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Restoring 20th Century Architecture:Few Words about a Possible Theory
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作者 Susanna Caccia Gherardini 《Journal of Civil Engineering and Architecture》 2023年第11期536-538,共3页
The restoration of twentieth-century architecture has led the discipline to develop a solid theory which,considering the complexity of new issues to be resolved,can provide useful instruments,above all critical ones,f... The restoration of twentieth-century architecture has led the discipline to develop a solid theory which,considering the complexity of new issues to be resolved,can provide useful instruments,above all critical ones,for operational practice. 展开更多
关键词 20th century architecture restoration PRESERVATION HERITAGE
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Influence of Genetic Drift of Restoring Gene (Rf) on Seed Purity of Yuetai A, a Honglian-Type Cytoplasmic Male Sterile Line in Hybrid Rice
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作者 WANG Ji-feng Lu Zuo-mei 《Rice science》 SCIE 2008年第2期101-109,共9页
The seed samples of Yuetai A, a Honglian (HL) type cytoplasmic male sterile (CMS) line in hybrid rice were investigated to assess the seed purity and to analyze the cause of off-type plants by imitating the biolog... The seed samples of Yuetai A, a Honglian (HL) type cytoplasmic male sterile (CMS) line in hybrid rice were investigated to assess the seed purity and to analyze the cause of off-type plants by imitating the biological contaminant to Yuetai A in Nanjing, Jiangsu Province and Lingshui, Hainan Province during 2004-2006. The seed impurity of Yuetai A mainly resulted from the genetic drift of restoring fertility gene (Rt) after biological contamination but not from its sterility unstability. All of the ten maintainer lines, five restorer lines and three thermo-sensitive genic male sterile lines used in the study could pollinate Yuetai A and Yuetai B to produce F1 plants, directly or indirectly resulting in Rf-gene drifting into Yuetai A and generating 'iso-cytoplasm restoring-generations'. Furthermore, high outcrossing rate and similar heading date of Yuetai A with many varieties used in rice production might easily result in the biological contamination. After removing all plants with Rf-gene mixed in Yuetai A and preventing Rf-gene drifting into Yuetai A, the seed purity of Yuetai A and Yuetai B had been raised to 100%. 展开更多
关键词 seed purity restoring gene sterility stability iso-cytoplasm restoring-generations cytoplasmic male sterile line hybrid rice
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基于SRT和Restoring算法的双精度浮点除法器设计 被引量:2
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作者 孙一 张鑫 +2 位作者 王波 冯为 金西 《电子测量技术》 2008年第9期50-53,共4页
提出了一种基于SRT迭代算法的除法器的改进方法,采用Restoring和SRT算法来互补共同完成双精度浮点除法器的设计,当被除数的位数很大时采用改进过的Restoring算法来完成除法运算,并通过倒数查找表把Restoring和SRT运算结果统一起来;在SR... 提出了一种基于SRT迭代算法的除法器的改进方法,采用Restoring和SRT算法来互补共同完成双精度浮点除法器的设计,当被除数的位数很大时采用改进过的Restoring算法来完成除法运算,并通过倒数查找表把Restoring和SRT运算结果统一起来;在SRT运算中应用了On-the-fly飞速转换算法,查找表模块采用Quine-McCluskey化简方法使用高度简化的与或逻辑代替大量的比较器来实现。上述做法有效提高了除法器的整体运算速度,使得当被除数前十位有"1"的位时运算时间减少了22.22%。 展开更多
关键词 SRT算法 restoring算法 查找表 倒数
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Mapping of Fertility Restoring Gene for Aegilops kotschyi Cytoplasmic Male Sterility in Wheat Using SSR Markers 被引量:13
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作者 LIU Bao-shen, SUN Qi-xin, GAO Qing-rong, SUN Lan-zhen, XIE Chao-jie, LI Chuan-you, NI Zhong-fu and DOU Bing-de( Agronomy Department, Shandong Agricultural University, Taian 271018, P.R.China Department of Plant Genetics and Breeding, China Agricultural University, Beijing 100094 , P. R . China ) 《Agricultural Sciences in China》 CAS CSCD 2002年第8期845-849,共5页
LK783 was found to be a good fertility restorer for K-type male sterility of wheat. Microsatel-lite markers were employed to map the major restoring gene in LK783. Maintainer and restorer DNA pools were established us... LK783 was found to be a good fertility restorer for K-type male sterility of wheat. Microsatel-lite markers were employed to map the major restoring gene in LK783. Maintainer and restorer DNA pools were established using the extreme sterile and fertile plants among (KJ5418A//911289/LK783)F1 population, respectively. Seventy-nine sets of SSR primers were screened for polymorphism between the two pools, 6 of which were found polymorphic. Linkage analysis showed that Xgwm11, Xgwm18, Xgwm264a and Xgwm273 were linked to the restoring gene in LK783, while Xgwm11, Xgwm18 and Xgwm273 were co-segregated. The distance between the Rf gene in LK783 and the three co-segregated markers was 6.54 ± 4.37 cM, the distance between Rf gene and Xgwm264a was 5. 71 ± 4.10 cM. The four SSR markers were located on chromosome IBS by amplifying the DNA of nulli-tetrasomics and ditelosomics of CS with the 4 sets of primers, indicating that the major restoring gene in LK783 was located on IBS, but the relative location of the gene was different from Rfv1, allelism of the two genes should be further investigated. The breeding for new fertility restorer lines of K-type cytoplasmic male sterility in wheat would be facilitated by using the four polymorphic markers. 展开更多
