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Influence of pressure disturbance wave on dynamic response characteristics of liquid film seal for multiphase pump
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作者 Qing-Ping Li Jin-Ya Zhang +1 位作者 Jia-Xiang Zhang Yong-Xue Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期2048-2065,共18页
Slug flow or high GVF(Gas Volume Fraction)conditions can cause pressure disturbance waves and alternating loads at the boundary of mechanical seals for multiphase pumps,endangering the safety of multiphase pump units.... Slug flow or high GVF(Gas Volume Fraction)conditions can cause pressure disturbance waves and alternating loads at the boundary of mechanical seals for multiphase pumps,endangering the safety of multiphase pump units.The mechanical seal model is simplified by using periodic boundary conditions and numerical calculations are carried out based on the Zwart-Gerber-Belamri cavitation model.UDF(User Define Function)programs such as structural dynamics equations,alternating load equations,and pressure disturbance equations are embedded in numerical calculations,and the dynamic response characteristics of mechanical seal are studied using layered dynamic mesh technology.The results show that when the pressure disturbance occurs at the inlet,as the amplitude and period of the disturbance increase,the film thickness gradually decreases.And the fundamental reason for the hysteresis of the film thickness change is that the pressure in the high-pressure area cannot be restored in a timely manner.The maximum value of leakage and the minimum value of axial velocity are independent of the disturbance period and determined by the disturbance amplitude.The mutual interference between enhanced waves does not have a significant impact on the film thickness,while the front wave in the attenuated wave has a promoting effect on the subsequent film thickness changes,and the fluctuation of the liquid film cavitation rate and axial velocity under the attenuated wave condition deviates from the initial values.Compared with pressure disturbance conditions,alternating load conditions have a more significant impact on film thickness and leakage.During actual operation,it is necessary to avoid alternating load conditions in multiphase pump mechanical seals. 展开更多
关键词 Multiphase pump Liquid film seal Pressure disturbance wave Dynamic response characteristics
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Dynamic response mechanism and precursor characteristics of gneiss rockburst under different initial burial depths 被引量:1
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作者 LIU Dongqiao SUN Jie +4 位作者 MENG Wen HE Manchao ZHANG Chongyuan LI Ran CAO Binghao 《Journal of Mountain Science》 SCIE CSCD 2024年第3期1004-1018,共15页
To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system... To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system and acoustic emission(AE)monitoring system were used to monitor the entire rockburst process in real time.The experimental results show that when the initial burial depth increases from 928 m to 1320 m,the proportion of large fracture scale in rockburst increases by 154.54%,and the AE energy increases by 565.63%,reflecting that the degree and severity of rockburst increase with the increase of burial depth.And then,two mechanisms are proposed to explain this effect,including(i)the increase of initial geostress improves the energy storage capacity of gneiss,and then,the excess energy which can be converted into kinetic energy of debris ejection increases,consequently,a more pronounced violent ejection phenomenon is observed at rockburst;(ii)the increase of initial geostress causes more sufficient plate cracks of gneiss after unloading ofσh,which provides a basis for more severe ejection of rockburst.What’s more,a precursor with clear physical meaning for rockburst is proposed under the framework of dynamic response process of crack evolution.Finally,potential value in long term rockburst warning of the precursor obtained in this study is shown via the comparison of conventional precursor. 展开更多
关键词 Traffic Engineering Gneiss Rockburst Crack propagation Excess energy Precursor characteristic
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Eco-physiological characteristics of Tetracentron sinense Oliv.saplings in response to different light intensities
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作者 Rong Wang Xueheng Lu +4 位作者 Hongyan Han Xuemei Zhang Yonghong Ma Qinsong Liu Xiaohong Gan 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第3期29-44,共16页
