This study examines the time and regime dependencies of sensitive areas identified by the conditional nonlinear optiflml perturbation （CNOP） method for forecasts of two typhoons. Typhoon Meari （2004） was weakly no...This study examines the time and regime dependencies of sensitive areas identified by the conditional nonlinear optiflml perturbation （CNOP） method for forecasts of two typhoons. Typhoon Meari （2004） was weakly nonlinear and is herein referred to as the linear case, while Typhoon Matsa （2005） was strongly nonlinear and is herein referred to as the nonlinear case. In the linear case, the sensitive areas identified for special forecast times when the initial time was fixed resembled those identified for other forecast times. Targeted observations deployed to improve a special time forecast would thus also benefit forecasts at other times. In the nonlinear case, the similarities among the sensitive areas identified for different forecast times were more limited. The deployment of targeted observations in the nonlinear case would therefore need to be adapted to achieve large improvements for different targeted forecasts. For both cases, the closer the forecast time, the higher the similarities of the sensitive areas. When the forecast time was fixed, the sensitive areas in the linear case diverged continuously from the verification area as the forecast period lengthened, while those in the nonlinear case were always located around the initial cyclones. The deployment of targeted observations to improve a special forecast depends strongly on the time of deployment. An examination of the efficiency gained by reducing initial errors within the identified sensitive areas confirmed these results. In general, the greatest improvement in a special time forecast was obtained by identifying the sensitive areas for the corresponding forecast time period.展开更多
BACKGROUND： Drug addiction involves two main central nervous systems, namely the dopamine and noradrenaline systems. These systems are primarily distributed in five brain regions： the ventral tegmental area, the nuc...BACKGROUND： Drug addiction involves two main central nervous systems, namely the dopamine and noradrenaline systems. These systems are primarily distributed in five brain regions： the ventral tegmental area, the nucleus accumbens, the prefrontal cortex, the hippocampus, and the locus coeruleus. OBJECTIVE： To investigate regional changes of guanine nucleotide binding protein-inhabitant 2 （Gi2） in dopaminergic and noradrenergic neurons in brains of morphine-tolerant and -dependent rats. DESIGN, TIME, AND SETTING： A randomized control study was performed at the Department of Neurobiology in the Second Military Medical University of Chinese PLA （Shanghai, China） between September 2002 and March 2004. MATERIALS： Thirty-six, healthy, male, Sprague-Dawley （SD） rats were used to establish morphine-dependent models. Morphine hydrochloride was a product of Shenyang First Pharmaceutical Factory （China）; naloxone hydrochloride was a product of Beijing Four-Ring Pharmaceutical Factory （China）; and α subunit of Gi2 antibody was offered by Santa Cruz Biotechnology, lnc （USA）. METHODS： Thirty-six SD rats were randomly divided into six groups （n = 6）： （1） acute morphine-dependent group, （2） acute abstinent group, （3） acute control group, （4） chronic morphine-dependent group, （5） chronic abstinent group, and （6） chronic control group. Rats in the acute morphine-dependent and the acute groups were injected with morphine （5 mg/kg）, one injection every two hours, for a total of eight injections. In the acute and chronic morphine-dependent rat models, morphine withdrawal syndrome was precipitated by an injection of naloxone （5 mg/kg）. Rats in the acute control group were given a peritoneal injection of physiological saline at the same administration time as the above two groups. Rats in the chronic morphine-dependent and chronic abstinent groups were injected with morphine three times per day. The administration dose on day 1 was initially 5 mg/kg at 20：00, which increased by 5 mg/kg at 8：00, 12：00, and 20：00 until day 7. On day 13, the dose continuously increased by 10 mg/kg until a chronic morphine-dependent rat model was successfully induced. Afterwards, the rats presented with withdrawal syndromes on naloxone （5 mg/kg） at 8：00 on the same day. Rats in the chronic control group were injected with physiological saline at the same time of the two chronic groups. MAIN OUTCOME MEASURES： The concentration of Gi2 protein in the five brain regions （ventral tegmental area, nucleus accumbens, prefrontal cortex, locus coeruleus, and hippocampus） was detected by immunohistochemistry. RESULTS： In the acute morphine-dependent and acute abstinent groups, Gi2 protein concentration was significantly decreased in the nucleus accumbens, compared to the acute control group （P 〈 0.01）, while no obvious changes were detected in other brain regions. In the chronic morphine-dependent and chronic abstinent groups, Gi2 protein concentration was significantly decreased in the nucleus accumbens, but significantly increased in the locus coeruleus （P 〈 0.01 ） compared to the chronic control group. CONCLUSION： Morphine dependence and tolerance may induce obvious reductions of Gi2 protein levels in the nucleus accumbens of rats. Chronic morphine dependence desensitizes the homologous neurons.展开更多
