Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of previously replication-competent cells.

Geological reservoir and resource potential(10^(13)m^(3))of gas hydrates in the South China Sea

A detailed understanding of the distribution and potential of natural gas hydrate(NGHs)resources is crucial to fostering the industrialization of those resources in the South China Sea,where NGHs are abundant.In this study,this study analyzed the applicability of resource evaluation methods,including the volumetric,genesis,and analogy methods,and estimated NGHs resource potential in the South China Sea by using scientific resource evaluation methods based on the factors controlling the geological accumulation and the reservoir characteristics of NGHs.Furthermore,this study compared the evaluation results of NGHs resource evaluations in representative worldwise sea areas via rational analysis.The results of this study are as follows:(1)The gas hydrate accumulation in the South China Sea is characterized by multiple sources of gas supply,multi-channel migration,and extensive accumulation,which are significantly different from those of oil and gas and other unconventional resources.(2)The evaluation of gas hydrate resources in the South China Sea is a highly targeted,stratified,and multidisciplinary evaluation of geological resources under the framework of a multi-type gas hydrate resource evaluation system and focuses on the comprehensive utilization of multi-source heterogeneous data.(3)Global NGHs resources is n×10^(15)m^(3),while the NGHs resources in the South China Sea are estimated to be 10^(13)m^(3),which is comparable to the abundance of typical marine NGHs deposits in other parts of the world.In the South China Sea,the NGHs resources have a broad prospect and provide a substantial resource base for production tests and industrialization of NGHs.

Analysis on Development Potential of Agricultural Resources of Farming System in Shandong Province

Based on the characteristics of agricultural resources and social resources in Shandong Province, the approaches of developing farming system potential were discussed, which provide important references for sustainable development of modern farming system.

The temporal and spatial patterns and potential evaluation of China＇s energy resources development

The issue of China＇s energy supply security is not only the key problem which af- fects China＇s rapid and sustainable development in the 21st century, but also the one which international attention focuses on. Based on the notable characteristic of spatial imbalance between energy production and consumption in China, this paper takes the evolution of China＇s primary energy resources development（excluding hydropower） from 1949 to 2007 as the study object, with the aim to sum up the evolutive characteristics and laws of China＇s energy resources development in the past nearly 60 years. Then, based on comprehensive considerations of coal＇s, oil＇s and natural gas＇s basic reserves, qualities, geological conditions production status, and ecological service function of every province, this paper adopts development potential index （DP）to evaluate the development potential of every province＇s en- ergy resources, and divide them into different ranks. Conclusions are drawn as follows： （1） Generally speaking, China＇s gross energy production was increasing in waves from 1949 to 2007. From the viewpoint of spatial patterns, China＇s energy resources development has shown a characteristic of ＂concentrating to the north and central areas, and evolving from linear-shaped to ＂T-shaped＂ pattern gradually since 1949. （2） The structure evolution of China＇s energy resources development in general has shown a trend of ＂coal proportion is dominant but decreasing, while oil and gas proportions are increasing＂ since 1949. （3） At the provincial scale, China＇s energy resources development potential could be divided into large, sub-large, general and small ranks, four in all. In the future, the spatial pattern of China＇s energy production will evolve from ＂T-shaped＂ to ＂R-shaped pattern＂. These conclusions will help to clarify the temporal and spatial characteristics and laws of China＇s energy resources development, and will be beneficial for China to design scientific and rational energy development strategies and plans, coordinate spatial imbalance of energy production and consumption, ensure national energy supply, avoid energy resources waste and disorderly development, and promote regional sustainable development under the globalization back-ground with changeful international energy market.

Formation mechanisms and resource potential of carbonate geothermal reservoirs in the Beijing-Tianjin-Hebei plain