The regeneration of Tetracentron sinense Oliv.is poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in gaps.It is unclear whether different ... The regeneration of Tetracentron sinense Oliv.is poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in gaps.It is unclear whether different light intensities in various habitats affect eco-physiological characteristics of saplings and their natural regeneration.In this study,the light intensity in T.sinense habitats was simulated by artificial shading(L1:100%NS(natural sunlight)in the open;L2:50%NS in a forest gap or edge;L3:10%NS in understory)to investigate differences in morphology,leaf structure,physiology,and photosynthesis of 2-year-old sap-lings,and to analyze the mechanism of light intensity on sapling establishment.Significant differences were observed in morphology(including leaf area,and specific leaf area)under different light intensities.Compared to L1 and L3,chloroplast structure in L2 was intact.With increasing time,superoxide dismutase(SOD)and catalase(CAT)activities in L2 became gradually higher than under the other light intensities,while malondialdehyde(MDA)content was opposite.Shading decreased osmoregulation substance contents of leaves but increased chlorophyll.The results suggest that light intensities significantly affect the eco-physiological characteristics of T.sinense saplings and they would respond most favorably at intermediate levels of light by optimizing eco-physiological characteristics.Therefore,50%natural sunlight should be created to promote saplings establishment and population recovery of T.sinense during in situ conservation,including sowing mature seeds in forest edges or gaps and providing appropriate shade protection for seedlings and saplings in the open. 展开更多
关键词 Chloroplast ultrastructure Eco-physiological characteristics Light intensities Sapling establishment Tetracentron sinense Oliv
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Dynamic response characteristics of a circular lined tunnel under anisotropy frost heave of overlying soil at the tunnel portal section in cold regions
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作者 ZHANG Shuo-cheng CHEN Wen-hua 《Journal of Mountain Science》 SCIE CSCD 2023年第5期1424-1440,共17页
The rapid development of traffic engineering in cold regions and its consequent problems need to be considered.In this paper,the dynamic response characteristics of the tunnel portal section in cold regions with harmo... The rapid development of traffic engineering in cold regions and its consequent problems need to be considered.In this paper,the dynamic response characteristics of the tunnel portal section in cold regions with harmonic load acting on the lining were studied in the frequency domain.The lining is in close contact with the frozen soil,and there is relative movement between the frozen and unfrozen soil due to the phase change.The analytical solution of the vibration of tunnel portal section caused by the harmonic load acting on the lining was derived under the consideration of the anisotropy frost heave of overlying soil.Based on the continuity conditions and boundary conditions,the undetermined coefficients were obtained,and the analytical solutions for different medium displacements and stresses of the cold-region tunnel system were acquired.The vertical pressure coefficient was equivalently simplified as a variable that could be used to replace the thickness of the overlying soil above the tunnel.The analysis of the parameter model shows that the change of the medium parameters(lining,frozen,and unfrozen soil)affects the circumferential stresses,the radial displacements and their peak frequencies of the soil.For example,the increase of density ratio of tunnel lining to frozen soil decreases the radial stresses of the frozen and unfrozen soil;the increase of volumetric frost heaving strain of the frozen soil increases the radial displacements of the frozen surface and decreases the stability of the frozen surface;the increasing of thickness of the frozen soil significantly reduces the radial displacement of unfrozen soil at dimensionless radius η=4.5 compared with that of frozen soil at η=1.5. 展开更多
关键词 Frost heave Tunnel portal section Relative movement Dynamic response characteristics Cold region
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Experimental study of the dynamic mechanical responses and failure characteristics of coal under true triaxial confinements 被引量:4
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作者 Zhanguo Ma Pengfei Yan +3 位作者 Shixing Cheng Peng Gong Fuzhou Qi Jianguo Wang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第6期761-772,共12页
Investigations on the dynamic mechanical properties and failure mechanisms of coal under in-situ stress is essential for the prevention of dynamic disasters in deep coal mines.Thus,a modified true triaxial Hopkinson b... Investigations on the dynamic mechanical properties and failure mechanisms of coal under in-situ stress is essential for the prevention of dynamic disasters in deep coal mines.Thus,a modified true triaxial Hopkinson bar was employed to explore the dynamic mechanical behaviors of coal at different confining pressures(0–20 MPa)and strain rates(40–220 s^(-1)).The results show that the dynamic peak stress is positively correlated with lateral static pre-stressσy andσz,but negatively correlated with axial static prestressσx.At approximate strain rates,increasing the lateral static pre-stress facilitates increasing the dynamic peak stress,but the minimum lateral static pre-stress is the primary factor limiting a significant increase in dynamic peak stress of coal.Furthermore,the dynamic differential stress is linearly related to the logarithm of strain rate,and the peak strain varies linearly with strain rate.However,there is no significant correlation between confining pressure and peak strain.Moreover,X-ray CT images and photographic fracture observations of coal samples show the failure patterns under uniaxial and triaxial conditions are splitting failure and shear failure,respectively.The device provides a viable approach for fully comprehending the dynamic mechanical behaviors of rock-like material in complex stress conditions. 展开更多
