High rate of clinically relevant improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis

BACKGROUND The minimal clinically important difference(MCID)is defined as the smallest meaningful change in a health domain that a patient would identify as important.Thus,an improvement that exceeds the MCID can be used to define a successful treatment for the individual patient.AIM To quantify the rate of clinical improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis.METHODS Patients were treated with the Global Unite total shoulder platform arthroplasty between March 2017 and February 2019 at Herlev and Gentofte Hospital,Denmark.The patients were evaluated preoperatively and 3 months,6 months,12 months,and 24 months postoperatively using the Western Ontario Osteoarthritis of the Shoulder index(WOOS),Oxford Shoulder Score(OSS)and Constant-Murley Score(CMS).The rate of clinically relevant improvement was defined as the proportion of patients who had an improvement 24 months postoperatively that exceeded the MCID.Based on previous literature,MCID for WOOS,OSS,and CMS were defined as 12.3,4.3,and 12.8 respectively.RESULTS Forty-nine patients with a Global Unite total shoulder platform arthroplasty were included for the final analysis.Mean age at the time of surgery was 66 years(range 49.0-79.0,SD:8.3)and 65%were women.One patient was revised within the two years follow-up.The mean improvement from the preoperative assessment to the two-year follow-up was 46.1 points[95%confidence interval(95%CI):39.7-53.3,P<0.005]for WOOS,18.2 points(95%CI:15.5-21.0,P<0.005)for OSS and 37.8 points(95%CI:31.5-44.0,P<0.005)for CMS.Two years postoperatively,41 patients(87%)had an improvement in WOOS that exceeded the MCID,45 patients(94%)had an improvement in OSS that exceeded the MCID,and 42 patients(88%)had an improvement in CMS that exceeded the MCID.CONCLUSION Based on three shoulder-specific outcome measures we find that approximately 90%of patients has a clinically relevant improvement.This is a clear message when informing patients about their prognosis.

Relevant Visual Semantic Context-Aware Attention-Based Dialog

The existing dataset for visual dialog comprises multiple rounds of questions and a diverse range of image contents.However,it faces challenges in overcoming visual semantic limitations,particularly in obtaining sufficient context from visual and textual aspects of images.This paper proposes a new visual dialog dataset called Diverse History-Dialog(DS-Dialog)to address the visual semantic limitations faced by the existing dataset.DS-Dialog groups relevant histories based on their respective Microsoft Common Objects in Context(MSCOCO)image categories and consolidates them for each image.Specifically,each MSCOCO image category consists of top relevant histories extracted based on their semantic relationships between the original image caption and historical context.These relevant histories are consolidated for each image,and DS-Dialog enhances the current dataset by adding new context-aware relevant history to provide more visual semantic context for each image.The new dataset is generated through several stages,including image semantic feature extraction,keyphrase extraction,relevant question extraction,and relevant history dialog generation.The DS-Dialog dataset contains about 2.6 million question-answer pairs,where 1.3 million pairs correspond to existing VisDial’s question-answer pairs,and the remaining 1.3 million pairs include a maximum of 5 image features for each VisDial image,with each image comprising 10-round relevant question-answer pairs.Moreover,a novel adaptive relevant history selection is proposed to resolve missing visual semantic information for each image.DS-Dialog is used to benchmark the performance of previous visual dialog models and achieves better performance than previous models.Specifically,the proposed DSDialog model achieves an 8% higher mean reciprocal rank(MRR),11% higher R@1%,6% higher R@5%,5% higher R@10%,and 8% higher normalized discounted cumulative gain(NDCG)compared to LF.DS-Dialog also achieves approximately 1 point improvement on R@k,mean,MRR,and NDCG compared to the original RVA,and 2 points improvement compared to LF andDualVD.These results demonstrates the importance of the relevant semantic historical context in enhancing the visual semantic relationship between textual and visual representations of the images and questions.

