Based on the Characteristics of Respondents and the Voice of the Urban Neighborhood Public Space Business Facilities Noise Environment Evaluation Research

Comfort is one of the important indicators evaluation of voice. In order to understand the urban neighborhood public space environment of comfort,this paper is to explore characteristics of consumer society on the public space environment evaluation of the effect,and using the questionnaire survey method,to evaluate the Harbin city neighborhood area public space as the typical case analysis. Based on one of the main sound source in neighborhood public space,environment,business facilities environment as the breakthrough point,it is to consider neighborhood public space environment evaluation and social characteristics.

Biomarkers,a Useful Correction for Respondent Error in Survey Research

One long standing limitation of survey research is the issue of respondent error.Until present there have been no research methods able to correct for this problem.In this study we present two approaches to correct for respondent error.In the first approach,we demonstrate how a valid instrument can be used,and the second approach requires two additional indicators.One is used to measure the response error and the second is used to correct for endogeneity.The second half of this study presents possible sources for valid indicators to correct for respondent error and make consistent estimation possible.

Revisiting the Outsiders: Innovative Recruitment of a Marijuana User Network via Web-Based Respondent Driven Sampling

This study uses an innovative, network-based recruitment strategy (non-monetary, web-based respondent driven sampling) to gather a sample of il/legal marijuana users. Network-driven effects amongst marijuana users are examined to test the explanatory validity of several theories of social deviance. The study finds that respondent driven sampling techniques lack effectiveness without primary monetary incentives, even when meaningful secondary incentives are utilized. Additionally, the study suggests that marijuana user networks exhibit strong homophilic attachment tendencies.

RARRES2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(TAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway.This commentary aims to elaborate on the key findings and their relevance to the field.

The role of tazarotene-induced gene 1 in carcinogenesis:is it a tumor suppressor gene or an oncogene?

Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer.TIG1 is widely expressed in various tissues;yet in many cancer tissues,it is not expressed because of the methylation of its promoter.Additionally,the expression of TIG1 in cancer cells inhibits their growth and invasion,suggesting that TIG1 acts as a tumor suppressor gene.However,in some cancers,poor prognosis is associated with TIG1 expression,indicating its protumor growth characteristics,especially in promoting the invasion of inflammatory breast cancer cells.This review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development,with the aim of understanding its various roles in cancer development.

Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics

BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.

Features Desired in Public Transport in a Developing City: Users’ Perspective

Excessive growth of population and urbanization in the developing countries set an increasing demand of mobility services. To meet this demand, public transport plays a significant role by providing an easy and affordable mobility service. Public transport service is a process evolving over time nevertheless is not always directly responsive to the changing demand of the passengers. Recently in developing countries, the unpleasant experience in public transport services is seen as one of the main reasons behind increased passenger car share, which eventually lead to traffic congestion. However, the situation can be ameliorated if the features of the public transport are improved by addressing the users’ demand. In this study, the primary features desired and demanded by the passengers of a developing country are identified by three phase survey. These identified features are also categorized based on public responses. And finally, the required features in an appropriate public transport mode are prioritized by using a common Multi Criteria Decision Making approach (AHP—Analytic Hierarchy Process). The study suggests that residents of the developing city are not that much concern on the outlook and ambience of the service rather they are concerned about finishing their trips safely in time at an affordable rate. The findings of this research will help planners and decision makers to make the best use of the investment in public transport services and infrastructure to promote these modes over privately owned vehicle.

Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet

BACKGROUND After receiving entecavir or combined with FuzhengHuayu tablet(FZHY)treatment,some sufferers with hepatitis B virus(HBV)-related liver fibrosis could achieve a histological improvement while the others may fail to improve even worsen.Serum metabolomics at baseline in these patients who were effective in treatment remain unclear.AIM To explore baseline serum metabolites characteristics in responders.METHODS A total of 132 patients with HBV-related liver fibrosis and 18 volunteers as healthy controls were recruited.First,all subjects were divided into training set and validation set.Second,the included patients were subdivided into entecavir responders(E-R),entecavir no-responders(E-N),FZHY+entecavir responders(FR),and FZHY+entecavir no-responders(F-N)following the pathological histological changes after 48 wk’treatments.Then,Serum samples of all subjects before treatment were tested by high performance liquid chromatographytandem mass spectrometry(LC-MS)high-performance LC-MS.Data processing was conducted using multivariate principal component analysis and orthogonal partial least squares discriminant analysis.Diagnostic tests of selected differential metabolites were used for Boruta analyses and logistic regression.RESULTS As for the intersection about differential metabolic pathways between the groups E-R vs E-N and F-R vs F-N,results showed that 4 pathways including linoleic acid metabolism,aminoacyl-tRNA biosynthesis,cyanoamino acid metabolism,alanine,aspartate and glutamate metabolism were screened out.As for the differential metabolites,these 7 intersected metabolites including hydroxypropionic acid,tyrosine,citric acid,taurochenodeoxycholic acid,benzoic acid,2-Furoic acid,and propionic acid were selected.CONCLUSION Our findings showed that 4 metabolic pathways and 7 differential metabolites had potential usefulness in clinical prediction of the response of entecavir or combined with FZHY on HBV fibrotic liver.

