Numerical Study of the High-Frequency Wave Loads and Ringing Response of A Bottom-Hinged Vertical Cylinder in Focused Waves

This paper presents a numerical study on the high-frequency wave loads and ringing response of offshore wind turbine foundations exposed to moderately steep transient water waves.Input wave groups are generated by the technique of frequency-focusing,and the numerical simulation of focused waves is based on the NewWave model and a Fourier time-stepping procedure.The proposed model is validated by comparison with the published laboratory data.In respect of both the wave elevations and the underlying water particle kinematics,the numerical results are in excellent agreement with the experimental data.Furthermore,the local evolution of power spectra and the transfer of energy into higher frequencies can be clearly identified.Then the generalized FNV theory and Rainey’s model are applied respectively to calculate the nonlinear wave loads on a bottom-hinged vertical cylinder in focused waves.Resonant ringing response excited by the nonlinear high-frequency wave loads is found in the numerical simulation when frequency ratios(natural frequency of the structure to peak frequency of wave spectra)are equal to 3–5.Dynamic amplification factor of ringing response is also investigated for different dynamic properties(natural frequency and damping ratio)of the structure.

Study on Technologies for Information Monitoring and Quick Response of Agricultural Focuses and Significant Events

This article analyzed the importance of information monitoring and quick response on agricultural focuses and significant events, proposed the workflow and technical framework for information monitoring and quick response based on modern information technologies, and explained key technologies during implementation and the functional structure for prototype system of the technical support platform.

Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

AIM:To investigate whether tumor debris created by high-intensity focused ultrasound(HIFU)could trigger antitumor immunity in a mouse hepatocellular carcinoma model. METHODS:Twenty C57BL/6J mice bearing H22 hepatocellular carcinoma were used to generate antitumor vaccines.Ten mice underwent HIFU ablation,and the remaining 10 mice received a sham-HIFU procedure with no ultrasound irradiation.Sixty normal mice were randomly divided into HIFU vaccine,tumor vaccine and control groups.These mice were immunized with HIFU-generated vaccine,tumor-generated vaccine,and saline,respectively.In addition,20 mice bearing H22 tumors were successfully treated with HIFU ablation. The protective immunity of the vaccinated mice was investigated before and after a subsequent H22 tumor challenge.Using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay,the cytotoxicity of splenic lymphocytes co-cultured with H22 cells wasdetermined in vitro before the tumor challenge,and tumor volume and survival were measured in vivo after the challenge in each group.The mechanism was also explored by loading the vaccines with bone marrowderived dendritic cells(DCs). RESULTS:Compared to the control,HIFU therapy, tumor-generated and HIFU-generated vaccines significantly increased cytolytic activity against H22 cells in the splenocytes of the vaccinated mice(P<0.001). The tumor volume was significantly smaller in the HIFU vaccine group than in the tumor vaccine group(P <0.05)and control group(P<0.01).However,there was no tumor growth after H22 rechallenge in the HIFU therapy group.Forty-eight-day survival rate was 100%in mice in the HIFU therapy group,30%in both the HIFU vaccine and tumor vaccine groups,and 20% in the control group,indicating that the HIFU-treated mice displayed significantly longer survival than the vaccinated mice in the remaining three groups(P< 0.001).After bone marrow-derived DCs were incubated with HIFU-generated and tumor-generated vaccines, the number of mature DCs expressing MHC-Ⅱ + ,CD80 + and CD86 + molecules was significantly increased,and interleukin-12 and interferon-γlevels were significantly higher in the supernatants when compared with immature DCs incubated with mouse serum(P<0.001). However,no differences of the number of mature DCs and cytokine levels were observed between the HIFU- generated and tumor-generated vaccines(P>0.05). CONCLUSION:Tumor debris remaining after HIFU can improve tumor immunogenicity.This debris releases tumor antigens as an effective vaccine to develop host antitumor immune response after HIFU ablation.

