Five molecular related indexes: MOL, SIM, d2, H0and PIC of 15 turbot parent pairs were estimated by using 10 SSR loci, which were used in correlation analysis with growth traits, DIL and DIW, of family filial from tho...Five molecular related indexes: MOL, SIM, d2, H0and PIC of 15 turbot parent pairs were estimated by using 10 SSR loci, which were used in correlation analysis with growth traits, DIL and DIW, of family filial from those 15 parent pairs.DIL and DIW were regressed on the MOL, SIM, d2, H0and PIC. Results showed MOL of five SSR loci(12, 17, 24, 81 and 85) and SIM of five loci(17, 21, 24, 81and 85) all shared significant positive correlation with DIL(r=0.482, P=0.035 and r=0.479, P=0.035, respectively); H0of six SSR loci(11, 17, 21, 24, 26 and 85) had significant positive correlation with DIW(r=0.551, P=0.017); PIC of two SSR loci(9and 26) had significant positive(r=0.519, P=0.024) correlation with DIL, while that and of four loci(17, 24, 27 and 85) had significant negative correlation(r=-0.519,P=0.024), with DIL. This present study suggested that filial growth expression could be predicted by using molecular related indexes in turbot breeding practice, and the accuracy of prediction depends on more SSR loci, especially associated with QTL.展开更多
The Cheng index distinguishes indica andjaponica rice based on six taxonomic traits.This index has been widely used for classifi- cation of indica and japonica varieties in China.In this study,a double haploid(DH)popu...The Cheng index distinguishes indica andjaponica rice based on six taxonomic traits.This index has been widely used for classifi- cation of indica and japonica varieties in China.In this study,a double haploid(DH)popula-tion derived from anther culture of ZYQ8/JX17 F,a typical inter-subspecies hybrid,was used to investigate the six taxonomictraits,i.e.leaf hairiness(LH),color of hullwhen heading(CHH),hairiness of hull(HH),length of the first and second panicle internode(LPI),length/width of grain(L/W),andphenol reaction(PH).The morphological in- dex(MI)was also calculated.Based on themolecular linkage map constructed from this展开更多
SCIENCE CITATION INDEX EXPANDED-NEUROSCIENCES-JOURNAL LIST Total journals: 245 1. ACS CHEMICAL NEUROSCIENCE Monthly ISSN: 1948-7193 AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036 · Science Cita...SCIENCE CITATION INDEX EXPANDED-NEUROSCIENCES-JOURNAL LIST Total journals: 245 1. ACS CHEMICAL NEUROSCIENCE Monthly ISSN: 1948-7193 AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036 · Science Citation Index Expanded · BIOSIS Previews展开更多
Objective Airborne microbial communities include a significant number of uncultured and poorly characterized bacteria.No effective method currently exists to evaluate the health risks of such complex bacterial populat...Objective Airborne microbial communities include a significant number of uncultured and poorly characterized bacteria.No effective method currently exists to evaluate the health risks of such complex bacterial populations,particularly for pneumonia.Methods We developed a method to evaluate risks from airborne microorganisms,guided by the principle that closer evolutionary relationships reflect similar biological characteristics,and thus used16 S rDNA sequences of 10 common pneumonia-related bacterial pathogens.We calculated a risk of breath-related(Rbr)index of airborne bacterial communities and verified effectiveness with artificial flora and a clinical project.Results We suggested applying Rbr80 to evaluate the health risks of airborne bacterial communities that comprise 80% of dominant operational taxonomic units(OTUs).The feasibility of Rbr80 was confirmed by artificial flora and by pneumonia data from a hospital.A high Rbr80 value indicated a high risk of pneumonia from airborne bacterial communities.Conclusion Rbr80 is an effective index to evaluate the pneumonia-associated risk from airborne bacteria.Values of Rbr80 greater than 15.40 are considered high risk.展开更多
Background:This study compared the validity of the creatinine-to-cystatin C ratio(CCR),sarcopenia index(SI),and relative skeletalmuscle index(RSMI)as predictors of sarcopenia in patients with colorectal cancer(CRC)and...Background:This study compared the validity of the creatinine-to-cystatin C ratio(CCR),sarcopenia index(SI),and relative skeletalmuscle index(RSMI)as predictors of sarcopenia in patients with colorectal cancer(CRC)and explored their impact on the patient prognosis.Methods:We retrospectively studied patients with CRC who underwent surgical intervention at the Department of Colorectal and Anal Surgery,situatedwithin the First Affiliated Hospital of GuangxiMedical University.The investigation spanned from January 