Objective In this study, we evaluated the difference of progression-free survival （PFS） and overall survival （OS） between extensive-stage small-cell lung cancer （ES-SCLC） patients who acquired partial response ...Objective In this study, we evaluated the difference of progression-free survival （PFS） and overall survival （OS） between extensive-stage small-cell lung cancer （ES-SCLC） patients who acquired partial response （PR） or complete remission （CR） after two cycles of first-line chemotherapy with the etoposide plus cisplatin （EP） regimen and those who acquired PR or CR after four or six cycles. Methods A total of 106 eligible patients treated with the EP chemotherapy regimen for two to six cycles, at The General Hospital of Shenyang Military Region （China） between November 2004 and Way 2011, were enrolled in this study. RECIST version 1.1 was used for the evaluation of chemotherapy efficiency. We followed up all eligible patients every 4 weeks. All statistical data were analyzed by using SPSS 21.0 statistical package for Windows. Results After a median follow-up of 293 days （range, 62-1531 days）, all patients had died by the cutoff date. Fifty-one patients acquired PR or CR after two cycles of chemotherapy; the median PFS reached 6.0 months （95% CI, 5.1-6.9）, and the median OS was 10.5 months （95% CI, 8.6-12.4）. Twenty-eight patients acquired PR or CR after four or six cycles; the median PFS was 4.8 months （95% CI, 4.4-5.2）, and the median OS was 7.5 months （95% CI, 6.8-8.2）. Both PFS and OS showed a statistical difference between the two groups. Conclusion ES-SCLC patients who acquired PR or CR after two cycles of the EP regimen as first-line therapy had longer PFS and OS than those who acquired PR or CR after four or six cycles.展开更多
采用超声乳化法,以蔗糖酯为乳化剂,通过单因素试验和响应面分析,对植物甾醇超声乳化的工艺条件进行研究,结果表明:超声功率330 W、超声时间35 min、植物甾醇加入量0.53%、超声频率28 k Hz、超声温度30℃、蔗糖酯质量分数6%条件下,植物...采用超声乳化法,以蔗糖酯为乳化剂,通过单因素试验和响应面分析,对植物甾醇超声乳化的工艺条件进行研究,结果表明:超声功率330 W、超声时间35 min、植物甾醇加入量0.53%、超声频率28 k Hz、超声温度30℃、蔗糖酯质量分数6%条件下,植物甾醇乳化液吸光度为1.57,吸光度与理论预测值基本一致。对超声乳化法与水浴乳化法制备的植物甾醇乳化液的稳定性进行评价,并采用倒置显微镜观察植物甾醇乳化液的粒径大小及形态,结果表明:超声乳化法制备的植物甾醇乳化液稳定性更好,粒径较小且更均匀。展开更多
基金Supported by grants from the National Research Key Project of the Twelfth Five-year Plan of the Republic of China(No.2012ZX09303016-002)the Science and Technology Key Programs of Liaoning Province(No.2012225019)
文摘Objective In this study, we evaluated the difference of progression-free survival （PFS） and overall survival （OS） between extensive-stage small-cell lung cancer （ES-SCLC） patients who acquired partial response （PR） or complete remission （CR） after two cycles of first-line chemotherapy with the etoposide plus cisplatin （EP） regimen and those who acquired PR or CR after four or six cycles. Methods A total of 106 eligible patients treated with the EP chemotherapy regimen for two to six cycles, at The General Hospital of Shenyang Military Region （China） between November 2004 and Way 2011, were enrolled in this study. RECIST version 1.1 was used for the evaluation of chemotherapy efficiency. We followed up all eligible patients every 4 weeks. All statistical data were analyzed by using SPSS 21.0 statistical package for Windows. Results After a median follow-up of 293 days （range, 62-1531 days）, all patients had died by the cutoff date. Fifty-one patients acquired PR or CR after two cycles of chemotherapy; the median PFS reached 6.0 months （95% CI, 5.1-6.9）, and the median OS was 10.5 months （95% CI, 8.6-12.4）. Twenty-eight patients acquired PR or CR after four or six cycles; the median PFS was 4.8 months （95% CI, 4.4-5.2）, and the median OS was 7.5 months （95% CI, 6.8-8.2）. Both PFS and OS showed a statistical difference between the two groups. Conclusion ES-SCLC patients who acquired PR or CR after two cycles of the EP regimen as first-line therapy had longer PFS and OS than those who acquired PR or CR after four or six cycles.
文摘采用超声乳化法,以蔗糖酯为乳化剂,通过单因素试验和响应面分析,对植物甾醇超声乳化的工艺条件进行研究,结果表明:超声功率330 W、超声时间35 min、植物甾醇加入量0.53%、超声频率28 k Hz、超声温度30℃、蔗糖酯质量分数6%条件下,植物甾醇乳化液吸光度为1.57,吸光度与理论预测值基本一致。对超声乳化法与水浴乳化法制备的植物甾醇乳化液的稳定性进行评价,并采用倒置显微镜观察植物甾醇乳化液的粒径大小及形态,结果表明:超声乳化法制备的植物甾醇乳化液稳定性更好,粒径较小且更均匀。