关键词 Wheat ( Triticum aestivum) Cytoplasmic male sterility restoring gene Molecular marker MICROSATELLITE
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Development of elite restoring lines by integrating blast resistance and low amylose content using MAS 被引量:2
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作者 XIAO Wu-ming PENG Xin +10 位作者 LUO Li-xin LIANG Ke-qin WANG Jia-feng HUANG Ming LIU Yong-zhu GUO Tao LUO Wen-long YANG Qi-yun ZHU Xiao-yuan WANG Hui CHEN Zhi-qiang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2018年第1期16-27,共12页
Blast resistance and grain quality are major problems in hybrid rice production in China. In this study, two resistance (R) genes, Pi46 and Pita, along with the gene Wxb, which mainly affects rice endosperm amylose ... Blast resistance and grain quality are major problems in hybrid rice production in China. In this study, two resistance (R) genes, Pi46 and Pita, along with the gene Wxb, which mainly affects rice endosperm amylose content (AC), were introgressed into an elite indica restoring line, R8166, which has little blast resistance and poor grain quality through marker-assisted selection (MAS). Eight improved lines were found to have recurrent genome recovery ratios ranging from 88.68 to 96.23%. Two improved lines, R163 and R167, were selected for subsequent studies. R167, which has the highest recovery ratio (96.23%), showed no significant differences in multiple agronomic traits. In contrast, R163 with the lowest recovery ratio (88.68%) exhibited significant differences in heading date and yield per plant compared with the recurrent parent. At two developmental stages, R163 and R167 had greatly enhanced resistance to blast over the recurrent parent. Similar trends were also observed for agronomic traits and blast resistance in R163- and R167-derived hybrids when compared with the counterparts from R8166. In addition, R163, R167, and their derived hybrids significantly improved the grain quality traits, including amylose content (AC), gel consistency (GC), chalky grain rate (CGR), and degree of endosperm chalkiness (DEC). It confirmed the success of efficiently developing elite restoring lines using MAS in this study. 展开更多
关键词 RICE restoring line blast resistance grain quality MAS
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FINITE TIME BLOW UP OF THE SOLUTIONS TO BOUSSINESQ EQUATION WITH LINEAR RESTORING FORCE AND ARBITRARY POSITIVE ENERGY 被引量:2
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作者 nikolay kutev natalia kolkovska milena dimova 《Acta Mathematica Scientia》 SCIE CSCD 2016年第3期881-890,共10页
Finite time blow up of the solutions to Boussinesq equation with linear restoring force and combined power nonlinearities is studied. Sufficient conditions on the initial data for nonexistence of global solutions are ... Finite time blow up of the solutions to Boussinesq equation with linear restoring force and combined power nonlinearities is studied. Sufficient conditions on the initial data for nonexistence of global solutions are derived. The results are valid for initial data with arbitrary high positive energy. The proofs are based on the concave method and new sign preserving functionals. 展开更多
关键词 Boussinesq equation with linear restoring force finite time blow up arbitrary high positive energy combined power nonlinearities sign preserving functionals
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Restoring force correction based on online discrete tangent stiffness estimation method for real-time hybrid simulation 被引量:2
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作者 Huang Liang Guo Tong +1 位作者 Chen Cheng Chen Menghui 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2018年第4期805-820,共16页
In real-time hybrid simulation(RTHS), it is difficult if not impossible to completely erase the error in restoring force due to actuator response delay using existing displacement-based compensation methods. This pa... In real-time hybrid simulation(RTHS), it is difficult if not impossible to completely erase the error in restoring force due to actuator response delay using existing displacement-based compensation methods. This paper proposes a new force correction method based on online discrete tangent stiffness estimation(online DTSE) to provide accurate online estimation of the instantaneous stiffness of the physical substructure. Following the discrete curve parameter recognition theory, the online DTSE method estimates the instantaneous stiffness mainly through adaptively building a fuzzy segment with the latest measurements, constructing several strict bounding lines of the segment and calculating the slope of the strict bounding lines, which significantly improves the calculation efficiency and accuracy for the instantaneous stiffness estimation. The results of both computational simulation and real-time hybrid simulation show that:(1) the online DTSE method has high calculation efficiency, of which the relatively short computation time will not interrupt RTHS; and(2) the online DTSE method provides better estimation for the instantaneous stiffness, compared with other existing estimation methods. Due to the quick and accurate estimation of instantaneous stiffness, the online DTSE method therefore provides a promising technique to correct restoring forces in RTHS. 展开更多
