A Proposal for the Restitution of the World’s First Baptistry and University, Mor Yakup Church, Turkey

The structure known today as St.Jacob’s Church represents one of the oldest Christian medieval monuments in the region.With the emergence of findings suggesting that the structure was the world’s first university during recent excavation efforts,it has gained even more significance.Since 2006,the excavation works conducted by the Mardin Museum Directorate in the vicinity of Mor Yakup Church have yielded information about various phases of the structure.However,assessments regarding the nature of the structure are still debated within the academic environment.This study aimed to thoroughly investigate the functional changes and periods that St.Jacob’s Church underwent throughout history and to provide a detailed description and restitution for each period.In this study,we utilized excavation reports,data from written sources related to the settlement and structure,information obtained from the structure itself,traces existing on the structure,and data derived from architectural necessities(logic/scenario).The results indicate that this structure served three different functions(baptistry,church,university)and went through two main periods(pre-Christianity and post-Christianity).

Production of aneuhaploid and euhaploid sporocytes by meiotic restitution in fertile hybrids between durum wheat Langdon chromosome substitution lines and Aegilops tauschii

Fertile F1 hybrids were obtained between durum wheat （Triticum durum Desf.） Langdon （LDN） and its 10 disomic substitution （LDN DS） lines with Aegilops tauschii accession AS60 without embryo rescue. Selfed seedset rates for hybrids of LDN with AS60 were 36.87% and 49.45% in 2005 and 2006, respectively. Similar or higher selfed seedset rates were observed in the hybrids of 1D （1A）, 1D （1B）, 3D （3A）, 4D （4B）, 7D （7A）, and 2D （2B） with AS60, while lower in hybrids of 3D （3B） ＋ 3BL, 5D （5A） ＋ 5AL, 5D （5B） ＋ 5B and 6D （6B） ＋ 6BS with AS60 compared with the hybrids of LDN with AS60. Observation of male gametogenesis showed that meiotic restitution, both first-division restitution （FDR） and single-division meiosis （SDM） resulted in the formation of functional unreduced gametes, which in turn produced seeds. Both euhaploid and aneuhaploid gametes were produced in F1 hybrids. This suggested a strategy to simultaneously transfer and locate major genes from the ancestral species T. turgidum or Ae. tauschii. Moreover, there was no significant difference in the aneuhaploid rates between the F1 hybrids of LDN and LDN DS lines with AS60, suggesting that meiotic pairing between the two D chromosomes in the hybrids of LDN DS lines with AS60 did not promote the formation of aneuhaploid gametes.

Transformations of phosphatidylinositol phosphates in the outer and inner nuclear membrane are linked to synthesis and restitution of cellular membranes

The ultimate goal in phosphoinositides cellular metabolism is to decipher their global functional organization and coordination of the com- partmentalized signaling processes. In this report we present evidence linking nuclear phos- phoinositides cycle with endoplasmic reticulum synthesis and function. The rapid transformation of [3H]inositol-labeled phosphoinositides in the intact nuclei (IN) was captured in chase studies for 0-5 min, followed by examination of phosphatidylinositides in the inner nuclear me- mbrane (INM), the outer nuclear membrane (ONM) and endoplasmic reticulum (ER). We revealed that synthesis of phosphatidylinositol phosphates (PIPs) occurs in ONM and the de- phosphorylation takes place in the INM. The rapid transformation of the radiolabeled PIPs in ONM reverberated in their appearance and successive transformation in INM, and in the 5min chased nuclei was tracked to ONM as the re- emerging radiolabeled phosphatidylinositol (PI). These chase-uncovered changes in ONM and INM PIPs profiles allow us to conclude that the observed conversions in the nuclear membrane continuum are induced by the lateral movement of the membrane and its transit from the cytosolic to nuclear and back to cytosolic environment. The suggested membrane synthesisinduced movement provides the means to transport the membrane- and the membrane lipid ligand-associated cytosolic proteins to the intranuclear spaces and renewal of INM. Export of the nuclear components interacting with the modified INM, by exiting from nuclear to cytosolic site, endows ER with a steady influx of the membrane that is conditioned to generate vesicles according to the nucleus delivered templates.