关键词 COAL True triaxial SHPB test Dynamic mechanical properties Failure characteristics
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Stress response characteristics of BFRP anchors on loess mudstone slope under rainfall conditions
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作者 WEI Hong WU Hong-gang +3 位作者 WU Dao-yong TANG Lin PAI Li-fang GUAN Wei 《Journal of Mountain Science》 SCIE CSCD 2023年第5期1469-1482,共14页
To investigate the stress response characteristics and shear stress transfer mechanism of BFRP(basalt fiber reinforced plastics)anchors under rainfall conditions and to explore the reinforcement effect of BFRP anchors... To investigate the stress response characteristics and shear stress transfer mechanism of BFRP(basalt fiber reinforced plastics)anchors under rainfall conditions and to explore the reinforcement effect of BFRP anchors,a comparative indoor physical model test was conducted in this study using loess mudstone slope as a typical case,and multi-attribute response data,such as slope displacement,BFRP anchor strain and axial force,were obtained.Based on the variation law of slope displacement,it can be concluded that the deformation displacement of the slope on the side reinforced by BFRP anchors is smaller than that of slopes reinforced with steel anchors;the bearing capacity of BFRP anchor is given priority in time,and the anchoring effect of BFRP anchor at the top of the slope is given priority,and the axial force value of anchor is characterized by a surface amplification effect in space;the axial force is higher around the anchor head and tends to decay as a negative exponential function as the anchor extends in the direction of the interior of the slope;the shear stress of BFRP anchor and anchorage body are unevenly distributed along the axial direction,with the maximum value occurring in the free section near the slope surface and decreases as the BFRP anchor extends towards the interior of the slope.These results can provide a theoretical basis for the optimal design of BFRP anchors. 展开更多
关键词 BFRP Stress response characteristics Stress transfer mechanism Load transfer curve
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Dynamic geomorphology and storm response characteristics of the promontory-straight beach-a case of Gulei Beach, Fujian 被引量:1
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作者 Chao Cao Zijian Mao +5 位作者 Feng Cai Hongshuai Qi Jianhui Liu Gang Lei Shaohua Zhao Gen Liu 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第7期64-78,共15页
As one of the main areas of tropical storm action in the northwestern Pacific Ocean,South China experiences several typhoons each year,and coastal erosion is a problem,making the area a natural testing ground for stud... As one of the main areas of tropical storm action in the northwestern Pacific Ocean,South China experiences several typhoons each year,and coastal erosion is a problem,making the area a natural testing ground for studying the dynamic geomorphological processes and storm response of promontory-straight coasts.This study is based on three years of topographic data and remote sensing imagery of Gulei Beach and uses topographic profile morphology,single width erosion-accretion and mean change,combined with the Coastsat model to quantify the seasonal and interannual variability and storm response of the beach and to explain the evolution of shoreline change and beach dynamics geomorphology in the last decade.Gulei Beach has been in a state of overall erosion and local accretion for a long time,with relatively obvious cyclical changes;seasonal changes are also obvious,which are mainly characterized by summer accretion and winter erosion,with accretion at the top of the bay and accretion and erosion on the north and south sides of the bay corner,respectively;the seasonal erosion-accretion volume of the beach profile ranges from-80 m3/m to 95.52 m3/m,and the interannual erosion-accretion volume ranges from-69.09 m3/m to 87.31 m3/m.The response of beaches to typhoons with different paths varies greatly depending on the length,slope,orientation and scale of beach development.The large and gently developing Futou beach is less responsive to storms,while the less developed headlands in the southern Gulei Peninsula are more susceptible to disturbance by external factors and respond more strongly to typhoons.Storm distance is more influential than storm intensity.Under the influence of human activities,obvious erosion hotspots develop during normal weather,but storm processes produce redistribution of beach material patterns,and erosion hotspots disappear after storms.The results of this study enrich the theory of beach dynamics geomorphology and provide technical support for disaster prevention and mitigation,as well as ecological restoration of coastal zones. 展开更多
