A Pragmatic Template for Quadcopter Development

This article presents a pragmatic quadcopter development template for parcel delivery in Nigeria. The quadcopter is equipped with a camera, parcel pouch and wireless telecommunication to capture live events and send them back to the control station for real-time delivery feedback. The study also discusses the design methodology adopted as a conceptual design approach vital to product development, it encompasses information gathering and identifying the problem, creating the solutions systematically and eventually evaluating and developing a concept for the drone and its attributes and presenting clear results for design calculations.

Analytic Hierarchy Process for Technological Risks in the Process of Innovative Drug Development in China

Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.

Research on the Countermeasures for the Development of Biopharmaceutical Industrial Parks in China

Objective To systematically analyze the current development status of biopharmaceutical industrial park in China,sort out the problems and put forward some countermeasures and suggestions.Methods Relevant literature was searched and reviewed to find out the problems faced by the development of biopharmaceutical industrial parks in China.Results and Conclusion Biopharmaceutical industrial parks are developing rapidly due to their unique industrial clustering advantages,but there are problems such as lack of overall planning at the top level,insufficient government support,imperfect talent support services and weak innovation capacity of the parks.It is recommended to promote the rapid development of biopharmaceutical industrial parks and biopharmaceutical enterprises by strengthening top-level design,increasing government support,focusing on talent introduction,and enhancing the innovative strength of the parks.

Research Plan on the Strategic Development of High-value Eco-agriculture in the Middle-lower Reaches of Yangtze River

At present,high-value eco-agriculture research in China is till limited and controversial,theoretical innovation and practices on eco-agriculture should be conducted.The key problems which should be solved urgently on the development of high-value eco-agriculture in the middle-lower reaches of Yangtze River now including：the connotation and characteristics of high-value eco-agriculture,the construction of high-value eco-agriculture system and the policies of the development of high-value eco-agriculture.Therefore,the strategic development research on high-value eco-agriculture mainly includes the following aspects：development of agriculture modernization and theory and practices of eco-economics;theory of high-value eco-agriculture;practice of high-value eco-agriculture in the middle-lower reaches of Yangtze River;construction of high-value eco-agriculture in the middle-lower reaches of Yangtze River;development strategy and system innovation of high-value eco-agriculture in the lower and medium reaches of Yangtze River.

Research Progress on the Development and Utilization of Proteins in Edible Insects

The recent progress on the proteins in edible insects was summarized, in- cluding the nutritional value, healthy value, food safety, extraction and content mea- surement of the proteins in edible insects, as well as the main development direc- tion of edible insect proteins. And we also pointed out the bottlenecks that restricted the development and utilization of proteins in edible insects, and proposed the prospect of the research, development and utilization of edible insects proteins.

Normative Analysis and Strategy Research on Harmonized Development of Modern Industrialization, Urbanization, Agricultural Modernization and IT Application

Targeting modernization, we should keep to the Chinese-style path of car- rying out industrialization in a new way and advancing IT application, urbanization, and agricultural modernization. In the research, the scientific concepts of IT applica- tion, urbanization, agricultural modernization and industrialization were illustrated and the interrelations were analyzed, with measures on harmonized development pro- posed based on existing problems.

Action Research——the Way to Enhancing Teacher Professional Development

This paper introduces the notion of action research in its international academic context. Action research is potentially beneficial to both pre-service teachers and in-service teachers in their professional development and it should play an important role in the curriculum renewal of English teaching methodology in China.

Development Tendency in Main Fields of Reading Researches

The last few decades have witnessed the publication of a considerable amount of empirical evidence supporting what Krashen has called "the power of reading"(Krashen,1993).There is a widespread approval that reading itself leads to better reading,better vocabulary,better writing,and better control of grammar in both first and second languages.In this article,the following research areas will be discussed,which can be mainly divided into the following 20 categories.

Recent Progress in Surface Integrity Research and Development

1.Introduction Surface integrity has great significance for the quality and performance of machined components,and has therefore been increasingly recognized by industry.In particular,within certain industries that require high reliability,such as the aerospace industry,surface integrity is one of the most relevant indexes used to evaluate the quality of machined parts.Thus,obtaining updated knowledge on surface integrity is of great interest to both the academic community and industry[1].

Progress in Research and Development of Refractory Oxide-Nonoxide Composites

Some of the progress made in our laboratories in collaboration with industry in research and development work on high performance oxide-nonoxide composites for metallurgical applications has been reviewed. （1） SiAlON bonded corundum composites for blast furnace usage have been produced by reduction-nitridation sinte-ring at high temperature, using bauxite instead of alu-mina in the matrix. （2） Low carbon Al2O3 - SiAlON slide plate materials successfully used in high quality steel continuous casting have been developed in which most or all of the graphite in Al2O3 - C brick is replaced by bauxite-based β-SiAlON. （3） A1/Si metal bonded A12 03 - C material characterized by low carbon content, low firing temperature and in-situ formation of carbides and nitrides at high temperature during service are found to possess very high hot strength and very good thermal shock resistance and have also been successfully used as slide plates in ladles and tundishes for high quality steel casting.