Determination of action potential wavelength restitution in Scn5a^＋/- mouse hearts modelling human Brugada syndrome

Brugada syndrome is a primary electrical disorder of theheart, predisposing affected individuals to potentially lethal,ventricular tachy-arrhythmias. A number of mechanismshave been identified as being important increasing the riskof these rhythms. Wavelength （γ） restitution has beensuggested to predict the onset of action potential duration（APD） alternans in mouse Scn5a^＋/- hearts modelling Bru-gada syndrome.

Modeling of softsphere normal collisions with characteristic of coefficient of restitution dependent on impact velocity

This letter presents a theoretical model of the normal （head-on） collisions between two soft spheres for predicting the experimental characteristic of the coefficient of restitution dependent on impact velocity. After the contact force law between the contacted spheres during a collision is phenomenologically formulated in terms of the compression or overlap displacement under considera- tion of an elastic-plastic loading and a plastic unloading subprocesses, the coefficient of restitution is gained by the dynamic equation of the contact process once an initial impact velocity is input. It is found that the theoretical predictions of the coefficient of restitution varying with the impact velocity are well in agreement with the existing experimental characteristics which are fitted by the explicit formula.

Mitochondrial Membranes Restitution Proceeds via Vesicular Import from ER and Cytosol. Counterparts’ Resemblances and Variances in Mitochondria and Golgi Pathways

The processes of mitochondrial restitution are controlled by nuclear genes that encode proteins synthesized in ER and cytosol and delivered as organelle- and membrane-specific transport vesicles. The analysis of the transporters recovered from inner mitochondrial space (Mitosol) revealed that the ER-synthesized mitochondria-specific transport vesicles consist of two carriers, one remaining in outer mitochondrial membrane (OMM), and the other that transfers specific membrane segments to the inner mitochondrial membrane (IMM). The ER-assembled and IMM-committed membrane segments, while first integrated into OMM, undergo intra-mitochondrial lipid modification reflected in the synthesis of cardiolipin (CL) and inversion into Mitosol with load of IMM associated cytosolic proteins. Then, the CL-bedecked vesicles are released from OMM to Mitosol and upon contact with IMM fuse with the membrane, and the release of cytosolic cargo ensues. While ER-assembled mitochondria-specific transport vesicles fuse with OMM with the aid of the cytosolic, phosphatidylglycerol (PG)-specific phospholipase A2 (PLA2), the Mitosol-contained CL-specific PLA guides vesicles fusion with IMM. The described path of translocation of the membrane segments and the cytosol synthesized proteins into the designated mitochondrial compartments sustains growth and identity of OMM, IMM, maintains protein delivery for intra-mitochondrial lipid and protein modification in Mitosol, and ensures conformity of the cytosolic proteins cargo delivered to matrix.

Concluding Step in Cell Restitution Cycle: ER Transport Vesicles with Sphingolipids in the Outer Leaflet of the Membrane Restore Lysosomes

Restitution of the cell organelles and the membrane implicates serine palmitoyltransferase (SPT) in signal-specific and selective assembly of the transport vesicles. Here, we reveal that SPT, embedded in the outer leaflet (OL) of endoplasmic reticulum (ER), is engaged in the synthesis of ER transport vesicles that recondition cell organelles, and the inner leaflet (IL) SPT in the restitution of the cell membrane. The OL SPT impacts assembly of sphingomyelinase (SMase)—susceptible ER vesicles but not the SMase-resistant and sphingolipid (SPhL) core—carrying vesicles that refurbish the cell membrane. The investigation of the SPT-initiated differences in the placement of SPhL in vesicular membranes by utilizing ER depleted of OL SPT, allows us to conclude that the restitution of endosomal and lysosomal membranes is achieved with the involvement of OL SPT, whereas the IL SPT is involved in formation of the lipid core for glycosphingolipids (GSL) and sphingomyelin (SM) of the apical and basolateral cell membrane. These findings along with our previously published report (Slomiany and Slomiany, Advances in Biological Chemistry, 2013, 3, 275-287), provide a clear distinction between the processes that renovate cell membrane and its organelles from that of the endocytotic cell debridement, and show that vesicles are navigated to the specific organelles and the cell membrane by the biomembrane constituents programmed in ER.

