and ＂subjectivism.＂

A Relation Matrix Approach to Labelling Temporal Relations in Scheduling

In this paper,we present a relation matrix description of temporal relations.Based on this modela new algorithm for labelling temporal relations is proposed.Under certain conditions the algorithm iscompleted and has a polynomial complexity.In general cases it is still an efficient algorithm comparedto some known algorithms.

资源行动视角下中国企业跨国并购的合作型整合机制——基于海信的案例研究

随着贸易保护主义和单边主义的盛行,跨国并购和整合发达国家企业成为中国企业参与国际分工与合作、重塑开放型世界经济体系的重要方式。然而,面对与发达国家企业在制度文化、战略资产、管理模式等方面的差异,中国企业如何通过支持性合作模式实现高效整合,仍未得到充分的理论解释。本文基于资源行动视角,以中国家电领军企业海信集团为研究对象,通过对海信跨国并购后整合TVS和Gorenje的嵌入式案例研究,探讨跨国并购后如何采取资源行动策略以形成支持性合作模式,进而实现高效整合。研究发现,第一,跨国并购后整合中的资源相关性可以解构为资源可转移性和资源互补性两个维度,并在不同类型的跨国并购后整合中呈现出差异化特征;第二,由于并购双方资源的可转移性和互补性特征差异,并购企业分别聚焦于整合中的资源嵌入和资源桥接,采取不同的资源构建、资源重组和资源利用等行动策略;第三,在不同的资源行动策略下,并购企业分别形成了驱动型和联动型两类支持性合作模式,实现跨国并购后的高效整合。本文形成的理论机制对理解中国企业独特的跨国并购后整合模式具有重要意义,响应了近期学者对研究如何实现新兴市场企业跨国并购后有效整合的呼吁。

Two topological approaches to resonance energy and the relation between them

Two of the present authors recently put forward a novel approach to resonance energy which is based on a similar topological reasoning as a previously elaborated resonance energy concept. It is shown that these two approaches are not completely equivalent. Several other properties of the new resonance energy are pointed out.