Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the A...Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the Asian yellow pond turtle Mauremys mutica(designated as MaMMP3). The MaMMP3 cDNA is 1805 bp and consists of a 5'-untranslated region(UTR) of 56 bp, a 3'-UTR of 243 bp, and an open reading frame(ORF) of 1506 bp encoding 481 amino acids. Homology analysis of MaMMP3 revealed that the MaMMP3 shared 25%–63% similarity to other known MMP3 sequences. The genomic sequence covers 6007 bp. Comparative analysis of the cDNA sequence revealed that the Asian yellow pond turtle MMP3 has eight exons and seven introns. The phylogenetic tree showed that the MaMMP3 is closely related to Gallus gallus MMP3 and Taeniopygia guttata MMP3. The mRNA expression of the MaMMP3 in normal group without any bacterial challenge could be detected in all studied tissues including kidney, heart, live and spleen, with the highest level in the spleen. The results of immune challenge showed that the expression level of MaMMP3 was up-regulated in the spleen and liver. These results provided an important information for studying the roles of Asian yellow pond turtle MMP3 in immunity further.展开更多
In solving a response function by the boundary element method, the use of the singular valued method and the Laplace transform in a time domain makes the solving process be simplified and the result be accurate. The r...In solving a response function by the boundary element method, the use of the singular valued method and the Laplace transform in a time domain makes the solving process be simplified and the result be accurate. The restricted condition matrix formed by the response matrix method is much smaller than that by embedding method. In addition, the response function may realize directly the management decision making. So it is efficient for establishing and solving hydraulics management models.展开更多
In this paper, we consider a MUSIC algorithm for locating point-like scatterers contained in a sample on flat substrate. Based on an asymptotic expansion of the scattering amplitude proposed by Ammari et al., the reco...In this paper, we consider a MUSIC algorithm for locating point-like scatterers contained in a sample on flat substrate. Based on an asymptotic expansion of the scattering amplitude proposed by Ammari et al., the reconstruction problem can be reduced to a calculation of Green function corresponding to the background medium. In addition, we use an explicit formulation of Green function in the MUSIC algorithm to simplify the calculation when the cross-section of sample is a half-disc. Numerical experiments are included to demonstrate the feasibility of this method.展开更多
In this paper, we present numerically and experimentally the linear beam-optics distortion in the SSRF storage ring and the correction of optics by using a number of quadrupole magnets installed in the storage ring. T...In this paper, we present numerically and experimentally the linear beam-optics distortion in the SSRF storage ring and the correction of optics by using a number of quadrupole magnets installed in the storage ring. The measured orbit-response matrices were fitted to the model-response matrices to obtain the β and the dispersion functions in the storage ring. By readjusting the currents of quadrupole-magnet power supplies, we were able to successfully restore the optics parameters to values very close to the design ones, with rms deviations around 1%. This periodicity restoration is verified with the β function measurement.展开更多
Matrix metalloproteinase-9(MMP-9) plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier(BBB),which has limited its use for the treatmen...Matrix metalloproteinase-9(MMP-9) plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier(BBB),which has limited its use for the treatment of brain ischemia.In the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after stroke.Hypoxia response element(HRE)was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion.Lentiviruses were injected into the peri-infarct area on day 7 after transient ischemia.We found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV group.Furthermore,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT groups.Therefore,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke.展开更多
In the management of unconfined aquifer systems, if the thickness of the aquifer is very small and the drawdown is relatively big, errors may arise when the superposition principle is adopted. directly. In allusion to...In the management of unconfined aquifer systems, if the thickness of the aquifer is very small and the drawdown is relatively big, errors may arise when the superposition principle is adopted. directly. In allusion to this limitation, a new management model for the management of unconfined aquifer systems called two-level response matrix method is put forward. This method is applied in groundwater resources management in Shenyang city. The managing results show that this method can, in some degree, increase the efficiency of management and decrease the risk of management.展开更多