The Graphical Method for Decision of Restitution Coefficient and Its Applications

In this paper we present a graphical method for decision of restitution coefficient based on ODE. To simulate and illustrate our proposed method and efficient characteristics that demonstrate for two colliding bodies we used MatLab. In simulation to approach to the real case we used an assumption of additional virtual body’s position and velocity for characterizing material of the body which is involved to express the restitution coefficient. The graphic animation program is developed based on ODE for the computer simulation of the proposed graphical method. Additionally, we determined this new characteristic for some sport game balls such as basketball, volleyball, etc.

CFD Simulation of Particles Mixing and Segregation in a Rotary Coating Disk: Influence of Drag Models and Restitution Coefficient

In this paper, the dynamics of a transverse plane of a rotary coating disk of a binary mixture system comprising sand and urea particles were simulated using the two-fluid model along with the kinetic theory of granular flow in Fluent 19.1. Although some parameters relating to the material properties and size of the rotary coating disk have been researched, the effects of both drag force and restitution coefficient on the flow characteristics have yet to be examined. Thus, this paper numerically examines the effect of the inclusion of drag models and particle-particle restitution coefficients on particle dynamics in a rotary disk operating in the rolling regime of the granular bed. Three particle-particle drag models were considered: the Schiller-Naumann, Syamlal-O’Brien, and Gidaspow. The Syamlal-O’Brien and Gidaspow models were both able to successfully simulate particle segregation in a perfect rolling regime, whereas the Schiller-Naumann drag model appeared to be unable to predict the segregation of the particles and the rolling flow regime under the assumed conditions. Four different values of the restitution coefficient were also investigated: 0.7, 0.8, 0.9, and 0.95. The higher restitution values of 0.9 and 0.95 were found to substantially affect flow characteristics, ensuring suitable rolling regime behaviour for the bed during the rotational movement. The lower restitution coefficients of 0.7 and 0.8, on the other hand, indicated that irregular velocity vectors could be obtained in the active region of the granular bed.

SIMPLE MEASUREMENT OF RESTITUTION COEFFICIENT OF IRREGULAR PARTICLES

Restitution is an important physical and mechanical property of granular materials. However, measuring its values in instantaneous collisions between particles is very difficult, especially for ore particles of irregular shapes. In this paper, restitution is measured indirectly and statistically with two cameras recording from different angles the trajectories of the ore particles rebounding from a steel plate. The momenta of the particles prior to and after the collision are calculated from the trajectories to give the restitutions of these collisions. The restitution between ore particles is then derived from the restitution of a steel ball with the steel plate measured in the same way. The approach has been proved to be practical and reliable for a variety of ore particles with moderate restitutions.

Measurement and analysis of restitution coefficient between maize seed and soil based on high-speed photography

The restitution coefficient is an important elementary physical parameter related to the research and development of agricultural machinery.The kinematic model of maize seed in the falling and impacting processes was developed to measure the restitution coefficient between maize seed and soil.A test bench for measuring the restitution coefficient was designed and built referred to the theory of mirror reflection.The velocities for impacting maize seed were measured and analyzed in a three-dimensional space via high-speed photography,and then restitution coefficients of in different impact conditions were obtained.On this basis,this study took flat dent seed and round seed as samples.Single factor tests were conducted to analyze the influences of these factors on the restitution coefficient.The impact angle,falling height,soil compaction,soil moisture,maize moisture content and different parts of seed were selected as test factors.The corresponding regression equations were obtained by analysis.The results showed that,as the impact angle was bigger than 25°,the restitution coefficient increased with the increase of impact angle.The restitution coefficient had a linear decreasing trend with the increase of falling height.As the soil compaction strength was 200-350 kPa,the restitution coefficient increased with the increase of soil compaction.As the soil compaction strength was larger than 350 kPa,the changing trend of the restitution coefficient was relatively stable.As the soil moisture content was 13.5%-18%,the restitution coefficient decreased with the increase of soil moisture.As the soil moisture content was 18%,the restitution coefficient was the minimum.As the maize moisture content was 11%-16%,the restitution coefficient decreased with the increase of maize moisture content.The rotational motion always occurred in falling process of flat dent seed and round seed.The probabilities of crown part and lateral part of maize seed impacting with soil were the highest,and the restitution coefficient between crown part and soil was higher than that of other parts in the same condition.

