Research Progress on the Preparation of Inorganic/Natural Materials Composite Microspheres

Microspheres are a new type of drug carrier with great potential for development and application.Natural polymers have good biocompatibility,biodegradability,and are easily dispersed in living organisms,making them suitable for preparing microspheres.Inorganic materials(mainly inorganic minerals)have excellent mechanical properties and are inexpensive and easy to obtain.Through the coupling and hybridization of natural polymers and inorganic materials,they can complement each other's advantages and synergistically enhance efficiency,resulting in many excellent physical and chemical properties.Inorganic materials/natural polymer composite microspheres can be prepared by modifying natural polymers with inorganic materials through various methods such as emulsification crosslinking,solution mixing,in-situ synthesis,extrusion,etc.The application of inorganic materials/natural polymer composite microspheres in drug delivery systems has significant sustained-release effects,is safe and non-toxic,and the cost of carrier materials is relatively low,which has certain significance for the development of new drug carriers.This article reviews the recent research on the preparation,drug loading and release properties of inorganic material/natural polymer composite microspheres,analyzes the advantages and disadvantages of commonly used preparation methods,and looks forward to the development direction of composite microspheres.

Research progress on natural products against hepatocellular carcinoma

Hepatocellular carcinoma(HCC)remains a prevalent and challenging malignancy globally,characterized by its numerous causal factors and generally unfavorable prognosis.In the relentless pursuit of effective treatment modalities,natural products have emerged as a promising and relatively non-toxic alternative,garnering significant interest.The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC.This review offers a comprehensive overview of the causal factors underlying HCC,and the diverse treatment options available,and highlights the advancements made by natural products in anti-HCC research.Particularly,we provide an outline of the various types of natural products,their corresponding nomenclature,target molecules,and mechanisms of action that exhibit anti-HCC activities.Natural products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer,potentially offering patients improved survival rates and an enhanced quality of life.

SOME PERSONAL VIEWS ON THE BASIC RESEARCH OF NATURAL SCIENCES IN CHINA

Mankind is going to stride across the threshold of the new century while world science advances by leaps and bounds. At the same time, China will enter a comparatively well-off state in terms of its economic development and its next step forward is to be a moderately developed country in the international community. At the 15th National Congress

A BRIEF INTRODUCTION TO THE RESEARCH PROJECTS WINNING FIRST-GRADE PRIZES OF THE 1993 CAS AWARDS FOR NATURAL SCIENCES

In the wake of examination, appraisal and recommendation by the jury of the CAS Awards for Natural Sciences.a total of 17 research projects was finally approved by the CAS President’s Working Conference as laureates of the first-grade prizes of the 1993 CAS Awards for Natural Sciences.A brief introduction of them is as follows: 1. A Study on the Steiner

Research Progress in the Petroleum and Natural Gas Geological Theory of China

The Chinese landmass, as a composite region, consists of multiple small continental blocks, such as Sino-Korea, Yangtze, Tarim, etc., and orogenic belts. Because of its distinctive tectono-sedimentary evolution, China＇s oil/gas-bearing regions differ remarkably from that elsewhere in the world. For instance, in comparison to the Middle East oil/gas-bearing regions which are characterized by Mesozoic-Cenozoic marine oil/gas-bearing beds, early oil and gas discoveries in China are distributed mainly in Mesozoic-Cenozoic continental sedimentary basins. Generation of oil from terrestrial organic matter, or terrestrial oil generation, and the formation of large oil/gas fields in continental sedimentary basins were previously the major characteristics of petroleum geology of China. However, in the past 20 years, a series of major oil and gas discoveries from marine strata have been made. Marine oil/gas fields in China are mainly distributed in the Tarim, Sichuan, and Ordos basins, which are tectonically stable and covered with Mesozoic-Cenozoic deposits. In these basins, hydrocarbon-bearing strata are of old age and the oil/gas fields are commonly deeply-buried. Cumulatively, 995 oil/gas fields have been found so far, making China the fourth largest oil-producing country and the sixth largest gas-producing country in the world. In terms of petroleum and natural gas geology, theories of hydrocarbon generation from continental strata, such as terrestrial oil generation and coal-generated hydrocarbons, etc., have been established. Significant progress has been made in research on the sequence stratigraphy of continental strata, formation mechanisms of ultra-deep clastic reservoirs, and hydrocarbon accumulation in the continental subtle reservoir. Regarding research on the marine petroleum geology of China, with respect to the major characteristics, such as deeply-buried reservoirs, old strata, and multiple phases of transformation, important advances have been made, in areas such as the multiple-elements of hydrocarbon supply, formation of reservoirs jointly controlled by deposition, tectonic activities, and diagenetic fluid-rock reactions, and oil/gas reservoirs formed through superimposed multi-stage hydrocarbon accumulation. As more and more unconventional hydrocarbon resources are discovered, unconventional oil and gas reservoirs are under study by Chinese petroleum geologists, who endeavor to come up with new discoveries on their formation mechanisms.