2015 to December 2017,encompassing a cohort of patients subject to surgical management forCRC during this period.Pearson’s correlation analysis was employed to evaluate the relationships between the CCR,SI,RSMI,and skeletal muscle index(SMI)and the patient prognosis.Receiver operating characteristic(ROC)curves were generated to evaluate the predictive precision of these biomarkers and ascertain the optimal cutoff values.Multivariate logistic regression analysis was conducted to pinpoint the independent factors linked with sarcopenia.Survival analyses,contingent on different surrogate markers of muscle mass and sarcopenia,were performed utilizing the Kaplan-Meier method alongside the log-rank test.Results:Weenrolled 815 patientswithCRC(522 male and 293 female patients)whowere eligible for the analysis.In accordancewith the guidelines set forth by the International Consensus on Sarcopenia,sarcopenia was diagnosed in a collective total of 503 patients.A Pearson’s correlation coefficient(r)analysis demonstrated that the CCR,SI,and RSMI were positively correlated with the SMI.In both male and female patients,the RSMI(male:r=0.400,P<0.001;female:r=0.640,P<0.001)was more strongly correlated with the SMI than with the CCR(male:r=0.203,P<0.001;female:r=0.192,P<0.001)or SI(male:r=0.335,P<0.001;female:r=0.285,P<0.001).In male patients,the areas under the ROC curves(AUC)for the CCR,SI,and RSMI were 0.596[(95%confidence interval(CI)=0.545-0.647)],0.648(95%CI=0.599-0.698),and 0.681(95%CI=0.629-0.733),respectively.In female patients,the AUC for the CCR,SI,and RSMI were 0.615(95%CI=0.551-0.680),0.660(95%CI=0.598-0.722),and 0.772(95%CI=0.719-0.825),respectively.A multivariable logistic regression analysis demonstrated that the CCR remained an influential factor for sarcopenia after correcting for confounding[odds ratio(OR)=0.993,95%CI=0.986-1.000,P=0.038].The SI and RSMI also remained influential factors for sarcopenia after correcting for confounding factors(OR=0.983,95%CI=0.972-0.994,P=0.002;and OR=0.401,95%CI=0.320-0.502,P<0.001,respectively).The groups characterized by low CCR and SI demonstrated notably reduced overall survival compared with their counterparts with high CCR and SI(P=0.007 and P=0.001,respectively),whereas the RSMI and sarcopenia did not exhibit a significant correlation with survival(P=0.608 and P=0.062,respectively).Conclusions:The CCR,SI,and RSMI all have predictive value for sarcopenia in patients with CRC.TheRSMI was a better predictor of sarcopenia than either the CCR or SI in both male and female patientswith CRC.However,the RSMI did not have any significant value for predicting the prognosis of patients with CRC.Subsequent prospective investigations are warranted to elucidate a superiormarker or amalgamation thereof,capable of accurately prognosticating sarcopenia and the overall prognosis in individuals diagnosed with CRC.Such studies should aim to meticulously evaluate a comprehensive array of potential markers,considering their individual and collective predictive value in delineating the clinical trajectory of CRC patients.By conducting rigorous prospective analyses,researchers can strive to uncover novel insights into the complex interplay between sarcopenia and CRC outcomes,thereby facilitating the development of more precise prognostic models and tailored therapeutic approaches.展开更多
Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai Lake.The results from Relative Brightness ...Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai Lake.The results from Relative Brightness In-dex(RBI )as well as those from the lithological analyses of bulk sediments,total organic carbon and granulometric analy-ses have been used to reconstruct the environmental and climatic evoluti on of the area.The ages were provided by three 14 C datings.The record suggested a climate fluctuation between warm-dry a nd cool-wet from ca.57to 32ka B.P.,which led a shallowing and swamping of the l ake.The water level again increased quickly at ca.32ka B.P.,reached it’ s peak during LGM(Last Glacial Maximum,ca.18-20ka B.P.)and remained relative high until ca.15ka B.P.The high wa-ter level at LGM is attributed to cold-wet conditions.The area experienced an abrupt and unstable climatic ch anges dur-ing the transition period from15to 10ka B.P.with a dominated littoral en vironment.Awarm-dry climate led to the contrac-tion of the lake during the Holocene a nd reed-swamps became dominant.After a minor wet-cool pulse during the L ate Holocene,the modern climate became to be established.展开更多
In this paper,with the relative Morse index,we will study the existence of solutions of(1.1)under the assumptions that V satisfies some weaker conditions than those in[2].
