Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0...Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury.展开更多
In mathematics, space encompasses various structured sets such as Euclidean, metric, or vector space. This article introduces temporal space—a novel concept independent of traditional spatial dimensions and frames of...In mathematics, space encompasses various structured sets such as Euclidean, metric, or vector space. This article introduces temporal space—a novel concept independent of traditional spatial dimensions and frames of reference, accommodating multiple object-oriented durations in a dynamical system. The novelty of building temporal space using finite geometry is rooted in recent advancements in the theory of relationalism which utilizes Euclidean geometry, set theory, dimensional analysis, and a causal signal system. Multiple independent and co-existing cyclic durations are measurable as a network of finite one-dimensional timelines. The work aligns with Leibniz’s comments on relational measures of duration with the addition of using discrete cyclic relational events that define these finite temporal spaces, applicable to quantum and classical physics. Ancient formulas have symmetry along with divisional and subdivisional orders of operations that create discrete and ordered temporal geometric elements. Elements have cyclically conserved symmetry but unique cyclic dimensional quantities applicable for anchoring temporal equivalence relations in linear time. We present both fixed equivalences and expanded periods of temporal space offering a non-Greek calendar methodology consistent with ancient global timekeeping descriptions. Novel applications of Euclid’s division algorithm and Cantor’s pairing function introduce a novel paired function equation. The mathematical description of finite temporal space within relationalism theory offers an alternative discrete geometric methodology for examining ancient timekeeping with new hypotheses for Egyptian calendars.展开更多
Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people＇s daily use of English language. This paper would adopt ...Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people＇s daily use of English language. This paper would adopt the theoretical framework of pragmatics and use relevance theory as well as face theory to discuss the unique pragmatic functions of non-restrictive relational clauses in English news report discourse. The three major pragmatic functions are： （1） optimizing the relevance of information; （2） seeking for the consistence with readers; and （3） avoiding imposing the author＇s opinion on readers.展开更多
Homogeneous binary function products are frequently encountered in the sub-universes modeled by databases,spanning from genealogical trees and sports to education and healthcare,etc.Their properties must be discovered...Homogeneous binary function products are frequently encountered in the sub-universes modeled by databases,spanning from genealogical trees and sports to education and healthcare,etc.Their properties must be discovered and enforced by the software applications managing such data to guarantee plausibility.The(Elementary)Mathematical Data Model provides 17 types of dyadic-based homogeneous binary function product constraint categories.MatBase,an intelligent data and knowledge base management system prototype,allows database designers to simply declare them by only clicking corresponding checkboxes and automatically generates code for enforcing them.This paper describes the algorithms that MatBase uses for enforcing all 17 types of homogeneous binary function product constraint,which may also be employed by developers without access to MatBase.展开更多
Objective To investigate therelationships between serum concentration of insulin -like growth factor - I (IGF-I) and left ventricular function as well as coronary collateral circulation in patients with coronary arter...Objective To investigate therelationships between serum concentration of insulin -like growth factor - I (IGF-I) and left ventricular function as well as coronary collateral circulation in patients with coronary artery disease (CAD) . Methods In 41 patients with CAD and 15 control subjects without CAD, the concentrations of serum IGF - I were measured using radioimmunoassay. The relationships between the concentration of serum IGF - I and Leaman coronary artery score, Rentrop grade of coronary collateral circulation, left ventricular ejection fraction (LVEF) as well as left ventricular wall motion Cortina score were assessed. Results 1. There was no significant difference in the mean level of serum IGF -I between the CAD group and the control group (107. 92±44.74 ng/ml vs 113.05 ±33. 65 ng/ml, P> 0. 05), but the IGF - I concentrations in the subgroup with collateral circulation were significantly greater than that in the control group (147. 33 ±29. 92 ng/ml vs 113. 05±33. 65 ng/ml, P < 0. 01) or in the subgroup without collateral circulation (147. 33 ±29. 92 ng/ml vs 80. 01±29. 75 ng/ml , P < 0. 01). 2. The serum concentration of IGF -I had no significant correlation to the Leaman coronary artery score. 3. The serum level of IGF -I had significantly positive correlation to both LVEF ( r = 0. 45, P < 0. 001) and the Rentrop grade of coronary collateral circulation ( r = 0. 74, P < 0. 001), and was negatively related to the left ventricular wall motion Cortina score (r = -0. 53, P < 0. 001). 4. The Leaman coronary artery score had no significant correlation to the Rentrop grade of coronary collateral circulation. 5. The Leaman coronary artery score was related to neither the LVEF nor the Cortina score in the whole CAD group. In the subgroup without coronary collateral circulation, however, the Leaman score had significantly negative correlation to LVEF ( r = - 0. 46, P < 0. 05) and positive correlation to the Cortina score (r = 0. 47, P < 0. 05) . Conclusions The serum concentration of IGF -I was associated with both left ventricular function and coronary collateral circulation in patients with CAD. IGF -I may play a role in promoting coronary collateral circulation and in protecting left ventricular function in patients with coronary artery disease.展开更多