Information Extraction Based on Multi-turn Question Answering for Analyzing Korean Research Trends

Analyzing Research and Development(R&D)trends is important because it can influence future decisions regarding R&D direction.In typical trend analysis,topic or technology taxonomies are employed to compute the popularities of the topics or codes over time.Although it is simple and effective,the taxonomies are difficult to manage because new technologies are introduced rapidly.Therefore,recent studies exploit deep learning to extract pre-defined targets such as problems and solutions.Based on the recent advances in question answering(QA)using deep learning,we adopt a multi-turn QA model to extract problems and solutions from Korean R&D reports.With the previous research,we use the reports directly and analyze the difficulties in handling them using QA style on Information Extraction(IE)for sentence-level benchmark dataset.After investigating the characteristics of Korean R&D,we propose a model to deal with multiple and repeated appearances of targets in the reports.Accordingly,we propose a model that includes an algorithm with two novel modules and a prompt.A newly proposed methodology focuses on reformulating a question without a static template or pre-defined knowledge.We show the effectiveness of the proposed model using a Korean R&D report dataset that we constructed and presented an in-depth analysis of the benefits of the multi-turn QA model.

Research progress of natural products in treating polycystic ovary syndrome

Polycystic ovary syndrome(PCOS)is a common metabolic disorder reproductive endocrine disease in puberty and women of childbearing age.At present,metformin is mainly used in clinical to treat PCOS.From recent researches,many natural products,such as flavonoids,alkaloids,cumarins,etc,showed curing effects on PCOS.These have been attracting more and more attention.By searching the researches from database of CNKI,PubMed etc,this paper aims at providing a reference for PCOS drug research and development.

Spread of Zika virus:The key role of mosquito vector control

Mosquitoes(Diptera: Culicidae) represent a key threat for millions of humans and animals worldwide, since they act as vectors for important parasites and pathogens,including malaria, filariasis and a wide number of arboviruses. The recent outbreaks of Zika virus infections occurring in South America, Central America, and the Caribbean,represent the most recent four arrivals of important arboviruses in the western hemisphere, over the last 20 years, namely dengue, West Nile virus, and chikungunya. Since there are no specific treatments for Zika virus and the other arboviruses mentioned above,it should be highlighted that the eco-friendly and effective control of mosquito vectors is of pivotal importance. Besides radiation, transgenic and symbiont-based mosquito control approaches, an effective option may be the employ of biological control agents of mosquito young instars, in presence of ultra-low quantities of green-synthesized nanoparticles, which magnify their predation efficiency. Furthermore, behaviour-based control tools relying on the employ of swarming behaviour manipulation(i.e. the "lure and kill"approach), pheromone traps, sound traps need further research attention. In particular,detailed basic information on the physical and chemical cues routing mosquito swarming and mating dynamics is urgently required.

Window Views of Wards in Foreign Hospitals

Through the collection and systematic analysis of documents related to window views of hospitals,it is found that natural window views had a significant impact on patients’health benefits.The research focused on three aspects:“shortening length of stay”,“pain reduction”and“improvement of recovery rate”,mainly covering three types of patients:“heart patients”,“postoperative patients”and“patients of rehabilitation centers”.Based on the above analysis,summary and sorting,new directions and perspectives of hospital environment design and research under the concept of comprehensive health of people’s physiological,psychological and social adaptation will be obtained to provide references for the research and practice of health architecture,rehabilitation architecture,biophile design and other fields.

Measurement of Natural and Artificial Radioactivity in Soil at Some Selected Thanas around the TRIGA Mark-II Research Reactor at AERE, Savar, Dhaka

The activity concentration of natural and fallout radionuclides in the soil at some selected Thanas around the TRIGA Mark-II Research Reactor at Atomic Energy Research Establishment (AERE), Savar, Dhaka were measured by using a high purity germanium detector (HPGe). The study revealed that only natural radionuclides were present in the samples and no trace of any artificial radionuclide was found. The average activity concentration of 238U, 232Th and 40K were found to be 37.8 ± 5.6 Bq.kg-1, 58.2 ± 11.0 Bq.kg-1 and 790.8 ± 153.4 Bq.kg-1 respectively. The radium equivalent activity (Req), absorbed dose rate (D), external radiation hazard index (Hex) and internal radiation hazard index (Hin) were also calculated to find out the probable radiological hazard of the natural radioactivity.

Analyzing the Impact of Different Factors on Software Cost Estimation in Today’s Scenario

Software cost estimation is a main concern of the software industry. However, the fact is also that in today’s scenario, software industries are more interested in other issues like new technologies in the market, shorter development time, skill shortage etc. They are actually deviating from critical issues to routine issues. Today, people expect high quality products at very low costs and same is the goal of software engineering. An accuracy in software cost estimation has a direct impact on company’s reputation and also affects the software investment decisions. Accurate cost estimation can minimize the unnecessary costs and increase the productivity and efficiency of the company. The objective of this paper is to identify the existing methods of software cost estimation prevailing in the market and analyzing some of the important factors impacting the software cost estimation process. In order to achieve the objective, a survey was conducted to find out: ● Nature of projects that companies prefer. ● Impact of training on employees in software cost estimation. ● How many people review the estimated cost? ● How much risk buffer the company keeps for future prospects?

