目的·探讨前列腺癌患者血液中前列腺特异抗原(prostate specific antigen,PSA)、肿瘤异常蛋白(tumor abnormal protein,TAP)及结肠癌转移相关基因1(colon cancer metastasis related gene 1,MACC1)的表达及临床诊断价值。方法·...目的·探讨前列腺癌患者血液中前列腺特异抗原(prostate specific antigen,PSA)、肿瘤异常蛋白(tumor abnormal protein,TAP)及结肠癌转移相关基因1(colon cancer metastasis related gene 1,MACC1)的表达及临床诊断价值。方法·以2019年1月至2020年12月于上海市徐汇区大华医院就诊的107例前列腺癌患者为病例组,另选择同期该院60名健康体检者为对照组。回顾性分析2组患者血液中PSA、TAP及MACC1的水平,及其与Gleason评分、T分期的相关性;采用受试者操作特征(receiver operating characteristic,ROC)曲线评价各项指标诊断前列腺癌的灵敏度和特异度。结果·病例组患者血液PSA、TAP及MACC1水平均显著高于对照组(P<0.05);随着Gleason分级的升高,病例组患者血液PSA、TAP及MACC1水平逐渐升高;随着T分期的进展,病例组患者血液PSA、TAP及MACC1水平逐渐升高;有淋巴结转移的患者血液PSA和MACC1水平高于无淋巴结转移患者,TAP水平低于无淋巴结转移患者,差异均有统计学意义(P<0.05)。血液PSA诊断前列腺癌的ROC曲线下面积(area under the curve,AUC)为0.764,灵敏度为86.12%,特异度为88.63%,截断值为6.01μg/L;血液TAP诊断前列腺癌的AUC为0.796,灵敏度为88.18%,特异度为89.58%,截断值为135.62μm^(2);血液MACC1诊断前列腺癌的AUC为0.873,灵敏度为78.46%,特异度为80.10%,截断值为37.80 pg/mL;3项指标联合检测的AUC为0.941,灵敏度为93.15%,特异度为94.08%,均高于各单项指标(P<0.05)。Spearman相关分析结果显示,血液PSA、TAP及MACC1水平均与Gleason评分呈正相关(r值分别为0.648、0.513和0.501,均P=0.000),与T分期呈正相关(r值分别为0.616、0.537和0.542,均P=0.000)。结论·前列腺癌患者血液PSA、TAP及MACC1水平均与Gleason评分、T分期之间关系密切,对前列腺癌有一定的诊断价值;3项联合检测,诊断价值更高。展开更多
By means of a characterization of compact spaces in terms of open CD*-filters induced by a , a - and open CD*-filters process of compactifications of an arbitrary topological space Y is obtained in Sec. 3 by embedding...By means of a characterization of compact spaces in terms of open CD*-filters induced by a , a - and open CD*-filters process of compactifications of an arbitrary topological space Y is obtained in Sec. 3 by embedding Y as a dense subspace of , YS = {ε |ε is an open CD*-filter that does not converge in Y}, YT = {A|A is a basic open CD*-filter that does not converge in Y}, is the topology induced by the base B = {U*|U is open in Y, U ≠φ} and U* = {F∈Ysw (or YTw)|U∈F}. Furthermore, an arbitrary Hausdorff compactification (Z, h) of a Tychonoff space X?can be obtained from a by the?similar process in Sec.3.展开更多
Although congenital sensorineural hearing loss (SHL) in the bilateral cochleae mainly results from genetic abnormalities, chronic SHL progressing in later life is often influenced by systemic immune disturbances, incl...Although congenital sensorineural hearing loss (SHL) in the bilateral cochleae mainly results from genetic abnormalities, chronic SHL progressing in later life is often influenced by systemic immune disturbances, including autoimmunity, chronic inflammation, and immunosenescence. We have investigated the relationship between the inner ear and systemic immunity and reviewed the possibilities to prevent SHL, including autoimmune SHL and age-related SHL. We also demonstrated two lymphocyte populations, interleukin 1 receptor type II (IL-1R2)-positive T cells (T1R2) and naturally occurring regulatory T cells (nTregs) in CD4+ T cells, which increase with aging, suppress host immune function and promote organ degeneration. Alterations in systemic immunity by fewer microbial antigen challenges in the living environment, elimination of immune suppressive lymphocytes, or immune rejuvenation with a reconstituted thymus may contribute not only to renew the cochlear function in SHL, but also to extend the healthy life of functional organs in a vigorous and youthful body, one of humanity’s greatest dreams.展开更多
目的探讨妇科肿瘤经外周静脉置入中心静脉导管(Peripherally Inserted Central Venous Catheters,PICC)置管后,导管相关性血流感染(Catheter Related Blood Stream Infection,CRBSI)患者可溶性髓系细胞触发受体-1(Soluble Triggering Re...目的探讨妇科肿瘤经外周静脉置入中心静脉导管(Peripherally Inserted Central Venous Catheters,PICC)置管后,导管相关性血流感染(Catheter Related Blood Stream Infection,CRBSI)患者可溶性髓系细胞触发受体-1(Soluble Triggering Receptor Expressed On Myeloid cell-1,sTREM-1)、降钙素原(Procalcitonin,PCT)及T细胞亚群等免疫指标的表达及意义。方法随机选取2015年4月-2018年4月于天津市第三中心医院和天津市第一中心医院妇科收治的经CT或MRI确诊的行PICC术的妇科肿瘤患者253例,根据是否发生感染分为感染组和对照组,其中感染组39例,对照组214例。对感染组PICC术后CRBSI病原菌、感染相关因素和感染率进行临床统计和分析。并对感染组和对照组sTREM-1、PCT及T细胞亚群水平进行检测和对比分析。结果39例CRBSI患者共检测43株病原菌,革兰阳性菌21株占48.84%,以表皮葡萄球菌为主;革兰阴性菌16株占37.21%,以阴沟肠杆菌为主;真菌6株占13.95%,以假丝酵母为主。单因素分析显示年龄、导管留置时间、肠外输注营养与PICC置管后CRBSI感染率相关(P<0.05)。术后感染组sTREM-1及PCT增加高于术前;术前对照组CD4^+/CD8^+高于感染组(P<0.05);术后对照组CD3^+、CD4^+水平升高,CD8^+水平下降,感染组术后CD3^+、CD4^+水平及CD4^+/CD8^+降低,CD8^+水平上升,均具有统计学意义(P<0.05);且对照组与感染组CD3^+、CD4^+、CD8^+及CD4^+/CD8^+术前术后差值比较,均具有统计学意义(P<0.05)。结论妇科肿瘤患者PICC置管后CRBSI感染病原学分布以革兰阳性球菌为主,年龄、导管留置时间、肠外输注营养及CD4^+/CD8^+水平对感染的发生有影响,术后CRBSI感染者sTREM-1、PCT、CD8^+明显升高,CD3^+、CD4^+及CD4^+/CD8^+水平下降,免疫功能降低,具有临床诊断意义。展开更多
文摘目的·探讨前列腺癌患者血液中前列腺特异抗原(prostate specific antigen,PSA)、肿瘤异常蛋白(tumor abnormal protein,TAP)及结肠癌转移相关基因1(colon cancer metastasis related gene 1,MACC1)的表达及临床诊断价值。方法·以2019年1月至2020年12月于上海市徐汇区大华医院就诊的107例前列腺癌患者为病例组,另选择同期该院60名健康体检者为对照组。回顾性分析2组患者血液中PSA、TAP及MACC1的水平,及其与Gleason评分、T分期的相关性;采用受试者操作特征(receiver operating characteristic,ROC)曲线评价各项指标诊断前列腺癌的灵敏度和特异度。结果·病例组患者血液PSA、TAP及MACC1水平均显著高于对照组(P<0.05);随着Gleason分级的升高,病例组患者血液PSA、TAP及MACC1水平逐渐升高;随着T分期的进展,病例组患者血液PSA、TAP及MACC1水平逐渐升高;有淋巴结转移的患者血液PSA和MACC1水平高于无淋巴结转移患者,TAP水平低于无淋巴结转移患者,差异均有统计学意义(P<0.05)。血液PSA诊断前列腺癌的ROC曲线下面积(area under the curve,AUC)为0.764,灵敏度为86.12%,特异度为88.63%,截断值为6.01μg/L;血液TAP诊断前列腺癌的AUC为0.796,灵敏度为88.18%,特异度为89.58%,截断值为135.62μm^(2);血液MACC1诊断前列腺癌的AUC为0.873,灵敏度为78.46%,特异度为80.10%,截断值为37.80 pg/mL;3项指标联合检测的AUC为0.941,灵敏度为93.15%,特异度为94.08%,均高于各单项指标(P<0.05)。Spearman相关分析结果显示,血液PSA、TAP及MACC1水平均与Gleason评分呈正相关(r值分别为0.648、0.513和0.501,均P=0.000),与T分期呈正相关(r值分别为0.616、0.537和0.542,均P=0.000)。结论·前列腺癌患者血液PSA、TAP及MACC1水平均与Gleason评分、T分期之间关系密切,对前列腺癌有一定的诊断价值;3项联合检测,诊断价值更高。
文摘By means of a characterization of compact spaces in terms of open CD*-filters induced by a , a - and open CD*-filters process of compactifications of an arbitrary topological space Y is obtained in Sec. 3 by embedding Y as a dense subspace of , YS = {ε |ε is an open CD*-filter that does not converge in Y}, YT = {A|A is a basic open CD*-filter that does not converge in Y}, is the topology induced by the base B = {U*|U is open in Y, U ≠φ} and U* = {F∈Ysw (or YTw)|U∈F}. Furthermore, an arbitrary Hausdorff compactification (Z, h) of a Tychonoff space X?can be obtained from a by the?similar process in Sec.3.