The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless ...The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless fermion. It is demonstrated explicitly that the transverse vector vertex function derived this way to one-loop order leads to the same result as one obtained in perturbation theory. This provides a basic approach to determine the transverse part of basic vertex function from the symmetry relations of the system.展开更多
Objective: To investigate the correlation of serum calcitonin (PCT), interleukin -6 (IL-6), C reactive protein (CRP) and pulmonary ventilation function in patients with acute exacerbation of chronic obstructive pulmon...Objective: To investigate the correlation of serum calcitonin (PCT), interleukin -6 (IL-6), C reactive protein (CRP) and pulmonary ventilation function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 70 patients with AECOPD in our hospital from May 2017 to May 2018 were selected to be included in the case group, and 70 healthy persons in the same period were selected as the control group. The serum levels of PCT, IL-6, CRP and lung function were compared between the two groups, and the relationship between the serum levels of PCT, IL-6 and CRP and the pulmonary ventilation function of the patients was analyzed. Results: the levels of PCT, IL-6 and CRP in the case group were significantly higher than those in the control group. The difference was statistically significant (P < 0.05), and the FEV1, FEV1/FVC and FEV1% in the case group were significantly lower than those in the control group (P < 0.05), and the difference of PCT, IL-6 and CRP was significant between the patients with different pulmonary function levels, and the statistics were statistically significant. The study significance (P < 0.05), and the level of PCT, IL-6 and CRP increased gradually with the increase of lung function grade, and the level of PCT, IL-6 and CRP in AECOPD patients were negatively correlated with FEV1, FEV1/FVC and FEV1%, and the difference was statistically significant (P < 0.05). Conclusion: the serum levels of PCT, IL-6 and CRP in patients with AECOPD are abnormal increased and are closely related to the pulmonary ventilation function of the patients, which can be used as an important indicator of the monitoring of the patient's condition in AECOPD.展开更多
For two subsets W and V of a Banach space X, let Kn（W, V, X） denote the relative Kolmogorov n-width of W relative to V defined by Kn（W,V,X）：=inf sup inf/Ln f∈W g∈V∩Ln‖f-g‖x, where the infimum is taken over ...For two subsets W and V of a Banach space X, let Kn（W, V, X） denote the relative Kolmogorov n-width of W relative to V defined by Kn（W,V,X）：=inf sup inf/Ln f∈W g∈V∩Ln‖f-g‖x, where the infimum is taken over all n-dimensional linear subspaces Ln of X. Let W2（△^τ） denote the class of 2π-periodic functions f with d-variables satisfying ∫[-π, π]^d｜△^τf（x）｜^2dx≤1, while △^τ is the r-iterate of Laplace operator △. This article discusses the relative Kolmogorov n-width of W2（△^τ） relative to W2（△^τ） in Lq（[-π, π]^d） （1≤ q ≤ ∞）, and obtain its weak asymptotic result.展开更多
AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patie...AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patients were recruited among children referred to the Department of Paediatrics,Medical University of Warsaw.Included in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome Ⅲ diagnostic criteria.The children were randomly assigned to receive GNN,a polysaccharide of 1,4-D-glucose and D-mannose,a soluble fiber from the Japanese Konjac plant,at a dosage of 2.52 g/d(1 sachet of 1.26 g 2 times a day),or a comparable placebo(maltodextrin) at the same dosage.The content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 wk.RESULTS:Of the 89 eligible children,84(94%) completed the study."No pain" and "treatment success"(defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN(n = 41) and placebo(n = 43) groups [no pain(12/41 vs 6/43,respectively;RR = 2.1,95%CI:0.87-5.07) as well as treatment success(23/41 vs 20/43;RR = 1.2,95%CI:0.79-1.83)].No significant differences between the groups were observed in the secondary outcomes,such as abdominal cramps,abdominal bloating/gassiness,episodes of nausea or vomiting,or a changed in stool consistency.GNN demonstrated no significant influence on the number of children requiring rescue therapy,school absenteeism,or daily activities.CONCLUSION:In our setting,GNN,as dosed in this study,was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children.展开更多