关键词 online discrete tangent stiffness estimation restoring force correction fuzzy segment parameter updating real-time hybrid simulation
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Neural prostheses for restoring functions lost after spinal cord injury 被引量:2
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作者 Marc Fakhoury 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第10期1594-1595,共2页
Spinal cord injury(SCI)is a debilitating condition that affects more than 2.5 million individuals worldwide(Thuret et al.,2006).In addition to its devastating effects on the individual,this disease is a heavy burd... Spinal cord injury(SCI)is a debilitating condition that affects more than 2.5 million individuals worldwide(Thuret et al.,2006).In addition to its devastating effects on the individual,this disease is a heavy burden to the society in terms of health care costs, which are estimated in billions of dollars annually in most developed countries (Cadotte and Fehlings, 2011). 展开更多
关键词 MORE SCI Neural prostheses for restoring functions lost after spinal cord injury
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Bifurcations and chaotic threshold for a nonlinear system with an irrational restoring force 被引量:1
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作者 田瑞兰 杨新伟 +1 位作者 曹庆杰 吴启亮 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第2期136-147,共12页
Nonlinear dynamical systems with an irrational restoring force often occur in both science and engineering, and always lead to a barrier for conventional nonlinear techniques. In this paper, we have investigated the g... Nonlinear dynamical systems with an irrational restoring force often occur in both science and engineering, and always lead to a barrier for conventional nonlinear techniques. In this paper, we have investigated the global bifurcations and the chaos directly for a nonlinear system with irrational nonlinearity avoiding the conventional Taylor's expansion to retain the natural characteristics of the system. A series of transformations are proposed to convert the homoclinic orbits of the unperturbed system to the heteroclinic orbits in the new coordinate, which can be transformed back to the analytical expressions of the homoclinic orbits. Melnikov's method is employed to obtain the criteria for chaotic motion, which implies that the existence of homoclinic orbits to chaos arose from the breaking of homoclinic orbits under the perturbation of damping and external forcing. The efficiency of the criteria for chaotic motion obtained in this paper is verified via bifurcation diagrams, Lyapunov exponents, and numerical simulations. It is worthwhile noting that our study is an attempt to make a step toward the solution of the problem proposed by Cao Q J et al. (Cao Q J, Wiercigroch M, Pavlovskaia E E, Thompson J M T and Grebogi C 2008 Phil. Trans. R. Soe. A 366 635). 展开更多
关键词 nonlinear dynamical system Melnikov boundary irrational restoring force saddle-likesingularity homoclinic-like orbit
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Experimental study on characteristic curves of restoring forces of Populus alba var. pyramidalis 被引量:1
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作者 ZHOU Jian-zhong 《Forestry Studies in China》 CAS 2011年第4期315-320,共6页
Static tests under cyclic loading were carried out on Populus alba var. pyramidalis to determine its characteristic curves of restoring forces. The results show that P alba var. pyramidalis had good elastic performanc... Static tests under cyclic loading were carried out on Populus alba var. pyramidalis to determine its characteristic curves of restoring forces. The results show that P alba var. pyramidalis had good elastic performance. There was degradation of strength and stiffness under cyclic loading and unloading, where characteristic curves of restoring forces ofP. alba var. pyrarnidalis assumed a "flat and contrary S-shape" form. Simultaneously, P alba vat. pyramidalis showed typical characteristics of brittle destruction under large high peak loading and unloading. Furthermore, dynamic tests were carried out under wind loads to obtain dynamic displacement curves and dynamic strain curves. P alba var. pyramidalis reflected its stochastic dynamic performance in building up its resistance to the stochastic wind loads and its dynamically hysteretic properties. The dynamic response of this species was random and fuzzy under stochastic wind loads. This study has theoretical significance and reference value to research on the static characteristics and wind-induced dynamic performance of forests. 展开更多
