Global learning professional competencies (GLPCs) are essential for college students to be able to address the impact of globalization in the 21st century. Organizations and society-at-large look to higher education t...Global learning professional competencies (GLPCs) are essential for college students to be able to address the impact of globalization in the 21st century. Organizations and society-at-large look to higher education to prepare college students with GLPCs. In addition, there is a body of literature that suggest personal tacit knowledge enhance GLPCs. However, researchers have done little from an empirical perspective to determine the relationship between the use of P-T K and enhancement of GLPCs, hence the purpose of this study. The statistical results revealed significant correlations, p st century knowledge society through use of P-T K.展开更多
文摘Global learning professional competencies (GLPCs) are essential for college students to be able to address the impact of globalization in the 21st century. Organizations and society-at-large look to higher education to prepare college students with GLPCs. In addition, there is a body of literature that suggest personal tacit knowledge enhance GLPCs. However, researchers have done little from an empirical perspective to determine the relationship between the use of P-T K and enhancement of GLPCs, hence the purpose of this study. The statistical results revealed significant correlations, p st century knowledge society through use of P-T K.
文摘目的:探讨“冬病夏治”全方配伍和无白芥子配伍延胡索乙素在模型家兔“肺俞”穴皮下药代动力学特征及药代动力学-药效动力学(PK-PD)模型的相关性。方法:支气管哮喘模型家兔随机分成延胡索单方组、缺白芥子组、全方组,微透析技术收集14 h穴位皮下透析液,液相色谱-质谱法(Liquid Chromatography Mass Spectrometry,LCMS)法检测方中君药延胡索主要成分延胡索乙素浓度,获得药代动力学参数;酶联免疫吸附试验(ELISA)法检测对应时间点模型动物血清中IgE水平,获得药效学参数;对药动学、药效学参数进行PK-PD模型拟合。结果:白芥子配伍后的药峰浓度(C_(max))、药时曲线下面积(AUC_(0-t))、平均滞留时间(MRT_(0-t))均显著增加(P<0.01,P<0.01,P<0.05),达峰时间(T_(max))提前(P<0.01);“浓度-时间-效应”三维曲线表明,方中有白芥子配伍时,药效出现更快、消退更慢,起效时间晚于峰浓度,具有一定滞后性。结论:动力学参数、PK-PD模型结果表明,白芥子配伍能够改变“方中君药”——延胡索的主要成分延胡索乙素穴位局部的皮下分布,促进方中君药有效成分快速吸收,延长滞留时间,在方剂中起到主药、改善其他药物分布的“双重”作用。