Anesthetic effect of dexmedetomidine in high intensity focused ultrasound treatment of uterine fibroids

Objective: To study the effect of dexmedetomidine in high intensity focused ultrasound treatment of uterine fibroids on pain degree, pain mediator and stress mediator secretion as well as stress signal molecule expression. Methods: 78 patients with uterine fibroids who received high intensity focused ultrasound treatment in Shaanxi Second Provincial People's Hospital between February 2015 and February 2018 were selected as the research subjects and randomly divided into the Dex group who accepted dexmedetomidine + fentanyl + midazolam anesthesia and the control group who accepted fentanyl + midazolam anesthesia. The pain degree was assessed 1 day and 3 d after surgery;the secretion of pain mediators and stress mediators in serum as well as the expression levels of stress signaling molecules in peripheral blood were measured before surgery and 3 d after surgery. Results: 1 d and 3 d after surgery, the NRS pain scores of Dex group were significantly lower than those of control group;3 d after surgery, serum SP, BK, 5-HT, IL-6, IL-8, NE, COR, ACTH and MDA contents as well as peripheral blood NF-κB, p38MAPK, NOX4 and Nrf2 expression of both groups of patients were higher than those before surgery whereas serum SOD and HO-1 contents as well as peripheral blood Keap1 expression were lower than those before surgery, and serum SP, BK, 5-HT, IL-6, IL-8, NE, COR, ACTH and MDA contents as well as peripheral blood NF-κB, p38MAPK, NOX4 and Nrf2 expression of Dex group 3 d after surgery were lower than those of control group whereas serum SOD and HO-1 contents as well as peripheral blood Keap1 expression were higher than those of control group. Conclusion: The application of dexmedetomidine in high intensity focused ultrasound treatment of uterine fibroids can reduce the degree of postoperative pain and stress response.

The Effect of Corporate Social Responsibility on Employees＇ Organizational Commitment in High-tech Enterprises of Jiangsu Province--Based on the Mediating Role of Regulatory Focus

With China＇s rapid economic development, corporate social responsibility （CSR） plays greater impact on its direct stakeholder employees＇ organizational commitment （EOC）. A questionnaire survey was conducted on 426 employees of high-tech enterprises within Jiangsu Province. Multiple regression method was used to test the hypothesis based on the questionnaire reliability and validity analysis. The results show that the four dimensions of CSR including employees responsibility, products responsibility, environment responsibility and charitable responsibility have positive effect on the affective commitment;while the continuance commitment might be more influenced by the environment and charitable responsibility. The regulatory focus plays a moderate effect between CSR and EOC. Promote regulatory focus have positive impact on affective commitment and negative impact on continuance commitment. Defense regulatory focus is just on the opposite.

Effect of high-intensity focused ultrasound (HIFU) combined with radiotherapy on tumor malignancy in patients with advanced pancreatic cancer and evaluation of side effects

Objective:To study the effect of high-intensity focused ultrasound (HIFU) combined with radiotherapy on tumor malignancy in patients with advanced pancreatic cancer and the corresponding side effects.Methods:A total of 84 patients with advanced pancreatic cancer treated in our hospital between May 2013 and March 2016 were selected and randomly divided into HIFU group and IGRT group, HIFU group accepted high-intensity focused ultrasound combined with radiotherapy and IGRT group received radiotherapy alone. 4 weeks after treatment, the levels of tumor markers, liver and kidney function indexes, perineural invasion-related molecules and cytokines in serum as well as the levels of immune cells in peripheral blood were determined.Results:4 weeks after treatment, serum CA199, CA242, OPN, NGAL, RBP4, NGF, TrkA, p75, BDNF and TrkB levels of HIFU group were significantly lower than those of IGRT group, serum IL-2, TNF-α, IFN-γ and IL-13 levels as well as peripheral blood NKT cell and CD4+T cell levels were significantly higher than those of IGRT group, and serum ALT, AST, Cr and BUN levels were not significantly different from those of IGRT group.Conclusion:HIFU combined with radiotherapy treatment of advanced pancreatic cancer can more effectively kill cancer cells, inhibit pancreatic cancer cell invasion to the peripheral nerve and enhance the antitumor immune response mediated by NKT cells and CD4+T cells.

The response of a semisubmersible model under focused wave groups: Experimental investigation

In recent years,extreme wave events have occurred more frequently than have been predicted using theoretical methods.It is,therefore,a requirement to investigate the impact of these events on coastal and offshore structures.This paper reports on results of an experimental investigation into the interaction between unidirectional waves and a horizontally moored semisubmersible model.The target crest height was created at a focal point and time using the focused wave technique.Different values of wave steepness were tested in order to ascertain the nonlinear effects on the quality of waves generated by a piston-type wavemaker.The measured crest height was in good agreement with the theoretical one within 4%relative error.The magnitudes of heave and pitch motions of the model were found to increase as the wave steepness increased.Overall,the paper contributes towards establishing the application of focused wave technique to floating offshore platforms.

感激导向人力资源管理实践的驱动机制及其作用机理

目前关于战略人力资源管理实践的研究过度关注结果导向而忽视了员工福祉,员工作为企业最重要的资源,其付出需要组织给予认可与肯定。然而,感激导向人力资源管理实践是由何种因素形成,又会给组织、部门及个体带来何种影响,既有文献缺乏系统思考和实证研究。鉴于此,本文将探究中国情境下感激导向人力资源管理实践的驱动机制与作用机理。首先,探讨感激导向人力资源管理实践的形成因素。其次,探讨感激导向人力资源管理实践对组织韧性与企业社会责任的影响机制。再次,探讨感激导向人力资源管理实践对领导感激表达的影响机制。最后,探讨感激导向人力资源管理实践对员工帮助行为的影响机制。本文拓展了工作场所组织感激的研究视角,为组织优化人力资源管理实践提供参考和借鉴。

高强度聚焦超声消融与子宫动脉栓塞术治疗子宫肌瘤的临床效果比较

目的 比较高强度聚焦超声(HIFU)与子宫动脉栓塞术(UAE)在治疗子宫肌瘤(UF)患者中的应用效果。方法 收集2020年1月至2022年6月在我院接受介入治疗的UF患者86例,根据治疗方法分为HIFU组(n=44例)与UAE组(n=42例)。比较两组应激反应、子宫内膜容受性、性激素水平、并发症及复发率。结果 术后3 d, HIFU组血清去甲肾上腺素(NE)、丙二醛(MDA)低于UAE组,超氧化物歧化酶(SOD)高于UAE组(P<0.05);术后1个月,HIFU组子宫内膜厚度高于UAE组,子宫内膜动脉血流搏动指数、子宫内膜动脉血流阻力指数低于UAE组(P<0.05);术后3个月,HIFU组血清雌二醇(E2)低于UAE组,促卵泡生长素(FSH)、促黄体生长素(LH)高于UAE组(P<0.05);随访12个月,HIFU组并发症34.09%低于UAE组57.14%,复发率22.73%高于UAE组7.14%(χ^(2)=4.607, 4.067,P<0.05)。结论 HIFU治疗能够缓解UA患者应激反应程度,改善子宫内膜容受性及性激素水平,减少并发症的发生,但有诱发术后复发的风险。

聚焦超声换能器电阻抗谱实时在线监测系统

高强度聚焦超声(HIFU)换能器作为聚焦超声消融手术(FUAS)系统的核心部件,其电阻抗谱是确定FUAS系统工作参数的重要参考依据,故对其进行实时在线监测具有重要意义。该文采用脉冲响应时域测量方法,将探测脉冲信号与HIFU换能器的工作时序相融合,并基于LabVIEW平台构建了一套HIFU换能器电阻抗谱实时在线监测系统,实现了对HIFU换能器电阻抗幅值与相位的高重复性及准确性的实时测量。通过对长时工作在大功率、高占空比条件下HIFU换能器电阻抗谱的实时在线监测,表明该监测系统可准确反应HIFU换能器的特征频率漂移、阻抗幅值和相位的非线性变化。这为HIFU换能器电阻抗谱实时在线监测及驱动参数优化调节提供了技术方案,对HIFU换能器的设计优化和能量损耗机制研究具有重要的应用价值。