关键词 promontory-straight beach dynamic geomorphology storm response Gulei Peninsula
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Logging curves characteristics and response mechanisms of basaltic facies and sub-facies: A case study from eastern sag of Liaohe depression, Northeast China 被引量:1
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作者 YU Xiaojian QIU Wen +3 位作者 GUO Qiang FENG Yuhui WANG Guodong LENG Qinglei 《Global Geology》 2023年第3期146-156,共11页
Based on five types of conventional logging curves including GR,RLLD,CNL,DEN and AC,and 39 core samples from 30 representative boreholes,the logging characteristics and lithofacies and sub-facies of the basaltic rocks... Based on five types of conventional logging curves including GR,RLLD,CNL,DEN and AC,and 39 core samples from 30 representative boreholes,the logging characteristics and lithofacies and sub-facies of the basaltic rocks were studied.Three basaltic facies and four sub-facies are recognized from the well logs,includ-ing volcanic conduit facies(post intrusive sub-facies),explosive facies,and effusive lava flow facies(tabular flow,compound flow and hyaloclastite sub-facies).The post intrusive,tabular flow and compound flow sub-facies logging curves are mainly controlled by the distribution of vesiculate zones and vesiculate content,which are characterized by four curves with good correlation.Post intrusive sub-facies are characterized by high RLLD,high DEN,with a micro-dentate logging curve pattern,abrupt contact relationships at the top and base.Tabular flow sub-facies are characterized by high RLLD,high DEN,with a bell-shaped log curve pattern,abrupt contact at the base and gradational contact at the top.Compound flow sub-facies are characterized by medium-low RLLD,with a micro-dentate or finger-like logging curve pattern,abrupt contact at the base and gradational contact at the top.Explosive facies and hyaloclastite sub-facies logging curves are mainly controlled by the distribution of the size and sorting of rock particles,which can be recognized by four kinds of logging curves with poor cor-relation.Explosive facies are characterized by low RLLD,medium-low CNL and low DEN,with a micro-dentate logging curve pattern.Hyaloclastite sub-facies are characterized by low RLLD,high CNL,low DEN and high AC,with a micro-dentate logging curve pattern.The present research is beneficial for the prediction of basaltic reser-voirs not only in the Liaohe depression but also in the other volcanic-sedimentary basins. 展开更多
关键词 CENOZOIC Liaohe depression eastern sag logging characteristics basaltic facies
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Microbial community composition and environmental response characteristics of typical brackish groundwater in the North China Plain 被引量:1
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作者 Huai-sheng Zhang Wu-tian Cai +5 位作者 Feng Guo Chao Bian Fu-dong Liu Lei Zhang Jin-wei Liu Miao Zhao 《China Geology》 CAS CSCD 2023年第3期383-394,共12页
To reveal the microbial community composition of regional shallow porous brackish groundwater and its response characteristics to groundwater environment,the first and second aquifers in Taocheng District,Hengshui Cit... To reveal the microbial community composition of regional shallow porous brackish groundwater and its response characteristics to groundwater environment,the first and second aquifers in Taocheng District,Hengshui City were selected,and 10 groundwater source samples were collected for hydrochemical analysis and microbial 16S RNA gene V4-V5 regional sequencing.The results showed that the shallow brackish groundwater in the study area is weakly alkaline and has high ion content.The hydrochemical types are SO_(4)·Cl-Na·Mg type and HCO3·Cl-Na·Mg type as a whole.The spatial zonation of the abundance and diversity of groundwater microorganisms is obvious.The number of endemic bacteria in groundwater from upstream,midstream to downstream is 11,135 and 22 respectively,with a total of 22 bacteria.Proteobacteria is the most dominant in groundwater level(38.82%-86.88%),and there are obvious differences in different sections.At the genus level,the main dominant species in each group and sample are Pseudomonas and Hydrogenophaga.In terms of composition difference,Pseudohongiella,Pseudorhodobacter and Limnohabitans are the representatives of UR,MR and LR.On the whole,the composition of flora in groundwater in the study area is sensitive and closely related to hydrochemical processes.Species abundance is affected by alkaline and high salinity environmental indicators,while species diversity is related to depth and dissolved oxygen in weak reduction environment. 展开更多
关键词 Groundwater microorganism Microbial Endemic bacteria BIOCHEMISTRY Pseudomonas Hydrogenophage Brackish groundwater Environmental response Hydrogeological survey engineering Environmental geological survey engineering
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Microtremor-based analysis of the dynamic response characteristics of a site containing grouped earth fissures 被引量:1
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作者 Deng Yahong Xuan You +5 位作者 Mu Huandong Chang Jiang Cao Ge He Nainan Zhao Xunchang Sun Longfei 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第3期689-702,共14页