关键词 Populus alba var. pyramidalis characteristic curve of restoring forces degradation of strength and stiffness stochasticwind loads
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Stochastic response analysis of noisy system with non-negative real-power restoring force by generalized cell mapping method
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作者 Qun HAN Wei XU Xiaole YUE 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2015年第3期329-336,共8页
The stochastic response of a noisy system with non-negative restoring force is investigated. The generalized cell mapping (GCM) method compute the transient and stationary probability density functions (PDFs) real... The stochastic response of a noisy system with non-negative restoring force is investigated. The generalized cell mapping (GCM) method compute the transient and stationary probability density functions (PDFs) real-power is used to Combined with the global properties of the noise-free system, the evolutionary process of the tran- sient PDFs is revealed. The results show that stochastic P-bifurcation occurs when the system parameter varies in the response analysis and the stationary PDF evolves from bimodal to unimodal along the unstable manifold during the bifurcation. 展开更多
关键词 stochastic response probability density function (PDF) generalized cell mapping (GCM) method real-power restoring force bifurcation
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A Visual Secret Sharing Scheme for Progressively Restoring Secrets
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作者 Chin-Chen Chang Yi-Pei Hsieh Chi-Cheng Liao 《Journal of Electronic Science and Technology》 CAS 2011年第4期325-331,共7页
Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to... Visual secret sharing has received more and more attention over the past years due to the fact that neither complex computation nor cryptographic knowledge is required to decrypt the secret image directly according to the characteristics of the human vision system. Considering the issue of sharing the secret image at multiple image resolutions with the meaningful shadows, in this paper, we present a friendly progressive visual secret sharing scheme without expanding the image size in the shadows and the reconstructed secret image based on applying a 2x2-sized block-wise operation to generate the shadows block by block. The proposed method can achieve these benefits: 1) the generated shadows are meaningful, and their sizes are not expanded, and 2) the secret image can be recovered at different resolutions by stacking different quantities of shadows together. The experimental results also show that the proposed method is superior to other compared schemes. 展开更多
关键词 Friendly management multiple image resolutions progressive restoring secrets visual secret sharing.
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Analysis of restoring gene in Heizhenmi
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作者 YANG Changdeng ZHAO Chengzhang QI Xiufang Wu Lianbin CNRRI,Hangzhou 310006,China 《Chinese Rice Research Newsletter》 1994年第2期8-9,共2页
The purple pigment is controlled by three domi-nant genes.According to the theory ofdominance-super dominance in Fgeneration, breeding purple black hybrid rice can be an effec-tive way to overcome lower yield and weak... The purple pigment is controlled by three domi-nant genes.According to the theory ofdominance-super dominance in Fgeneration, breeding purple black hybrid rice can be an effec-tive way to overcome lower yield and weak resist-ance to disease of purple black rice. 展开更多
关键词 Analysis of restoring gene in Heizhenmi LINE GENE
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Conserving and restoring the Caicos pine forests: The first decade 被引量:2
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作者 Michele Dani Sanchez Bryan Naqqi Manco +2 位作者 Junel Blaise Marcella Corcoran Martin Allen Hamilton 《Plant Diversity》 SCIE CAS CSCD 2019年第2期75-83,共9页
The severe and rapid attack on the Caicos pine Pinus caribaea var. bahamensis(Pinaceae) by the nonnative invasive pine tortoise scale, Toumeyella parvicornis, has resulted in the death of most of the trees in the Turk... The severe and rapid attack on the Caicos pine Pinus caribaea var. bahamensis(Pinaceae) by the nonnative invasive pine tortoise scale, Toumeyella parvicornis, has resulted in the death of most of the trees in the Turks and Caicos Islands(TCI) in just over a decade. Local and international conservation efforts have enabled the necessary multi-disciplinary research, data gathering, and monitoring to develop and implement a restoration strategy for this endemic tree from the Bahaman archipelago. The native plant nursery established on North Caicos and horticultural expertise acquired throughout the years were crucial to the successful rescue of Caicos pine saplings from the wild populations and cultivation of new saplings grown from locally sourced seeds. These saplings have been used to establish six Restoration Trial Plots on Pine Cay and a seed orchard on North Caicos in TCI. Core Conservation Areas(CCAs) for the Caicos pine forests have been identified and mapped. To date, forest within the Pine Cay CCA has been supplemented by planting more than 450 pine trees, which have survived at a high(>80%)rate. 展开更多
