Efficient cache replacement framework based on access hotness for spacecraft processors

A notable portion of cachelines in real-world workloads exhibits inner non-uniform access behaviors.However,modern cache management rarely considers this fine-grained feature,which impacts the effective cache capacity of contemporary high-performance spacecraft processors.To harness these non-uniform access behaviors,an efficient cache replacement framework featuring an auxiliary cache specifically designed to retain evicted hot data was proposed.This framework reconstructs the cache replacement policy,facilitating data migration between the main cache and the auxiliary cache.Unlike traditional cacheline-granularity policies,the approach excels at identifying and evicting infrequently used data,thereby optimizing cache utilization.The evaluation shows impressive performance improvement,especially on workloads with irregular access patterns.Benefiting from fine granularity,the proposal achieves superior storage efficiency compared with commonly used cache management schemes,providing a potential optimization opportunity for modern resource-constrained processors,such as spacecraft processors.Furthermore,the framework complements existing modern cache replacement policies and can be seamlessly integrated with minimal modifications,enhancing their overall efficacy.

An Aggregation Cache Replacement Algorithm Based on Ontology Clustering

This paper describes the theory, implementation, and experimental evaluation of an Aggregation Cache Replacement （ ACR ） algorithm. By considering application background, carefully choosing weight values, using a special formula to calculate the similarity, and clustering ontologies by similarity for getting more embedded deep relations, ACR combines the ontology similarity with the value of object and decides which object is to be replaced. We demonstrate the usefulness of ACR through experiments. （a） It is found that the aggregation tree is created wholly differently according to the application cases. Therefore, clustering can direct the content adaptation more accurately according to the user perception and can satisfy the user with different preferences. （b） After comparing this new method with widely-used algorithm Last-Recently-Used （LRU） and First-in-First-out （FIFO） method, it is found that ACR outperforms the later two in accuracy and usability. （c） It has a better semantic explanation and makes adaptation more personalized and more precise.

Periodical Inspections and Delay Replacement Model Based on Age Preventive Replacement Policy

Periodical inspections and an age-based preventive replacement( APR) model were proposed based on a two-stage failure process for a single component system. Inspection activities were performed at regular intervals. Once the system was identified to be at defective state by inspection,a maintenance decision needed to be made that whether to replace the defective system immediately or wait till the preset APR time. So a threshold was introduced into the model and called as inspection-based preventive replacement( IPR) threshold. If the distance from the defect identification point to the APR time was longer than the threshold, a preventive replacement( PR) action was made; otherwise PR action was to wait till the APR time. Two models were proposed and compared,and a numerical example was conducted to illustrate the applicability of the model.

SATELLITE-BASED ANALYSIS ON THE CONCENTRIC EYEWALL REPLACEMENT CYCLES OF SUPER TYPHOON MUIFA (1109)

Multisatellite data is used to analyze the characteristics of three eyewall replacement cycles(ERCs) during the lifetime of Typhoon Muifa(1109).Spiral rainbands evolutions,concentric eyewall(CE) structure modes,CE durations,and intensity changes are discussed in detail.In addition,an ERC evolution model of Typhoon Muifa is given.There are four main findings.(1) The outer spiral rainband joins end to end to form the outer eyewall after it disconnects from the original(inner) eyewall.The inner eyewall weakens as the outer eyewall becomes axisymmetric and is intensified.The contraction of the outer eyewall causes the inner eyewall to dissipate rapidly.Finally,the ERC ends with an annular eyewall or spiral rainbands.(2) Although the CE duration times of Typhoon Muifa's three ERCs covered a large range,the CE structures were all maintained for approximately 5 h from the formation of the axisymmetric outer eyewall to the end of the cycle.(3) There is no obvious precipitation reflectivity in the eye or moat region for the subsidence flow.The convection within the two eyewalls is organized as a radially outward slope with increasing height.(4) Typhoon intensity estimation results based on ADT may not explain the intensity variations associated with ERC correctly,while the typhoon's warm core data retrieved from AMSU-A works well.