Prospect Conceiving of Joint Research and Development of Shale Gas and Coalbed Methane in China

Inspired by successful development of shale gas in USA and influenced by hydrocarbon resources shortage currently, China has strengthened shale gas research and accelerated its exploration process. In order to enrich coalbed methane (CBM) and shale gas geological theory and promote their development process, this paper compared shale gas with CBM in accumulation, distribution, reservoir and production. It expatiated on the background and significance of the combined research and development, and analyzed the geological foundation and future prospects. Our investigation demonstrated that there are many sets of coal-bearing strata in Shanxi formation of Permian system in Ordos in North China, Longtan formation of Upper Permian and Xujiahe formation of Upper Triassic in Southern Yangtze region, Xishanyao formation of Middle Jurassic in Turpan-Hami Basin and Junggar Basin in Northwest China, and Shahezi formation of Cretaceous in Songliao Basin in northeast China. In these regions, shales which are interbeded with coal seams have the characters of big thickness, continuous distribution, high content of organic matter, good parent material and high maturity, accord with the basic geological conditions to format shale gas and CBM reservoir and composite gas reservoir, thus form appropriate regions and layers to carry out joint research and exploration with good prospects for development.

Research and development of deepwater offshore linepipe of Baosteel UOE SAWL X70 of heavy wall thickness and large diameter

Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.

China’s environmental scientific research and technology development:review and envisage

The topic was concentrated on environmental technology development in China within the context of China's economic acceleration and reform. Firstly, cleaner technology should be adopted where possible in industrial production; secondly, eco agricultural technological system, especially biological technology, should be developed in agricultural production; thirdly, end of pipe solution should focus on waste utilization or recycling technology where appropriate clean technology does not exist; lastly but not the least, existing technologies to minimize eco environmental deterioration such as soil erosion, salinization, desertification and deforestation should also be extended and developed. The mentioned ways of environmental technology development can only be realized on the condition that a resource conservation based production system and life style could be established and appropriate policy secured.

Effect of a near-zero magnetic field on development and flight of oriental armyworm(Mythimna separata)

The geomagnetic field affects all living organisms on the Earth.In this study we investigated the developmental and behavioral effects of rearing Mythimna separata in a near-zero magnetic field(<500 n T)compared to the local geomagnetic field(approximately 50μT).The near-zero magnetic field produced by a Helmholtz coil system significantly lengthened larval and pupal development durations,increased male longevity,and reduced pupal weight,female reproduction,and the relative expression level of the vitellogenin(Vg)gene in newly emerged females.Moreover,the near-zero magnetic field had a considerable negative effect on the mating ratio of M.separata adults.In addition,the moths in the near-zero magnetic field displayed less flight activity late in the night than those in the Earth's normal geomagnetic field,indicating that the flight rhythm of M.separata may be affected by the near-zero magnetic field.Reduction in magnetic field intensity may have negative effects on the development and flight of oriental armyworm,with consequent additional effects on its migration.

Progress and Problems of Development Research and Application of Sand Barriers

Due to the restrictions on the conditions for afforestation and sand control,the development research,and application of sand barriers have accelerated in recent years,but some problems that cannot be ignored have emerged in practice. In this paper,the functions of wind prevention,sand blocking and fixation,improving soil physical and chemical properties and increasing plant diversity of sand barriers,accretion coefficient and capacity between sand barriers,and mobile sand barriers were analyzed firstly,and then several issues that should be noted in the development and application of sand barriers were proposed. The results show that sand barriers can fix sand on the spot and maintain the stability of sand surface. As an auxiliary measure before afforestation on a mobile sand surface,they are practical and feasible. The biggest drawback of sand barriers is that they are easy to be saturated. Although they can increase plant diversity and surface roughness,they lose the function of blocking sand flow after being saturated,and their function of in-situ sand fixation also rapidly decreases with the degradation of sand barriers. Mobile sand barriers overcome the disadvantage of sand barriers being easy to be saturated to some extent,but the cost greatly increases. In terms of desertification prevention and control by plants,plants are used as sand barriers to study their functions of sand blocking and sand fixation in many researches and practices,but the more important ecological functions of adjusting temperature on sand surface and achieving surface thermodynamic equilibrium of plants are ignored.