Culturally Relevant Pedagogy in Teaching Proficiency through Reading and Storytelling

When the demographics in American public schools became more diverse,educators have faced the challenge of working with diverse student learners.In the education field,culturally relevant pedagogy has been widely recognized as an effective practice for teaching about diversity and is used across different school subject areas.This article discusses the four aspects in which teachers can implement culturally relevant pedagogy in TPRS language classrooms:a caring learning community,establishing meaning,story asking,and story reading.Teachers can include and empower students by validating them as learning subjects and engaging them in knowledge creation and representation in curriculum and instruction.The goal is to develop academic success,culture and identity,equity,and excellence for all student learners in a multicultural and global society.

Correction to:The dissemination of relevant information on wildlife utilization and its connection with the illegal trade in wildlife

Correction to:J.For.Res.https://doi.org/10.1007/s11676-021-01306-y The article“The dissemination of relevant information on wildlife utilization and its connection with the illegal trade in wildlife”,written by Zhifan Song·Qiang Wang·Zhen Miao·Wei Zhang and Xuehong Zhou,was originally pub-lished electronically on the publisher’s internet portal on 11th March 2021 without open access.

Relevant Analysis of Grassland Temperature and Ground Net Radiation in Guilin

[Objective] The aim was to study the relevance of grassland temperature and ground net radiation in Guilin.[Method] By dint of ground observation data and net radiation of national benchmark climate station in Guilin from 2007 to 2009,the changes of grassland temperature and ground net radiation were expounded and their relations were pointed out.[Result] The annual changes trends of grassland temperature and ground net radiation in Guilin were basically the same.Monthly average maximum value all appeared in summer(July to August).Monthly average lowest value appeared in winter(December to next January);monthly average grassland temperature and monthly average ground net radiation had positive relation.Grassland temperature and ground net radiation had basically same distribution in four seasons.The average largest value of ground net radiation in summer was the largest and average smallest value was the smallest;the average largest value of ground net radiation in cloudy days was the smallest and average minimum value was the largest;the daily difference was the largest in sunny day and daily difference was the smallest in cloudy day.The daily changes trend of grassland temperature and ground net radiation in different weather state were basically the same;when it was sunny or cloudy,the daily largest value of grassland temperature and ground net radiation occurred between 15:00 and 19:00;when it was overcast,there was no distinct peak and daily changes.The largest value of the daily extreme value of grassland temperature and ground net radiation took place from 12:00 to 15:00.The daily lowest value took place from 20:00 to 07:00 on the next day.[Conclusion] The study provided reference for the analysis of temperature changes in Guilin.

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula:A narrative review

Clinically relevant postoperative pancreatic fistula(CR-POPF)has continued to compromise patient recovery post-pancreatectomy despite decades of research seeking to improve risk prediction and diagnosis.The current diagnostic criteria for CR-POPF requires elevated drain fluid amylase to present alongside POPFrelated complications including infection,haemorrhage and organ failure.These worrying sequelae necessitate earlier and easily obtainable biomarkers capable of reflecting evolving CR-POPF.Drain fluid has recently emerged as a promising source of biomarkers as it is derived from the pancreas and hence,capable of reflecting its postoperative condition.The present review aims to summarise the current knowledge of CR-POPF drain fluid biomarkers and identify gaps in the field to invigorate future research in this critical area of clinical need.These findings may provide robust diagnostic alternatives for CR-POPF and hence,to clarify their clinical utility require further reports detailing their diagnostic and/or predictive accuracy.

Relevant Enzymes, Genes and Regulation Mechanisms in Biosynthesis Pathway of Stilbenes

Stilbenes are natural phenolic compounds which function as antimicrobial phytoalexins in plants and affect human health as cardioprotective, antibaceteria, antioxidative and antineoplastic agents. In this review, the progresses of study on relevant enzymes, genes, and regulation mechanism in biosynthesis pathway of stilbenes are described. Here we introduce a holistic and systematic method of researching relevant enzymes, genes and other regulatory factors in biosynthesis pathway of stilbenes—Systems biology. The application of knowledge of relative enzymes, genes and regulation mechanisms in stilbenes biosynthesis in metabolic engineering which is used as a tool of improving the disease resistance of plants and health caring quality of crops is also discussed.