Conflict between conservation and community livelihood is a significant issue in China.Based on Sustainable Livelihood Framework(SLA),this study systematically analyzed livelihoods assets of a community in a Yunnan sn...Conflict between conservation and community livelihood is a significant issue in China.Based on Sustainable Livelihood Framework(SLA),this study systematically analyzed livelihoods assets of a community in a Yunnan snub-nosed monkey conservation area and found that the livelihood pentagon of the community was shaped by multiple but frail and unstable income sources,abundant natural resources with restricted use right,underutilized labors,inadequate financial resources,inconvenient physical capital and weak social capital.Villagers'income heavily depended on forest,and grazing and nontimber forest products(NTFP)collection are common and major income sources for villagers.However,differentiation of income dependence on forest among villagers'groups showed that there is no close correlation between the level of income and the level of income dependence on forest.Households'daily life also heavily depended on the forest due to heating and pig-feed cooking;hence,fuelwood cannot be easily replaced by any other energy resource for a long period.展开更多
The probability of occurrence of strong ( M W≥6 0) earthquakes in the area of Aeghion (Central Greece) is determined by Bayes statistics. A catalogue of strong shocks around the city of Aeghion since 1794 is used. Fo...The probability of occurrence of strong ( M W≥6 0) earthquakes in the area of Aeghion (Central Greece) is determined by Bayes statistics. A catalogue of strong shocks around the city of Aeghion since 1794 is used. For the purposes of our study two distributions of earthquakes’ occurrence are considered. In applying the Bayes approach, a Poisson distribution, which is a memoryless one, is assumed. In order to reinforce the result a time dependent model (normal distribution) is also used. An effort is made to find the probabilities of earthquake occurrence for successive decades are determined by both distributions. The estimated probability for a strong earthquake to occur during 1996～2005 in relation to the Bayes approach shows that the year 2004 is the most likely for this future event. A pattern is also revealed which suggests that the earthquakes in the examined area occurred in clusters (in time). The strong earthquakes in these clusters occurred in quadruplets.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.41105038and40830955)the NationalKey Technology R&D Program(Grant No.2012BAC22B03)
文摘This study examines the time and regime dependencies of sensitive areas identified by the conditional nonlinear optiflml perturbation （CNOP） method for forecasts of two typhoons. Typhoon Meari （2004） was weakly nonlinear and is herein referred to as the linear case, while Typhoon Matsa （2005） was strongly nonlinear and is herein referred to as the nonlinear case. In the linear case, the sensitive areas identified for special forecast times when the initial time was fixed resembled those identified for other forecast times. Targeted observations deployed to improve a special time forecast would thus also benefit forecasts at other times. In the nonlinear case, the similarities among the sensitive areas identified for different forecast times were more limited. The deployment of targeted observations in the nonlinear case would therefore need to be adapted to achieve large improvements for different targeted forecasts. For both cases, the closer the forecast time, the higher the similarities of the sensitive areas. When the forecast time was fixed, the sensitive areas in the linear case diverged continuously from the verification area as the forecast period lengthened, while those in the nonlinear case were always located around the initial cyclones. The deployment of targeted observations to improve a special forecast depends strongly on the time of deployment. An examination of the efficiency gained by reducing initial errors within the identified sensitive areas confirmed these results. In general, the greatest improvement in a special time forecast was obtained by identifying the sensitive areas for the corresponding forecast time period.