Background Most of the global orbit feedback algorithms in storage rings are based on response matrix(RM)singular value decomposition method.Commonly,the RM is the orbit distortion along the ring responding to the ste...Background Most of the global orbit feedback algorithms in storage rings are based on response matrix(RM)singular value decomposition method.Commonly,the RM is the orbit distortion along the ring responding to the steering magnet changes.For those methods RF frequency feedback is in a separated process.Methods and Results In this paper,the response matrix is expanded to the orbit distortion caused by the RF frequency variation.With this expanded RM,the orbit correction via steering magnet changes and RF frequency adjustment can be accomplished in one step.The commissioning results are carried out showing that the algorithm works stably.展开更多
If H and G are the transfer function matrix and the free response matrix of a linear finite automaton,then G is called a free response matrix matched to H.Given H,let(H)be the set of all possible free response matrice...If H and G are the transfer function matrix and the free response matrix of a linear finite automaton,then G is called a free response matrix matched to H.Given H,let(H)be the set of all possible free response matrices matched to H.A classification and an enumeration on the set(H)are given in this paper.展开更多
In groundwater management,the exchanges between groundwater and other water such as surface water and spring water need to be considered.Some exchange is dependent on the ground-water level,which is called covariate.T...In groundwater management,the exchanges between groundwater and other water such as surface water and spring water need to be considered.Some exchange is dependent on the ground-water level,which is called covariate.The pumping rate,groundwater level,and covariate interact and the relation of mutual-feed joint-variation is used to describe their interaction.This article presents a new approach of dealing with the relation in groundwater management model.The mathematical for-mulation of the relation,as an additional equality constraint in the optimization model,is developed using response matrix method.Thereby the groundwater management model with covariate is set up.The code for the simulation and management of groundwater system with covariate is programmed with Fortran 90,and the optimal pumping rate,groundwater level,and covariate are obtained.The approach is verified with a hypothetical case.Finally,the approach is applied to the groundwater management of Qianguo(前郭) area in western Jilin(吉林) Province.The results indicate that the ap-proach is feasible.It provides a universal solution for various covariates and reduces the computational complexity compared to iteration method.The approach is proven to be very efficient to solve ground-water management problem with covariate.展开更多
基金supported by the Ministry of Science and Technology funds (No. 2011GB23260021)Major State Basic Research Development Program of China (No. 2004CB117401)+1 种基金Science and Technology New Star from Guangzhou City (No. 2012089)Fundamental Research Funds from CAFS (No. 2012A0403)
文摘Matrix metallopeptidase 3 is a zinc-containing proteinase that participates in tissue remodeling and immune responses. In this study, a cDNA encoding matrix metallopeptidase 3 was isolated and characterized from the Asian yellow pond turtle Mauremys mutica(designated as MaMMP3). The MaMMP3 cDNA is 1805 bp and consists of a 5'-untranslated region(UTR) of 56 bp, a 3'-UTR of 243 bp, and an open reading frame(ORF) of 1506 bp encoding 481 amino acids. Homology analysis of MaMMP3 revealed that the MaMMP3 shared 25%–63% similarity to other known MMP3 sequences. The genomic sequence covers 6007 bp. Comparative analysis of the cDNA sequence revealed that the Asian yellow pond turtle MMP3 has eight exons and seven introns. The phylogenetic tree showed that the MaMMP3 is closely related to Gallus gallus MMP3 and Taeniopygia guttata MMP3. The mRNA expression of the MaMMP3 in normal group without any bacterial challenge could be detected in all studied tissues including kidney, heart, live and spleen, with the highest level in the spleen. The results of immune challenge showed that the expression level of MaMMP3 was up-regulated in the spleen and liver. These results provided an important information for studying the roles of Asian yellow pond turtle MMP3 in immunity further.
文摘In solving a response function by the boundary element method, the use of the singular valued method and the Laplace transform in a time domain makes the solving process be simplified and the result be accurate. The restricted condition matrix formed by the response matrix method is much smaller than that by embedding method. In addition, the response function may realize directly the management decision making. So it is efficient for establishing and solving hydraulics management models.
基金supported by the National Natural Science Foundation of China (10971083, 10801063)the School of Mathematical Sciences Foundation of Jilin University
文摘In this paper, we consider a MUSIC algorithm for locating point-like scatterers contained in a sample on flat substrate. Based on an asymptotic expansion of the scattering amplitude proposed by Ammari et al., the reconstruction problem can be reduced to a calculation of Green function corresponding to the background medium. In addition, we use an explicit formulation of Green function in the MUSIC algorithm to simplify the calculation when the cross-section of sample is a half-disc. Numerical experiments are included to demonstrate the feasibility of this method.