The sulfide-based solid-state electrolytes(SEs)reactivity toward moisture and Li-metal are huge barriers that impede their large-scale manufactu ring and applications in all-solid-state lithium batteries(ASSLBs).Herei...The sulfide-based solid-state electrolytes(SEs)reactivity toward moisture and Li-metal are huge barriers that impede their large-scale manufactu ring and applications in all-solid-state lithium batteries(ASSLBs).Herein,we proposed an Al and O dual-doped strategy for Li_(3)PS_(4)SE to regulate the chemical/electrochemical stability of anionic PS_(4)^(3-)tetrahedra to mitigate structural hydrolysis and parasitic reactions at the SE/Li interface.The optimized Li_(3.08)A_(10.04)P_(0.96)S_(3.92)O_(0.08)SE presents the highestσLi+of 3.27 mS cm^(-1),which is~6.8 times higher than the pristine Li_(3)PS_(4)and excellently inhibits the structural hydrolysis for~25 min@25%humidity at RT.DFT calculations confirmed that the enhanced chemical stability was revealed to the intrinsically stable entities,e.g.,POS33-units.Moreover,Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)SE cycled stably in Li//Li symmetric cell over 1000 h@0.1 mA cm^(-2)/0.1 mA h cm^(-2),could be revealed to Li-Al alloy and Li_(2)Oat SE/Li interface impeding the growth of Li-dendrites during cycling.Resultantly,LNO@LCO/Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)/Li-In cell delivered initial discharge capacities of 129.8 mA h g^(-1)and 83.74%capacity retention over 300 cycles@0.2 C at RT.Moreover,the Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)SE presented>90%capacity retention over 200 and 300 cycles when the cell was tested with LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)(NCA)cathode material vs.5 and 10 mg cm^(-2)@RT.展开更多
In this report the combined method of correlation radar signal(RS)processing based on the theory of atomic functions(AF)is examined.Examples of using of new Kravchenko probability weight functions(WF)designs are prese...In this report the combined method of correlation radar signal(RS)processing based on the theory of atomic functions(AF)is examined.Examples of using of new Kravchenko probability weight functions(WF)designs are presented.Quality functional to estimate accuracy and efficiency of RS processing for concrete physical models is constructed.It is shown that the proposed approach significantly improves the quality of the coherent analysis of RS.展开更多
In this paper.the boundary value problems of plane problems with a simply-ormultiply-connected domain for isotropic linear visca-elosticity are first established byterms of Airy stress function F(Xu t). Secondly some ...In this paper.the boundary value problems of plane problems with a simply-ormultiply-connected domain for isotropic linear visca-elosticity are first established byterms of Airy stress function F(Xu t). Secondly some identity relations betweendisplacements and stresses for plane problems of sisco-and elasticity are discussed indetait and some meaningful conclusions are obtained As an example the deformationresponse for viscoelastic plate with a small circular hote at the center is analyzed undera uniasial uniform extension.展开更多
We study a general framework for assessing the injury probability corresponding to an input dose quantity. In many applications, the true value of input dose may not be directly measurable. Instead, the input dose is ...We study a general framework for assessing the injury probability corresponding to an input dose quantity. In many applications, the true value of input dose may not be directly measurable. Instead, the input dose is estimated from measurable/controllable quantities via numerical simulations using assumed representative parameter values. We aim at developing a simple modeling framework for accommodating all uncertainties, including the discrepancy between the estimated input dose and the true input dose. We first interpret the widely used logistic dose-injury model as the result of dose propagation uncertainty from input dose to target dose at the active site for injury where the binary outcome is completely determined by the target dose. We specify the symmetric logistic dose-injury function using two shape parameters: the median injury dose and the 10 - 90 percentile width. We relate the two shape parameters of injury function to the mean and standard deviation of the dose propagation uncertainty. We find 1) a larger total uncertainty will spread more the dose-response function, increasing the 10 - 90 percentile width and 2) a systematic over-estimate of the input dose will shift the injury probability toward the right along the estimated input dose. This framework provides a way of revising an established injury model for a particular test population to predict the injury model for a new population with different distributions of parameters that affect the dose propagation and dose estimation. In addition to modeling dose propagation uncertainty, we propose a new 3-parameter model to include the skewness of injury function. The proposed 3-parameter function form is based on shifted log-normal distribution of dose propagation uncertainty and is approximately invariant when other uncertainties are added. The proposed 3-parameter function form provides a framework for extending skewed injury model from a test population to a target population in application.展开更多
A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and...A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and strong in generality. In order to reveal its availability, a comparison is made between the results obtained with it and the experimental results of grey cast iron has be done, both seem to be in good agreement. At the same time, taking the yield function obtained here as a potential function, a new associative plastic constitutive equation taking effect of hydrostatic stress into account is built, and the plastic volume change ratio of plastic deformation is given.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82204360(to HM)and 82270411(to GW)National Science and Technology Innovation 2030 Major Program,No.2021ZD0200900(to YL)。
文摘Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury.
