University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and students.This study adopts an affordance research perspe...University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and students.This study adopts an affordance research perspective originating from ecological psychology to explore the optimization path of research support services in libraries in the new media era.Based on the characteristics of university library services,this research analyzes three aspects:production affordance,mobile affordance,and social affordance,and proposes practical recommendations to guide future research service practices of university libraries.展开更多
University College Dublin(UCD) has implemented the Output-Based Research Support Scheme(OBRSS) since 2016. Adapted from the Norwegian model, the OBRSS awards individual academic staff using a points system based on th...University College Dublin(UCD) has implemented the Output-Based Research Support Scheme(OBRSS) since 2016. Adapted from the Norwegian model, the OBRSS awards individual academic staff using a points system based on the number of publications and doctoral students. This article describes the design and implementation processes of the OBRSS, including the creation of the ranked publication list and points system and infrastructure requirements. Some results of the OBRSS will be presented, focusing on the coverage of publications reported in the OBRSS ranked publication list and Scopus, as well as information about spending patterns. Challenges such as the evaluation of the OBRSS in terms of fairness, transparency, and effectiveness will also be discussed.展开更多
Research has been an important responsibility for university professors. Although there has been an increased demand for research, few studies have been conducted directly with university professors to obtain their pe...Research has been an important responsibility for university professors. Although there has been an increased demand for research, few studies have been conducted directly with university professors to obtain their perceptions of the challenges the increased focus on research have presented. This study employed a qualitative methodology to inquire into the change of work life bought about by the increased demand for research, and the strategies professors have adopted to balance their teaching, research and service. It also inquired into the barriers to conducting research, and effective support strategies. Some barriers and support identified in this study were in accordance with what previous studies have identified. Perhaps because the professors interviewed were all tenured, they noted that the increased demand for research had not significantly changed their work life. Strategies they used to help them meet the demands for research included, but were not limited to, integrating their teaching and research, and collaborating with others on research projects. Barriers to research included bureaucratic constraints, newness to research, lack of time, and lack of funding.展开更多
Traditional Folk relations of debit and credit have existed for thousands of years in Chinese society. In the rapidly develop of the context of mobile internet and social network, the borrowing that relies on the rela...Traditional Folk relations of debit and credit have existed for thousands of years in Chinese society. In the rapidly develop of the context of mobile internet and social network, the borrowing that relies on the relationship among people is not just a financial domain scope discussion topic. In the rapidly developing Chinese mobile Internet, a new anonymous mechanism which is based on interpersonal credit extension and evaluation ultimately form borrowing is continuously formed.?In this paper, the author researches and analyzes on what is relationship lending mechanism, the basic operation modes of relationship lending mechanism, a part of theoretical supporting and values.展开更多
IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet a...IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet and relevant equipment interfaces are not perfect. A Network Management System (NMS) at the network layer helps implement the integrated management of a network with equipment from multiple vendors, including the network resources and topology, end-to-end network performance, network failures and customer Service Level Agreement (SLA) management. Though the NMS will finally realize pure IPv6 network management, it must be accommodated to the management of relevant IPv4 equipment. Therefore, modularized and layered structure is adopted for the NMS in order to implement its smooth transition.展开更多
AIM: To set up a new method to detect tissue inhibitors of metalloproteinase-1 and -2(TIMP-1 and TIMP-2) in sera of patients with hepatic cirrhosis, and to investigate the expression and location of TIMP-1 and TIMP-2 ...AIM: To set up a new method to detect tissue inhibitors of metalloproteinase-1 and -2(TIMP-1 and TIMP-2) in sera of patients with hepatic cirrhosis, and to investigate the expression and location of TIMP-1 and TIMP-2 in liver tissue of patients with hepatic cirrhosis, and the correlation between TIMPs in liver and those in sera so as to discuss whether TIMPs can be used as a diagnosis index of hepatic fibrosis. METHODS: The monoclonal antibodies (McAbs) of TIMP-1 and TIMP-2 were used to sensitize erythrocytes, and solid-phase absorption to sensitized erythrocytes (SPASE) was used to detect TIMP-1 and TIMP-2 in the sera of patients with hepatic cirrhosis. Meanwhile, with the method of in situ hybridization and immunohistochemistry, we studied the mRNA expression and antigen location of TIMP-1 and TIMP-2 in the livers of 40 hepatic cirrhosis patients with pathologic diagnosis. RESULTS: With SPASE, they were 16.4% higher in the