Investigating the formation mechanisms of carbonate geothermal reservoirs is of theoretical and practical significance for summarizing the formation pattern of geothermal resources and further guiding their effective exploitation.The Beijing-Tianjin-Hebei Plain(BTHP),predominantly located within the Jizhong Depression and Cangxian Uplift in the Bohai Bay Basin,serves as the primary region for geothermal exploitation and utilization in China.More than 1500 geothermal wells have been drilled therein,with water temperature at the wellhead ranging from 55 to 110°C,single-well flow rate ranging between 80 and 120 m^(3)/h,and cumulative heating area exceeding 100×10^(6)m^(3).However,the exploration and research in the region remain limited overall.As per the previous geothermal and petroleum exploration results and the latest geothermal drilling data,this study comprehensively evaluated the geothermal resources of karst geothermal reservoirs.The results show that two suites of carbonate karst reservoirs,namely the Jxw Formation and the Ordovician strata,have primarily developed in the BTHP,and their formation and evolution can be divided into four stages:the Mesoproterozoic-Early Paleozoic stage with carbonate sedimentation and the development of interlayer karst,the Late Paleozoic stage with the development of direct sedimentary cover,the Mesozoic stage with compressional uplifting and development of buried hill karst,and the Cenozoic stage with regional cover deposition and the modification and finalization of karst geothermal reservoirs.Accordingly,the porosity evolution history of the geothermal reservoirs is composed of three stages,namely a significant decrease followed by a minor increase,a gradual decline,and then a small fluctuation from increase to decrease before slowly rising again.The karstification in geothermal reservoirs can be summarized into quasi-syngenetic karstification,epigenetic karstification,and burial karstification,which can be subdivided into seven subcategories.The carbonate geothermal reservoirs in the study area boast total geothermal resources of 53.821×10^(9)GJ,or 184.155×10^(9)t of standard coal equivalent(tce),and the annual exploitable geothermal resources in the urban area can heat an area of(400‒500)×10^(6)m^(3),indicating great potential of geothermal exploitation.

Alteration and Reformation of Hydrocarbon Reservoirs and Prediction of Remaining Potential Resources in Superimposed Basins

Complex hydrocarbon reservoirs developed widely in the superimposed basins of China formed from multiple structural alterations, reformation and destruction of hydrocarbon reservoirs formed at early stages. They are characterized currently by trap adjustment, component variation, phase conversion, and scale reformation. This is significant for guiding current hydrocarbon exploration by revealing evolution mechanisms after hydrocarbon reservoir formation and for predicting remaining potential resources. Based on the analysis of a number of complex hydrocarbon reservoirs, there are four geologic features controlling the degree of destruction of hydrocarbon reservoirs formed at early stages： tectonic event intensity, frequency, time and caprock sealing for oil and gas during tectonic evolution. Research shows that the larger the tectonic event intensity, the more frequent the tectonic event, the later the last tectonic event, the weaker the caprock sealing for oil and gas, and the greater the volume of destroyed hydrocarbons in the early stages. Based on research on the main controlling factors of hydrocarbon reservoir destruction mechanisms, a geological model of tectonic superimposition and a mathematical model evaluating potential remaining complex hydrocarbon reservoirs have been established. The predication method and technical procedures were applied in the Tazhong area of Tarim Basin, where four stages of hydrocarbon accumulation and three stages of hydrocarbon alteration occurred. Geohistorical hydrocarbon accumulation reached 3.184 billion tons, of which 1.271 billion tons were destroyed. The total volume of remaining resources available for exploration is -1.9 billion tons.

THE BALANCE BETWEEN SUPPLY AND DEMAND OF WATER RESOURCES AND THE WATER-SAVING POTENTIAL FOR AGRICULTURE IN THE HEXI CORRIDOR

The Hexi Corridor is an important base of agriculture development inNorthwest China. According to recent statistics, there are 65. 94 x 10~8m^3 of water resourcesavailable in the Hexi Corridor. At present, net consumption in development and utilization is 43. 33x 10~8m^3. Water supply and demand reach a balance on the recent level of production, but loss ofevaporation and evapotranspiration is as much as 25. 69 x 1010~8m^3. So net use efficiency of waterresources is 59% Based on analyzing balance between water and land considering ecologicalenvironment at present, there exists the serious water shortage in the Shiyang River system whereirrigation lands have overloaded. There is a comparative balance between supply and demand of waterresource in the Heihe River system; and the Sule River system has some surplus water to extendirrigation land. Use of agriculture water accounts for 83. 3% and ecological forest and grass for 6.9% . The Hexi Corridor still has a great potential for water saving in agriculture production.Water-saving efficiency of irrigation is about 10% by using such traditional technologies as furrowand border-dike irrigation and small check irrigation, and water-saving with plastic film cover andtechniques of advanced sprinkler and drip/micro irrigation etc. can save more than 60% of irrigatedwater. Incremental irrigation area for water-saving potential in the Hexi Corridor has beenestimated as 56% - 197% to original irrigation area. So the second water sources can be developedfrom water saving agriculture in the Hexi Corridor under Development of the Western Part of China inlarge scale. This potential can be realized step by step through developing the water-savingmeasures, improving the ecological condition of oasis agriculture, and optimizing allocation ofwater resources in three river systems.