文摘In mathematics, space encompasses various structured sets such as Euclidean, metric, or vector space. This article introduces temporal space—a novel concept independent of traditional spatial dimensions and frames of reference, accommodating multiple object-oriented durations in a dynamical system. The novelty of building temporal space using finite geometry is rooted in recent advancements in the theory of relationalism which utilizes Euclidean geometry, set theory, dimensional analysis, and a causal signal system. Multiple independent and co-existing cyclic durations are measurable as a network of finite one-dimensional timelines. The work aligns with Leibniz’s comments on relational measures of duration with the addition of using discrete cyclic relational events that define these finite temporal spaces, applicable to quantum and classical physics. Ancient formulas have symmetry along with divisional and subdivisional orders of operations that create discrete and ordered temporal geometric elements. Elements have cyclically conserved symmetry but unique cyclic dimensional quantities applicable for anchoring temporal equivalence relations in linear time. We present both fixed equivalences and expanded periods of temporal space offering a non-Greek calendar methodology consistent with ancient global timekeeping descriptions. Novel applications of Euclid’s division algorithm and Cantor’s pairing function introduce a novel paired function equation. The mathematical description of finite temporal space within relationalism theory offers an alternative discrete geometric methodology for examining ancient timekeeping with new hypotheses for Egyptian calendars.
文摘Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people＇s daily use of English language. This paper would adopt the theoretical framework of pragmatics and use relevance theory as well as face theory to discuss the unique pragmatic functions of non-restrictive relational clauses in English news report discourse. The three major pragmatic functions are： （1） optimizing the relevance of information; （2） seeking for the consistence with readers; and （3） avoiding imposing the author＇s opinion on readers.
文摘Homogeneous binary function products are frequently encountered in the sub-universes modeled by databases,spanning from genealogical trees and sports to education and healthcare,etc.Their properties must be discovered and enforced by the software applications managing such data to guarantee plausibility.The(Elementary)Mathematical Data Model provides 17 types of dyadic-based homogeneous binary function product constraint categories.MatBase,an intelligent data and knowledge base management system prototype,allows database designers to simply declare them by only clicking corresponding checkboxes and automatically generates code for enforcing them.This paper describes the algorithms that MatBase uses for enforcing all 17 types of homogeneous binary function product constraint,which may also be employed by developers without access to MatBase.
文摘Objective To investigate therelationships between serum concentration of insulin -like growth factor - I (IGF-I) and left ventricular function as well as coronary collateral circulation in patients with coronary artery disease (CAD) . Methods In 41 patients with CAD and 15 control subjects without CAD, the concentrations of serum IGF - I were measured using radioimmunoassay. The relationships between the concentration of serum IGF - I and Leaman coronary artery score, Rentrop grade of coronary collateral circulation, left ventricular ejection fraction (LVEF) as well as left ventricular wall motion Cortina score were assessed. Results 1. There was no significant difference in the mean level of serum IGF -I between the CAD group and the control group (107. 92±44.74 ng/ml vs 113.05 ±33. 65 ng/ml, P> 0. 05), but the IGF - I concentrations in the subgroup with collateral circulation were significantly greater than that in the control group (147. 33 ±29. 92 ng/ml vs 113. 05±33. 65 ng/ml, P < 0. 01) or in the subgroup without collateral circulation (147. 33 ±29. 92 ng/ml vs 80. 01±29. 75 ng/ml , P < 0. 01). 2. The serum concentration of IGF -I had no significant correlation to the Leaman coronary artery score. 3. The serum level of IGF -I had significantly positive correlation to both LVEF ( r = 0. 45, P < 0. 001) and the Rentrop grade of coronary collateral circulation ( r = 0. 74, P < 0. 001), and was negatively related to the left ventricular wall motion Cortina score (r = -0. 53, P < 0. 001). 4. The Leaman coronary artery score had no significant correlation to the Rentrop grade of coronary collateral circulation. 5. The Leaman coronary artery score was related to neither the LVEF nor the Cortina score in the whole CAD group. In the subgroup without coronary collateral circulation, however, the Leaman score had significantly negative correlation to LVEF ( r = - 0. 46, P < 0. 05) and positive correlation to the Cortina score (r = 0. 47, P < 0. 05) . Conclusions The serum concentration of IGF -I was associated with both left ventricular function and coronary collateral circulation in patients with CAD. IGF -I may play a role in promoting coronary collateral circulation and in protecting left ventricular function in patients with coronary artery disease.