关键词 PINE forest restoration Plant NURSERY PINUS caribaea var. bahamensis Caribbean Conservation TURKS and Caicos ISLANDS
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Capturing, protecting and restoring plant diversity in the UK: RBG Kew and the Millennium Seed Bank 被引量:1
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作者 Ted Chapman Stephanie Miles Clare Trivedi 《Plant Diversity》 SCIE CAS CSCD 2019年第2期124-131,共8页
Ex situ seed banking is a practical and cost-effective means of preserving wild plant diversity and a crucial complement to the in situ conservation and restoration of species and habitats. As pressures on the natural... Ex situ seed banking is a practical and cost-effective means of preserving wild plant diversity and a crucial complement to the in situ conservation and restoration of species and habitats. As pressures on the natural environment have grown, so has the call for seed banks to provide scientifically-robust,practical solutions to seed-related problems in nature conservation, from single-species recovery and reintroduction to the restoration of complex, dynamic communities at the largest scales. In this paper, we discuss how the Royal Botanic Gardens, Kew and its Millennium Seed Bank have responded to this call in the United Kingdom. We demonstrate that banked seed collections can provide a range of otherwiseunavailable, high quality, known-origin, genetically-diverse biological materials. The data, expertise and specialist facilities that accompany these collections are also valuable, helping overcome constraints to the collection, production and effective use of native seed. Challenges remain-to ensure ex situ collections protect the species and genetic diversity that will enable plants to adapt to a changing environment, and to find new ways for seed banks to mobilise their resources at a landscape scale. 展开更多
关键词 SEED BANKING Ex SITU conservation Botanic garden Species-reintroduction Ecological restoration Native SEED production
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Evaluation of Four Methods for Restoring a Degraded Swamp Forest 被引量:2
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作者 Gisele Mondoni Marconato Rita C. S. Maimoni-Rodella Claudia Mira Attanasio 《Open Journal of Forestry》 2015年第5期500-509,共10页
Swamp Forests occur in permanently wet soils, with specific ecosystem which contributes to the conservation of biodiversity and water resources. However, there are many gaps in knowledge about the restoration of these... Swamp Forests occur in permanently wet soils, with specific ecosystem which contributes to the conservation of biodiversity and water resources. However, there are many gaps in knowledge about the restoration of these forests. The present study was conducted in a degraded wetland in the town of Mineiros do Tietê, located in the state of S?o Paulo, Brazil, in order to test the efficiency of four methods for restoring a Swamp Forest (small mound, acclimated seedling, dry season and conventional tillage), using six forest tree species typical of this type of forest: Calophyllum brasiliense Cambess., Citharexylon myrianthum Cham., Cedrela odorata L., Tapirira guianensis Aubl., Ficus insipida Willd. and Croton urucurana Baill. The least favorable methods for all plant species were: conventional and soil pit tillageindry seasons. Analyzing the plant species individually, the best results in descending order were: Croton urucurana Baill. (acclimated seedling tillage in dry season), followed by Calophyllum brasiliense Cambess. (insmall mounds), Citharexylon mirianthum Cham. (with acclimated seedlings), Ficus insipida Willd. and Tapirira guianensis Aubl. (insmall mounds). Cedrela odorata L. presented low performance in all conditions, probably because it suffered the Hypsipyla grandella Zeller. The results have been successful for the establishment of Swamp Forest restoration strategies. 展开更多
关键词 RESTORATION METHODS ACCLIMATIZATION Soil Water SATURATION RIPARIAN ZONE
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THE WAY OF RESTORING AND REESTABLISHING BROADLEAVED/CONIFEROUS MIXED FOREST ECOSYSTEM FROM SECONDARY FOREST OF MONGOLIAN OAK
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作者 Shen Hailong WangKeNortheast Forestry UniversityXu ChcngyangResearch Institute of Forestry, Jilin ProvinceZhang WenNorthern Afforestation Center 《Journal of Northeast Forestry University》 SCIE CAS CSCD 1992年第2期47-53,共7页