On-time completion of road infrastructure projects is a critical goal.When projects were not completed on schedule and real construction progress is slower than expected,the inconvenience and disruption to business ac...On-time completion of road infrastructure projects is a critical goal.When projects were not completed on schedule and real construction progress is slower than expected,the inconvenience and disruption to business access increases.On time completion is linked to economic and social welfare,as well as safety.Construction delays continue to be a typical occurrence,despite the need of prompt completion.A literature study is conducted in this context in order to learn more about the causes and factors that contribute to delays.Following a thorough review of the literature,it was determined that a questionnaire survey is the most effective and trustworthy way for gathering information about the causes and quantifying delays caused by emergent factors.The Relative Importance Index(RII)method was used to analyze the data,and the reasons for the delay were prioritized according to their importance.This study focuses on the emergent concerns/causes and reasons of concern in road infrastructure projects,as well as how to priorities these issues sequentially during the planning stage.This study survey can assist construction companies doing business in India in understanding the essential or sensitive issues that require special attention in order to conduct their businesses smoothly in this country while employing appropriate project management practices.展开更多
Urban heritage is a vital resource that connects communities to their local identity.Unplanned developments and rapid urbanisation often harm the authenticity of historic areas,disrupting the cultural fabric and alter...Urban heritage is a vital resource that connects communities to their local identity.Unplanned developments and rapid urbanisation often harm the authenticity of historic areas,disrupting the cultural fabric and altering their character.This study introduces the Relative Positive Impact Index(RPll),a novel technique for assessing the socio-cultural impacts of urban revitalisation.The significance of RPII lies in its ability to quantitatively evaluate the impacts on the cultural fabric and integrity of historic urban areas,which is crucial for sustainable urban development.The study's objective is to apply RPII in evaluating qualitative socio-cultural characteristics in historic urban areas,with a focus on four main criteria and 16 sub-criteria,in the case of the Kuttichira precinct.The methodology integrates the analysis of published literature,a quantitative survey mapping the stakeholders'perception,and qualitative insights.This approach facilitates an in-depth understanding of how urban revitalisation affects local socio-cultural dynamics,preserving the authenticity and character of historic areas.The study reveals that the revitalisation project in Kuttichira positively impacts the socio-cultural fabric of the area,maintaining cultural integrity and addressing social challenges.These findings offer valuable insights for sustainable urban development and policymaking in historic areas.The study recommends the application of RPll in other urban precincts for comparative analysis and further development of urban development practices,contributing to informed urban policy and planning decisions.展开更多
现有的链路预测方法仅考虑单种链路类型预测或多种链路类型的独立预测,经常使得预测结果不够准确。为此,研究了异构信息网络中多种链路类型的协同预测问题。根据源节点的相似节点和目标节点的相似节点之间的当前链路信息,提出了同质连...现有的链路预测方法仅考虑单种链路类型预测或多种链路类型的独立预测,经常使得预测结果不够准确。为此,研究了异构信息网络中多种链路类型的协同预测问题。根据源节点的相似节点和目标节点的相似节点之间的当前链路信息,提出了同质连接原理,设计了一种针对不同类型节点的相关性指标,用于描述不同类型节点间的链路存在概率,并将其与传统的邻近性指标相结合拓展到异构链路预测中。然后,将异构信息网络中的被标记数据和无标记数据融合起来,提出一种异构链路协同预测算法(Heterogeneous Collective Link Prediction,HCLP),通过获得不同类型链路间的各种复杂关系,结合互补性预测信息,实现多种链路类型的协同预测。基于真实场景的实验结果表明,所提的链路协同预测方法可有效提升异构信息网络的链路预测性能。展开更多
为探索研究尺度、零模型与群落谱系结构的关系,在小秦岭自然保护区建立1 hm^2样地,运用约束型、非约束型零模型分别从10、20、25 m 3个研究尺度上分析群落谱系结构,结果表明:(1)非约束型模型下,谱系结构聚集;约束型模型下,10、20 m尺度...为探索研究尺度、零模型与群落谱系结构的关系,在小秦岭自然保护区建立1 hm^2样地,运用约束型、非约束型零模型分别从10、20、25 m 3个研究尺度上分析群落谱系结构,结果表明:(1)非约束型模型下,谱系结构聚集;约束型模型下,10、20 m尺度上,谱系聚集,25 m尺度上谱系分散。对比发现,随研究尺度增大,谱系聚集程度降低,趋于分散,可能是由于环境异质性对物种分布的影响程度降低,密度制约作用增强所致。(2)空间因子对谱系结构的影响远远大于地形因子,随研究尺度增加,空间因子及地形因子的解释量逐渐增大。地形的不同营造了不同的空间差异,二者密切相关。因此,空间因子是影响谱系结构形成的直接因素,而地形因子是间接因素。展开更多
This paper describes a new semi-quantitative streamlined life cycle assessment(SLCA)method,the Environmental Relative Burden Index(ERBI),for describing and ranking the relative environmental burdens associated with fa...This paper describes a new semi-quantitative streamlined life cycle assessment(SLCA)method,the Environmental Relative Burden Index(ERBI),for describing and ranking the relative environmental burdens associated with facility operations and maintenance options.The long-range goal is for this ERBI method to serve as a pollution-prevention decision support tool for facilities managers,when faced with competing operations and maintenance alternatives.The specific application pre-sented in this paper evaluates asbestos-containing materials(ACM)and lead-based paint(LBP)management options in public school facilities.The ERBI methodol-ogy is adapted from previous streamlined semi-quantitative LCA methodologies and is described in detail.The ERBI is then employed to evaluate the relative environmental impacts of six management strategies for these hazardous building materials:management in-situ,encapsulation/containment,and full abatement/disposal,for both ACM and LBP.SLCA goal definition,system boundaries,ERBI matrix,and overall ERBI Ratings(RERB)for each material management strategy are presented.The ERBI can be a useful tool in prioritizing building maintenance alternatives,especially in cases where detailed quantitative data are unavailable.展开更多