acute hepatitis group, 33.3% higher in the chronic hepatitis group, and the positive rates were 73.6% and 61.2% respectively in sera of hepatic cirrhosis patients, which were remarkably higher than those in chronic hepatitis and acute hepatitis group (P【0.001). In 40 samples of hepatic cirrhosis tissues, all of them showed positive expression of TIMP-1 and TIMP-2 mRNA detected with immunohistochemistry or in situ hybridization (positive rate was 100%). Expression of TIMPs in different degrees could be found in liver tissue with cirrhosis. TIMPs were located in cytoplasm of liver cells of patients with hepatic cirrhosis. There was a significant correlation between serum TIMPs level and liver TIMPs level. CONCLUSION: SPASE is a useful method to detect the TIMP-1 and TIMP-2 in sera of patients with hepatic cirrhosis, and TIMP-1 and TIMP-2 can be considered as a useful diagnostic index of hepatic fibrosis, especially TIMP-1.展开更多
AIM: To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute live...AIM: To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS: The porcine liver cells (1-2) x 10(10) were separated from the Chinese small swine and cultured in the bioreactor of TECA-BALSS at 37.0 degrees C and circulated through the outer space of the hollow fiber tubes in BALSS. The six liver failure patients with various degree of hepatic coma were treated by TECA-HALSS and with conventional medicines. The venous plasma of the patients was separated by a plasma separator and treated by charcoal adsorbent or plasma exchange. The plasma circulated through the inner space of the hollow fiber tubes of BALSS and mixed with the patients' blood cells and flew back to their blood circulation. Some small molecular weight substances were exchanged between the plasma and porcine liver cells. Each treatment lasted 6.0-7.0 h. Physiological and biochemical parameters were measured before,during and after the treatment. RESULTS: The average of porcine liver cells was (1.0-3.0) x 10(10) obtained from each swine liver using our modified enzymatic digestion method. The survival rate of the cells was 85%-93% by trypan blue stain and AO/PI fluorescent stain. After cultured in TECA-BALSS bioreactor for 6 h, the survival rate of cells still remained 70%-85%. At the end of TECA-HALSS treatment, the levels of plasma NH(3), ALT, TB and DB were significantly decreased. The patients who were in the state of drowsiness or coma before the treatment improved their appetite significantly and regained consciousness, some patients resumed light physical work on a short period after the treatment.One to two days after the treatment, the ratio of PTA increased warkedly. During the treatment, the heart rates, blood pressure, respiration condition and serum electrolytes (K(+), Na(+) and Cl(-)) were stable without thrombosis and bleeding in all the six patients. CONCLUSION: TECA-HALSS treatment could be a rapid, safe and efficacious method to provide temporary liver support for patients with ALF.展开更多
INTRODUCTIONFulminant hepatic failure(FHF)is a severe disease with devastating consequences;the incidence is high in China.Before the availability of liver transplantation,the mortality rate was more than 80%[1,2].The...INTRODUCTIONFulminant hepatic failure(FHF)is a severe disease with devastating consequences;the incidence is high in China.Before the availability of liver transplantation,the mortality rate was more than 80%[1,2].The advent of liver transplantation revolutionized the outcome of FHF[3,4].However,many patients were unwilling to accept liver transplantation until very late,hence most of them died because of donor shortage and urgency of the disease[5-7],To overcome he problems,we performed orthotopic liver transplantation(OLT)in combination with artificial liver support(ALS) in the treatment of FHF in the past 2 years with satisfactory results.Our experience was reported below.展开更多
AIM: To study preliminarily the properties of myosin light chain kinase (MLCK) in rabbit liver. METHODS: The expression of MLCK was detected by reverse transcription-polymerase chain reaction(RT-PCR); the MLCK was obt...AIM: To study preliminarily the properties of myosin light chain kinase (MLCK) in rabbit liver. METHODS: The expression of MLCK was detected by reverse transcription-polymerase chain reaction(RT-PCR); the MLCK was obtained from rabbit liver, and its activity was analyzed by gamma-(32)P incorporation technique to detect the phosphorylation of myosin light chain. RESULTS: MLCK was expressed in rabbit liver, and the activity of the enzyme was similar to rabbit smooth muscle MLCK, and calmodulin-dependent. When the concentration was 0.65 mg x L(-1), the activity was at the highest level. CONCLUSION: MLCK expressed in rabbit liver may catalyze the phosphorylation of myosin light chain, which may play important roles in the regulation of hepatic cell functions.展开更多
为解决传统数字滤波器在有限精度实现时因有限字长(Finite Word Length,FWL)效应导致滤波器性能下降的问题,提出一种L_(2)灵敏度最小化的数字滤波器状态空间实现稀疏化方法.推导前向差分算子数字滤波器结构传输函数及其等效状态空间实现...为解决传统数字滤波器在有限精度实现时因有限字长(Finite Word Length,FWL)效应导致滤波器性能下降的问题,提出一种L_(2)灵敏度最小化的数字滤波器状态空间实现稀疏化方法.推导前向差分算子数字滤波器结构传输函数及其等效状态空间实现,根据可控及可观格莱姆矩阵得到基于相似变换矩阵的L_(2)灵敏度表达式,并进行稀疏化校准,将L_(2)灵敏度最小化问题转换为凸函数求最值问题,求导得到L_(2)灵敏度最小化表达式,代回即得前向差分算子数字滤波器的稀疏化状态空间实现.仿真结果表明,所提方法设计的数字滤波器具有更好的抗FWL效应.展开更多
文摘University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and students.This study adopts an affordance research perspective originating from ecological psychology to explore the optimization path of research support services in libraries in the new media era.Based on the characteristics of university library services,this research analyzes three aspects:production affordance,mobile affordance,and social affordance,and proposes practical recommendations to guide future research service practices of university libraries.
