The Relationship Between Resistance to Controlled Atmosphere and Insecticides of Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae)

The cross resistance of four resistant strains of Liposcelis bostrychophila Badonnel, an important stored-product insect pest, was investigated. These four strains included the HCO2-R (hypercarbia-resistant strain), HCLO-R (hypoxia and hypercarbia resistant strain), DDVP-R (DDVP-resistant strain) and PH3-R (PH3-resistant strain). The results indicated that there were cross-resistances between CA and insecticides, and the quantities of the cross-resistance were different. The cross-resistance factor (RF) of HCO2-R to hypoxia and hypercarbia was 3.2458, whilst, that of HCLO-R to hypercarbia was 1.8280. The RF of DDVP-R to PH3 was 3.9614, whilst, that of PH3-R to DDVP was 2.7852. The RF values of DDVP- R and PH3-R to hypercarbia were 1.3550 and 1.1816, respectively. However, the RF of HCO2- R to DDVP was 2.1372. There also was a low cross-resistance between DDVP-R and HCO2-R. The RF of HCO2-R to PH3 was 3.3698. This suggested that the insects resistant to high CO2 concentration atmosphere would develop significant resistance to PH3. However, the insects resistant to PH3 remain sensitive to hypercarbia atmosphere. Both DDVP-R and PH3- R developed resistance to high CO2 treatment. There was a low cross-resistance between DDVP-R and HCLO-R. The insects resistant to hypoxia and hypercarbia were very sensitive to DDVP. There also was cross-resistance between HCLO-R and PH3-R, but the resistance of PH3-R to hypoxia and hypercarbia was lower than that of HCLO-R to PH3. The difference of the overlapping and separate values indicated that there were differences in the intercross-resistance of four resistant strains.

Failure mechanism of Mesozoic soft rock roadway in Shajihai coal mine and its surrounding rock control

In view of the buckling failure caused by large deformation of Mesozoic soft rock roadway in Shajihai mining area, such as serious roof fall, rib spalling, floor heave, etc., based on the detail site investigation,theoretical analysis, mineral composition test, microstructure test, water-physical property test and field experiments were carried out. And we revealed the compound failure mechanism of Mesozoic soft rock roadway in Shajihai mining area, namely the molecule expansion-shear slip of weak structural plane-construction disturbance. On this basis, the coupling support technology whose core is constant resistance with large deformation bolt was proposed. The feature of this supporting technology is that a new type of structural composite material was used, which makes the supporting system not only has the ideal deformation characteristics, but also has high supporting resistance. Thus the fully release of plastic energy within surrounding rock and reasonable control of the thickness of the plastic ring were realized. Then the differential deformation between the surrounding rock and support was eliminated by the secondary coupling support of bolt–mesh–cable, and the bolt with high strength was applied in the base angle to control floor. Eventually the collaborative bearing system of surrounding rock–support was formed. Through field tests the validity and rationality of support was also verified.

Coordinated Design of Thyristors Controlled Braking Resistors and Power System Stabilizer for Damping

This paper presents a new concept for damping electro-mechanical oscillations in large turbo generator. The proposed concept is based on coordination between Power System Stabilizer （PSS） and Thyristor Controlled Braking Resistor （TCBR）. This coordination will enhance the stability of the inertial and torsional oscillatory modes. The study is performed on system-I of the second IEEE benchmark for simulation of Sub-Synchronous Oscillations, using eigenvalue analysis and verified by detailed digital simulation. A dynamic fundamental frequency model for TCBR is developed. The pole placement technique is used to design the control system of TCBR and PSS. The shaft torque＇s following a disturbance is computed and analyzed. The obtained results indicate that substantial damping is achieved by the proposed coordination.

Influence of key factors on deflection of bonded prestressed concrete simply supported slabs subjected to fire

In order to validate the accuracy of nonlinear fire simulation programs,comparison analysis is carried out between simulation and experiment induced from small-scale specimens,and then fire resistance of large-scale prestressed concrete slabs is further investigated through parameter expansion.The influences on fire resistance ratings controlled by deflection are explored and discussed,including effective span,concrete cover thickness,load level,prestress degree,effective prestress,composite reinforcement index and other factors.The calculated results indicate that fire resistance ratings of large-scale bonded prestressed concrete simply supported slabs are bigger than those of small-scale ones.Finally,the calculation formulas of fire resistance ratings controlled by deflection are established,which rationally consider the influence of effective span,concrete cover thickness,load level,composite reinforcement index and so on key factors.