In this study,the Beibu earth fissure site in the northeastern part of Weihe Basin,which contains four nearly parallel earth fissures,was studied.A long straight microtremor measuring line,containing 49 measuring poin... In this study,the Beibu earth fissure site in the northeastern part of Weihe Basin,which contains four nearly parallel earth fissures,was studied.A long straight microtremor measuring line,containing 49 measuring points across four earth fissures,was established to investigate the dynamic response of this site using Fourier spectrum,response acceleration spectrum,Arias intensity,and HVSR analyses.The main results are as follows:(1)The fundamental frequencies of 44 measuring points obtained from HVSR analysis are concentrated within 1.67 Hz-2.25 Hz,and the existence of the earth fissures has little effect on the fundamental frequency changes.(2)There is an amplification effect near a single earth fissure.The dynamic responses are large at the measuring points near the earth fissure,and the values decrease with increasing distance from the earth fissure.In areas between two adjacent earth fissures,these values decrease and are even lower than those in sites without amplification effects.(3)In this earth fissure site,the general area(or less affected area)and affected areas were delineated based on the amplification effect.In engineering applications,construction design should avoid these affected areas and existing structures should be reinforced to satisfy the seismic fortification requirements. 展开更多
关键词 earth fissure sites MICROTREMORS Fourier amplitude spectrum response spectrum arias intensity H/V spectral ratio fundamental frequency amplification effect
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Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases 被引量:5
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作者 Yi-Fan Chang Jia-Jing Li +4 位作者 Tao Liu Chong-Qing Wei Li-Wei Ma Vladimir N Nikolenko Wei-Long Chang 《World Journal of Gastroenterology》 SCIE CAS 2024年第11期1524-1532,共9页
Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes.Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and de... Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes.Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and degradation.A large number of studies have shown that autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal(GI)cells.However,the role of autophagy in GI diseases remains controversial.This article focuses on the morphological and biochemical characteristics of autophagy in GI diseases,in order to provide new ideas for their diagnosis and treatment. 展开更多
关键词 AUTOPHAGY Morphological study Biochemical characteristics Subcellular structure Transmission electron microscopy Gastrointestinal diseases
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A theory for three-dimensional response of micropolar plates 被引量:1
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作者 Dianwu HUANG Linghui HE 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第8期1403-1414,共12页
Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding throu... Through combined applications of the transfer-matrix method and asymptotic expansion technique,we formulate a theory to predict the three-dimensional response of micropolar plates.No ad hoc assumptions regarding through-thickness assumptions of the field variables are made,and the governing equations are two-dimensional,with the displacements and microrotations of the mid-plane as the unknowns.Once the deformation of the mid-plane is solved,a three-dimensional micropolar elastic field within the plate is generated,which is exact up to the second order except in the boundary region close to the plate edge.As an illustrative example,the bending of a clamped infinitely long plate caused by a uniformly distributed transverse force is analyzed and discussed in detail. 展开更多
关键词 micropolar plate TRANSFER-MATRIX asymptotic expansion three-dimensional response
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Research on the influences of motion characteristics of jetting projectile charge under water 被引量:1
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作者 Xing Chen Yong-gang Lu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期411-425,共15页
Shaped charge warhead is important for enhancing the damage performance of underwater weapons.This paper used finite element analysis software and based on JPC water penetration experiments to examine the influence of... Shaped charge warhead is important for enhancing the damage performance of underwater weapons.This paper used finite element analysis software and based on JPC water penetration experiments to examine the influence of liner parameters(wall thickness,material),charge aspect ratio,and stand-off distance on the movement characteristics of JPC in water.The findings reveal that the head diameter of the JPC increases and experiences significant erosion after entering the water,the effective length of the JPC in water undergoes two distinct phases:a growth phase and a decrease phase,with the velocity of the JPC decaying exponentially.Increasing the liner thickness,stand-off distance and the charge aspect ratio can improve the erosion resistance and the velocity retention capacity of the JPC.The optimal ranges for liner thickness and stand-off distance are 0.0363D_(k) to 0.0545D_(k)(D_(k) is the charge diameter),the stand-off distance should be within 1.0D_(k).After the charge aspect ratio higher than 1.25,the charge structure exerts minimal influence the movement characteristics of the JPC in water.Material density plays a crucial role in the velocity decay pattern of the JPC during penetration.JPC with higher densities exhibit superior velocity retention capabilities in water,with the velocity decay pattern converging if the densities are similar.Consequently,copper,tantalum and tungsten liners are deemed appropriate for underwater shaped charge warhead.Finally,the results will provide an important reference for the design of underwater shaped charge warhead. 展开更多
关键词 JPC Movement characteristics Underwater penetration Numerical simulation
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Computed tomography radiomic features and clinical factors predicting the response to first transarterial chemoembolization in intermediate-stage hepatocellular carcinoma 被引量:1
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作者 Zhong-Xing Shi Chang-Fu Li +6 位作者 Li-Feng Zhao Zhong-Qi Sun Li-Ming Cui Yan-Jie Xin Dong-Qing Wang Tan-Rong Kang Hui-Jie Jiang 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第4期361-369,共9页
Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treat... Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treatment response can help patients choose a reasonable treatment plan.This study aimed to investigate the value of the radiomic-clinical model in predicting the efficacy of the first TACE treatment for HCC to prolong patient survival.Methods:A total of 164 patients with HCC who underwent the first TACE from January 2017 to September 2021 were analyzed.The tumor response was assessed by modified response evaluation criteria in solid tumors(mRECIST),and the response of the first TACE to each session and its correlation with overall survival were evaluated.The radiomic signatures associated with the treatment response were identified by the least absolute shrinkage and selection operator(LASSO),and four machine learning models were built with different types of regions of interest(ROIs)(tumor and corresponding tissues)and the model with the best performance was selected.The predictive performance was assessed with receiver operating characteristic(ROC)curves and calibration curves.Results:Of all the models,the random forest(RF)model with peritumor(+10 mm)radiomic signatures had the best performance[area under ROC curve(AUC)=0.964 in the training cohort,AUC=0.949 in the validation cohort].The RF model was used to calculate the radiomic score(Rad-score),and the optimal cutoff value(0.34)was calculated according to the Youden’s index.Patients were then divided into a high-risk group(Rad-score>0.34)and a low-risk group(Rad-score≤0.34),and a nomogram model was successfully established to predict treatment response.The predicted treatment response also allowed for significant discrimination of Kaplan-Meier curves.Multivariate Cox regression identified six independent prognostic factors for overall survival,including male[hazard ratio(HR)=0.500,95%confidence interval(CI):0.260–0.962,P=0.038],alpha-fetoprotein(HR=1.003,95%CI:1.002–1.004,P<0.001),alanine aminotransferase(HR=1.003,95%CI:1.001–1.005,P=0.025),performance status(HR=2.400,95%CI:1.200–4.800,P=0.013),the number of TACE sessions(HR=0.870,95%CI:0.780–0.970,P=0.012)and Rad-score(HR=3.480,95%CI:1.416–8.552,P=0.007).Conclusions:The radiomic signatures and clinical factors can be well-used to predict the response of HCC patients to the first TACE and may help identify the patients most likely to benefit from TACE. 展开更多
关键词 Hepatocellular carcinoma Transarterial chemoembolization Radiomics Treatment response Prediction
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Clinical characteristics of acute non-varicose upper gastrointestinal bleeding and the effect of endoscopic hemostasis 被引量:4
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作者 Xiao-Juan Wang Yu-Peng Shi +4 位作者 Li Wang Ya-Ni Li Li-Juan Xu Yue Zhang Shuang Han 《World Journal of Clinical Cases》 SCIE 2024年第9期1597-1605,共9页
BACKGROUND Acute non-variceal upper gastrointestinal bleeding(ANVUGIB)constitutes a prevalent emergency within Gastroenterology,encompassing 80%-90%of all gastrointestinal hemorrhage incidents.This condition is distin... BACKGROUND Acute non-variceal upper gastrointestinal bleeding(ANVUGIB)constitutes a prevalent emergency within Gastroenterology,encompassing 80%-90%of all gastrointestinal hemorrhage incidents.This condition is distinguished by its abrupt onset,swift progression,and notably elevated mortality rate.AIM To gather clinical data from patients with ANVUGIB at our hospital in order to elucidate the clinical characteristics specific to our institution and analyze the therapeutic effectiveness of endoscopic hemostasis.METHODS We retrospectively retrieved the records of 532 patients diagnosed with ANVUGIB by endoscopy at our hospital between March 2021 and March 2023,utilizing our medical record