By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentratio...By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.展开更多
Cross combinations from six rapeseed cultivars and lines were evaluated under waterlogging stress condition in order to understand the genetic mechanism of waterlogging tolerance of Brassica napus L.and provide reason...Cross combinations from six rapeseed cultivars and lines were evaluated under waterlogging stress condition in order to understand the genetic mechanism of waterlogging tolerance of Brassica napus L.and provide reasonable improvement programs.There were six germination traits investigated on combining ability and heritability using complete diallel crossing method designed for 30 combinations from those six cultivars and lines.The traits included relative root length,stem length,fresh weight per plant,survival rate,electrical conductivity,and vigor index.After flooding treatment,the six traits of parents and F1 were analyzed.The general combining ability(GCA) and special combining ability(SCA) of germination traits were analyzed using Griffing I method.Among 30 cross combinations,the GCA was significantly different among six waterlogging resistance traits.The SCA of these traits was significantly different except the SCA of electrical conductivity.As a representative trait of waterlogging tolerance in rapeseed,relative vigor index had the highest narrow heritability and relatively low broad heritability.The cultivars Zhongshuang 9 and P79 had higher tolerance potential to waterlogging stress.It can be concluded that combining ability and genetic effects of relative vigor index during germination stage could be used to identify the waterlogging tolerance of rapeseed in breeding program.展开更多
The present study area,Dadra and Nagar Haveli,contains several lineaments and traces of active faults.The various aspect of the geomo rphic analysis,i.e.,stream length(SL) gradient,hypsometric integral(HI),basin shape...The present study area,Dadra and Nagar Haveli,contains several lineaments and traces of active faults.The various aspect of the geomo rphic analysis,i.e.,stream length(SL) gradient,hypsometric integral(HI),basin shape(BS),valley floor(VF),have been applied to evaluate the relative index of active tectonics(RIAT) of the Damanganga watershed.The high and low zones of tectonic activity have been identified based on the geomorphic analysis of the watershed.After evaluation of all indices,three classes,class IIhigh(1.3 ≤RIAT <1.5),class Ⅲ-moderate(1.5 ≤RIAT <1.8),and class Ⅳ-low(1.8 ≤RIAT),have been obtained to outline the degree/gradation of comparative tectonic activities in the study area.The appraised outcome of the RIAT dispersal is also well reinforced by the geomorphic evidence in the field.The collective outcomes of geomorphic evidence,such as stream deflection and analysis of lineament,deflection of streams,and geomorphic indices,conceal that the Damanganga watershed is affected by tectonic activity.展开更多
Biodiversity distribution patterns are a basic and long-standing but crucial aspect of ecology research.These patterns form the primary source of data used to develop biodiversity protection practices,especially in mo...Biodiversity distribution patterns are a basic and long-standing but crucial aspect of ecology research.These patterns form the primary source of data used to develop biodiversity protection practices,especially in mountain ecosystems.Shrubs comprise one of the main types of vegetation on the Qinghai–Tibetan Plateau,where they serve vital ecological functions.In this study,we used a community phylogenetic approach to examine the distribution patterns of shrub communities along the longitudinal and latitudinal gradients on the northeastern Qinghai–Tibetan Plateau.We observed significant latitudinal trends in both the phylogenetic diversity(PD)and net relatedness index(NRI)values of shrub communities,such that the former decreased and the latter increased with increasing latitude.However,no significant PD,NRI and nearest taxon index(NTI)distribution patterns were observed along a longitudinal gradient.A further analysis revealed that the combination of temperature-related and precipitation-related climate variables most strongly affected the PD,NRI and NTI values of shrub communities,indicating that the latitudinal patterns in the PD,NRI and NTI of a shrub community may be determined mainly by interactions with these climate factors.展开更多