Ground pressure and overlying strata structure for a repeated mining face of residual coal after room and pillar mining

To investigate the abnormal ground pressures and roof control problem in fully mechanized repeated mining of residual coal after room and pillar mining, the roof fracture structural model and mechanical model were developed using numerical simulation and theoretical analysis. The roof fracture characteristics of a repeated mining face were revealed and the ground pressure law and roof supporting condi- tions of the repeated mining face were obtained. The results indicate that when the repeated mining face passes the residual pillars, the sudden instability causes fracturing in the main roof above the old goal and forms an extra-large rock block above the mining face. A relatively stable ＂Voussoir beam＂ structure is formed after the advance fracturing of the main roof. When the repeated mining face passes the old goaf, as the large rock block revolves and touches gangue, the rock block will break secondarily under overburden rock loads. An example calculation was performed involving an integrated mine in Shanxi province, results showed that minimum working resistance values of support determined to be reason- able were respectively 11,412 kN and 10,743 kN when repeated mining face passed through residual pillar and goaf. On-site ground pressure monitoring results indicated that the mechanical model and support resistance calculation were reasonable.

Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia:a single-blind randomized controlled trial

OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia,and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine.METHODS: In total,168 patients with type 2 diabetes mellitus and vascular dementia were enrolled in the study,and randomly divided into two groups by simple randomization. Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily,while patients in the control group received pioglitazone hydrochloride alone. The treatment course was for12 weeks. Mini-mental state examinations(Chinese version) and Montreal Cognitive Assessments(Beijing version) were performed,and fasting plasma glucose,fasting insulin,hemoglobin A1 c,homeostasis model assessment of insulin resistance,plasma nitric oxide and endothelin-1 levels were measured before and after the treatment.RESULTS: The post-treatment levels for all measurements in both groups were better than pre-treatment levels(P < 0.05). The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group(P < 0.05).CONCLUSION: Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-1. Therefore,the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine.

In situ-prepared homogeneous supramolecular organic framework drug delivery systems(sof-DDSs)：Overcoming cancer multidrug resistance and controlled release

Water-soluble three-dimensional porous supramolecular organic frameworks（SOFs） have been demonstrated as a new generation of homogeneous polycationic platforms for anti-cancer drug delivery.The new SOF drug delivery systems（sof-DDSs） can adsorb dianionic pemetrexed（PMX）,a clinically used chemotherapeutic agent instantaneously upon dissolving in water,which is driven by both electrostatic attraction and hydrophobicity.The in situ-prepared PMX@SOFs are highly stable and can avoid important release of the drug during plasm circulation and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells to enter the cancer cells.Acidic microenvironment of cancer cells promotes the release of the drug in cancer cells.Both in vitro and in vivo studies have revealed that sofDDSs considerably improve the treatment efficacy of PMX,leading to 6-12-fold reduction of the IC50 values,as compared with that of PMX alone.The new drug delivery strategy omits the loading process required by most of reported nanoparticle-based delivery systems and thus holds promise for future development of low-cost drug delivery systems

Security enhancement of artificial neural network using physically transient form of heterogeneous memristors with tunable resistive switching behaviors

As a critical command center in organisms,the brain can execute multiple intelligent interactions through neural networks,including memory,learning and cognition.Recently,memristive-based neuromorphic devices have been widely developed as promising technologies to build artificial synapses and neurons for neural networks.However,multiple information interactions in artificial intelligence devices potentially pose threats to information security.Herein,a transient form of heterogeneous memristor with a stacked structure of Ag/MgO/SiN_(x)/W is proposed,in which both the reconfigurable resistive switching behavior and volatile threshold switching characteristics could be realized by adjusting the thickness of the SiN_(x)layer.The underlying resistive switching mechanism of the device was elucidated in terms of filamentary and interfacial effects.Representative neural functions,including short-term plasticity(STP),the transformation from STP to long-term plasticity,and integrate-and-fire neuron functions,have been successfully emulated in memristive devices.Moreover,the dissolution kinetics associated with underlying transient behaviors were explored,and the water-assisted transfer printing technique was exploited to build transient neuromorphic device arrays on the water-dissolvable poly(vinyl alcohol)substrate,which were able to formless disappear in deionized water after 10-s dissolution at room temperature.This transient form of memristive-based neuromorphic device provides an important step toward information security reinforcement for artificial neural network applications.