system.Data pertaining to general patient information,etiological factors,disease outcomes,and other relevant variables were meticulously collected and analyzed.RESULTS Among the 532 patients diagnosed with ANVUGIB,the male-to-female ratio was 2.91:1,with a higher prevalence among males.Notably,43.6%of patients presented with black stool as their primary complaint,while 27.4%had hematemesis as their initial symptom.Upon admission,17%of patients exhibited both hematemesis and black stool,while most ANVUGIB patients primarily complained of overt gastrointestinal bleeding.Urgent routine blood examinations at admission revealed that 75.8%of patients had anemia,with 63.4%experiencing moderate to severe anemia,and 1.5%having extremely severe anemia(hemoglobin<30 g/L).With regard to etiology,53.2%of patients experienced bleeding without a definitive trigger,24.2%had a history of using gastric mucosa-irritating medications,24.2%developed bleeding after alcohol consumption,2.8%attributed it to improper diet,1.7%to emotional excitement,and 2.3%to fatigue preceding the bleeding episode.Drug-induced ANVUGIB was more prevalent in the elderly than middle-aged and young individuals,while bleeding due to alcohol consumption showed the opposite trend.Additionally,diet-related bleeding was more common among the young age group compared to the middle-aged group.Gastrointestinal endoscopy identified peptic ulcers as the most frequent cause of ANVUGIB(73.3%),followed by gastrointestinal malignancies(10.9%),acute gastric mucous lesions(9.8%),and androgenic upper gastrointestinal bleeding(1.5%)among inpatients with ANVUGIB.Of the 532 patients with gastrointestinal bleeding,68 underwent endoscopic hemostasis,resulting in an endoscopic treatment rate of 12.8%,with a high immediate hemostasis success rate of 94.1%. 展开更多
关键词 Acute non-varicose upper gastrointestinal bleeding Clinical characteristics Cause of disease Endoscopic homeostatic therapy
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Probiotics: Shaping the gut immunological responses 被引量:1
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作者 Eirini Filidou Leonidas Kandilogiannakis +2 位作者 Anne Shrewsbury George Kolios Katerina Kotzampassi 《World Journal of Gastroenterology》 SCIE CAS 2024年第15期2096-2108,共13页
Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate amounts.Among the most popular and adequately studied probiotics are bacteria from the families Lactob... Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate amounts.Among the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae,Bifidobacteriaceae and yeasts.Most of them have been shown,both in vitro and in vivo studies of intestinal inflammation models,to provide favorable results by means of improving the gut microbiota composition,promoting the wound healing process and shaping the immunological responses.Chronic intestinal conditions,such as inflammatory bowel diseases(IBD),are characterized by an imbalance in microbiota composition,with decreased diversity,and by relapsing and persisting inflammation,which may lead to mucosal damage.Although the results of the clinical studies investigating the effect of probiotics on patients with IBD are still controversial,it is without doubt that these microorganisms and their metabolites,now named postbiotics,have a positive influence on both the host’s microbiota and the immune system,and ultimately alter the topical tissue microenvironment.This influence is achieved through three axes:(1)By dis-placement of potential pathogens via competitive exclusion;(2)by offering protection to the host through the secretion of various defensive mediators;and(3)by supplying the host with essential nutrients.We will analyze and discuss almost all the in vitro and in vivo studies of the past 2 years dealing with the possible favorable effects of certain probiotic genus on gut immunological responses,highlighting which species are the most beneficial against intestinal inflammation. 展开更多
关键词 PROBIOTICS Lactobacillaceae Bifidobacteriaceae SACCHAROMYCES Intestinal inflammation Immune responses
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Inflammation: Complexity and significance of cellular and molecular responses 被引量:1
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作者 Serdar Ozdemir 《Journal of Acute Disease》 2024年第1期3-7,共5页
Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical sig... Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological conditions.Serving as a protective defense mechanism,the inflammatory response involves clinical signs like redness,swelling,pain,and increased body temperature.Immune cells,notably neutrophils and macrophages,play key roles in orchestrating this response.The delicate balance between proinflammatory and anti-inflammatory mediators,including cytokines and chemokines,regulates the inflammatory cascade.While acute inflammation is crucial for tissue repair,chronic inflammation may indicate an imbalance,contributing to conditions like autoimmune diseases.Understanding these mechanisms is vital for developing therapeutic strategies and managing chronic diseases. 展开更多
关键词 INFLAMMATION C-reactive protein PLATELETS SCUBE1 ADRENOMEDULLIN CALPROTECTIN Pentraxin-3 Immune response Acute phase response Vascular function