基金The project supported by National Natural Science Foundation of China under Grant No. 90303006
文摘The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless fermion. It is demonstrated explicitly that the transverse vector vertex function derived this way to one-loop order leads to the same result as one obtained in perturbation theory. This provides a basic approach to determine the transverse part of basic vertex function from the symmetry relations of the system.
文摘Objective: To investigate the correlation of serum calcitonin (PCT), interleukin -6 (IL-6), C reactive protein (CRP) and pulmonary ventilation function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 70 patients with AECOPD in our hospital from May 2017 to May 2018 were selected to be included in the case group, and 70 healthy persons in the same period were selected as the control group. The serum levels of PCT, IL-6, CRP and lung function were compared between the two groups, and the relationship between the serum levels of PCT, IL-6 and CRP and the pulmonary ventilation function of the patients was analyzed. Results: the levels of PCT, IL-6 and CRP in the case group were significantly higher than those in the control group. The difference was statistically significant (P < 0.05), and the FEV1, FEV1/FVC and FEV1% in the case group were significantly lower than those in the control group (P < 0.05), and the difference of PCT, IL-6 and CRP was significant between the patients with different pulmonary function levels, and the statistics were statistically significant. The study significance (P < 0.05), and the level of PCT, IL-6 and CRP increased gradually with the increase of lung function grade, and the level of PCT, IL-6 and CRP in AECOPD patients were negatively correlated with FEV1, FEV1/FVC and FEV1%, and the difference was statistically significant (P < 0.05). Conclusion: the serum levels of PCT, IL-6 and CRP in patients with AECOPD are abnormal increased and are closely related to the pulmonary ventilation function of the patients, which can be used as an important indicator of the monitoring of the patient's condition in AECOPD.
基金Supported partly by National Natural Science Foundation of China (10471010)partly by the project "Representation Theory and Related Topics" of the "985 Program" of Beijing Normal University
文摘For two subsets W and V of a Banach space X, let Kn（W, V, X） denote the relative Kolmogorov n-width of W relative to V defined by Kn（W,V,X）：=inf sup inf/Ln f∈W g∈V∩Ln‖f-g‖x, where the infimum is taken over all n-dimensional linear subspaces Ln of X. Let W2（△^τ） denote the class of 2π-periodic functions f with d-variables satisfying ∫[-π, π]^d｜△^τf（x）｜^2dx≤1, while △^τ is the r-iterate of Laplace operator △. This article discusses the relative Kolmogorov n-width of W2（△^τ） relative to W2（△^τ） in Lq（[-π, π]^d） （1≤ q ≤ ∞）, and obtain its weak asymptotic result.
文摘AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patients were recruited among children referred to the Department of Paediatrics,Medical University of Warsaw.Included in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome Ⅲ diagnostic criteria.The children were randomly assigned to receive GNN,a polysaccharide of 1,4-D-glucose and D-mannose,a soluble fiber from the Japanese Konjac plant,at a dosage of 2.52 g/d(1 sachet of 1.26 g 2 times a day),or a comparable placebo(maltodextrin) at the same dosage.The content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 wk.RESULTS:Of the 89 eligible children,84(94%) completed the study."No pain" and "treatment success"(defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN(n = 41) and placebo(n = 43) groups [no pain(12/41 vs 6/43,respectively;RR = 2.1,95%CI:0.87-5.07) as well as treatment success(23/41 vs 20/43;RR = 1.2,95%CI:0.79-1.83)].No significant differences between the groups were observed in the secondary outcomes,such as abdominal cramps,abdominal bloating/gassiness,episodes of nausea or vomiting,or a changed in stool consistency.GNN demonstrated no significant influence on the number of children requiring rescue therapy,school absenteeism,or daily activities.CONCLUSION:In our setting,GNN,as dosed in this study,was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children.