Population-Based and Personalized Design of Total Knee Replacement Prosthesis for Additive Manufacturing Based on Chinese Anthropometric Data

At present,most total knee replacement(TKR)prostheses on the market are designed according to the sizes of Caucasians.However,extensive studies have indicated that human anatomies differ among different ethnicities.A number of reports have indicated that Chinese TKR patients do not match with available prostheses.In this study,computed tomography(CT)images of 52 knees of Chinese men and women were used for anthropometric measurements.Index and geometric measurements were definedand used for correlation analysis.Key parameters from the measurement results were identified.Detailed geometries of knees were measured as coordinates.A deformable three-dimensional(3D)knee modelbased on anatomical coordinates correlating with the identified key parameters was generated.A pros-thesis was then designed according to the analyzed results.Surface matching analysis,bone resectionanalysis,and cadaveric trials were conducted and compared with commercial products to validate theproposed design.The femoral component designed by this study resulted in the highest accuracy(rootmean square point-to-surface(RMS PS),(1.08±0.20)mm)and lowest amount of resected bone volume(27412mm^(3))in comparison with two commercial knee prostheses.This study suggests a new approachfor population-based patient-specific femoral prosthesis design With a single,easilty acquired dimen-sion-namely,epicondyle width(ECW)-as input,a patient-specific femoral prosthesis can be designed according to the analyzed measured data and manufactured by additive manufacturing(AM)methods.Meanwhile,the reconstructed femoral condylar surface was compared with the femoral condylar surfacein the original CT scanning data The average RMS PS distance of the reconstructed femoral condylar surface among all data was(1.10±0.18)mm,which is comparable to other statistical shape modeling methods using multiple radiographs as input data.There is a need to develop an anthropometric-based knee prosthesis for the Chinese population.Based on the anthropometry of the Chinese population,our new design fits Chinese patients better and reserves more bone volume compared with current commercial prostheses,which is an essential step toward AM for personalized knee prostheses.

Prevalence of hypothyroidism and effect of thyroid hormone replacement therapy in patients with non-alcoholic fatty liver disease:A population-based study

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is currently considered as the most common cause of chronic liver disease worldwide.Risk factors for NAFLD have been well-described,including obesity,type 2 diabetes mellites(T2DM),dyslipidemia(DLP)and metabolic syndrome.Hypothyroidism has been identified as an independent risk factor for the development of NAFLD,although the literature is inconsistent AIM To evaluate the prevalence of hypothyroidism in patients with NAFLD,assess if it is an independent risk factor and explore the effect of thyroxine replacement therapy.METHODS Our cohort’s data was obtained using a validated,large,multicenter database(Explorys Inc,Cleveland,OH,United States)aggregated from pooled outpatient and inpatient records of 26 different healthcare systems,consisting of a total of 360 hospitals in the United States,and utilizing Systematized Nomenclature of Medicine-Clinical Terms for coding.We evaluated a cohort of patients with hypothyroidism and NAFLD.Multivariate analysis was performed to adjust for confounding risk factors including hypertension(HTN),T2DM,DLP,obesity and metabolic syndrome.SPSS version 25,IBM Corp was used for statistical analysis,and for all analyses,a 2-sided P value of<0.05 was considered statistically significant.Exclusion criteria were limited to age<18 years.RESULTS Among the 37648180 included individuals in this database who are above the age of 18 years,there were a total of 2320 patients with NAFLD(6.16 per 100000)in the last five years(2015-2020),amongst which 520 patients(22.4%)had hypothyroidism.Baseline characteristics of patients in this database are described in Table 1.Patients with NAFLD were also more likely to have obesity,T2DM,DLP,HTN,and metabolic syndrome(Table 2).While males and females were equally affected,patients in the age group 18-65 years as well as Caucasians seem to be at a higher risk.There was an increased risk of NAFLD among patients with hypothyroidism(OR=1.587).Furthermore,thyroid hormone replacement was not associated with a decreased risk for developing NAFLD(OR=1.106,C=0.952-1.285,P=0.303).CONCLUSION Hypothyroidism seems to be an independent risk factor for the development of NAFLD.Thyroid hormone replacement did not provide a statistically significant risk reduction.Further studies are needed to evaluate the effect of thyroid hormone replacement and assess if being euthyroid while on thyroid replacement therapy affects development and/or progression of NAFLD.