文摘In this paper, we present numerically and experimentally the linear beam-optics distortion in the SSRF storage ring and the correction of optics by using a number of quadrupole magnets installed in the storage ring. The measured orbit-response matrices were fitted to the model-response matrices to obtain the β and the dispersion functions in the storage ring. By readjusting the currents of quadrupole-magnet power supplies, we were able to successfully restore the optics parameters to values very close to the design ones, with rms deviations around 1%. This periodicity restoration is verified with the β function measurement.
基金supported by the grants from the National Natural Science Foundation of China (U1232205)the National Basic Research Development Program (973 Program) of China (2011CB504405)+2 种基金the Science and Technology Commission of Shanghai Municipality, China (13140903500 and 13ZR1422600)Shanghai Jiao Tong University Foundation for Technological Innovation in Major Projects (12X190030021)the KC Wong Foundation
文摘Matrix metalloproteinase-9(MMP-9) plays a beneficial role in the sub-acute phase after ischemic stroke.However,unrestrained MMP-9 may disrupt the blood-brain barrier(BBB),which has limited its use for the treatment of brain ischemia.In the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after stroke.Hypoxia response element(HRE)was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion.Lentiviruses were injected into the peri-infarct area on day 7 after transient ischemia.We found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV group.Furthermore,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT groups.Therefore,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke.
基金This work was supported partly by the National Plan for Basic Studies of China under Grant G1999043606 and National Social Science Foundation under Grant 03CJL006
文摘In the management of unconfined aquifer systems, if the thickness of the aquifer is very small and the drawdown is relatively big, errors may arise when the superposition principle is adopted. directly. In allusion to this limitation, a new management model for the management of unconfined aquifer systems called two-level response matrix method is put forward. This method is applied in groundwater resources management in Shenyang city. The managing results show that this method can, in some degree, increase the efficiency of management and decrease the risk of management.
基金supported by the National Natural Science Foundation of China(No.11975298).
文摘Background Most of the global orbit feedback algorithms in storage rings are based on response matrix(RM)singular value decomposition method.Commonly,the RM is the orbit distortion along the ring responding to the steering magnet changes.For those methods RF frequency feedback is in a separated process.Methods and Results In this paper,the response matrix is expanded to the orbit distortion caused by the RF frequency variation.With this expanded RM,the orbit correction via steering magnet changes and RF frequency adjustment can be accomplished in one step.The commissioning results are carried out showing that the algorithm works stably.
基金Supported by National Natural Science Foundation
文摘If H and G are the transfer function matrix and the free response matrix of a linear finite automaton,then G is called a free response matrix matched to H.Given H,let(H)be the set of all possible free response matrices matched to H.A classification and an enumeration on the set(H)are given in this paper.
基金supported by the Special Fund for Basic Scientific Research of Central Colleges,South-Central University for Nationalities(No.CZY12021)the National Natural Science Foundation of China(No.40672157)the 863 Program of China(No.2007AA06Z337)
文摘In groundwater management,the exchanges between groundwater and other water such as surface water and spring water need to be considered.Some exchange is dependent on the ground-water level,which is called covariate.The pumping rate,groundwater level,and covariate interact and the relation of mutual-feed joint-variation is used to describe their interaction.This article presents a new approach of dealing with the relation in groundwater management model.The mathematical for-mulation of the relation,as an additional equality constraint in the optimization model,is developed using response matrix method.Thereby the groundwater management model with covariate is set up.The code for the simulation and management of groundwater system with covariate is programmed with Fortran 90,and the optimal pumping rate,groundwater level,and covariate are obtained.The approach is verified with a hypothetical case.Finally,the approach is applied to the groundwater management of Qianguo(前郭) area in western Jilin(吉林) Province.The results indicate that the ap-proach is feasible.It provides a universal solution for various covariates and reduces the computational complexity compared to iteration method.The approach is proven to be very efficient to solve ground-water management problem with covariate.