基于聚焦解决模式的心理干预对CT增强扫描检查患者的影响

目的:观察基于聚焦解决模式的心理干预对CT增强扫描检查患者的影响分析。方法:选取惠州市第六人民医院在2024年2月-2024年5月收治的基于聚焦解决模式的心理干预并接受CT增强扫描检查65例患者为研究组,另选取在2023年10月至2024年1月收治的常规护理并接受CT增强扫描检查65例患者为对照组。比较两组患者在护理前、后对检查的应对态度评分、心理、生理应激反应,评价患者检查依从性、一次性检查成功率及不良反应发生情况。结果:在护理后两组积极应对方式均较护理前提升,消极应对方式、检查的心理、生理应激反应较护理前下降,研究组更低(P<0.05)。研究组检查依从性优良率96.92%、一次性检查功能率93.85%均高于对照组,而不良反应发生率4.62%低于对照组,差异有统计学意义(P<0.05)。结论:对CT增强扫描检查患者实施基于聚焦解决模式的心理干预,可明显改变患者对于检查的应对态度,降低心理、生理性的应激反应,提升患者对于检查的依从性与一次性检查成功率,降低不良反应的发生率,效果理想。

聚焦解决护理模式对产后出血患者疾病应对及心理健康与自我效能感的影响

目的:探讨聚焦解决护理模式的应用对产后出血患者疾病应对、心理健康水平、自我效能感的影响效果。方法:选取2022年1月至2024年4月于本院产科分娩且发生产后出血的60例患者,利用抛币法进行分组,其中硬币正面的30例患者为对照组;硬币反面的30例患者为观察组。对照组按照传统产科产后护理模式进行护理,观察组按照聚焦解决护理模式进行护理。测定疾病应对评分、焦虑评分、抑郁评分,统计自我效能感优良率,对比上述观察指标差异。结果:观察组的自我效能感优良率高于对照组(P<0.05),护理后的焦虑评分、抑郁评分低于对照组(P<0.05),护理后的疾病应对评分优于对照组(P<0.05)。结论:聚焦解决护理模式的应用能够进一步提升产后出血患者疾病应对水平与心理健康水平,自我效能感更好,值得临床应用。

聚焦解决模式对骨科大手术患者围术期负性情绪和应对能力的影响

目的:探究聚焦解决模式对骨科大手术患者围术期负性情绪和应对能力的影响。方法:选取2023年3-5月在滨州医学院附属医院需进行人工全髋关节置换术、人工全膝关节置换术和髋部骨折手术的患者88例为研究对象,采用随机数字表法分为对照组和试验组,各44例。对照组采用常规护理,试验组在对照组基础上给予聚焦解决模式心理干预。比较两组医院焦虑抑郁量表(HADS)、中文版医学应对问卷、功能锻炼依从性量表、出院患者护理满意度评分。结果:干预后,试验组HADS评分降低,且低于对照组,差异有统计学意义(P<0.05)。干预后,试验组面对评分升高,且高于对照组,差异有统计学意义(P<0.05);两组干预前后屈服评分比较,差异无统计学意义(P>0.05);干预后,试验组回避评分降低,且低于对照组,差异有统计学意义(P<0.05)。试验组功能锻炼依从性得分高于对照组,差异有统计学意义(P=0.003)。试验组护理满意度得分高于对照组,差异有统计学意义(P=0.019)。结论:聚焦解决模式运用于骨科大手术患者围术期心理干预,可以明显改善骨科大手术患者围术期焦虑、抑郁情绪,提高患者医学应对能力、功能锻炼依从性及满意度。

原因调节与反应调节的情绪变化过程

采用生理心理实验法研究忽视、抑制、重视、宣泄等方式调节负情绪的情绪变化过程 ,发现忽视有效减弱了主观感受和表情行为 ,并引起R -R间期更大的增加 ;抑制不能减弱主观感受 ,并引起手指脉搏血容振幅更大的增幅 ;重视增强了主观感受 ;宣泄增强了主观感受 ,并相对地减弱了生理激活水平。研究表明原因调节可以更有效地调整负情绪主观感受 ,反应调节使负情绪成分变化出现“水压模型”式循环动力特点 ;情绪调节过程实现着情绪在心理适应中的促进 (或阻碍 )作用。

不同心理素质水平军人对恐惧情绪的原因调节和反应调节特点

目的探讨恐惧情绪条件下,原因和反应情绪调节方式对不同心理素质水平军人的自主神经反应的影响。方法整群抽取驻渝部队官兵,用军人心理素质量表施测并随机选取高、中、低心理素质军人各50名,共150名。通过情绪材料刺激诱发恐惧情绪,利用生物反馈仪记录被试的自主神经活动指标变化。结果①高心理素质军人采用认知重视时的皮电(SC)变化值显著小于中心理素质军人[(-2.16±2.18)vs(-0.67±1.05)μΩ,P<0.05];采用认知忽视时,低心理素质军人的指端血容振幅(BVP)变化值[(5.47±6.33)nU]显著大于其余两组(P<0.05);但是,其心律R-R间期标准差(SDNN)变化值显著小于高心理素质军人[(3.31±17.69)vs(52.23±47.30)ms,P<0.05]。②低心理素质军人采用认知忽视时的皮电恢复时间[(106.50±24.95)s]以及采用认知重视时的指端血容振幅恢复时间[(65.50±43.43)s]都显著长于高心理素质军人[分别为(68.50±49.39)、(26.50±25.72)s,P<0.05]。③高心理素质军人中,表情宣泄组的皮电变化值上显著大于认知重视组[(-0.43±0.88)vs(-2.16±2.18)μΩ,P<0.05]。低心理素质军人中,表情抑制组的高频功率(HFnorm)变化值显著小于认知重视组[(-4.51±12.10)vs(5.18±3.58)nU]与简单观看组[(4.09±9.48)nU,P<0.05]。④高心理素质军人采用表情抑制的皮电恢复时间[(73.00±44.67)s]显著长于表情宣泄[(61.50±33.09)s,P<0.05]。低心理素质军人采用表情宣泄时,皮电恢复时间[(103.50±38.01)s]和指端血容振幅恢复时间[(21.00±35.50)s]显著长于高心理素质军人(P<0.05)。结论原因调节不利于低心理素质军人调控恐惧情绪;认知重视更有利于高心理素质军人调节恐惧情绪。反应调节下的表情宣泄能较快恢复高心理素质军人的交感神经指标。

自动情绪调节:基于社会文化与神经科学的考量

情绪调节的以往研究大多聚焦于有意情绪调节,而日常生活中普遍存在的自动情绪调节却较少受到关注。与自动加工类似,自动情绪调节无需意识努力、注意分配及有意控制,使个体在阈下知觉中自动有效地调节情绪,根据发生在情绪反应产生之前或之后分为先行聚焦自动情绪调节和反应聚焦自动情绪调节,前者会产生相对适应良性后果,后者则会产生相对适应不良后果,来自神经科学的证据显示两者存在不同的神经基础,这与社会文化考量相一致。社会文化对塑造自动情绪调节起着重要作用,情绪调节的自动认知加工在不断重复的社会文化实践和规范中内化而成。