Growth inhibitory activity has proven important in Qiufeng×Baiyu and Qingsong×Haoyue silkworm larvae. The consumption of mulberry leaves was reduced in both silkworm races while Qiufeng×Baiyu larvae s...Growth inhibitory activity has proven important in Qiufeng×Baiyu and Qingsong×Haoyue silkworm larvae. The consumption of mulberry leaves was reduced in both silkworm races while Qiufeng×Baiyu larvae showed the higher reduction in leaf consumption. From the results obtained, it was revealed that even at low concentrations of 400 mg/L of either Cr(Ⅲ) or Cr(Ⅵ) ions, growth of Qiufeng × Baiyu and Qingsong × Haoyue was significantly depressed. Depression in relative growth index(RGI) and high death rate in both silkworm races indicated that the different concentrations of the two ions used caused their growth inhibitions. Through linear regression analysis, the EC 50 (concentration of the compound that caused 50% reduction) was interpolated for both tested compounds. EC 50 (mg/L) of Cr (Ⅲ) ions in Qiufeng × Baiyu and Qingsong × Haoyue were 800 and 600 respectively. EC 50 (mg/L) of Cr(Ⅵ) ions in Qiufeng × Baiyu and Qingsong × Haoyue was 600 and 316 respectively. According to the analysis of relative growth index, and an analysis of linear regression technique for measuring the growth of the silkworm races, it was indicated that the form of Cr affected growth rates, growth inhibition responses of the larvae, and toxicological effects. Thus, form and quantity of Cr accumulating in silkworms reared with contaminated leaves are likely to influence their population dynamics.展开更多
文摘Five molecular related indexes: MOL, SIM, d2, H0and PIC of 15 turbot parent pairs were estimated by using 10 SSR loci, which were used in correlation analysis with growth traits, DIL and DIW, of family filial from those 15 parent pairs.DIL and DIW were regressed on the MOL, SIM, d2, H0and PIC. Results showed MOL of five SSR loci(12, 17, 24, 81 and 85) and SIM of five loci(17, 21, 24, 81and 85) all shared significant positive correlation with DIL(r=0.482, P=0.035 and r=0.479, P=0.035, respectively); H0of six SSR loci(11, 17, 21, 24, 26 and 85) had significant positive correlation with DIW(r=0.551, P=0.017); PIC of two SSR loci(9and 26) had significant positive(r=0.519, P=0.024) correlation with DIL, while that and of four loci(17, 24, 27 and 85) had significant negative correlation(r=-0.519,P=0.024), with DIL. This present study suggested that filial growth expression could be predicted by using molecular related indexes in turbot breeding practice, and the accuracy of prediction depends on more SSR loci, especially associated with QTL.
文摘The Cheng index distinguishes indica andjaponica rice based on six taxonomic traits.This index has been widely used for classifi- cation of indica and japonica varieties in China.In this study,a double haploid(DH)popula-tion derived from anther culture of ZYQ8/JX17 F,a typical inter-subspecies hybrid,was used to investigate the six taxonomictraits,i.e.leaf hairiness(LH),color of hullwhen heading(CHH),hairiness of hull(HH),length of the first and second panicle internode(LPI),length/width of grain(L/W),andphenol reaction(PH).The morphological in- dex(MI)was also calculated.Based on themolecular linkage map constructed from this
文摘SCIENCE CITATION INDEX EXPANDED-NEUROSCIENCES-JOURNAL LIST Total journals: 245 1. ACS CHEMICAL NEUROSCIENCE Monthly ISSN: 1948-7193 AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036 · Science Citation Index Expanded · BIOSIS Previews
基金supported by the CAMS Innovation Fund for Medical Science[CIFMS,2018-I2M-1-001]the National Key R&D Program of China[2017YFC0702800]+1 种基金the National Natural Science Foundation of China[82070103]the Central Public-interest Scientific Institution Basal Research Fund[2016ZX310037]。
文摘Objective Airborne microbial communities include a significant number of uncultured and poorly characterized bacteria.No effective method currently exists to evaluate the health risks of such complex bacterial populations,particularly for pneumonia.Methods We developed a method to evaluate risks from airborne microorganisms,guided by the principle that closer evolutionary relationships reflect similar biological characteristics,and thus used16 S rDNA sequences of 10 common pneumonia-related bacterial pathogens.We calculated a risk of breath-related(Rbr)index of airborne bacterial communities and verified effectiveness with artificial flora and a clinical project.Results We suggested applying Rbr80 to evaluate the health risks of airborne bacterial communities that comprise 80% of dominant operational taxonomic units(OTUs).The feasibility of Rbr80 was confirmed by artificial flora and by pneumonia data from a hospital.A high Rbr80 value indicated a high risk of pneumonia from airborne bacterial communities.Conclusion Rbr80 is an effective index to evaluate the pneumonia-associated risk from airborne bacteria.Values of Rbr80 greater than 15.40 are considered high risk.
基金supported by the Guangxi Medical and Health Appropriate Technology Development and Application Project(No.S2021095)Undergraduate Enrollment Project of Guangxi Medical University(No.S202410598186).
