Introduction: A new electromechanical instrument has been developed to measure relative dorsal mobility of the first ray in an objective and reliable way by simulating ground reaction forces during gait. This device e...Introduction: A new electromechanical instrument has been developed to measure relative dorsal mobility of the first ray in an objective and reliable way by simulating ground reaction forces during gait. This device equally applies a standardized, electronically controlled, and precise force under the first metatarsal head M1 as well as under the heads of the lesser metatarsals M2 to M5. The relative dorsal mobility between these two bearings is then measured. The purpose of this study is to assess the intra- and inter-examiners reliabilities of the measurements obtained with this device. Methods: The protocol included two examiners and 36 feet (18 volunteers with healthy feet and no history of forefoot disorders). A total of nine measurements were performed on each foot separated into three sets of three trials for the assessment of inter-rater and intra-rater reliability. For this purpose, the interclass correlation coefficient (ICC), the error of measurement (SEM) and the Bland and Altman (B&A) graphical analysis were computed. Results: Excellent ICC values (≥0.91) were obtained with the novel device for inter-rater and intra-rater reliability when using the FRRM calculation. The B&A analysis presented a bias between examiners of -0.25 mm ranging from -1.66 to 1.18 mm. Conclusion: This study demonstrated the capability of the developed device to reliably measure the relative dorsal mobility of the first ray of the foot. This is a promising first step for further studies to better understand, qualify and quantify first ray hypermobility.展开更多
In order to test the reliability of γ-GT foci(γ-glutamyltranspeptidase positive hepatocyticfoci) as a preneoplastic marker in AFB-inducedhepatocarcinogenesis, this experiment was car-ried out for a long period after...In order to test the reliability of γ-GT foci(γ-glutamyltranspeptidase positive hepatocyticfoci) as a preneoplastic marker in AFB-inducedhepatocarcinogenesis, this experiment was car-ried out for a long period after a short-term invivo test model of AFB-induced hepatocarcino-展开更多
Because of poor ground conditions, stoping methods of underhand headings withcemented fill were used in the Jinchuan No. 2 mine, a paste fill system was set up. In order toevaluate the reliability of the new system, i...Because of poor ground conditions, stoping methods of underhand headings withcemented fill were used in the Jinchuan No. 2 mine, a paste fill system was set up. In order toevaluate the reliability of the new system, investigations and trial running have been done. Morethan 20 items of modification or improvements related to paste preparation subsystem, pump and pipesubsystem, auto-controlling and monitoring subsystem were finished. The reliability of the pastefill system was analyzed by using the theory of large complex system, and it is useful inreliability study on paste fill system.展开更多
On the basis of Miner's linear cumulative damage theorem, random variables are introduced to evaluate objectively the fatigue damage of a semi-submerged platform structure and a method is presented to analyze the ...On the basis of Miner's linear cumulative damage theorem, random variables are introduced to evaluate objectively the fatigue damage of a semi-submerged platform structure and a method is presented to analyze the fatigue reliability of the structure in its design life. The reliability of the method is verified through numerical examples and some conclusions are drawn, which have certain guiding and reference value for design and inspection.展开更多
The reliability of fingerprint has been called into question by a study that tested whether forensic experts make consistent judgments on print matches.Despite the perceived infallibility of fingerprint evidence, the ...The reliability of fingerprint has been called into question by a study that tested whether forensic experts make consistent judgments on print matches.Despite the perceived infallibility of fingerprint evidence, the study found that experts do not always make the same judgment on whether a print matches a mark at a crime scene when presented with the same evidence twice.The findings come in the wake of two high profile cases in which fingerprint matches were subsequently shown to be wrong. The Scottish ...展开更多
Microarray analyses of gene expression are widely used, but reports of the same analyses by different groups give widely divergent results, and raise questions regarding reproducibility and reliability. We take as an ...Microarray analyses of gene expression are widely used, but reports of the same analyses by different groups give widely divergent results, and raise questions regarding reproducibility and reliability. We take as an example recent published reports on microarray experiments that were designed to identify retinoic acid responsive genes. These reports show substantial differences in their results. In this article, we review the methodology, results, and potential causes of differences in these applications of microarrays. Finally, we suggest practices to improve the reliability and reproducibility of microarray experiments.展开更多
文摘Introduction: A new electromechanical instrument has been developed to measure relative dorsal mobility of the first ray in an objective and reliable way by simulating ground reaction forces during gait. This device equally applies a standardized, electronically controlled, and precise force under the first metatarsal head M1 as well as under the heads of the lesser metatarsals M2 to M5. The relative dorsal mobility between these two bearings is then measured. The purpose of this study is to assess the intra- and inter-examiners reliabilities of the measurements obtained with this device. Methods: The protocol included two examiners and 36 feet (18 volunteers with healthy feet and no history of forefoot disorders). A total of nine measurements were performed on each foot separated into three sets of three trials for the assessment of inter-rater and intra-rater reliability. For this purpose, the interclass correlation coefficient (ICC), the error of measurement (SEM) and the Bland and Altman (B&A) graphical analysis were computed. Results: Excellent ICC values (≥0.91) were obtained with the novel device for inter-rater and intra-rater reliability when using the FRRM calculation. The B&A analysis presented a bias between examiners of -0.25 mm ranging from -1.66 to 1.18 mm. Conclusion: This study demonstrated the capability of the developed device to reliably measure the relative dorsal mobility of the first ray of the foot. This is a promising first step for further studies to better understand, qualify and quantify first ray hypermobility.
文摘In order to test the reliability of γ-GT foci(γ-glutamyltranspeptidase positive hepatocyticfoci) as a preneoplastic marker in AFB-inducedhepatocarcinogenesis, this experiment was car-ried out for a long period after a short-term invivo test model of AFB-induced hepatocarcino-
文摘Because of poor ground conditions, stoping methods of underhand headings withcemented fill were used in the Jinchuan No. 2 mine, a paste fill system was set up. In order toevaluate the reliability of the new system, investigations and trial running have been done. Morethan 20 items of modification or improvements related to paste preparation subsystem, pump and pipesubsystem, auto-controlling and monitoring subsystem were finished. The reliability of the pastefill system was analyzed by using the theory of large complex system, and it is useful inreliability study on paste fill system.
基金A part of the project supported financially by the National Natural Science Foundation of China
文摘On the basis of Miner's linear cumulative damage theorem, random variables are introduced to evaluate objectively the fatigue damage of a semi-submerged platform structure and a method is presented to analyze the fatigue reliability of the structure in its design life. The reliability of the method is verified through numerical examples and some conclusions are drawn, which have certain guiding and reference value for design and inspection.
文摘The reliability of fingerprint has been called into question by a study that tested whether forensic experts make consistent judgments on print matches.Despite the perceived infallibility of fingerprint evidence, the study found that experts do not always make the same judgment on whether a print matches a mark at a crime scene when presented with the same evidence twice.The findings come in the wake of two high profile cases in which fingerprint matches were subsequently shown to be wrong. The Scottish ...
文摘Microarray analyses of gene expression are widely used, but reports of the same analyses by different groups give widely divergent results, and raise questions regarding reproducibility and reliability. We take as an example recent published reports on microarray experiments that were designed to identify retinoic acid responsive genes. These reports show substantial differences in their results. In this article, we review the methodology, results, and potential causes of differences in these applications of microarrays. Finally, we suggest practices to improve the reliability and reproducibility of microarray experiments.