阶段性责任制健康教育在产科实施的效果评价

目的探讨在产科实施阶段性责任制健康教育的方法和效果。方法根据产妇住院阶段实施健康教育,制订产妇住院期间不同阶段的健康教育内容以及产科健康教育实施表。住院的全过程责任到人,落实和接受情况由宣教者及受教育者双方签名,纳入护士的工作职责及质量控制,并进行实施前后的效果比较。结果在护士人力资源不变的情况下,实施阶段性责任制健康教育后产科健康教育的覆盖面达100.00%,产妇母婴康复保健知识的认知度高于实施前(P<0.01)。无护理投诉、纠纷发生。护理综合质量连续2年位于全院前3名。结论阶段性责任制健康教育纳入护士工作职责及护理质量控制,能有效保证健康教育的落实,促进工作质量的提高,确保母婴安全。

项目反应理论原理与当前应用热点概览

本文首先分析了经典测验理论存在的局限,然后在潜在特质理论和项目特征曲线两大概念基础上阐述了项目反应理论及其基础模型的测量学原理,介绍了多个项目反应理论基础模型。最后简要介绍了七项当前应用项目反应理论指导大型题库建设和指导编制各种新型测验的热点内容。

稳健的宽带多径干扰抑制波束形成算法

针对传统宽带多径干扰抑制波束形成算法计算量大、稳健性差的问题,提出一种基于均匀直线阵的稳健宽带多径干扰抑制波束形成算法。当期望信号垂直入射时,该算法首先在波束旁瓣区域引入虚拟干扰源构造能量聚焦矩阵,通过主瓣宽度的迭代处理,整体控制输出波束旁瓣级,将旁瓣区域能量聚焦到主瓣区域,实现多径干扰条件下的宽带波束形成;然后对期望信号和辅助方位角施加相位响应约束,将其扩展至期望信号非垂直入射和存在指向误差的情况,与传统宽带多径干扰抑制波束形成算法相比,在提高算法稳健性的同时大大降低了计算复杂度;最后仿真分析与实际数据验证表明,该算法能够有效的抑制多径干扰,稳健性较好且具有较高的输出信干噪比。

调肝理脾化积方联合高强度聚焦超声治疗局部晚期胰腺癌临床研究

目的探讨调肝理脾化积方联合高强度聚焦超声(HIFU)对局部晚期胰腺癌患者临床疗效。方法采用随机、平行对照,选取局部晚期胰腺癌患者60例,采用随机数字表法分为治疗组和对照组各30例。治疗组予调肝理脾化积方,每日1剂,每日2次,口服,28 d为1个疗程,共6个疗程;同时予HIFU,每次30~60 min,隔日1次,每周2~3次,将肿瘤完全覆盖2遍。对照组予吉西他滨1000 mg/m^2,静脉滴注,第1、8日,21~28 d为1个周期,共6个周期。观察2组临床受益反应、生活质量QOL-C30评分、生存情况、无进展生存期(PFS),检测CA199、CEA水平。结果治疗1、3、6个月临床受益率,治疗组分别为64.29%、63.16%、50.00%,对照组分别为48.15%、40.00%、44.44%,治疗1、3个月2组比较差异有统计学意义(P<0.05)。治疗1、3、6个月,2组同一时点QOL-C30评分比较差异有统计学意义(P<0.05)。治疗1~6个月,2组CA199呈下降趋势,差异无统计学意义(P>0.05)。治疗组同一时点CEA水平均低于对照组(除治疗2、6个月),差异有统计学意义(P<0.05)。治疗3、6、12个月,治疗组生存率分别为82.14%、46.42%、32.14%,对照组分别为96.67%、59.32%、37.04%,2组比较差异无统计学意义(P>0.05)。1年时治疗组生存时间为(253.90±18.06)d,对照组为(246.77±17.31)d,2组比较差异无统计学意义(P>0.05)。治疗组PFS为(136.73±16.22)d,对照组为(145.77±19.74)d,2组比较差异无统计学意义(P=0.801)。结论调肝理脾化积方联合聚焦超声治疗局部晚期胰腺癌具有一定临床效果,可提高患者生活质量。