Gold Resources Potential Assessment in Eastern Kunlun Mountains of China Combining Weights-of-evidence Model with GIS Spatial Analysis Technique

Resources potential assessment is one of the fields in geosciences,which is able to take great advantage of GIS technology as a substitution of traditional working methods.The gold resources potential in the eastern Kunlun Mountains,Qinghai Province,China was assessed by combining weights-of-evidence model with GIS spatial analysis technique.All the data sets used in this paper were derived from an established multi-source geological spatial database,which contains geological,geophysical,geochemical and remote sensing data.Three multi-class variables,i.e.,structural intersection,Indosinian k-feldspar granite and regional fault,were used in proximity analysis to examine their spatial association with known gold deposits.A prospectivity map was produced by weights-of-evidence model based on seven binary evidential maps,all of which had passed a conditional independence test.The study area was divided into three target zones of high potential,moderate potential and low potential areas,among which high potential areas and moderate potential areas accounted for 20% of the total area and contained 32 of the 43 gold deposits.The results show that the gold resources potential assessment in the eastern Kunlun Mountains has a higher precision.

Potential recoverable natural gas resources in China

Natural gas resources in China are abundant. The undiscovered recoverable natural gas resources in China are estimated to be 19.27 ×10^12 m^3. Natural gas is mainly distributed in the middle and west China and offshore areas of China. The Tarim Basin, Sichuan Basin, Ordos Basin, East China Sea Basin, Tsaidam Basin, Yinggehai Basin, and Qiongdongnan Basin are the main gas-bearing basins. The natural gas resources are not distributed evenly and are under-explored in China. The deeper horizons in east China, foreland basins and craton paleo-uplifts in the middle and west China, and the offshore basins are the main exploration areas in the future.

Potentials and Exploration Prospect of China＇s Hydrocarbon Resources

The potentials of Chinas hydrocarbon resources has risen as an important factor influencing the current policies of the country. Chinas oil industry is a developing industry. Gas reservoirs can be classified in light of their accumulation mechanisms into six types: water-sealed gas, hydrate, dissolved gas, conventional entrapped gas, capillary gas and adsorbed gas.

Distribution and potential of global oil and gas resources

Using conventional and unconventional oil and gas resource evaluation methods with play as a unit, this study evaluates the oil and gas geology and resource potential of conventional oil and gas resources and seven types of unconventional resources in the global major oil and gas basins(excluding China). For the first time, resource evaluation data with independent intellectual property rights has been obtained. According to evaluation and calculation, the global recoverable conventional oil resources are 5 350.0×108 t, the recoverable condensate oil resources are 496.2×108 t, and the recoverable natural gas resources are 588.4×1012 m3. The remaining oil and gas 2 P recoverable reserves are 4 212.6×108 t, the reserve growth of oil and gas fields are 1 531.7×108 t. The undiscovered oil and gas recoverable resources are 3 065.5×108 t. The global unconventional oil recoverable resources are 4 209.4×108 t and the unconventional natural gas recoverable resources are 195.4×1012 m3. The evaluation results show that the global conventional and unconventional oil and gas resources are still abundant.

A New Parameter of Cleanability to Determine the Clean Potential of Coal Resources

Objective This work is based on analysis on large numbers of coal data such as the latest national coal potential evaluation data and previous data published by REN Deyi, TANG Xiuyi and LU Xukun, and the evaluation methods of clean potential of coal resources proposed by predecessors. It is found that previous method rank coal is only in accordance with raw coal or washed coal, which fail to take full account of the changes in elements before and after coal washing. Some elements can be removed by washing or other methods, and others may be even enriched after the coal is washed. For this reason, this work defined a new parameter of cleanability and developed its calculation formula to determine the clean potential of coal resources. Cleanability is a comprehensive indicator based on the removal rate of each indicator harmful element in coal. The clean potential of coal is proportional to the value of cleanability. The higher the cleanability value is, the better the clean potential is, and vice versa.