基金supported by the National Natural Science Foundation of China(Nos.21203008,21975025,12274025)the Hainan Province Science and Technology Special Fund(Nos.ZDYF2021SHFZ232,ZDYF2023GXJS022)the Hainan Province Postdoctoral Science Foundation(No.300333)。
文摘The sulfide-based solid-state electrolytes(SEs)reactivity toward moisture and Li-metal are huge barriers that impede their large-scale manufactu ring and applications in all-solid-state lithium batteries(ASSLBs).Herein,we proposed an Al and O dual-doped strategy for Li_(3)PS_(4)SE to regulate the chemical/electrochemical stability of anionic PS_(4)^(3-)tetrahedra to mitigate structural hydrolysis and parasitic reactions at the SE/Li interface.The optimized Li_(3.08)A_(10.04)P_(0.96)S_(3.92)O_(0.08)SE presents the highestσLi+of 3.27 mS cm^(-1),which is~6.8 times higher than the pristine Li_(3)PS_(4)and excellently inhibits the structural hydrolysis for~25 min@25%humidity at RT.DFT calculations confirmed that the enhanced chemical stability was revealed to the intrinsically stable entities,e.g.,POS33-units.Moreover,Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)SE cycled stably in Li//Li symmetric cell over 1000 h@0.1 mA cm^(-2)/0.1 mA h cm^(-2),could be revealed to Li-Al alloy and Li_(2)Oat SE/Li interface impeding the growth of Li-dendrites during cycling.Resultantly,LNO@LCO/Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)/Li-In cell delivered initial discharge capacities of 129.8 mA h g^(-1)and 83.74%capacity retention over 300 cycles@0.2 C at RT.Moreover,the Li_(3.08)Al_(0.04)P_(0.96)S_(3.92)O_(0.08)SE presented>90%capacity retention over 200 and 300 cycles when the cell was tested with LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)(NCA)cathode material vs.5 and 10 mg cm^(-2)@RT.
基金Russian Foundation for Basic Research(No.12-02-90425)
文摘In this report the combined method of correlation radar signal(RS)processing based on the theory of atomic functions(AF)is examined.Examples of using of new Kravchenko probability weight functions(WF)designs are presented.Quality functional to estimate accuracy and efficiency of RS processing for concrete physical models is constructed.It is shown that the proposed approach significantly improves the quality of the coherent analysis of RS.
文摘In this paper.the boundary value problems of plane problems with a simply-ormultiply-connected domain for isotropic linear visca-elosticity are first established byterms of Airy stress function F(Xu t). Secondly some identity relations betweendisplacements and stresses for plane problems of sisco-and elasticity are discussed indetait and some meaningful conclusions are obtained As an example the deformationresponse for viscoelastic plate with a small circular hote at the center is analyzed undera uniasial uniform extension.
文摘We study a general framework for assessing the injury probability corresponding to an input dose quantity. In many applications, the true value of input dose may not be directly measurable. Instead, the input dose is estimated from measurable/controllable quantities via numerical simulations using assumed representative parameter values. We aim at developing a simple modeling framework for accommodating all uncertainties, including the discrepancy between the estimated input dose and the true input dose. We first interpret the widely used logistic dose-injury model as the result of dose propagation uncertainty from input dose to target dose at the active site for injury where the binary outcome is completely determined by the target dose. We specify the symmetric logistic dose-injury function using two shape parameters: the median injury dose and the 10 - 90 percentile width. We relate the two shape parameters of injury function to the mean and standard deviation of the dose propagation uncertainty. We find 1) a larger total uncertainty will spread more the dose-response function, increasing the 10 - 90 percentile width and 2) a systematic over-estimate of the input dose will shift the injury probability toward the right along the estimated input dose. This framework provides a way of revising an established injury model for a particular test population to predict the injury model for a new population with different distributions of parameters that affect the dose propagation and dose estimation. In addition to modeling dose propagation uncertainty, we propose a new 3-parameter model to include the skewness of injury function. The proposed 3-parameter function form is based on shifted log-normal distribution of dose propagation uncertainty and is approximately invariant when other uncertainties are added. The proposed 3-parameter function form provides a framework for extending skewed injury model from a test population to a target population in application.
文摘A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and strong in generality. In order to reveal its availability, a comparison is made between the results obtained with it and the experimental results of grey cast iron has be done, both seem to be in good agreement. At the same time, taking the yield function obtained here as a potential function, a new associative plastic constitutive equation taking effect of hydrostatic stress into account is built, and the plastic volume change ratio of plastic deformation is given.