文摘University College Dublin(UCD) has implemented the Output-Based Research Support Scheme(OBRSS) since 2016. Adapted from the Norwegian model, the OBRSS awards individual academic staff using a points system based on the number of publications and doctoral students. This article describes the design and implementation processes of the OBRSS, including the creation of the ranked publication list and points system and infrastructure requirements. Some results of the OBRSS will be presented, focusing on the coverage of publications reported in the OBRSS ranked publication list and Scopus, as well as information about spending patterns. Challenges such as the evaluation of the OBRSS in terms of fairness, transparency, and effectiveness will also be discussed.
文摘Research has been an important responsibility for university professors. Although there has been an increased demand for research, few studies have been conducted directly with university professors to obtain their perceptions of the challenges the increased focus on research have presented. This study employed a qualitative methodology to inquire into the change of work life bought about by the increased demand for research, and the strategies professors have adopted to balance their teaching, research and service. It also inquired into the barriers to conducting research, and effective support strategies. Some barriers and support identified in this study were in accordance with what previous studies have identified. Perhaps because the professors interviewed were all tenured, they noted that the increased demand for research had not significantly changed their work life. Strategies they used to help them meet the demands for research included, but were not limited to, integrating their teaching and research, and collaborating with others on research projects. Barriers to research included bureaucratic constraints, newness to research, lack of time, and lack of funding.
文摘Traditional Folk relations of debit and credit have existed for thousands of years in Chinese society. In the rapidly develop of the context of mobile internet and social network, the borrowing that relies on the relationship among people is not just a financial domain scope discussion topic. In the rapidly developing Chinese mobile Internet, a new anonymous mechanism which is based on interpersonal credit extension and evaluation ultimately form borrowing is continuously formed.?In this paper, the author researches and analyzes on what is relationship lending mechanism, the basic operation modes of relationship lending mechanism, a part of theoretical supporting and values.
文摘IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet and relevant equipment interfaces are not perfect. A Network Management System (NMS) at the network layer helps implement the integrated management of a network with equipment from multiple vendors, including the network resources and topology, end-to-end network performance, network failures and customer Service Level Agreement (SLA) management. Though the NMS will finally realize pure IPv6 network management, it must be accommodated to the management of relevant IPv4 equipment. Therefore, modularized and layered structure is adopted for the NMS in order to implement its smooth transition.
基金the Postdoctoral Science Foundation of China,No.1999-10 State Postdoctoral Foundation Commission
文摘AIM: To set up a new method to detect tissue inhibitors of metalloproteinase-1 and -2(TIMP-1 and TIMP-2) in sera of patients with hepatic cirrhosis, and to investigate the expression and location of TIMP-1 and TIMP-2 in liver tissue of patients with hepatic cirrhosis, and the correlation between TIMPs in liver and those in sera so as to discuss whether TIMPs can be used as a diagnosis index of hepatic fibrosis. METHODS: The monoclonal antibodies (McAbs) of TIMP-1 and TIMP-2 were used to sensitize erythrocytes, and solid-phase absorption to sensitized erythrocytes (SPASE) was used to detect TIMP-1 and TIMP-2 in the sera of patients with hepatic cirrhosis. Meanwhile, with the method of in situ hybridization and immunohistochemistry, we studied the mRNA expression and antigen location of TIMP-1 and TIMP-2 in the livers of 40 hepatic cirrhosis patients with pathologic diagnosis. RESULTS: With SPASE, they were 16.4% higher in the acute hepatitis group, 33.3% higher in the chronic hepatitis group, and the positive rates were 73.6% and 61.2% respectively in sera of hepatic cirrhosis patients, which were remarkably higher than those in chronic hepatitis and acute hepatitis group (P【0.001). In 40 samples of hepatic cirrhosis tissues, all of them showed positive expression of TIMP-1 and TIMP-2 mRNA detected with immunohistochemistry or in situ hybridization (positive rate was 100%). Expression of TIMPs in different degrees could be found in liver tissue with cirrhosis. TIMPs were located in cytoplasm of liver cells of patients with hepatic cirrhosis. There was a significant correlation between serum TIMPs level and liver TIMPs level. CONCLUSION: SPASE is a useful method to detect the TIMP-1 and TIMP-2 in sera of patients with hepatic cirrhosis, and TIMP-1 and TIMP-2 can be considered as a useful diagnostic index of hepatic fibrosis, especially TIMP-1.