Subsoil Natural Physico-chemical Reactor: The Property of Deep Abiogenic Methane-Containing High-Thermobaric Fluid to Form Coal Seams

For the first time,the property of deep abiogenic methane-containing high-thermobaric fluid to decompose organic residues in the Earth’s crust and form coal seams was established.

Researching the Research: Applying Machine Learning Techniques to Dissertation Classification

This research examines industry-based dissertation research in a doctoralcomputing program through the lens of machine learning algorithms todetermine if natural language processing-based categorization on abstractsalone is adequate for classification. This research categorizes dissertationby both their abstracts and by their full-text using the GraphLabCreate library from Apple’s Turi to identify if abstract analysis is anadequate measure of content categorization, which we found was not. Wealso compare the dissertation categorizations using IBM’s Watson Discoverydeep machine learning tool. Our research provides perspectiveson the practicality of the manual classification of technical documents;and, it provides insights into the: (1) categories of academic work createdby experienced fulltime working professionals in a Computing doctoralprogram, (2) viability and performance of automated categorization of theabstract analysis against the fulltext dissertation analysis, and (3) natuallanguage processing versus human manual text classification abstraction.

Analysis on natural circulation capacity of the CARR

The investigation on natural circulation (NC) characteristics of the China Advanced Research Reac- tor(CARR) is very valuable for practical engineering application and also a key subject for the CARR. In this study, a computer code was developed to calculate the NC capacity of the CARR under different pool water temperatures. Ef- fects of the pool water temperature on NC characteristics were analyzed. The results show that with increasing pool water temperature, the NC flow rate increases while the NC capacity decreases. Based on the computation results and theoretical deduction, a correlation was proposed on predicting the relationship between the NC mass flow and the core power under different conditions. The correlation prediction agrees well with the computational result within ±10% for the maximal deviation. This work is instructive for the actual operation of the CARR.

Delayed assessment and eager adoption of laparoscopic cholecystectomy:Implications for developing surgical technologies

Despite the prevailing emphasis in the medical literature on establishing evidence,many changes in the practice of surgery have not been achieved using proper evidence-based assessment.This paper examines the adoption of laparoscopic cholecystectomy(LC)into regular use for the treatment of cholecystitis and the process of its acceptance,focusing on the limited role of technology assessment in its appraisal.A review of the published medical literature concerning LC was performed.Approximately 3000 studies of LC have been conducted since 1985,and there have been nearly 8500 publications to date.As LC was adopted enthusiastically into practice,the results of outcome studies generally showed that it compared favorably with the traditional,open cholecystectomy with regard to mortality,complications,and length of hospital stay.However,despite the rapid general agreement on surgical technique,efficacy,and appropriateness,there remained lingering doubts about safety,outcomes,and cost of the procedure that suggested that essential research questions were ignored even as the procedure became standard.Using LC as a case study,there are important lessons to be learned about the need for important guidelines for surgical innovation and the adoption of minimally invasive surgical techniques into current clinical and surgical practice.We highlight one recent example,natural orifice transluminal endoscopic surgery and how necessary it is to properly evaluate this new technology before it is accepted as a safe and effective surgical option.

Increasing Visitor Knowledge of Park History and Natural Resources via Non-Traditional Recreation: An Exploratory Study of Quicksand Enthusiasts

Sinkers are quicksand enthusiasts that crave the sensation of being trapped in deep mud while being sucked downward. Although humans have been interested in quicksand over the years (particularly through film), there remains a void of research into the meaning and value in the lives of those who engage in a recreational pursuit of quicksand, most notably the community of individuals who self-describe as sinkers. The purpose of this exploratory study was to examine if sinking can contribute to a participant’s understanding of history and natural resources at state parks. In order to obtain a better understanding of the effects, a qualitative study was conducted in the summer of 2016 at Stephen C. Foster State Park, a state park adjacent to Okefenokee Swamp. The researchers exercised grounded theory techniques and inductive content analysis to analyze interview data and compile coded text into four main categories: learning, enjoyment, traveling, and economic impact. Findings suggest that participants believed their knowledge of park history and natural resources increased through a recreational pursuit of quicksand.

Bone Research首获影响因子

美国Thomson Reuter发布最新期刊引文报告（Journal Citation Report,JCR）,四川大学华西口腔医院主办的期刊Bone Research首获影响因子1.31,成为亚洲排名第一的骨科学英文杂志。Bone Research2013年创刊,编委会由国内外著名口腔科学、骨科学学者和专家组成,是连接口腔科学和医学的重要桥梁,

Bone Research首获影响因子

美国Thomson Reuter发布最新期刊引文报告（Journal Citation Report,JCR）,由口腔疾病研究国家重点实验室、四川大学华西口腔医院主办的骨科学英文期刊Bone Research首获影响因子1.31,成为亚洲排名第一的骨科学英文杂志。Bone Research2013年创刊,编委会由国内外著名口腔科学、骨科学学者和专家组成,是连接口腔科学和医学的重要桥梁,先后被Pubmed Central,Science Citation Index-Expanded,Chemical Abstracts，Scopus等国际知名数据库收录。