Differential transcriptome analysis between Populus and its synthesized allotriploids driven by second-division restitution

in this report, we compared transcriptomic differ- ences between a synthetic Populus section Tacamahaca triploid driven by second-division restitution and its parents using a high-throughput RNA-seq method. A total of 4,080 genes were differentially expressed between the high-growth vigor allotriploids （SDR-H） and their parents, and 719 genes were non-additively expressed in SDR-H. Differences in gene expres- sion between the allotriploid and male parent were more significant than those between the allotriploid and female parent, which may be caused by maternal effects. We observed 3,559 differentially expressed genes （DEGs） between the SDR-H and male parent. Notably, the genes were mainly involved in metabolic process, cell proliferation, DNA methylation, cell division, and meristem and developmental growth. Among the 1,056 DEGs between SDR-H and female parent, many genes were associated with metabolic process and carbon utilization. In addition, 1,789 DEGs between high- and low-growth vigorallotriploid were mainly associated with metabolic process, auxin poplar transport, and regulation of meristem growth. Our results indicated that the higher poplar ploidy level can generate extensive transcriptomic diversity compared with its parents. Overall, these results increased our understanding of the driving force for phenotypic variation and adaptation in allopolyploids driven by second-division restitution.

Experimental determination of restitution coefficient of garlic bulb based on high-speed photography

Restitution coefficient(RC)of garlic bulb is an important mechanical property that is required to establish the kinematics model of bulb collision and research the damage mechanism of bulb collision.In this study,kinetic equations of bulb collision were established based on Hertz's contact theory.The kinematics characteristics,elastoplastic deformation and contact damage during bulb collision were analyzed by using high-speed photography.The effects of bulb mass,moisture content,collision material,material thickness and release height on the RC were investigated by mixed orthogonal experiments and single-factor experiments.The results showed that the movement of bulb in the compression stage was translation,and the movement in the rebound stage was translation and rotation.During collision,the larger the rotational angular velocity of the bulb was,the smaller the measured RC would be.The contact damage of bulb included internal damage of the tissue,epidermis stretch and tear.The significance of effects of factors on RC decreased with the following sequence:collision material,release height,material thickness,bulb mass,and moisture content.Collision material,release height,material thickness,and bulb mass were significant factors.The RC between the bulb and Q235,nylon,and rubber decreased sequentially.The RC decreased with the increase of release height and bulb mass.The RC increased with the increase of material thickness of Q235,while it decreased with the increase of material thickness of rubber or Nylon.The determination coefficients of the regression equations between the significant factors and the RC were all greater than 0.96.The results will be helpful for damage mechanism analysis and design of garlic production equipment.