The necessity,basis,characteristic and methods of restoring and reestabling broadleaved/coniferous mixed forest ecosystem from the secondary forest of Mongolian oak(Quercus mongolica)are briefly set forth;then several... The necessity,basis,characteristic and methods of restoring and reestabling broadleaved/coniferous mixed forest ecosystem from the secondary forest of Mongolian oak(Quercus mongolica)are briefly set forth;then several effective methods of restoration and reestablishment are put forward and discussed as follows:openning up effect belt or island to establish horizontal order mixture;replenishing the blank niche to make vertical orderly mix-ture;planting artificial mixed forest to create biological diversity;developing ecological forestry,establishing integrated agroforestry ecosystem;and closing the land for forest and pre-serving some stands considering special conditions and demads. 展开更多
关键词 QUERCUS mongolica. Secondary FOREST Mixed FOREST Restoration and reestablishment ECOSYSTEM
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Restoring the Health Of Rivers
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《ChinAfrica》 2021年第3期2-2,共1页
China has reached a milestone in its ecological protection along big rivers.On March 1,the Yangtze River Protection Law came into effect,turning a new chapter in the restoration of water ecology through legislation to... China has reached a milestone in its ecological protection along big rivers.On March 1,the Yangtze River Protection Law came into effect,turning a new chapter in the restoration of water ecology through legislation to protect a single river basin. 展开更多
关键词 TURNING YANGTZE RESTORATION
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Assessing Donor Liver Quality and Restoring Graft Function in the Era of Extended Criteria Donors 被引量:2
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作者 Yimou Lin Haitao Huang +4 位作者 Lifeng Chen Ruihan Chen Jimin Liu Shusen Zheng Qi Ling 《Journal of Clinical and Translational Hepatology》 SCIE 2023年第1期219-230,共12页
Liver transplantation(LT)is the final treatment option for patients with end-stage liver disease.The increasing donor shortage results in the wide usage of grafts from extended criteria donors across the world.Using s... Liver transplantation(LT)is the final treatment option for patients with end-stage liver disease.The increasing donor shortage results in the wide usage of grafts from extended criteria donors across the world.Using such grafts is associated with the elevated incidences of post-transplant complications including initial nonfunction and ischemic biliary tract diseases,which significantly reduce recipient survival.Although several clinical factors have been demonstrated to impact donor liver quality,accurate,comprehensive,and effective assessment systems to guide decision-making for organ usage,restoration or discard are lacking.In addition,the development of biochemical technologies and bioinformatic analysis in recent years helps us better understand graft injury during the perioperative period and find potential ways to restore graft function.Moreover,such advances reveal the molecular profiles of grafts or perfusate that are susceptible to poor graft function and provide insight into finding novel biomarkers for graft quality assessment.Focusing on donors and grafts,we updated potential biomarkers in donor blood,liver tissue,or perfusates that predict graft quality following LT,and summarized strategies for restoring graft function in the era of extended criteria donors.In this review,we also discuss the advantages and drawbacks of these potential biomarkers and offer suggestions for future research. 展开更多
关键词 Liver transplantation Extended criteria donors Graft quality ASSESSMENT Biomarkers RESTORATION
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Advantages of nanocarriers for basic research in the field of traumatic brain injury 被引量:1
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作者 Xingshuang Song Yizhi Zhang +1 位作者 Ziyan Tang Lina Du 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期237-245,共9页
A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researche... A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researchers have begun to focus on nanocarriers and other brain-targeting drug delivery systems.In this review,we summarize the epidemiology,basic pathophysiology,current clinical treatment,the establishment of models,and the evaluation indicators that are commonly used for traumatic brain injury.We also report the current status of traumatic brain injury when treated with nanocarriers such as liposomes and vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains in the basic research stage and has yet to be fully translated to the clinic. 展开更多
关键词 blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell NANOCARRIERS nanoparticles neural restoration traumatic brain injury
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