文摘Background:This study compared the validity of the creatinine-to-cystatin C ratio(CCR),sarcopenia index(SI),and relative skeletalmuscle index(RSMI)as predictors of sarcopenia in patients with colorectal cancer(CRC)and explored their impact on the patient prognosis.Methods:We retrospectively studied patients with CRC who underwent surgical intervention at the Department of Colorectal and Anal Surgery,situatedwithin the First Affiliated Hospital of GuangxiMedical University.The investigation spanned from January 2015 to December 2017,encompassing a cohort of patients subject to surgical management forCRC during this period.Pearson’s correlation analysis was employed to evaluate the relationships between the CCR,SI,RSMI,and skeletal muscle index(SMI)and the patient prognosis.Receiver operating characteristic(ROC)curves were generated to evaluate the predictive precision of these biomarkers and ascertain the optimal cutoff values.Multivariate logistic regression analysis was conducted to pinpoint the independent factors linked with sarcopenia.Survival analyses,contingent on different surrogate markers of muscle mass and sarcopenia,were performed utilizing the Kaplan-Meier method alongside the log-rank test.Results:Weenrolled 815 patientswithCRC(522 male and 293 female patients)whowere eligible for the analysis.In accordancewith the guidelines set forth by the International Consensus on Sarcopenia,sarcopenia was diagnosed in a collective total of 503 patients.A Pearson’s correlation coefficient(r)analysis demonstrated that the CCR,SI,and RSMI were positively correlated with the SMI.In both male and female patients,the RSMI(male:r=0.400,P<0.001;female:r=0.640,P<0.001)was more strongly correlated with the SMI than with the CCR(male:r=0.203,P<0.001;female:r=0.192,P<0.001)or SI(male:r=0.335,P<0.001;female:r=0.285,P<0.001).In male patients,the areas under the ROC curves(AUC)for the CCR,SI,and RSMI were 0.596[(95%confidence interval(CI)=0.545-0.647)],0.648(95%CI=0.599-0.698),and 0.681(95%CI=0.629-0.733),respectively.In female patients,the AUC for the CCR,SI,and RSMI were 0.615(95%CI=0.551-0.680),0.660(95%CI=0.598-0.722),and 0.772(95%CI=0.719-0.825),respectively.A multivariable logistic regression analysis demonstrated that the CCR remained an influential factor for sarcopenia after correcting for confounding[odds ratio(OR)=0.993,95%CI=0.986-1.000,P=0.038].The SI and RSMI also remained influential factors for sarcopenia after correcting for confounding factors(OR=0.983,95%CI=0.972-0.994,P=0.002;and OR=0.401,95%CI=0.320-0.502,P<0.001,respectively).The groups characterized by low CCR and SI demonstrated notably reduced overall survival compared with their counterparts with high CCR and SI(P=0.007 and P=0.001,respectively),whereas the RSMI and sarcopenia did not exhibit a significant correlation with survival(P=0.608 and P=0.062,respectively).Conclusions:The CCR,SI,and RSMI all have predictive value for sarcopenia in patients with CRC.TheRSMI was a better predictor of sarcopenia than either the CCR or SI in both male and female patientswith CRC.However,the RSMI did not have any significant value for predicting the prognosis of patients with CRC.Subsequent prospective investigations are warranted to elucidate a superiormarker or amalgamation thereof,capable of accurately prognosticating sarcopenia and the overall prognosis in individuals diagnosed with CRC.Such studies should aim to meticulously evaluate a comprehensive array of potential markers,considering their individual and collective predictive value in delineating the clinical trajectory of CRC patients.By conducting rigorous prospective analyses,researchers can strive to uncover novel insights into the complex interplay between sarcopenia and CRC outcomes,thereby facilitating the development of more precise prognostic models and tailored therapeutic approaches.
文摘Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai Lake.The results from Relative Brightness In-dex(RBI )as well as those from the lithological analyses of bulk sediments,total organic carbon and granulometric analy-ses have been used to reconstruct the environmental and climatic evoluti on of the area.The ages were provided by three 14 C datings.The record suggested a climate fluctuation between warm-dry a nd cool-wet from ca.57to 32ka B.P.,which led a shallowing and swamping of the l ake.The water level again increased quickly at ca.32ka B.P.,reached it’ s peak during LGM(Last Glacial Maximum,ca.18-20ka B.P.)and remained relative high until ca.15ka B.P.The high wa-ter level at LGM is attributed to cold-wet conditions.The area experienced an abrupt and unstable climatic ch anges dur-ing the transition period from15to 10ka B.P.with a dominated littoral en vironment.Awarm-dry climate led to the contrac-tion of the lake during the Holocene a nd reed-swamps became dominant.After a minor wet-cool pulse during the L ate Holocene,the modern climate became to be established.
基金Supported by DEU of Henan(Grant No.19A110011)and PSF of China(Grant No.188576).