Effect of CICARE communication nursing model combined with motivational psychological intervention in patients with postintensive care unit syndrome

BACKGROUND Post-intensive care syndrome(PICS)is a term used to describe a constellation of new or worsened dysfunctions in the physical,cognitive,or mental health status of critically ill patients after their discharge from the intensive care unit(ICU).These dysfunctions persist beyond the acute phase of illness and have a significant impact on both the patient and their family.Connect,Introduce,Communicate,Ask,Respond,Exit(CICARE)communication advocates that patients should be respected and accepted when receiving medical services.Clinicians should attach importance to the communication mode of feelings,including connection,introduction,communication,ask,response,and exit 6 steps.AIM To assess the impact of CICARE communication on the reduction of anxiety,depression,and post-traumatic stress disorder(PTSD)symptoms in patients transitioning from the ICU to other care settings.METHODS This prospective,randomized,controlled study was performed between October 2021 and March 2023.Intensive Care Unit Memory Tool was used to evaluate patients’ICU memory.The Hospital Anxiety and Depression Scale was employed to determine the presence of anxiety or depression symptoms.Impact of Event Scale-Revised was utilized to assess the presence of PTSD.All data were processed and analyzed using R language software version 4.1.0.The measurement data were expressed as mean±SD,and the t test was used.The count data were analyzed by theχ2 test and expressed as[n(%)].RESULTS In total,248 subjects were included in this study.Among them,206 were successfully followed up for three months after transfer from the ICU,and 42 cases were lost to follow-up.There was no significant difference in the composition of ICU memory between the two groups.The application of the CICARE communication nursing model combined with the motivational psychological intervention nursing model,as well as the adoption of only the motivational psychological intervention nursing model,demonstrated favorable effects on PICS.Both groups of patients showed a reduction in anxiety scores,depression scores,and PTSD scores following the implementation of these two nursing models.However,it is noteworthy that the experimental group exhibited greater improvements compared to the control group.CONCLUSION Our findings suggest that CICARE communication nursing mode may have good influence on relieving PICS.

Comparison of Emergency Management Strategies for Nosocomial Infections Between Two Earthquakes

Aim:Based on the experience of the 5.12 Wenchuan Earthquake and the 8.8 Jiuzhaigou Earthquake,the emergency management strategies for nosocomial infections were compared between the two earthquakes.The experience shared in the present study provides a guideline for the emergency medical rescue of future earthquake.Methods:The patients involved in this study were those injured in the earthquake and admitted to the hospital for treatment.As an earthquake relief center,the hospital participated in the emergency rescue work of the two recent major earthquakes in western China.Review analysis was carried out in the hospital's infection control experience adopted in the two major earthquakes.It was emphasized that,targeting the characteristics and difficulties in the prevention and control of nosocomial infection,different innovative infection control emergency strategies were adopted by the frontline disaster relief hospitals,under the special circumstances and medical conditions in an earthquake disaster.Results:According to the different focus of infection control in the two earthquakes,different hospital infection control strategies were adopted,and the incidence of nosocomial infections was effectively controlled.

Understanding the Effects of Various Factors on the Public Response to Congestion Charge: A Latent Class Modeling Approach

The standard ordered response model (SORM) is a common disaggregate approach with ordered outcomes in which the effects of various exogenous attributes are assumed constant across ordinal choices. In this study, an innovative latent class based generalized ordered response model (LC-GORM) is formulated and used to assess the effects of various factors on respondents’ choice behavior with respect to congestion charge proposal for Jakarta, Indonesia. The proposed model probabilistically assigns respondents into selfish and altruistic class memberships (latently) based on their knowledge of the proposed scheme and their specific attributes. Aiming to capture observable preference heterogeneity across ordinal choices and allow the thresholds to be varied across observations, we parameterize the thresholds as a linear function of the exogenous variables for each ordinal preference. Using stated preference data collected in Jakarta in December 2013, we incorporate the influence of a comprehensive set of explanatory variables into four categories: charges, latent variables related to respondent’s psychological motivations, mobility attributes and socio-demographic characteristics. Empirical results obviously verify the existence of preference heterogeneity across outcomes. The findings confirm that the altruistic class are more sensitive with respect to acceptance of the scheme, while the selfish class are more sensitive with respect to rejection. The key factors influencing public acceptability include the charge level and respondent variables such as car dependency, awareness of the problem of cars in society, frequency of visits to the city center and frequency of private mode usage.