文摘Although congenital sensorineural hearing loss (SHL) in the bilateral cochleae mainly results from genetic abnormalities, chronic SHL progressing in later life is often influenced by systemic immune disturbances, including autoimmunity, chronic inflammation, and immunosenescence. We have investigated the relationship between the inner ear and systemic immunity and reviewed the possibilities to prevent SHL, including autoimmune SHL and age-related SHL. We also demonstrated two lymphocyte populations, interleukin 1 receptor type II (IL-1R2)-positive T cells (T1R2) and naturally occurring regulatory T cells (nTregs) in CD4+ T cells, which increase with aging, suppress host immune function and promote organ degeneration. Alterations in systemic immunity by fewer microbial antigen challenges in the living environment, elimination of immune suppressive lymphocytes, or immune rejuvenation with a reconstituted thymus may contribute not only to renew the cochlear function in SHL, but also to extend the healthy life of functional organs in a vigorous and youthful body, one of humanity’s greatest dreams.
文摘目的探讨妇科肿瘤经外周静脉置入中心静脉导管(Peripherally Inserted Central Venous Catheters,PICC)置管后,导管相关性血流感染(Catheter Related Blood Stream Infection,CRBSI)患者可溶性髓系细胞触发受体-1(Soluble Triggering Receptor Expressed On Myeloid cell-1,sTREM-1)、降钙素原(Procalcitonin,PCT)及T细胞亚群等免疫指标的表达及意义。方法随机选取2015年4月-2018年4月于天津市第三中心医院和天津市第一中心医院妇科收治的经CT或MRI确诊的行PICC术的妇科肿瘤患者253例,根据是否发生感染分为感染组和对照组,其中感染组39例,对照组214例。对感染组PICC术后CRBSI病原菌、感染相关因素和感染率进行临床统计和分析。并对感染组和对照组sTREM-1、PCT及T细胞亚群水平进行检测和对比分析。结果39例CRBSI患者共检测43株病原菌,革兰阳性菌21株占48.84%,以表皮葡萄球菌为主;革兰阴性菌16株占37.21%,以阴沟肠杆菌为主;真菌6株占13.95%,以假丝酵母为主。单因素分析显示年龄、导管留置时间、肠外输注营养与PICC置管后CRBSI感染率相关(P<0.05)。术后感染组sTREM-1及PCT增加高于术前;术前对照组CD4^+/CD8^+高于感染组(P<0.05);术后对照组CD3^+、CD4^+水平升高,CD8^+水平下降,感染组术后CD3^+、CD4^+水平及CD4^+/CD8^+降低,CD8^+水平上升,均具有统计学意义(P<0.05);且对照组与感染组CD3^+、CD4^+、CD8^+及CD4^+/CD8^+术前术后差值比较,均具有统计学意义(P<0.05)。结论妇科肿瘤患者PICC置管后CRBSI感染病原学分布以革兰阳性球菌为主,年龄、导管留置时间、肠外输注营养及CD4^+/CD8^+水平对感染的发生有影响,术后CRBSI感染者sTREM-1、PCT、CD8^+明显升高,CD3^+、CD4^+及CD4^+/CD8^+水平下降,免疫功能降低,具有临床诊断意义。