3D printing applications for healthcare research and development

There is a growing demand for customised,biocompatible,and sterilisable components in the medical busi-ness.3D Printing is a disruptive technology for healthcare and provides significant research and development avenues.Simple 3D printing service gives patients low-cost individualised prostheses,implants,and gadgets,en-abling surgeons to operate more effectively with customised equipment and models;and assisting medical device manufacturers in developing new and faster goods.3D printed tissue pieces can overcome various challenges and may eventually allow medication companies to streamline research and development.In the long run,it may also assist in lowering prices and making medicines more accessible and effective for everybody.There is a growing corpus of research on the advantages of employing 3D printed anatomic models in teaching and training.The capacity to 3D printing individual anatomical diseases for practical learning is one of the funda-mental contrasts between utilising 3D and regular anatomical models.3D printing is very appealing for producing patient-specific implants.This literature review-based paper explores the role of 3D printing and 3D bioprinting in healthcare.It briefs the need and progressive steps for implementing 3D printing in healthcare and presented various facilities and enablers of 3D printing for the healthcare sector.Finally,this paper identifies and discusses the significant applications of 3D printing for healthcare research and development.3D printing services can be deployed to easily construct complex geometries in plastic or metal with good precision.This results in improved prototypes,lower costs,and lower part processing times.They can now physically create with natural materials,previously unattainable with prior technologies.Every hospital should have 3D printers in the future,allowing new organs/parts to be developed in-house.

Current situation and development trend of design methods for subgrade structure of high speed railways

Purpose–This method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approach–This paper summarizes the structural types and design methods of subgrade bed for high speed railways in China,Japan,France,Germany,the United States and other countries based on the study and analysis of existing literature and combined with the research results and practices of high speed railway subgrade engineering at home and abroad.Findings–It is found that in foreign countries,the layered reinforced structure is generally adopted for the subgrade bed of high speed railways,and the unified double-layer or multi-layer structure is adopted for the surface layer of subgrade bed,while the simple structure is adopted in China;in foreign countries,different inspection parameters are adopted to evaluate the compaction state of fillers according to their respective understanding and practice,while in China,compaction coefficient,subsoil coefficient and dynamic deformation modulus are adopted for such evaluation;in foreign countries,the subgrade top deformation control method,the subgrade bottom deformation control method,the subsurface fill strength control method are mainly adopted in subgrade bed structure design of high speed railways,while in China,dynamic deformation control of subgrade surface and dynamic strain control of subgrade bed bottom layer is adopted in the design.However,the cumulative deformation of subgrade caused by train cyclic vibration load is not considered in the existing design methods.Originality/value–This paper introduces a new subgrade structure design method based on whole-process dynamics analysis that meets subgrade functional requirements and is established on the basis of the existing research at home and abroad on prediction methods for cumulative deformation of subgrade soil.

Research Developments and Prospects on Microseismic Source Location in Mines

Microseismic source location is the essential factor in microseismic monitoring technology, and its loca- tion precision has a large impact on the performance of the technique. Here, we discuss the problem of low-precision location identification for microseismic events in a mine, as may be obtained using conven-tional location methods that are based on arrival time. In this paper, microseismic location characteristics in mining are analyzed according to the characteristics of the mine＇s microseismic wavefield. We review research progress in mine-related microseismic source location methods in recent years, including the combination of the Geiger method with the linear method, combined microseismic event location method, optimization of relative location method, location method without pre-measured velocity, and location method without arrival time picking. The advantages and disadvantages of these methods are discussed, along with their feasible conditions. The influences of geophone distribution, first arrival time picking, and the velocity model on microseismic source location are analyzed, and measures are proposed to influence these factors. Approaches to solve the problem under study include adopting information fusion, combining and optimizing existing methods, and creating new methods to realize high-precision microseismic source location. Optimization of the velocity structure, along with applications of the time-reversal imaging technique, passive time-reversal mirror, and relative interferometric imag-ing, are expected to greatly improve microseismic location precision in mines. This paper also discusses the potential application of information fusion and deep learning methods in microseismic source location in mines. These new and innovative location methods for microseismic source location have extensive prospects for development.

Chris Barker’s Biological and Cultural Research in Development Theories of Physical Culture at Vietnam(In the Case of Nam Huynh Dao School)

In relation to human issues,the relationship between biology and culture has long been an important part of general social science research,cultural studies in particular.In which Chris Barker’s theory of biology and culture in relation to related theories can be considered as one of the noteworthy remarks about the method and methodology to pass on the actual field Nam Huynh Dao school,the article focuses on clarifying the basic content of the problem with orientation to contribute to research and development of physical culture in Vietnam at present.This article was selected to read and print in the conference proceedings of scientific conference entitled“Theory of Western Culture and Applied to Vietnamese Culture Research”organized by the University of Social Sciences and Humanities,Vietnam National University-HCM City(USSH,VNU-HCM,Vietnam)(29 November 2018).

Overview of Research and Development for Anticancer Drugs

Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.