文摘BACKGROUND： Drug addiction involves two main central nervous systems, namely the dopamine and noradrenaline systems. These systems are primarily distributed in five brain regions： the ventral tegmental area, the nucleus accumbens, the prefrontal cortex, the hippocampus, and the locus coeruleus. OBJECTIVE： To investigate regional changes of guanine nucleotide binding protein-inhabitant 2 （Gi2） in dopaminergic and noradrenergic neurons in brains of morphine-tolerant and -dependent rats. DESIGN, TIME, AND SETTING： A randomized control study was performed at the Department of Neurobiology in the Second Military Medical University of Chinese PLA （Shanghai, China） between September 2002 and March 2004. MATERIALS： Thirty-six, healthy, male, Sprague-Dawley （SD） rats were used to establish morphine-dependent models. Morphine hydrochloride was a product of Shenyang First Pharmaceutical Factory （China）; naloxone hydrochloride was a product of Beijing Four-Ring Pharmaceutical Factory （China）; and α subunit of Gi2 antibody was offered by Santa Cruz Biotechnology, lnc （USA）. METHODS： Thirty-six SD rats were randomly divided into six groups （n = 6）： （1） acute morphine-dependent group, （2） acute abstinent group, （3） acute control group, （4） chronic morphine-dependent group, （5） chronic abstinent group, and （6） chronic control group. Rats in the acute morphine-dependent and the acute groups were injected with morphine （5 mg/kg）, one injection every two hours, for a total of eight injections. In the acute and chronic morphine-dependent rat models, morphine withdrawal syndrome was precipitated by an injection of naloxone （5 mg/kg）. Rats in the acute control group were given a peritoneal injection of physiological saline at the same administration time as the above two groups. Rats in the chronic morphine-dependent and chronic abstinent groups were injected with morphine three times per day. The administration dose on day 1 was initially 5 mg/kg at 20：00, which increased by 5 mg/kg at 8：00, 12：00, and 20：00 until day 7. On day 13, the dose continuously increased by 10 mg/kg until a chronic morphine-dependent rat model was successfully induced. Afterwards, the rats presented with withdrawal syndromes on naloxone （5 mg/kg） at 8：00 on the same day. Rats in the chronic control group were injected with physiological saline at the same time of the two chronic groups. MAIN OUTCOME MEASURES： The concentration of Gi2 protein in the five brain regions （ventral tegmental area, nucleus accumbens, prefrontal cortex, locus coeruleus, and hippocampus） was detected by immunohistochemistry. RESULTS： In the acute morphine-dependent and acute abstinent groups, Gi2 protein concentration was significantly decreased in the nucleus accumbens, compared to the acute control group （P 〈 0.01）, while no obvious changes were detected in other brain regions. In the chronic morphine-dependent and chronic abstinent groups, Gi2 protein concentration was significantly decreased in the nucleus accumbens, but significantly increased in the locus coeruleus （P 〈 0.01 ） compared to the chronic control group. CONCLUSION： Morphine dependence and tolerance may induce obvious reductions of Gi2 protein levels in the nucleus accumbens of rats. Chronic morphine dependence desensitizes the homologous neurons.
基金supported by the Nature Conservancy[grant number NA/KUNMING/YU030112]Yunnan Provincial Fund of Social Science[grant number YB2013024]
文摘Conflict between conservation and community livelihood is a significant issue in China.Based on Sustainable Livelihood Framework(SLA),this study systematically analyzed livelihoods assets of a community in a Yunnan snub-nosed monkey conservation area and found that the livelihood pentagon of the community was shaped by multiple but frail and unstable income sources,abundant natural resources with restricted use right,underutilized labors,inadequate financial resources,inconvenient physical capital and weak social capital.Villagers'income heavily depended on forest,and grazing and nontimber forest products(NTFP)collection are common and major income sources for villagers.However,differentiation of income dependence on forest among villagers'groups showed that there is no close correlation between the level of income and the level of income dependence on forest.Households'daily life also heavily depended on the forest due to heating and pig-feed cooking;hence,fuelwood cannot be easily replaced by any other energy resource for a long period.
文摘The probability of occurrence of strong ( M W≥6 0) earthquakes in the area of Aeghion (Central Greece) is determined by Bayes statistics. A catalogue of strong shocks around the city of Aeghion since 1794 is used. For the purposes of our study two distributions of earthquakes’ occurrence are considered. In applying the Bayes approach, a Poisson distribution, which is a memoryless one, is assumed. In order to reinforce the result a time dependent model (normal distribution) is also used. An effort is made to find the probabilities of earthquake occurrence for successive decades are determined by both distributions. The estimated probability for a strong earthquake to occur during 1996～2005 in relation to the Bayes approach shows that the year 2004 is the most likely for this future event. A pattern is also revealed which suggests that the earthquakes in the examined area occurred in clusters (in time). The strong earthquakes in these clusters occurred in quadruplets.
