China reshapes the East Asian production network

From the perspective of intra-product specialization and with in-depth analysis of trade statistics,this paper investigates the influence of China's rise on the East Asian production network.Our conclusions suggest that in integrating into the East Asian production network,China has gradually emerged as the manufacturing center of East Asia,weakening the regional influence of the Four Asian Tigers.Meanwhile,the competitive effect of China's rise has helped promote the specialization levels of the network's members and even the network as a whole.With cooperation in various processes of intra-product specialization,internal connections of the East Asian production network were further strengthened.In addition,China became an export platform of East Asia,transforming the export pattern of the East Asian production network to world markets from "bilateral trade" into "triangular trade," trade via China.

Teaching Reform of “Probability Theory and Mathematical Statistics” Under the Background of New Engineering

Probability theory and mathematical statistics are fundamental courses for various majors in science and engineering.In response to the current teaching situation,we should integrate theory with practice,implement teaching reform,and carry out teaching innovation.The article carries out blended teaching with deep integration of online and offline modes and within and outside of class,constructing innovative measures of“four integrations and four reshaping.”The article conducts diversified evaluations to stimulate learning motivation and help achieve talent cultivation goals.Through the close integration of probability theory and mathematical statistics course teaching with professional education and practical application,the“three-in-one”teaching goal of value shaping,ability cultivation,and knowledge exploration is achieved.The fundamental task of“cultivating morality and talents”is implemented.

DNA Methylation Reshapes Sex Development in Zebrafish

Sex determination is a complex biological process,through which the sex of an organism is established in a binary fate decision[1,2].There are two main determining mechanisms:1)genotypic sex determination(GSD),whereby the individual’s sex is determined by its genotype;and 2)environmental sex determination(ESD),where the sex is driven by different external factors,such as temperature,p H,and social interactions[1].

Effects of different pelvic osteotomies on acetabular morphology in developmental dysplasia of hip in children

Developmental dysplasia of hip seriously affects the health of children,and pelvic osteotomy is an important part of surgical treatment.Improving the shape of the acetabulum,preventing or delaying the progression of osteoarthritis is the ultimate goal of pelvic osteotomies.Re-directional osteotomies,reshaping osteotomies and salvage osteotomies are the three most common types of pelvic osteotomy.The influence of different pelvic osteotomy on acetabular morphology is different,and the acetabular morphology after osteotomy is closely related to the prognosis of the patients.But there lacks comparison of acetabular morphology between different pelvic osteotomies,on the basis of retrospective analysis and measurable imaging indicators,this study predicted the acetabular shape after developmental dysplasia of the hip pelvic osteotomy in order to help clinicians make reasonable and correct decisions and improve the planning and performance of pelvic osteotomy.

The Concept of Digital Human Rights and Its Reshaping of Basic Rights

Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often overlooking the revolutionary nature of digital media.Digital media has the sweeping potential to unify all forms of media and reshape social life,giving rise to new demands for a new generation of human rights.The concept of digital human rights can be defined as the legitimate rights of human's infinitely extended personalities through digital media.Its core characteristic is its transcendency,where every person lives in a networked space that surpasses physical boundaries,nations,and individual personalities.Human rights are generally considered the foundation for basic constitutional rights,which,in turn,form the basis for legislative acts across various sectors.In recent years,China has enacted numerous laws in the digital domain to keep pace with the times,but due to the lack of guidance on digital human rights,these laws tend to be fragmented and disjointed.It is urgent to unify digital legislation at all levels on the basis of reshaping basic constitutional rights.Thus,it is essential to reshape the basic rights based on the concept and characteristics of digital human rights and streamline legislation at all levels under the unified guidance of basic rights.This can help establish a comprehensive digital human rights protection system that meets the demands of the modern era.

Weight loss endoscopy: Development, applications, and current status

Obesity and its comorbidities- including diabetes and obstructive sleep apnea- have taken a large and increasing toll on the United States and the rest of the world. The availability of commercial, clinical, and operative therapies for weight management have not been effective at a societal level. Endoscopic bariatric therapy is gaining acceptance as more effective than diet and lifestyle measures, and less invasive than bariatric surgery. Various endoscopic therapies are analogues of the restrictive or bypass components of bariatric surgery, utilizing gastric remodeling or intestinal anastomosis to achieve proven weight loss and metabolic benefits. Others, such as aspiration therapy, employnovel mechanisms of action. Intragastric balloons have recently been approved by the United States Food and Drug Administration, and a number of other technologies have completed large multicenter trials(such as AspireA ssist aspiration therapy and Primary Obesity Surgery Endolumenal). Endoscopic sleeve gastroplasty and transoral outlet reduction for endoscopic revision of gastric bypass have proven safe and effective in a number of studies. As devices are approved for use, data will continue to accumulate for safety, effectiveness, and cost effectiveness. Bariatric endoscopists should be prepared to appropriately target and apply various endoscopic bariatric therapies in the context of a comprehensive long-term weight management program.

Dynamics and response reshaping of nonlinear predator-prey system undergoing random abrupt disturbances

An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.

Evidence for the role of KIF17 in fish spermatid reshaping:expression pattern of KIF17 in Larimichthys polyactis spermiogenesis

The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.

Report on 220 cases of endoscopic septoplasty with submucous resection

Objective To explore the efficiency of endoscopic septoplasty with submucous resection for the treatment of 220 patients with deviated nasal septum and report our experience in this field.Methods From May 2006 to May 2010,220 patients with deviated nasal septum were treated by endoscopic septoplasty with submucous resection to decompress the stress points,resect the deviated parts and implant the reshaped bone of nasal septum,while retaining the normal structure of nasal septum with minimally invasive technique.Results Satisfactory effects were achieved in all the 220 patients,showing centered septal structure and disappeared symptoms such as nasal obstruction,headache and nasal hemorrhage,but no complications including perforation of nasal septum,depressed nasal bridge and septal chalasia and flaring.Conclusion Rhino-endoscopic septoplasty with submucous resection can substantially retain the original structure of nasal septum and thus is proven to be a desirable operation with multiple advantages including minimal invasiveness,quicker healing and fewer complications.

Construction of Reshaping Single-domain Antibody against CD3

The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequences,some residues werechanged and the reshaping VL and VH genes were designed.The full VH gene was assem-bled in three steps with eight chemically synthesized oligonucleotide fragments using over-lapping PCR and sequenced.The VH gene was expressed as active protein and inclusion bod-ies in the vectors of pCOMB3 and pGEX-4T-1 by ELISA and Western blot analysis.

Thermal Stability and Hot Carrier Dynamics of Gold Nanoparticles of Different Shapes

Anisotropic shapes of gold nanoparticles are prepared using a modified seed method in the presence of silver ions or clusters in order to study the thermal stability and the dynamics of the hot carriers induced by femtosecond laser pulses. Although gold nanospheres are stable towards thermal treatment, the decomposition of the gold nanorods into spherical nanoparticle aggregates upon thermal treatment is mechanistically different from the case of nanoprisms. Great enhancement of thermal stability is achieved by modifying the surface of the nanoparticles by adding specific amounts of polyvinyl pyrrolidone (PVP) after preparation of gold particles of different shapes capped with cetyltrimethylammonium bromide (CTAB). The surface plasmon resonance spectra of the gold nanostructures are used to monitor their morphological changes. In regards to the hot carrier dynamics, it is found that the phonon-phonon (ph-ph) coupling is much slower in dots than in rods and prisms while electron-phonon (e-ph) coupling is almost the same in these particles.

Crossing the Growth Threshold： Service-Based Economy, Knowledge Process and Reshaping of Efficiency Model

The transition from middle-income to high-income stage is fraught with risks of growth divergence.Economic transition is clouded by the following possibilities:(1) falling share of industrial sector through industrial depression and weakening growth momentum caused by the large urbanization costs;(2) the subordination of service sector as a result of nearly irreversibly industrial professional,which falters the process of service sector transition and upgrading;(3) inefficient knowledge production allocation and human capital upgrade due to the absence of incentivized compensation of knowledge consumption.We suggest that a country should reshape its efficiency model by upgrading knowledge factor and human capital as the pre-requisite.Given the dilemmas of transition,China should take the factorization trend of service sector and reshape efficiency model through institutional reform,ensuring that service sector will develop in tandem with industrial sector.

2018: INTERNATIONAL SECURITY ORDER IN VIBRATION AND RESHAPING

The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism and populism,the resurgent power politics and authoritarianism,theintensified competition in geopolitical and other new areas,and the incessant regional turmoil and conflicts.