A Cache Replacement Policy Based on Multi-Factors for Named Data Networking

Named Data Networking(NDN)is one of the most excellent future Internet architectures and every router in NDN has the capacity of caching contents passing by.It greatly reduces network traffic and improves the speed of content distribution and retrieval.In order to make full use of the limited caching space in routers,it is an urgent challenge to make an efficient cache replacement policy.However,the existing cache replacement policies only consider very few factors that affect the cache performance.In this paper,we present a cache replacement policy based on multi-factors for NDN(CRPM),in which the content with the least cache value is evicted from the caching space.CRPM fully analyzes multi-factors that affect the caching performance,puts forward the corresponding calculation methods,and utilize the multi-factors to measure the cache value of contents.Furthermore,a new cache value function is constructed,which makes the content with high value be stored in the router as long as possible,so as to ensure the efficient use of cache resources.The simulation results show that CPRM can effectively improve cache hit ratio,enhance cache resource utilization,reduce energy consumption and decrease hit distance of content acquisition.

Research on replacement depth of black cotton soil based on cracking behavior of embankment

In order to analyze the influence of replacement depth of black cotton soil(BCS)foundation on the initial cracking depth of a highway embankment,the laboratory tests were performed to construct the constitutive relationship between state variables and stress variables of BCS,and the coupled consolidation theory for unsaturated soils was employed to simulate the change in the major principal stress of the subgrade soils caused by water loss shrinkage of BCS with the help of Abaqus 6.11 codes.The simulation results indicate that the water losing shrinkage of BCS causes tensile stress within the subgrade,which leads to embankment cracking.The crack depth decreases with the increase in the BCS replacement depth and the embankment height,and increases with the increase in the burial depth of BCS.In the distribution area of deep BCS,the key values of foundation replacement depth for controlling the crack depth of the embankment with the height of 1 to 4 m are 1.2 and 1.5 m.In the low filling section,when the buried depth of BCS is 2,3 and 4 m,the key values of the foundation replacement depth to control the crack depth of the embankment are 0.8 and 1.2 m.In order to control the embankment cracking induced by the water losing shrinkage of BCS,a reasonable replacement depth of the foundation should be selected while slope protection is carried out well.

Optimal Replacement Time of Electrical Components Based on Constant-Interval Replacement Model: Equipment Inspection Method and Weibull Analysis

The operation of distribution system with the components in deteriorating condition makes the system reliability worsen. It is important to find the solution for balancing failure cost and maintenance benefits such as down-time and reliability. In this paper, time to replace the components in optimum condition based on constant-interval replacement mode is investigated. The optimal replacement time is mainly depended on component’s reliability and the cost ration of preventive replacement and failure replacement. In this paper, equipment inspection method and Weibull Analysis is applied to obtain the accurate reliability estimation. Weibull Analysis is applied with constant-interval replacement model to investigate the optimum replacement time for each component considering the different cost ratios. According to the quantitative results, the determination of the optimal replacement time (OPT) can minimize the total downtime and failure cost. Consequently, the reliability of the system is maximized and estimation also becomes more accurate due to sufficient approach.

A Transformer Replacement Decision Method Based on Probability Assessment of Failure Rate

Reasonable probability assessment of transformer failure rate (FR) is a critical reference to the transformer replacement work. At present, the lack of support theory for transformer replacement usually causes reliability and economy issues for power companies. For this reason, a transformer replacement decision method based on probability assessment of FR is proposed. Firstly, a first order model of transformer paper degradation is proposed. Then, the Weibull Distribution is used by Monte Carlo Simulation (MCS) to generate the variations of Degree of Polymerization (DP) along with time based on the historical data, and the transformer FR is determined. When the FR is higher than a pre-defined threshold value, the transformer should be replaced for reliability purpose. Finally, the effectiveness of the proposed method for the transformer replacement decision is verified by a typical engineering application.