基金Supported by the Research Initiation Fund for Returned Students from Overseas,Ministry of Education,No.94001
文摘AIM: To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS: The porcine liver cells (1-2) x 10(10) were separated from the Chinese small swine and cultured in the bioreactor of TECA-BALSS at 37.0 degrees C and circulated through the outer space of the hollow fiber tubes in BALSS. The six liver failure patients with various degree of hepatic coma were treated by TECA-HALSS and with conventional medicines. The venous plasma of the patients was separated by a plasma separator and treated by charcoal adsorbent or plasma exchange. The plasma circulated through the inner space of the hollow fiber tubes of BALSS and mixed with the patients' blood cells and flew back to their blood circulation. Some small molecular weight substances were exchanged between the plasma and porcine liver cells. Each treatment lasted 6.0-7.0 h. Physiological and biochemical parameters were measured before,during and after the treatment. RESULTS: The average of porcine liver cells was (1.0-3.0) x 10(10) obtained from each swine liver using our modified enzymatic digestion method. The survival rate of the cells was 85%-93% by trypan blue stain and AO/PI fluorescent stain. After cultured in TECA-BALSS bioreactor for 6 h, the survival rate of cells still remained 70%-85%. At the end of TECA-HALSS treatment, the levels of plasma NH(3), ALT, TB and DB were significantly decreased. The patients who were in the state of drowsiness or coma before the treatment improved their appetite significantly and regained consciousness, some patients resumed light physical work on a short period after the treatment.One to two days after the treatment, the ratio of PTA increased warkedly. During the treatment, the heart rates, blood pressure, respiration condition and serum electrolytes (K(+), Na(+) and Cl(-)) were stable without thrombosis and bleeding in all the six patients. CONCLUSION: TECA-HALSS treatment could be a rapid, safe and efficacious method to provide temporary liver support for patients with ALF.
基金the grant of key Clinical Programme of China Ministry Public Health,No.97040230
文摘INTRODUCTIONFulminant hepatic failure(FHF)is a severe disease with devastating consequences;the incidence is high in China.Before the availability of liver transplantation,the mortality rate was more than 80%[1,2].The advent of liver transplantation revolutionized the outcome of FHF[3,4].However,many patients were unwilling to accept liver transplantation until very late,hence most of them died because of donor shortage and urgency of the disease[5-7],To overcome he problems,we performed orthotopic liver transplantation(OLT)in combination with artificial liver support(ALS) in the treatment of FHF in the past 2 years with satisfactory results.Our experience was reported below.
基金Supported by the National Natural Science Foundation of China(39870324,YW)Key Innovation Project of Chinese Academy of Science,P.R.China(KSCX 2-2-01,XB Yao)Grant for Excellent Young Teachers of Ministry of Education of China(99044312,YW)
文摘AIM: To study preliminarily the properties of myosin light chain kinase (MLCK) in rabbit liver. METHODS: The expression of MLCK was detected by reverse transcription-polymerase chain reaction(RT-PCR); the MLCK was obtained from rabbit liver, and its activity was analyzed by gamma-(32)P incorporation technique to detect the phosphorylation of myosin light chain. RESULTS: MLCK was expressed in rabbit liver, and the activity of the enzyme was similar to rabbit smooth muscle MLCK, and calmodulin-dependent. When the concentration was 0.65 mg x L(-1), the activity was at the highest level. CONCLUSION: MLCK expressed in rabbit liver may catalyze the phosphorylation of myosin light chain, which may play important roles in the regulation of hepatic cell functions.
文摘为解决传统数字滤波器在有限精度实现时因有限字长(Finite Word Length,FWL)效应导致滤波器性能下降的问题,提出一种L_(2)灵敏度最小化的数字滤波器状态空间实现稀疏化方法.推导前向差分算子数字滤波器结构传输函数及其等效状态空间实现,根据可控及可观格莱姆矩阵得到基于相似变换矩阵的L_(2)灵敏度表达式,并进行稀疏化校准,将L_(2)灵敏度最小化问题转换为凸函数求最值问题,求导得到L_(2)灵敏度最小化表达式,代回即得前向差分算子数字滤波器的稀疏化状态空间实现.仿真结果表明,所提方法设计的数字滤波器具有更好的抗FWL效应.