Pattern of Opening Up,Integration and Reshaping Economic Geography——A New Economic Geography Analysis of the Belt and Road Initiative and the Yangtze River Economic Belt

Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,aiming to reshape the economic geography of China.This paper is based on the Belt and Road Initiative and the Yangtze River Economic Belt and outlines the pattern of opening up.To analyze the impact of the pattern of opening up on the regional integration of China's economic geography,this paper has developed a new economic geography model comprised of four regions and two countries.From this,it draws some conclusions.First,the change of pattern of opening up will lead to shifting centripetal and centrifugal forces from the international market.The greater the scale of neighboring markets,the stronger the agglomeration force will be; the more product varieties made in neighboring countries,the more potent its dispersion force.Second,developing an inland international trade corridor will decentralize industry distribution and reduce the impact of external market integration on home countries.Third,the inland international trade corridor could alter the effect of domestic market integration on the economic geography.When domestic integration occurs prior to international integration,further integration of a domestic market leads to greater industrial distribution along a bell-shaped curve,which describes economic activities from dispersion to agglomeration to decentralization.Therefore,developing an integrated market system of major countries and opening a corridor between China and Europe is not only the key to reshaping China's economic geography but also the path to solving the problems of the Heihe-Tengchong Line.

The Dilemma of the Times and the Remolding of the Way of Model Education

As a general method of ideological and political education,model education has played an irreplaceable role in Chinese history.But in this pluralistic social background,it has been questioned and misinterpreted by more and more people,and the role model of traditional model education is gradually weakening.Model Education contributes to the construction of a harmonious socialist society and is an important channel to promote the all-round development of human beings and realize the harmony of interpersonal relations.Combing the theory of model education,endowing it with new connotation of the times,analyzing the situation of the current development and reshaping the new educational path,it plays an inestimable role in the development of individuals and society,it also contributes to the innovation of ideological and political education methods and provides a reference for the overall development of model education.

Water-Driven Malleable,Weldable and Eco-Friendly Recyclable Carbon Fiber Reinforced Dynamic Composites

Traditional carbon fiber-reinforced polymers based on thermoset matrix have been extensively used in the fields of wind turbine blades,automotive sector,and aerospace,among many others.However,there is still a major challenge of recycling those polymers due to the high cost and adverse impacts on the environment.In this work,we apply a polyimine network as matrix,which possess considerable tensile and thermal properties,to prepare the carbon fiber reinforced polyimine materials with trifluoromethyl diphenoxybenzene units(CFRFP)using a prepreg-based compression molding method.The CFRFP can be reshaped or reprocessed by heat or with water rapidly,and exhibited multifunction,including welding,chemical recycling,etc.These unique findings gained from our study will facilitate the manufacturing capability and enrich the types of fiber-reinforced composites.

Role of adhesion molecules in cancer and targeted therapy

Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and transmit mechanical and chemical signals among them.Various mechanisms deregulate adhesion molecules in cancer,enabling tumor cells to proliferate without restraint,invade through tissue boundaries,escape from immune surveillance,and survive in the tumor microenvironment.Recent studies have revealed that adhesion molecules also drive angiogenesis,reshape metabolism,and are involved in stem cell self-renewal.In this review,we summarize the functions and mechanisms of adhesion molecules in cancer and the tumor microenvironment,as well as the therapeutic strategies targeting adhesion molecules.These studies have implications for furthering our understanding of adhesion molecules in cancer and providing a paradigm for exploring novel therapeutic approaches.

Adaptable "bubble particles" prepared by green aqueous phase reshaping for completely removing odor

Facile and ecofriendly loading of micro/nano function-specific substances to create functional materials is a trend being pursued by researchers.However,current micro/nano particles loading approaches are often hindered by issues such as uneven distribution,unsatisfactory stability and complicate procedure.In this work,we present an aqueous phase reshaping method that only utilizes the moisture to fabricate the"bubble particles",which could perfectly cater to the topography of the substrate.The green preparation of bubble particles adopts an absolutely zero-pollution method,realizing the firm loading of particles on the substrate.Integrating the preparation and loading of particles overcomes the traditional complicate process,while the aqueous phase reshaping ensures uniform and firm loading of the"bubble particles"onto the substrate.Our mechanism demonstrates a significant enhancement in the interface relation after aqueous phase reshaping,with a 121-fold increase in contact surface area achieved by reducing the height by 1μm.Furthermore,we explore for the first time the influence of the nature of the receiving substrate on the interface morphology of particles during electrostatic spraying,which has important guiding significance for the interface relationship of electrostatic spraying and even electrostatic spinning materials.We also screen out the natural antibacterial essential oil linalool as the effective specialized antibacterial agent,which can specifically inhibit the odor-producing Proteus in urine,with an antibacterial rate of up to 100%.Taken together,this simple,ecofriendly method for fabricating functional materials with optimal interface stability appears highly promising for use in various products formed by electrostatic spraying/spinning.