RITSD Analysis of the Agronomic Traits of Somaclonal in Rice

[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD changing of agronomic traits was studied by using 24 rice somaclonal and its donor parent under two sowing dates. [Result]The average values of RITSD were higher （over one） for the traits of pant height （PH）,density of spikelets （DS）,filled spikelets per panicle （FSP）,spikelets per panicle （SP） and grain weight per plant （GWP）,but lower for days of sowing to heading （DSH）,effective panicles （EP）,panicle length （PL）,seed setting rate （SS） and 1 000-grain weight （1 000-GW）. These showed that PH,DS,FSP,SP and GWP were easily affected by sowing date and tended to higher with the later sowing; the RITSD of somaclonal changed with the agronomic traits. The frequency of RITSD＇ variation of DSH and PH was higher than that of PL. The RITSD＇ value of EP,PL,DS,FSP,SP and SS became higher,and higher or lower for DSH and GWP in different somaclonal; compared with the donor,20 of 24 was significantly different,and the frequency of RITSD variation was over 83. 3%,however,RITSD of the most lines （75%） changed only for 1-2 characters; cluster analysis showed that the RITSD of agronomic traits belonged to different combinations of somaclonal in rice. [Conclusion]the study had provided a theoretical basis for the screening and using of the somaclonal.

基于PSR模式的江苏省区域生态环境可持续能力评价

基于压力—状态—响应(PSR)指标框架模式,从环境本底—环境压力—环境效应—社会响应等4个方面选出23个指标组成指标体系,采用全排列多边形综合图示指标法对江苏省区域生态环境可持续能力进行了评价,根据综合得分指数并结合ArcGIS软件对其进行空间表达,将江苏省13个地级市的生态环境可持续能力分成5类。评价结果显示,南京、无锡、常州、扬州、连云港的可持续能力较强,宿迁、淮安、盐城的可持续能力最弱。江苏省生态环境可持续能力具有显著的区域差异,南部地区自然条件优于北部地区,但南部地区环境压力较大;揭示了造成这种差异的原因。

Double-layer model updating for steel-concrete composite beam cable-stayed bridge based on GPS

In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.

KING GEORGE ISLAND GIS (KGIS) PROJECT OF WGGGI——A STATE OF THE ART

The presentation contains information on existing geodetic data for King George Island obtained from the questionnaires distributed among the members of the WGGGI.

Impacts of Zoological Garden in Schools (A Case Study of Zoological Garden, Kano State Nigeria)

In the course of this work which is the impact of zoological garden in schools, the questionnaire interviewed was used in the collection of data. Based on the finding it was observed that people visit zoological gardens for different purposes like educational, recreational, research, economic and cultural values. Also the chi-square (X2) is used in this research to show if there is significant difference or not. Result indicated that people from various works of life visited the zoo. Some recommendations were also made for further studies as well as the opposition of establishment of a zoo. Thus, the objectives of the this work are to identify the conservation areas in which zoos make a contribution, to develop understanding and support of the conservation potentials of zoos, to convince local zoos and conservation agencies that they can make important contributions to conservation, to help zoos formulate conservation priorities and policies and finally, to promote action of individual zoos by participation in the global zoo and other conservation network.

Evolution of Building Envelopes through Creating Living Characteristics

Building envelopes include facades and roof, which have the most interaction and exchange with outside and natural environment. In the future, meeting buildings various complicated needs with new technological advances necessitates a change and evolution in building envelopes. Controlling the energy consumption of the buildings is mostly through controlling the energy performance of the building envelopes. New technologies lead to the intelligent facades and envelopes. The envelope can be designed to be a part of the whole building＇s metabolism （energy production, storage and consumption） and morphology. The envelope would be a controlled part of the building which is managed through the central control system of the building, which connects it to other parts. It caused building envelope design to be changed fundamentally, so that there is a need to interact with engineering disciplines including computer engineering, mechanical engineering, material engineering and so on. All of these caused building envelope to get closer to biological and living systems. The physical restrictions which affect buildings system and living systems are the same. So they cause the same forces to shape the structure and form of the systems and the same rules to interact with the environment. The restrictions of material and energy resources caused living systems to be energy efficient and consuming less material. But the most important difference between living systems and building systems is in maximum use of different resources. As living systems use information maximally, the building system technology is based on using maximum energy. Now, there are many reasons and restrictions that building envelopes cannot act like living systems. But technological developments and contributing more disciplines in design and construction of building envelopes caused the future way of these envelopes get close to living systems for their energy efficiency. Some of living systems characteristics which the future building envelopes would have partially or benefit for the design process or construction are self-organization, evolution principles, hierarchical levels, processing energy, reaction to environmental stimuli and self-adjustment. Self-organization is achieved in some design software and in building material production for creating formal patterns. Evolution principles provide infrastructure for soft wares for optimization purposes and form creation. Hierarchical levels refer to giving hierarchical structure to the building envelopes through layering and designing different scales. Processing energy （metabolism） would be achieved through photovoltaic and solar collectors to produce energy and in passive systems for energy storage and distribution. Controlling solar radiation absorption and transmittance would help energy transfer from outside to building and vice versa. Reaction to environmental stimuli which is one of the most important characteristics of future building envelopes would use different types of active and passive sensors to create envelope mechanical reactions through material properties or collect data for processing in the control center to determine the right reaction. The reaction would be through different strategies such as changing properties and moving. Reaction could be passive or active. Self-adjustment can be achieved by control systems and processing units. All of these mean intelligent envelopes are essential parts of future buildings. Though it is now started with new design soft wares based on biological principles to optimize different parameters affecting the envelope function or to create the most efficient form.