X-Ray Induced Mutation Frequency at the <i>Hypoxanthine Phosphoribosyltransferase</i>Locus in Clinically Relevant Radioresistant Cells

To elucidate the molecular mechanisms underlying cellular radioresistance, clinically relevant radioresistant cell lines were established via long-term exposure to X-rays with stepwise dose escalation. Established cells continue to proliferate despite exposure to 2 Gy X-rays/day for more than 30 days, a standard protocol in cancer radiotherapy. DNA repair fidelity in radioresistant and the parental cells by evaluating the mutation frequency at the hypoxanthine phosphoribosyltransferase (HPRT) locus after exposure to X-rays was determined. Mutation spectrum at the HPRT locus was examined by multiplex polymerase chain reaction. Rejoining kinetics of X-ray-induced DNA double strand breaks (dsbs) was evaluated by the detection of phosphorylated histone H2AX (γH2AX) after X-irradiation. The fold increase in the HPRT mutation frequency due to acute radiation was similar between radioresistant and the parental cell lines. However, fractionated radiation (FR) consisting of 2 Gy X-rays/day increased the mutation frequency at the HPRT locus in parental but not in radioresistant cells. Analysis of the FR-induced mutations at the HPRT locus revealed a high frequency of deletion mutations (>70%) in parental but not in radioresistant cells. As assessed by γH2AX immunostaining, DNA dsbs induced by acute exposure to 10 Gy of X-rays were repaired to the control level within 7 days in radioresistant but not in the parental cells. Moreover, 2 Gy × 5 FR increased the number of γH2AX-positive cells in parental cultures but not in radioresistant cultures. DNA dsbs induced by 2 Gy/day FR are repaired with fidelity in radioresistant but not in parental cells.

Relevant State Agencies Will Conduct a Joint Annual Inspection on Foreign Invested Enterprises

The Ministry of Foreign Trade and Economic Coop-eration (MOFTEC),the State Administration forIndustry and Commerce (SAIC),the State Economicand Trade Commission (SETC),the Ministry of Finance(MOF),the State Administration for Exchange Control(SAEC),the State Taxation Bureau (STB) and the GeneralCustoms Administration (GCA) (hereinafter referred to asCompetent Joint Annual Inspection Agencies) have jointlyissued a circular a few days before which stipulates that,from the year 1997 onwards,a joint annual inspection willbe conducted on FIEs in order to further improve and stan-dardize China’s investment environment,lessen the burdenson the shoulders of enterprises and enhance the level of ad-ministration over FIEs.

How Can Commodity Quality Be Ensured and Relevant Disputes Be Settled?

China,the big factory offering various commodities to companies and individuals all over the world,is attracting more and more merchants purchasing goods in various ways,through agents,on site,via modern communication,etc.One essential concern of these merchants is the quality of these commodities.How can the commodity quality be ensured?If there are

The Relevant Analysis on the Stop Time in Winter and Times of Plateau and the Index in Early Days for Garrisonned Plateau Constructors

Objective: Study the influence of the stop time in winter, times of plateau on the index in early days for plateau constructors meet;Method:Is it participate in plateau construction of 2002-2004 to choose,enter into the plateau again of 2003-2005 practise clothes finish to mate 326 materials “physical examination in front of the worker",which is passed in Nanshankou Hospital in early days, divided into 3 groups according to the difference of year for the physical examination, examine by leaning towards relevant analytical methods;Result: （1） In the situation of day controlling about the stop time in winter, times of garrison in plateau and blood and oxygen saturation lever （SaO2）, the systolic pressure （sBP） is presented and shouldered relevantly winter to control. Present positive correlation with the value of hemoglobin （Hb）;（2） It is stopped that in case of controlling and is garrisoned in the number of times of plateau in winter day and blood and oxygen saturation lever （SaO2） to present positive correlation. Present and shoulder with the hemoglobin （Hb） relevantly.Conclusion: In order to ensure the health of plateau constructors to the maximum extent, should try one’s best to reduce the number of times of returning to the plateau in possible cases. At the same time each one constructs for year and returns to the time that the hinterland concentrates rest should be on above 90 days.

China's economic growth pushed by domestic demand and relevant measures

By contrast to a slowdown in the world economy, China kept up a rapid growth rate, a relatively high quality of growth and low inflation for the year 2001. This is mainly due to the result of proactive fiscal policies that the Chinese Government adopted to stimulate domestic demand. Domestic demand can be divided into investment demand and consumption demand,