Effect of coefficient of restitution in Euler-Euler CFD simulation of fluidized-bed hydrodynamics

Collision between particles plays an important role in determining the hydrodynamic characteristics of gas-solid flow in a fluidized bed. In the present work, earlier work （Loha, Chattopadhyay, ＆ Chatterjee, 2013） was extended to study the effect of the elasticity of particle collision on the hydrodynamic behavior of a bubbling fluidized bed filled with 530-~m particles. The Eulerian-Eulerian two-fluid model was used to simulate the hydrodynamics of the bubbling fluidized bed, where the solid-phase properties were calculated by applying the kinetic theory of granular flow. To investigate the effect of the elasticity of particle collision, different values of the coefficient of restitution were applied in the simulation and their effects were studied in detail. Simulations were performed for two different solid-phase wall boundary conditions. No bubble formation was observed for perfectly elastic collision. The bubble formation started as soon as the coefficient of restitution was set below 1.0, and the space occupied by bubbles in the bed increased with a decrease in the coefficient of restitution. Simulation results were also compared with experimental data available in the literature, and good agreement was found for coefficients of restitution of 0.95 and 0.99.

Coefficient of restitution for particles impacting on wet surfaces： An improved experimental approach

The coefficient of restitution is widely used to characterize the energy dissipation rate in numerical simulations involving particle collisions. The challenge in measuring the coefficient of restitution is the strong scatter seen in experimental data that results from varying particle properties, i.e. shape and surface roughness, and from imperfections in the experimental technique. To minimize this scattering, a novel experimental setup was developed based on two synchronized high-speed cameras capturing the collision behaviour of a particle in three dimensions. To measure the wet restitution coefficient, which describes particle impact in the presence of a liquid layer in the contact region, additional accuracy can be achieved by measuring the liquid layer thickness by a high-precision optical confocal sensor. The coefficient of restitution was measured for glass particles with two different diameters, at different relative velocities and liquid layer thicknesses, with a focus on small collision velocities and thin liquid layers, using both the improved （three dimensional） and the conventional （two dimensional） approaches to quantify the improvement of the new method＇s accuracy.

Cotton stalk restitution coefficient determination tests based on the binocular high-speed camera technology

The restitution coefficient(RC)of cotton stalks is an important elementary physical parameter that is required to establish the crushing mechanical model and research the film residue separation machinery.In this study,the calculation method of restitution coefficient considering the rotation motion of stalk-shaped agricultural materials was derived based on the principle of kinematics and the energy restitution coefficient method,and a test bench for measuring the RC was designed and built.The effects of collision material,moisture content,length,diameter,release height,and collision angle respectively on the RC were investigated by single-factor experiments and orthogonal experiments,and the regression models between influence factors and the RC were established.The results showed that Q235 showed the highest value of the RC,and it was followed by cotton stalks and soil lumps,sequentially.The RC of cotton stalks decreased with the increase of moisture content and diameter,while it increased at first and then decreased with the increase of length.As the release height was less than 500 mm,the RC increased with the increased release height.As the collision angle was less than 40°,the RC showed a linear increasing trend.The significance of the effects of factors on RC decreased with the following sequence:collision angle,length,release height,diameter,and moisture content.Length,collision angle,and release height were extremely significant.The contrast test results showed that the values based on Newton’s restitution coefficient method were smaller than that based on the energy restitution coefficient method.The verification test showed that the predicted rebound height of cotton stalks calculated based on the energy restitution coefficient method was closer to the actual rebound height,and the relative error was less than 5%.

Energetic Coefficient of Restitution for a Planar Two-Body Oblique Collision with Friction

Although the coefficient of restitution was originally thought to be only a material property, the coefficient of restitution also depends upon initial conditions as well as on the frictional effect for oblique collisions. The objective of this paper is to demonstrate a method for obtaining the coefficient of restitution for oblique collisions and thereby to provide a theoretical guide for collision experiments. In this paper, we derive expressions for the energetic coefficient of restitution (e*) based on general normal contact deformation law, by which the value of e* can be obtained according to the initial conditions. An example shows that the results calculated by the derived expressions are reasonable.