Encroachment of the Buriganga River in Bangladesh

A survey on different aspects of Buriganga River encroachment was conducted in a 300 meter long encroached part of the river located in Dhaka, Bangladesh. A total of 100 respondents were surveyed and three Focus Group Discussions (FGDs) were arranged prior to the semi-structured questionnaire survey. It was observed that almost all of the respondents migrated to the study area. The majority of the respondents had better business opportunity (69.23%) as the cause of encroachment. Significant portions of the respondents occupying the encroached area were found to be landless (36.84%), small businessmen (31.58%) and people with political affluence (26.32%). Major portions (23.33%) of the encroached land were used for industrial development as well as housing and developmental projects. Negative health impact (40%) was found to be the main adverse effect of encroachment of the river. Other adverse effects included economic loss through obliteration of fisheries (35.71%), scarcity of clean water (32.14%), reduction of aesthetic value of the surroundings (25%) etc. For the protection of the river, the majority of the respondents opted for relocation of the industries (46.15%) and enforcement of strict rules and regulations (38.46%).

Attitude of the Population to the Activities of National Parks: Territorial Aspect (on the Example of a Survey of Residents of the Khorug and Murgab Region)

The article describes and interprets the results of a study aimed at studying public opinion about the activities of national parks. The attitude of the local population to the activities of the State Institution “National Park of Tajikistan” was studied. A total of 40 respondents from local residents were surveyed. Fifteen local residents of Khorog, most of them educated people, students of Khorog University and teachers of the Biological Institute of the Pamirs who are familiar with the Tajik National Park in the vicinity have carried out several scientific studies. Twenty-five respondents of the residents of the Murghab district are directly the population who live in the park. They have less education, and they are more prone to a rural lifestyle, and livestock far more knowledgeable about the Tajik National Park than the residents of Khorog. Interviewed residents of the Murgab and Karakuls villages believe that the activities of the Tajik National Park should be more efficient and lay down ways to improve its activities and form a positive image. In their opinion, the employees of the national park should interact more with the local population, take into account their interests, improve information carrying out activities of the national park. Proceeding from the answers of the respondents, we can conclude that the Tajik national park is already widely known to the circle of researchers and scientific applicants as a place or testing ground for research. For the local populations who live in the park, they use it as a place for animal husbandry and natural resources. During the survey, it turned out that the park is currently being used by all means, but not protected in any way. The results of a public opinion poll conducted in the September of 2021 in the settlements of the Khorug town of the Gorno-Badakhshan Autonomous Oblast GBAO region, belonging to the central ecological zone of the Pamir natural territory, are presented. The attitude of the local population to the activities of the Tajik Nation Park was studied. Interviewed residents believe that the activities of the Tajik National Park should be more efficient and lay down ways to improve its activities and form a positive image.

Correlation Analysis of Attitudinal Responses of Men and Women Toward Wife Beating by Husband in Rural and Urban Ethiopia

The Central Statistical Agency （CSA） of Ethiopia included some questions in its 2005 Demographic and Health Survey （DHS） questionnaire, asking for the opinion of men and women if wives beaten by husbands is justified if wives commit some mistakes while they are undertaking their day to day family responsibilities and other personal functions. The sample size was about 14,000 women in the reproductive and productive ages of 15-49 and about 6,000 men in the age brackets of 15-59. The reasons for wife beating by husbands are examined against some selected independent background variables of the sampled men and women respondents, while the dependent variables are the responses to questions of wife beating. With respect to the analytical model, the author decided to focus on some descriptive statistics, such as frequency distributions tables, proportions, comparative analysis, and application of chi-squares （Xz） techniques to examine the variations in the responses of women and men amongst the independent backgrounds.