文摘In this paper,with the relative Morse index,we will study the existence of solutions of(1.1)under the assumptions that V satisfies some weaker conditions than those in[2].
文摘On-time completion of road infrastructure projects is a critical goal.When projects were not completed on schedule and real construction progress is slower than expected,the inconvenience and disruption to business access increases.On time completion is linked to economic and social welfare,as well as safety.Construction delays continue to be a typical occurrence,despite the need of prompt completion.A literature study is conducted in this context in order to learn more about the causes and factors that contribute to delays.Following a thorough review of the literature,it was determined that a questionnaire survey is the most effective and trustworthy way for gathering information about the causes and quantifying delays caused by emergent factors.The Relative Importance Index(RII)method was used to analyze the data,and the reasons for the delay were prioritized according to their importance.This study focuses on the emergent concerns/causes and reasons of concern in road infrastructure projects,as well as how to priorities these issues sequentially during the planning stage.This study survey can assist construction companies doing business in India in understanding the essential or sensitive issues that require special attention in order to conduct their businesses smoothly in this country while employing appropriate project management practices.
文摘Urban heritage is a vital resource that connects communities to their local identity.Unplanned developments and rapid urbanisation often harm the authenticity of historic areas,disrupting the cultural fabric and altering their character.This study introduces the Relative Positive Impact Index(RPll),a novel technique for assessing the socio-cultural impacts of urban revitalisation.The significance of RPII lies in its ability to quantitatively evaluate the impacts on the cultural fabric and integrity of historic urban areas,which is crucial for sustainable urban development.The study's objective is to apply RPII in evaluating qualitative socio-cultural characteristics in historic urban areas,with a focus on four main criteria and 16 sub-criteria,in the case of the Kuttichira precinct.The methodology integrates the analysis of published literature,a quantitative survey mapping the stakeholders'perception,and qualitative insights.This approach facilitates an in-depth understanding of how urban revitalisation affects local socio-cultural dynamics,preserving the authenticity and character of historic areas.The study reveals that the revitalisation project in Kuttichira positively impacts the socio-cultural fabric of the area,maintaining cultural integrity and addressing social challenges.These findings offer valuable insights for sustainable urban development and policymaking in historic areas.The study recommends the application of RPll in other urban precincts for comparative analysis and further development of urban development practices,contributing to informed urban policy and planning decisions.
文摘现有的链路预测方法仅考虑单种链路类型预测或多种链路类型的独立预测,经常使得预测结果不够准确。为此,研究了异构信息网络中多种链路类型的协同预测问题。根据源节点的相似节点和目标节点的相似节点之间的当前链路信息,提出了同质连接原理,设计了一种针对不同类型节点的相关性指标,用于描述不同类型节点间的链路存在概率,并将其与传统的邻近性指标相结合拓展到异构链路预测中。然后,将异构信息网络中的被标记数据和无标记数据融合起来,提出一种异构链路协同预测算法(Heterogeneous Collective Link Prediction,HCLP),通过获得不同类型链路间的各种复杂关系,结合互补性预测信息,实现多种链路类型的协同预测。基于真实场景的实验结果表明,所提的链路协同预测方法可有效提升异构信息网络的链路预测性能。
基金made possible through grant funding from the U.S.National Science Foundation(EEC-0926289).
文摘This paper describes a new semi-quantitative streamlined life cycle assessment(SLCA)method,the Environmental Relative Burden Index(ERBI),for describing and ranking the relative environmental burdens associated with facility operations and maintenance options.The long-range goal is for this ERBI method to serve as a pollution-prevention decision support tool for facilities managers,when faced with competing operations and maintenance alternatives.The specific application pre-sented in this paper evaluates asbestos-containing materials(ACM)and lead-based paint(LBP)management options in public school facilities.The ERBI methodol-ogy is adapted from previous streamlined semi-quantitative LCA methodologies and is described in detail.The ERBI is then employed to evaluate the relative environmental impacts of six management strategies for these hazardous building materials:management in-situ,encapsulation/containment,and full abatement/disposal,for both ACM and LBP.SLCA goal definition,system boundaries,ERBI matrix,and overall ERBI Ratings(RERB)for each material management strategy are presented.The ERBI can be a useful tool in prioritizing building maintenance alternatives,especially in cases where detailed quantitative data are unavailable.
文摘By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.
基金supported by the National High-Tech Research and Development Program of China (863 Program,2006AA10Z1C2)the Key Technologies R&D Program of China during the 10th Five-Year Plan period (2009BADA8B01,2110BAD01B09)the Natural Science Foundation of Hubei Province,China(2009CDA089)
文摘Cross combinations from six rapeseed cultivars and lines were evaluated under waterlogging stress condition in order to understand the genetic mechanism of waterlogging tolerance of Brassica napus L.and provide reasonable improvement programs.There were six germination traits investigated on combining ability and heritability using complete diallel crossing method designed for 30 combinations from those six cultivars and lines.The traits included relative root length,stem length,fresh weight per plant,survival rate,electrical conductivity,and vigor index.After flooding treatment,the six traits of parents and F1 were analyzed.The general combining ability(GCA) and special combining ability(SCA) of germination traits were analyzed using Griffing I method.Among 30 cross combinations,the GCA was significantly different among six waterlogging resistance traits.The SCA of these traits was significantly different except the SCA of electrical conductivity.As a representative trait of waterlogging tolerance in rapeseed,relative vigor index had the highest narrow heritability and relatively low broad heritability.The cultivars Zhongshuang 9 and P79 had higher tolerance potential to waterlogging stress.It can be concluded that combining ability and genetic effects of relative vigor index during germination stage could be used to identify the waterlogging tolerance of rapeseed in breeding program.
基金DG ISR and DST (GoG) for providing required supportDMC Dadra and Nagar Haveli (DNH/1255) for providing financial support。
文摘The present study area,Dadra and Nagar Haveli,contains several lineaments and traces of active faults.The various aspect of the geomo rphic analysis,i.e.,stream length(SL) gradient,hypsometric integral(HI),basin shape(BS),valley floor(VF),have been applied to evaluate the relative index of active tectonics(RIAT) of the Damanganga watershed.The high and low zones of tectonic activity have been identified based on the geomorphic analysis of the watershed.After evaluation of all indices,three classes,class IIhigh(1.3 ≤RIAT <1.5),class Ⅲ-moderate(1.5 ≤RIAT <1.8),and class Ⅳ-low(1.8 ≤RIAT),have been obtained to outline the degree/gradation of comparative tectonic activities in the study area.The appraised outcome of the RIAT dispersal is also well reinforced by the geomorphic evidence in the field.The collective outcomes of geomorphic evidence,such as stream deflection and analysis of lineament,deflection of streams,and geomorphic indices,conceal that the Damanganga watershed is affected by tectonic activity.
基金funded jointly by the Natural Science Foundation of Qinghai Province(2019-ZJ-910)the International Communication and Cooperation Project of Qinghai Province(2019-HZ-807)+1 种基金the National Program on Basic Work Project of China(2015FY11030001)the Qinghai Province High-level Innovative Talents Program
文摘Biodiversity distribution patterns are a basic and long-standing but crucial aspect of ecology research.These patterns form the primary source of data used to develop biodiversity protection practices,especially in mountain ecosystems.Shrubs comprise one of the main types of vegetation on the Qinghai–Tibetan Plateau,where they serve vital ecological functions.In this study,we used a community phylogenetic approach to examine the distribution patterns of shrub communities along the longitudinal and latitudinal gradients on the northeastern Qinghai–Tibetan Plateau.We observed significant latitudinal trends in both the phylogenetic diversity(PD)and net relatedness index(NRI)values of shrub communities,such that the former decreased and the latter increased with increasing latitude.However,no significant PD,NRI and nearest taxon index(NTI)distribution patterns were observed along a longitudinal gradient.A further analysis revealed that the combination of temperature-related and precipitation-related climate variables most strongly affected the PD,NRI and NTI values of shrub communities,indicating that the latitudinal patterns in the PD,NRI and NTI of a shrub community may be determined mainly by interactions with these climate factors.
文摘Growth inhibitory activity has proven important in Qiufeng×Baiyu and Qingsong×Haoyue silkworm larvae. The consumption of mulberry leaves was reduced in both silkworm races while Qiufeng×Baiyu larvae showed the higher reduction in leaf consumption. From the results obtained, it was revealed that even at low concentrations of 400 mg/L of either Cr(Ⅲ) or Cr(Ⅵ) ions, growth of Qiufeng × Baiyu and Qingsong × Haoyue was significantly depressed. Depression in relative growth index(RGI) and high death rate in both silkworm races indicated that the different concentrations of the two ions used caused their growth inhibitions. Through linear regression analysis, the EC 50 (concentration of the compound that caused 50% reduction) was interpolated for both tested compounds. EC 50 (mg/L) of Cr (Ⅲ) ions in Qiufeng × Baiyu and Qingsong × Haoyue were 800 and 600 respectively. EC 50 (mg/L) of Cr(Ⅵ) ions in Qiufeng × Baiyu and Qingsong × Haoyue was 600 and 316 respectively. According to the analysis of relative growth index, and an analysis of linear regression technique for measuring the growth of the silkworm races, it was indicated that the form of Cr affected growth rates, growth inhibition responses of the larvae, and toxicological effects. Thus, form and quantity of Cr accumulating in silkworms reared with contaminated leaves are likely to influence their population dynamics.