A method to calculate the acetabular cup anteversion after total hip replacement based on 3D coordinate system

Aim: To explore an accurate method to calculate acetabular cup anteversion after total hip arthroplasty. Method: 1) A 3D coordinate system was established with the center of the hip joint rotation center base as coordinate center. The acetabular exit plane and Pettersson formula acetabular anteversion and Riten Pradhan formula acetabular anteversion and acetabular true anteversion were drawn;2) Determine the mathematical expression of Pettersson formula acetabular anteversion α and Riten Pradhan formula acetabular anteversion β in the coordinate system. The true acetabular anteversion is projection angle of Pettersson formula acetabular anteversion α on cross-section in the presence of acetabular abduction δ, determining mathematical expression of the acetabular anteversion θ by trigonometric functions. Results: Real acetabular cup anteversion θ = arctg (tgβ/cosδ). Conclusion: The true acetabular cup anteversion and Pettersson formula anteversion and Riten Pradhan for mula anteversion were quite different. The difference was increased with the acetabular cup abduction angle increased. The formula was simple and accurate and worthy of clinical reference.

Effects of hormone replacement therapy on mood and sleep quality in menopausal women

BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal women.However,some patients report experiencing adverse effects.AIM To analyze the effects of hormone replacement therapy in menopausal female patients.METHODS A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group(n=76,conventional treatment+hormone replacement therapy)and the control group(n=76,conventional treatment only)via random casting.The improvement observed in the following items were compared between the groups:Kupperman menopausal index(KMI),emotional state[The Positive and Negative Affect Scale(PANAS)],sleep quality[Self-Rating Scale of Sleep(SRSS)],treatment effectiveness,and treatment safety.RESULTS The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of treatment.The improvement in the PANAS score observed in the observation group was greater than that observed in the control group(P<0.05).The total treatment effectivity rate in the observation group was higher than that in the control group(86.84%vs 96.05%,χ2=4.121,P=0.042).The incidence rate of adverse reactions in the two groups was comparable(6.58%vs 9.21%,χ2=0.361,P=0.547).CONCLUSION Hormone replacement therapy effectively improved the clinical symptoms,actively channeled negative emotions,and improved the quality of sleep in menopausal patients,indicating its effectiveness and safety.

Generation of mitochondrial replacement monkeys by female pronucleus transfer

Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising strategies for preventing the hereditary transmission of mtDNA diseases.While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos,its application in non-human primates has not been previously reported.In this study,we successfully generated four healthy cynomolgus monkeys(Macaca fascicularis)via female pronuclear transfer.These individuals all survived for more than two years and exhibited minimal mtDNA carryover(3.8%–6.7%),as well as relatively stable mtDNA heteroplasmy dynamics during development.The successful establishment of this nonhuman primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.

A Predicted Region based Cache Replacement Policy for Location Dependent Data in Mobile Environment

Caching frequently accessed data items on the mobile client is an effective technique to improve the system performance in mobile environment. Proper choice of cache replacement technique to find a suitable subset of items for eviction from cache is very important because of limited cache size. Available policies do not take into account the movement patterns of the client. In this paper, we propose a new cache replacement policy for location dependent data in mobile environment. The proposed policy uses a predicted region based cost function to select an item for eviction from cache. The policy selects the predicted region based on client’s movement and uses it to calculate the data distance of an item. This makes the policy adaptive to client’s movement pattern unlike earlier policies that consider the directional / non-directional data distance only. We call our policy the Prioritized Predicted Region based Cache Replacement Policy (PPRRP). Simulation results show that the proposed policy significantly improves the system performance in comparison to previous schemes in terms of cache hit ratio.

Current knowledge for the risk factors of early permanent pacemaker implantation following transcatheter aortic valve replacement and what is next for the primary prevention?

In this editorial,we comprehensively summarized the preoperative risk factors of early permanent pacemaker implantation after transcatheter aortic valve replacement(TAVR)among patients with severe aortic stenosis from several renowned clinical studies and focused on the primary prevention of managing the modifiable factors,e.g.,paroxysmal atrial fibrillation before the TAVR.

Optimal C-arm angulation during transcatheter aortic valve replacement: Accuracy of a rotational C-arm computed tomography based three dimensional heart model