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Thermo-hydro-poro-mechanical responses of a reservoir-induced landslide tracked by high-resolution fiber optic sensing nerves 被引量:3
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作者 Xiao Ye Hong-Hu Zhu +4 位作者 Gang Cheng Hua-Fu Pei Bin Shi Luca Schenato Alessandro Pasuto 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期1018-1032,共15页
Thermo-poro-mechanical responses along sliding zone/surface have been extensively studied.However,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond th... Thermo-poro-mechanical responses along sliding zone/surface have been extensively studied.However,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond the slip surface to progressive failure.Here,we aim to investigate the subsurface multiphysics of reservoir landslides under two extreme hydrologic conditions(i.e.wet and dry),particularly within sliding masses.Based on ultra-weak fiber Bragg grating(UWFBG)technology,we employ specialpurpose fiber optic sensing cables that can be implanted into boreholes as“nerves of the Earth”to collect data on soil temperature,water content,pore water pressure,and strain.The Xinpu landslide in the middle reach of the Three Gorges Reservoir Area in China was selected as a case study to establish a paradigm for in situ thermo-hydro-poro-mechanical monitoring.These UWFBG-based sensing cables were vertically buried in a 31 m-deep borehole at the foot of the landslide,with a resolution of 1 m except for the pressure sensor.We reported field measurements covering the period 2021 and 2022 and produced the spatiotemporal profiles throughout the borehole.Results show that wet years are more likely to motivate landslide motions than dry years.The annual thermally active layer of the landslide has a critical depth of roughly 9 m and might move downward in warmer years.The dynamic groundwater table is located at depths of 9e15 m,where the peaked strain undergoes a periodical response of leap and withdrawal to annual hydrometeorological cycles.These interface behaviors may support the interpretation of the contribution of reservoir regulation to slope stability,allowing us to correlate them to local damage events and potential global destabilization.This paper also offers a natural framework for interpreting thermo-hydro-poro-mechanical signatures from creeping reservoir bank slopes,which may form the basis for a landslide monitoring and early warning system. 展开更多
关键词 Reservoir landslide Thermo-hydro-poro-mechanical response Ultra-weak fiber bragg grating(UWFBG) subsurface evolution Engineering geological interface Geotechnical monitoring
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Spatiotemporal deformation characteristics of Outang landslide and identification of triggering factors using data mining 被引量:1
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作者 Beibei Yang Zhongqiang Liu +1 位作者 Suzanne Lacasse Xin Liang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期4088-4104,共17页
Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landsli... Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas. 展开更多
关键词 LANDSLIDE Deformation characteristics Triggering factor Data mining Three gorges reservoir
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Experimental investigation on coal pore-fracture variation and fractal characteristics synergistically affected by solvents for improving clean gas extraction 被引量:1
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作者 Feilin Han Sheng Xue +3 位作者 Chunshan Zheng Zhongwei Chen Guofu Li Bingyou Jiang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期413-425,共13页
Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal... Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal synergistically affected by solvents have not been fully understood.Ultrasonic testing,nuclear magnetic resonance analysis,liquid phase mass spectrometry was adopted to comprehensively analyze pore-fracture change characteristics of lean coal treated by combined solvent(NMP and CS_(2)).Meanwhile,quantitative characterization of above changing properties was conducted using geometric fractal theory.Relationship model between permeability,fractal dimension and porosity were established.Results indicate that the end face fractures of coal are well developed after CS2and combined solvent treatments,of which,end face box-counting fractal dimensions range from 1.1227 to 1.4767.Maximum decreases in ultrasonic longitudinal wave velocity of coal affected by NMP,CS_(2)and combined solvent are 2.700%,20.521%,22.454%,respectively.Solvent treatments could lead to increasing amount of both mesopores and macropores.Decrease ratio of fractal dimension Dsis 0.259%–2.159%,while permeability increases ratio of NMR ranges from 0.1904 to 6.4486.Meanwhile,combined solvent could dissolve coal polar and non-polar small molecules and expand flow space.Results could provide reference for solvent selection and parameter optimization of permeability-enhancement technology. 展开更多
关键词 Clean gas extraction Chemical solvent Experimental investigation Fractal characteristics Pore fracture
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