An assessment of the carrying capacity of groundwater resources in North China Plain region–Analysis of potential for development

Over-exploitation of groundwater in North China Plain(NCP) has resulted in a series of eco-environment problems. Sustainable use of groundwater resources in NCP, in particular management of groundwater resource carrying capacity(GRCC), faces an unprecedented challenge. Here we define GRCC, and a new assessment method is tentatively proposed and applied to evaluate GRCC based on the whole NCP, city administrative units and county administrative units. Our study divided the NCP into three zones, i.e. non-overexploited non-overloaded zone(NNZ), overexploited but non-overloaded zone(ONZ), and overexploited overloaded zone(OOZ). Results confirmed 27.6% of counties belonged to NNZ. However, 58.9% of counties and NCP as a whole belonged to ONZ, and 13.5% of counties belonged to OOZ. Spatially, NNZs were mainly distributed in Beijing, parts of eastern coastal cities and Henan Province. OOZs were mostly distributed in middle-eastern part of Cangzhou, parts of Dezhou, Tianjin and Binzhou, and the remaining areas belonged to ONZs. We suggest two approaches for enhancing GRCC, i) increasing the amount of available groundwater and ii) improving the water use efficiency. An increase of 11.0 billion cubic meters to the available groundwater levels combined with water use efficiency improvements up to 479 CNY per cubic meter of the world mean, the gross domestic product(GDP) sustained by groundwater in the NCP could reach 11.1 trillion CNY and maintain a 20 years of GDP development assuming the current rate of growth.

Deep geothermal resources in China:Potential,distribution,exploitation,and utilization

Deep geothermal resources mainly refer to the thermal energy stored in subsurface rocks and fluids therein at a depth of 3-10 km,which is a kind of renewable and sustainable clean energy unaffected by weather and seasonal changes.Large scale exploitation of the deep geothermal resources is of great significance to ensuring national energy security and achieving the“Carbon Peak and Carbon Neutrality”.Based on the latest terrestrial heat flow data,this paper estimated the potential of deep geothermal resources in the terrestrial areas of China,and the results show that the total amount of geothermal resources within 3e10 km under the Earth's surface in the terrestrial areas of China is 24.6×10^(15)GJ.In line with climate zones categorized,the geothermal resource proportion is 43.81%for severe cold regions,29.19%for cold regions,6.92%for mild regions,13.82%for hot summer and cold winter regions,and 6.26%for hot summer and warm winter regions.Statistics according to the burial depth range reveal that the resources within depth ranges of 3-5 km,5-7 km and 7-10 km under the Earth's surface are 4.3119×10^(15)GJ,6.37674×10^(15)GJ and 13.89594×10^(15)GJ respectively,showing an increasing trend of geothermal potential with increasing burial depth.The deep geothermal resources are mainly of medium-to-high temperature reserves,and the energy supply strategy can be optimized by combining the climate conditions and population distribution,as well as considering power generation.In regions of cold or severe cold climate,the geothermal resources may be applied to geothermal power generation and district heating in combination;in regions of hot summer and cold winter or mild climates,the resources can be used for geothermal power generation combined with cooling and heating;in regions of hot summer and warm winter climates,the resources may be applied to geothermal power generation combined with cooling and industrial and agricultural utilization.Exploitation of deep geothermal resources also can be combined with carbon dioxide sequestration,multi-mineral resources extraction and energy storage to realize comprehensive exploitation and utilization of various energy resources.It is suggested that theoretical technology research should be combined with pilot tests and field demonstrations,and large-scale economic exploitation of deep geothermal resources should be arranged in a coordinated manner,following the principles of overall planning and step-by-step implementation.

Delineation of Potential Mineral Resources RegionBased on Geo-anomaly Unit

The geological anomaly unit method (GAUM) is a new way to delineate and evaluate ore finding targets in line with the “geological anomaly ore finding theory”. Comprehensive ore finding information from geological, geochemical and geophysical data is used for quantitative measurement of the “ore forming geological anomaly unit” in this paper. The main procedures are shown as follows: (1) The geo anomalous events associated with gold mineralization are analyzed in Tongshi gold field; (2) The zonation in the concentrated heavy minerals and the stream sediment elements of ore forming geo anomaly are studied in detail; (3) The deep geological structural framework is deduced by means of the synthetic geological interpretation of gravity and magnetic information; (4) The ore controlling geo anomalies and ore anomalies are chosen as the variables of the favorable ore forming indexes that can be used for the quantitative delineation and evaluation of the potential ore forming regions.