AIMTo investigate the accuracy of a rotational C-arm CT-based 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement (TAVR).METHODSRotational C-arm CT (RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. From that the line of perpendicularity curve was obtained that generates a perpendicular view of the aortic annulus according to the right-cusp rule. To evaluate the accuracy of a model-based overlay we compared model- and expert-derived aortic root diameters.RESULTSFor all 57 patients in the RCT cohort diameter measurements were obtained from two independent operators and were compared to the model-based measurements. The inter-observer variability was measured to be in the range of 0&#x000b0;-12.96&#x000b0; of angular C-arm displacement for two independent operators. The model-to-operator agreement was 0&#x000b0;-13.82&#x000b0;. The model-based and expert measurements of aortic root diameters evaluated at the aortic annulus (r = 0.79, P &#x0003c; 0.01), the aortic sinus (r = 0.93, P &#x0003c; 0.01) and the sino-tubular junction (r = 0.92, P &#x0003c; 0.01) correlated on a high level and the Bland-Altman analysis showed good agreement. The interobserver measurements did not show a significant bias.CONCLUSIONAutomatic segmentation of the aortic root using an anatomical model can accurately predict an optimal C-arm configuration, potentially simplifying current clinical workflows before and during TAVR.

A comprehensive review of lunar lava tube base construction and field research on a potential Earth test site

The Moon,as the closest celestial body to the Earth,plays a pivotal role in the progression of deep space exploration,and the establishment of research outposts on its surface represents a crucial step in this mission.Lunar lava tubes are special underground caves formed by volcanic eruptions and are considered as ideal natural shelters and scientific laboratories for lunar base construction.This paper begins with an in-depth overview of the geological origins,exploration history,and distribution locations of lunar lava tubes.Subsequently,it delves into the presentation of four distinctive advantages and typical concepts for constructing bases within lava tubes,summarizing the ground-based attempts made thus far in lunar lava tube base construction.Field studies conducted on a lava tube in Hainan revealed rock compositions similar to those found during the Apollo missions and clear lava tube structures,making it a promising analog site.Lastly,the challenges and opportunities encountered in the field of geotechnical engineering regarding the establishment of lunar lava tube bases are discussed,encompassing cave exploration technologies,in-situ testing methods,geomechanical properties under lunar extreme environments,base design and structural stability assessment,excavation and reinforcement techniques,and simulated Earth-based lava tube base.

Component reallocation and system replacement maintenance based on availability and cost in series systems

Component reallocation(CR)is receiving increasing attention in many engineering systems with functionally interchangeable and unbalanced degradation components.This paper studies a CR and system replacement maintenance policy of series repairable systems,which undergoes minimal repairs for each emergency failure of components,and considers constant downtime and cost of minimal repair,CR and system replacement.Two binary mixed integer nonlinear programming models are respectively established to determine the assignment of CR,and the uptime right before CR and system replacement with the objective of minimizing the system average maintenance cost and maximizing the system availability.Further,we derive the optimal uptime right before system replacement with maximization of the system availability,and then give the relationship between the system availability and the component failure rate.Finally,numerical examples show that the CR and system replacement maintenance policy can effectively reduce the system average maintenance cost and improve the system availability,and further give the sensitivity analysis and insights of the CR and system replacement maintenance policy.

Imaging characteristics and treatment strategies for carotid artery occlusion caused by skull base fracture:Three case reports

BACKGROUND Traumatic internal carotid artery(ICA)occlusion is a rare complication of skull base fractures,characterized by high mortality and disability rates,and poor prognosis.Therefore,timely discovery and correct management are crucial for saving the lives of such patients and improving their prognosis.This article retrospectively analyzed the imaging and clinical data of three patients,to explore the imaging characteristics and treatment strategies for carotid artery occlusion,combined with severe skull base fractures.CASE SUMMARY This case included three patients,all male,aged 21,63,and 16 years.They underwent plain film skull computed tomography(CT)examination at the onset of their illnesses,which revealed fractures at the bases of their skulls.Ultimately,these cases were definitively diagnosed through CT angiography(CTA)examinations.The first patient did not receive surgical treatment,only anticoagulation therapy,and recovered smoothly with no residual limb dysfunction(Case 1).The other two patients both developed intracranial hypertension and underwent decompressive craniectomy.One of these patients had high intracranial pressure and significant brain swelling postoperatively,leading the family to choose to take him home(Case 2).The other patient also underwent decompressive craniectomy and recovered well postoperatively with only mild limb motor dysfunction(Case 3).We retrieved literature from PubMed on skull base fractures causing ICA occlusion to determine the imaging characteristics and treatment strategies for this type of disease.CONCLUSION For patients with cranial trauma combined with skull base fractures,it is essential to complete a CTA examination as soon as possible,to screen for blunt cerebrovascular injury.