Vascular endothelial growth factor（VEGF）in neurodevelopment and regeneration：VEGF is a well-known factor that promotes vascularization and angiogenesis.Besides this it participates in the pathogenesis of several di...Vascular endothelial growth factor（VEGF）in neurodevelopment and regeneration：VEGF is a well-known factor that promotes vascularization and angiogenesis.Besides this it participates in the pathogenesis of several diseases,such as colorectal carcinoma,lung cancer or diabetic retinopathy.Within the last decade,VEGF has been successfully integrated into the treatment of such diseases,for example as a therapy for colorectal cancer with the VEGF-receptor （VEGFR）-inhibitor axitinib.展开更多
The basic concepts and models of weapon-target assignment （WTA） are introduced and the mathematical nature of the WTA models is also analyzed. A systematic survey of research on WTA problem is provided. The present ...The basic concepts and models of weapon-target assignment （WTA） are introduced and the mathematical nature of the WTA models is also analyzed. A systematic survey of research on WTA problem is provided. The present research on WTA is focused on models and algorithms. In the research on models of WTA, the static WTA models are mainly studied and the dynamic WTA models are not fully studied in deed. In the research on algorithms of WTA, the intelligent algorithms are often used to solve the WTA problem. The small scale of static WTA problems has been solved very well, however, the large scale of dynamic WTA problems has not been solved effectively so far. Finally, the characteristics of dynamic WTA are analyzed and directions for the future research on dynamic WTA are discussed.展开更多
Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy ...Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.展开更多
ALINA研究[1]是首个成功将间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)抑制剂应用于非小细胞肺癌(non-small cell lung cancer,NSCLC)患者辅助治疗的Ⅲ期临床研究,首次公布在2023年欧洲肿瘤内科学会(European Society for Medica...ALINA研究[1]是首个成功将间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)抑制剂应用于非小细胞肺癌(non-small cell lung cancer,NSCLC)患者辅助治疗的Ⅲ期临床研究,首次公布在2023年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)大会。近期,the New England Journal of Medicine正式发表了这项全球性、Ⅲ期、开放、随机试验ALINA研究的中期分析结果[2].展开更多
基金the Heinrich and Alma Vogelsang Foundation for financial support in the form of a graduation scholarship
文摘Vascular endothelial growth factor（VEGF）in neurodevelopment and regeneration：VEGF is a well-known factor that promotes vascularization and angiogenesis.Besides this it participates in the pathogenesis of several diseases,such as colorectal carcinoma,lung cancer or diabetic retinopathy.Within the last decade,VEGF has been successfully integrated into the treatment of such diseases,for example as a therapy for colorectal cancer with the VEGF-receptor （VEGFR）-inhibitor axitinib.
基金This project was supported by the National Defense Pre-Research Foundation of China
文摘The basic concepts and models of weapon-target assignment （WTA） are introduced and the mathematical nature of the WTA models is also analyzed. A systematic survey of research on WTA problem is provided. The present research on WTA is focused on models and algorithms. In the research on models of WTA, the static WTA models are mainly studied and the dynamic WTA models are not fully studied in deed. In the research on algorithms of WTA, the intelligent algorithms are often used to solve the WTA problem. The small scale of static WTA problems has been solved very well, however, the large scale of dynamic WTA problems has not been solved effectively so far. Finally, the characteristics of dynamic WTA are analyzed and directions for the future research on dynamic WTA are discussed.
文摘Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.
文摘ALINA研究[1]是首个成功将间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)抑制剂应用于非小细胞肺癌(non-small cell lung cancer,NSCLC)患者辅助治疗的Ⅲ期临床研究,首次公布在2023年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)大会。近期,the New England Journal of Medicine正式发表了这项全球性、Ⅲ期、开放、随机试验ALINA研究的中期分析结果[2].