Potentially toxic metal concentration,spatial distribution,and health risk assessment in drinking groundwater resources of southeast Iran

In this study, the concentration and spatial distribution of potentially toxic metals(PTMs), including arsenic(As), cadmium(Cd), chromium(Cr), lead(Pb), copper(Cu), iron(Fe), manganese(Mn), and magnesium(Mg) in 23 wells and drinking groundwater distribution networks of Rafsanjan, located in southeast Iran were evaluated. Moreover, the assessment of carcinogenic and non-carcinogenic risks was estimated by Monte Carlo simulation(MCS). The results showed that the concentrations of As and Pb in more than 99% and 23.46% of the study area, respectively, were higher than the maximum concentration level(10 μg/L). The mean concentration of other metals, including Cd, Cr, Cu, Fe, Mg, and Mn in all drinking water resources was within the WHO standard level. The mean hazard quotient(HQ) for As in the age group of children was 9.246 and adults 2.972, indicating high non-carcinogenic risk of As in the study area. The lifetime cancer risk(LTCR) of As was 1.36 E-3 for adults and 1.52 E-2 for children, indicating high non-carcinogenic risk of As. The level of HQ and LTCR for Pb in both age groups was in the acceptable range. The results of sensitivity analysis showed that the most effective variables were pollutant concentration and body weight(BW), respectively. Finally, it can be concluded that exposure to PTMs, especially As through drinking water in the study area can have significant effects on people’s health living in the area;therefore, it is necessary to treat and remove As from groundwater resources before drinking or using for domestic purpose.

Non-seismic geophysical analysis of potential geothermal resources in the Longgang Block,Northeast China

Although geothermal energy has many clear advantages,including its sustainability and environmentally friendly nature,research into potential geothermal resources across the Longgang Block,Northeast China,has been limited.Here we present the first analysis of the potential geothermal resources in this region that employs joint geological and non-seismic geophysical methods to identify target areas that may be economically viable.We acquire and analyze high-precision gravity,magnetic,and magnetotelluric sounding data,which are constrained using the petrophysical parameters of outcropping rocks across the Longgang Block,to conduct a comprehensive evaluation of the region’s deep geological structures and their geothermal resources potential,with a focus on identifying faults,rock masses,and thermal storage structures.We find that Archean granitic gneiss and Mesozoic rock masses in the deeper section of the Longgang Block possess weak gravity anomalies and high resistivities.We also identify thermal storage structures near these deeper geological units based on their extremely low resistivities.The data are used to infer the dip and depth of known or hidden faults,to constrain the spatial distribution of intrusive rock masses,and to determine the spatial distribution of subsurface thermal storage structures.The potential of the target areas for geothermal resources exploitation is divided into three grades based on contact depths between faults and thermal storage structures,and the scale of their thermal storage structures.Our results suggest that a joint non-seismic geophysical approach can be effective in locating and evaluating geothermal resources in complex geological settings.

Geothermal Resources Potential Analyses of Tanggu Urban Area and the Vicinity,Tianjin

In order to construct a newly developed green area, the Tanggu urban area as the core part of Binhai new area,needs more and more clean energy year by year. This area is abound in geothermal resources endowed by the grand Nature.Based on the estimation of

STAGES AND POTENTIALITY OF WATER RESOURCES DEVELOPMENT INARID NORTHWESTERN CHINA

The processes of water resources exploitation and utilization can be divided into three stages by water resources transformation, and the history, present situation and future trend of water resources development in piedmont areas around high mountains of arid northwestern China. The three stages are: the stage of surface water development (the first stage), the stage of comprehensive development of surface and ground water (the second stage) and the stage of economical development of water rare (the third stage). The three stages link each other and show the law and processes of water resources exploitation and utilization associated with social and technological progess. The economical water policy should run through the three stages. On this point, however, the third stage differs from the others, particularly, refering to irrigated agriculture. The third stage has more progressive significance because it breaks the traditional ideas on water resources development. According to our investigation and calculation, under present conditions of water resources development, the net used water is about 160 × 108 m3, accounting for 18% of the total water resources of northwestern China. The water resources have not ben fully develop. If the first stage is finished, the exploitable water can be increased by 91 %. After the second stage, furthermore, it can be increased by 216%.

Bioeconomy in the Agrarian Resources Potential System of Ukraine

The main goal of this research is to determine the importance and prospects of bioeconomy development in agriculture of Ukraine for international economic integration.Actual reason for this research is military occupation of west regions and the macroeconomic instability.Available resources form supply potential for agrarian production,renewable energy,and sustainable development.However,unemployment of labour,land,and capital determine the inflationary gap,which could be closed in two main ways:The innovative economic growth in business and households’sectors in accordance to bio-based principles and rational government state regulation with fiscal and monetary policies instruments.The external and internal effects of bioeconomy development in the agrarian resources system are determined in accordance to strengths,weaknesses,opportunities,and threats(SWOT)-analysis.European integration requires entrepreneurial initiative,environmental protection,social benefits in the satisfaction of individual needs of the population,modern principles of competition,such as mutual beneficial cooperation and new market creation for food security and human resources development.