UNREDUCED MEGAGAMETOPHYTE FORMATION VIA SECOND DIVISION RESTITUTION CONTRIBUTES TO TETRAPLOID PRODUCTION IN INTERPLOIDY CROSSES WITH/ORAH/MANDARIN(CITRUS RETICULATA)

Seedless fruits are desirable in the citrus fresh fruit market.Triploid production via diploid x tetraploid interploidy crosses is thought to be the most efficient and widely-used strategy for the breeding of seedless citrus.Although'Orah'mandarin has desirable organoleptic qualities,seeds in the fruits weaken its market competitiveness.To produce new seedless cultivars that are similar to'Orah'mandarin,we performed three 2x x 4x crosses using'Orah'mandarin as the seed parent to regenerate triploid plantlets.A total of 182 triploid and 36 tetraploid plantlets were obtained.By analyzing their genetic origins using nine novel single nucleotide polymorphism(SNP)markers,all of the triploids and tetraploids derived from these three crosses were proven to be hybrids.Also,we demonstrated that 2n megagametophyte formation in'Orah'mandarin result in tetraploid production in these three interploidy crosses.These tetraploid plantlets were genotyped using eight pericentromeric SNP markers and nine centromere distal SNP markers.Based on the genotypes of the 2n megagametophytes,the parental heterozygosity rates in 16 SNP loci and all 2n megagametophytes were less than 50%,indicating that second division restitution was the mechanism underlying 2n megagametophyte formation at both the population and individual levels.These triploid hybrids enrich the germplasm available for seedless breeding.Moreover,the tetraploid hybrids are valuable as parents for ploidy breeding for the production of seedless citrus fruits.

A Contact Force Model Considering Meshing and Collision States for Dynamic Analysisin Helical Gear System

The current research on gear system dynamics mainly utilizes linear spring damping model to calculate the contact force between gears. However, this linear model cannot correctly describe the energy transfer process of collision that often occurs in gear system. Focus on the contact-impact events, this paper proposes an improved gear contact force model for dynamic analysis in helical gear transmission system. In this model, a new factor associated with hysteresis damping is developed for contact-impact state, whereas the traditional linear damping factor is utilized for normal meshing state. For determining the selection strategy of these two damping factors, the fundamental contact mechanics of contact-impact event affected by supporting forces are analyzed. During this analysis, an effect factor is proposed for evaluating the influence of supporting forces on collision. Meanwhile, a new restitution of coefficient is deduced for calculating hysteresis damping factor, which suitable for both separation and non-separation states at the end of collision. In addition, the time-varying meshing stiffness (TVMS) is obtained based on the potential energy approach and the slice theory. Finally, a dynamic analysis of a helical gear system is carried out to better understand the contact force model proposed in this paper. The analysis results show that the contribution of supporting forces to the dynamic response of contact-impact event within gear pair is important. The supporting forces and dissipative energy are the main reasons for gear system to enter a steady contact state from repeated contact-impact state. This research proposes an improved contact force model which distinguishes meshing and collision states in gear system.

Gut homeostasis, injury, and healing: New therapeutic targets

The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis,which depends upon the balance between mucosal injury by destructive factors and healing via protective factors.The persistence of noxious agents such as acid,pepsin,nonsteroidal anti-inflammatory drugs,or Helicobacter pylori breaks down the mucosal barrier and injury occurs.Depending upon the size and site of the wound,it is healed by complex and overlapping processes involving membrane resealing,cell spreading,purse-string contraction,restitution,differentiation,angiogenesis,and vasculogenesis,each modulated by extracellular regulators.Unfortunately,the gut does not always heal,leading to such pathology as peptic ulcers or inflammatory bowel disease.Currently available therapeutics such as proton pump inhibitors,histamine-2 receptor antagonists,sucralfate,5-aminosalicylate,antibiotics,corticosteroids,and immunosuppressants all attempt to minimize or reduce injury to the gastrointestinal tract.More recent studies have focused on improving mucosal defense or directly promoting mucosal repair.Many investigations have sought to enhance mucosal defense by stimulating mucus secretion,mucosal blood flow,or tight junction function.Conversely,new attempts to directly promote mucosal repair target proteins that modulate cytoskeleton dynamics such as tubulin,talin,Ehm^(2),filamin-a,gelsolin,and flightless I or that proteins regulate focal adhesions dynamics such as focal adhesion kinase.This article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets.