The authors have decided to retract the article published on World J Gastrointest Oncol(2023)for further consideration due to data errors and some misunderstandings in communication.
One of the most challenging factors affecting impression quality and good marginal fit is the gingival retraction method, which aims to separate the gingiva from the tooth to expose the finishing line of the prepared ...One of the most challenging factors affecting impression quality and good marginal fit is the gingival retraction method, which aims to separate the gingiva from the tooth to expose the finishing line of the prepared tooth. Bleeding and contamination from the crevicular fluid may compete for space with the impression material within the sulcus, leading to indistinct preparations and a lack of detail at the margin. In addition, such procedures might damage the PDL and cause permanent recession. Flowable composite cable, as opposed to traditional retraction cords, offers the proper marginal seal and visibility during the impression record because of its lower viscosity, improved adaptability, and elastic properties. The aim of this report is to present a brand-new, innovative method for controlling gingival hemorrhage in addition to the gingival retraction in restorative and prosthodontic treatment by utilizing a flowable composite during the final impression record procedure. In these case reports, the flowable composite cord technique is used instead of traditional gingival cords to modify and refine the gingival tissue before taking the traditional final impression or digital scan. Two cases were done for patients undergoing fixed prosthodontics and veneer treatment within a 2-year follow-up period. In addition, the flowable composite cord was used as temporary restoration before the final prosthetic cementation or under the provisional crowns. As a result, clean and healthy gingival tissues render cementation of the final prosthesis quicker and easier to perform. The patients in both cases claimed that their prosthodontic treatments, which involved the application of a flowable composite cord to temporarily retraction the gingiva, had produced good outcomes at the yearlong follow-up. In conclusion, the flowable composite cord technique is found to be a useful tool to improve the quality of impressions in fixed prosthodontics by providing excellent access for impression material to record fine details of the finish line of the prepared tooth structure, and to alter the inflamed tissue into a healthy tissue.展开更多
In this paper,we show that every super weakly compact convex subset of a Banach space is an absolute uniform retract,and that it also admits the uniform compact approximation property.These can be regarded as extensio...In this paper,we show that every super weakly compact convex subset of a Banach space is an absolute uniform retract,and that it also admits the uniform compact approximation property.These can be regarded as extensions of Lindenstrauss and Kalton's corresponding results.展开更多
BACKGROUND Mandibular retraction is the main etiological mechanism of class II malocclusion in China and the subsequent distal molar relationship can cause functional discomfort in mastication,breathing and the tempor...BACKGROUND Mandibular retraction is the main etiological mechanism of class II malocclusion in China and the subsequent distal molar relationship can cause functional discomfort in mastication,breathing and the temporomandibular joint.The use of mandibular advancement(MA)devices has recently emerged as an adolescent mandibular retraction treatment;however,current studies regarding the effect thereof are relatively few,and there is lack of sufficient clinical support.AIM To investigate the clinical effect of invisalign MA on the treatment of mandibular retraction in adolescents.METHODS This study included 30 adolescent patients who underwent treatment with the MA appliances from December 2017 to June 2021.The lateral cephalometric data before and after treatment were collected and imported into Dolphin Imaging software.The changes were measured by linear measurement superimposed with lateral cephalometric trajectory based on the Pancherz technology.RESULTS There was no significant difference in the length and position of maxilla before and after the treatment.The position of the mandible moved 3.13 mm,the length increased 4.14 mm,the mandibular ramus length increased 4.09 mm,the body length increased 4.25 mm,and the position of the condyle moved 1.03 mm forward after treatment.Additionally,changes in the incisor sagittal position and labial inclination were observed.The position of the upper incisor point moved back 1.33 mm,without statistical difference,the inclination and tooth angle decreased by 3.44°and 4.06°,respectively;the position of the lower incisor point was moved 2.98 mm,and the inclination and tooth angle increased by 2.62°and 1.23°,respectively.Furthermore,changes in the incisor overjet and molar relationship were seen.Overjet decreased by 4.31 mm,of which 1.78 mm was due to dental factors,accounting for 41.3%of the effect as opposed to 58.7%due to skeletal factors.Molar relationship improved 3.87 mm,with 1.34 mm due to dental factors,and dental and skeletal factors were accounted for 34.6%and 65.4%of the effect,respectively.CONCLUSION For adolescent patients with mandible retraction,invisalign MA can effectively promote the mandible growth,and it was proven to be mainly due to skeletal effects.展开更多
Purpose: The number of retracted papers from Chinese university-affiliated hospitals is increasing, which has raised much concern. The aim of this study is to analyze the retracted papers from university-affiliated ho...Purpose: The number of retracted papers from Chinese university-affiliated hospitals is increasing, which has raised much concern. The aim of this study is to analyze the retracted papers from university-affiliated hospitals in China’s mainland from 2000 to 2021. Design/methodology/approach: Data for 1,031 retracted papers were identified from the Web of Science Core collection database. The information of the hospitals involved was obtained from their official websites. We analyzed the chronological changes, journal distribution, discipline distribution and retraction reasons for the retracted papers. The grade and geographic locations of the hospitals involved were explored as well.Findings: We found a rapid increase in the number of retracted papers, while the retraction time interval is decreasing. The main reasons for retraction are plagiarism/self-plagiarism(n=255), invalid data/images/conclusions(n=212), fake peer review(n=175) and honesty error(n=163). The disciplines are mainly distributed in oncology(n=320), pharmacology & pharmacy(n=198) and research & experimental medicine(n=166). About 43.8% of the retracted papers were from hospitals affiliated with prestigious universities. Research limitations: This study fails to differentiate between retractions due to honest error and retractions due to research misconduct. We believe that there is a fundamental difference between honest error retractions and misconduct retractions. Another limitation is that authors of the retracted papers have not been analyzed in this study.Practical implications: This study provides a reference for addressing research misconduct in Chinese university-affiliated hospitals. It is our recommendation that universities and hospitals should educate all their staff about the basic norms of research integrity, punish authors of scientific misconduct retracted papers, and reform the unreasonable evaluation system.Originality/value: Based on the analysis of retracted papers, this study further analyzes the characteristics of institutions of retracted papers, which may deepen the research on retracted papers and provide a new perspective to understand the retraction phenomenon.展开更多
Cancer research is occasionally described as being in a reproducibility crisis.The cancer literature has ample papers retracted due to misconduct,including the use of paper mills,invalid authorship,or fake data.The ob...Cancer research is occasionally described as being in a reproducibility crisis.The cancer literature has ample papers retracted due to misconduct,including the use of paper mills,invalid authorship,or fake data.The objective of this paper was to gain an appreciation of the balance of retractions and associated retraction notices of 23 retracted Cancer Biotherapy and Radiopharmaceuticals papers associated with paper mills.By 23 March 2023,these retracted papers had already accumulated 287 citations according to Web of Science Core Collection,253 according to Scopus,and 365 according to Google Scholar,i.e.,metrically speaking,they were highly rewarded.All authors had an affiliation(71%being a hospital)in China.Most(12/21;57%)of corresponding authors had emails with a@163.com suffix.Four of the retraction notices(i.e.,17%)explicitly indicated paper mills as a reason for retraction although,in general,the retraction notices lacked details and background that could assist readers’understanding of the retractions.展开更多
The mitochondrial permeability transition pore is a nonspecific transmembrane channel.Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling,calcium overloa...The mitochondrial permeability transition pore is a nonspecific transmembrane channel.Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling,calcium overload,and axonal degeneration.Cyclophilin D is an important component of the mitochondrial permeability transition pore.Whether cyclophilin D participates in mitochondrial impairment and axonal injury after intracerebral hemorrhage is not clear.In this study,we established mouse models of intracerebral hemorrhage in vivo by injection of autologous blood and oxyhemoglobin into the striatum in Thy1-YFP mice,in which pyramidal neurons and axons express yellow fluorescent protein.We also simulated intracerebral hemorrhage in vitro in PC12 cells using oxyhemoglobin.We found that axonal degeneration in the early stage of intracerebral hemorrhage depended on mitochondrial swelling induced by cyclophilin D activation and mitochondrial permeability transition pore opening.We further investigated the mechanism underlying the role of cyclophilin D in mouse models and PC12 cell models of intracerebral hemorrhage.We found that both cyclosporin A inhibition and short hairpin RNA interference of cyclophilin D reduced mitochondrial permeability transition pore opening and mitochondrial injury.In addition,inhibition of cyclophilin D and mitochondrial permeability transition pore opening protected corticospinal tract integrity and alleviated motor dysfunction caused by intracerebral hemorrhage.Our findings suggest that cyclophilin D is used as a key mediator of axonal degeneration after intracerebral hemorrhage;inhibition of cyclophilin D expression can protect mitochondrial structure and function and further alleviate corticospinal tract injury and motor dysfunction after intracerebral hemorrhage.Our findings provide a therapeutic target for preventing axonal degeneration of white matter injury and subsequent functional impairment in central nervous diseases.展开更多
Casing-while-drilling(CWD)with down the hole(DTH)hammer drilling technology has been widely used in unconsolidated formations,due to its advantages in protecting the borehole wall,excellent rock cuttings capacity,and ...Casing-while-drilling(CWD)with down the hole(DTH)hammer drilling technology has been widely used in unconsolidated formations,due to its advantages in protecting the borehole wall,excellent rock cuttings capacity,and fast penetration rate in hard rock.As an important component of the CWD system,the structure of the retractable drill bit needs not only to ensure to form stronger reverse circulation,but also to be expandable or retractable as needed,otherwise the drill bit cannot be lift and put down smoothly in the casing,and may lead to drilling accidents.This paper developed a new type of reverse circulation DTH hammer drill bit used for CWD drilling technology.The retractable performance of this type of drill bit is studied using ADAMS software.The results show that it is smoothly expandable and retractable as designed under the conditions of the weight of the bit(WOB)of 0.5–2.0 t and the rotation speed of 30–60 r/min.To investigate the reverse circulation effect of the drill bit,Fluent software was used to simulate the flow characteristic inside it.The simulation results indicated that it can form strong reverse circulation,and the entrainment ratio h can reach 9.5%.展开更多
Our aim in the present article is to introduce and study new types of retractions of closed flat Robertson-Walker W4 model. Types of the deformation retract of closed flat Robertson-Walker W4 model are obtained. The r...Our aim in the present article is to introduce and study new types of retractions of closed flat Robertson-Walker W4 model. Types of the deformation retract of closed flat Robertson-Walker W4 model are obtained. The relations between the retraction and the deformation retract of curves in W4 model are deduced. Types of minimal retractions of curves in W4 model are also presented. Also, the isometric and topological folding in each case and the relation between the deformation retracts after and before folding have been obtained. New types of homotopy maps are deduced. New types of conditional folding are presented. Some commutative diagrams are obtained.展开更多
Our aim in the present article is to introduce and study types of retraction of one dimensional manifold. New types of geodesics in one dimensional manifold are presented. The deformation retracts of one dimensional m...Our aim in the present article is to introduce and study types of retraction of one dimensional manifold. New types of geodesics in one dimensional manifold are presented. The deformation retracts of one dimensional manifold into itself and onto geodesics is deduced. Also, the isometric and topological folding in each case and the relation between the deformations retracts after and before folding has been obtained. New types of conditional folding are described.展开更多
The purpose of this paper is to give a combinatorial characterization and also construct representations of the fundamental group of the submanifolds of elastic Klein Bottle by using some geometrical transformations. ...The purpose of this paper is to give a combinatorial characterization and also construct representations of the fundamental group of the submanifolds of elastic Klein Bottle by using some geometrical transformations. The homotopy groups of the limit elastic Klein Bottle are presented. The fundamental groups of some types of geodesics in elastic Klein Bottle are discussed. New types of homotopy maps are deduced. Theorems governing this connection are achieved.展开更多
We will introduce a new connection between some transformations and some aspects of differential geometry of some curves in Minkowski space. The concept of folding, retractions and contraction on some curves in Minkow...We will introduce a new connection between some transformations and some aspects of differential geometry of some curves in Minkowski space. The concept of folding, retractions and contraction on some curves in Minkowski space will be characterized by using some aspects of differential geometry. Types of the deformation retracts of some curves in Minkowski 3-space are obtained. The relations between the foldings and the deformation retracts of some curves are deduced. The connections between some transformations and time like, space like, light like of some curves in Minkowski 3-space are also presented.展开更多
AIM: To report the long-term outcomes of a large cohort of upper lid retraction patients treated with subconjunctival triamcinolone acetonide injections.METHODS: This retrospective clinical study was conducted from ...AIM: To report the long-term outcomes of a large cohort of upper lid retraction patients treated with subconjunctival triamcinolone acetonide injections.METHODS: This retrospective clinical study was conducted from 2009 to 2016. The documents of 97 patients(126 eyes) were reviewed. The patients were treated with subconjunctival triamcinolone acetonide injections monthly and evaluated pre-and post-treatment by taking measurements of the upper margin reflex distance(MRD1, the distance between the upper-lid margin and the pupil center), lid aperture, lagophthalmos and proptosis. The patients were divided into the cured group, the improved group and the ineffective group based on the final treatment effectiveness. The improved group and the ineffective group were combined into non-cured group.RESULTS: The follow-up time was 23.45±14.86 mo. Of the patients, 63(64.9%) were assigned to the cured group, 22(22.7%) in the improved group, 12(12.4%) in the ineffective group. Injection times for cured group was 4.66±1.74, and for non-cured group was 5.17±2.08(P≤0.05). The MRD1 was significantly reduced between baseline and 1 mo after the initiation of treatment in the cured and improved groups(P〈0.001). The values did not change significantly after 4 mo for the improved group, while they continued to decrease in the cured group. In the ineffective group, the MRD1 did not significantly change after treatment. A statistically significant difference was observed between the baseline and post-treatment values of the mean muscle thickness(2.95±0.99 mm vs 2.04±0.63 mm, P〈0.05) and surface area(27.27±10.5 mm2 vs 18.3±7.04 mm2,P〈0.05) of the levator superioris with magnetic resonance imaging examination. Twelve patients(12.4%) relapsed after treatment and required additional subconjunctival injections. The main side effects included menstrual cycle disturbances(32%) and elevations of intra-ocular pressure(18.6%). CONCLUSION: A repeated subconjunctival injection of triamcinolone is an effective and relatively safe treatment for upper lid retraction due to thyroid-associated ophthalmopathy. This is related to the anti-inflammation effect of the medicine and the levator thickness can become thinner. Patients must be monitored regularly for recurrences and side effects.展开更多
BACKGROUND Lumbar disc herniation(LDH)has emerged as one of the most common causes of low back pain.The routine treatment approach involves chemonucleolysis therapy,discectomy by percutaneous endoscopy,and percutaneou...BACKGROUND Lumbar disc herniation(LDH)has emerged as one of the most common causes of low back pain.The routine treatment approach involves chemonucleolysis therapy,discectomy by percutaneous endoscopy,and percutaneous laser disc decompression.Unfortunately,all of these methods carry inherent risk of causing harm to the patient and,as such,there is an unmet but urgent need for an effective and safe noninvasive treatment for LDH.The purpose of this report is to describe a non-invasive method for re-absorption of LDH.CASE SUMMARY A 34-year-old woman was admitted with a complaint of waist pain that she reported as having become acutely aggravated over the past 3 d and accompanied by discomfort in the right lower limb.Her self-reported medical history included persistent postpartum low back pain from 7 years prior.Physical exam showed positivity for neck flexion test(Lindner sign)and supine abdomen test;the straight leg-raising test showed right 60(+)and left 80(-).Findings from standard imaging(magnetic resonance)and collective physical examinations indicated a L5/S1 herniated lumbar disc.Treatment consisted of three-dimensional(balanced regulating)spinal manipulation and acupuncture,upon which the LDH resolved by retraction.CONCLUSION Following L5/S1 herniated lumbar disc diagnosis,three-dimensional(balanced regulating)spinal manipulation combined with acupuncture therapy is an effective treatment.展开更多
·AIM: To determine the prevalence of ophthalmopathy in Hashimoto’s patients and to make a comparison in subgroups of patients·METHODS: The study involved 110 Hashimoto’s thyroiditis patients and 50 control...·AIM: To determine the prevalence of ophthalmopathy in Hashimoto’s patients and to make a comparison in subgroups of patients·METHODS: The study involved 110 Hashimoto’s thyroiditis patients and 50 control subjects attending to the endocrinology department of the hospital. Subgroup classification of patients was made as euthyroid,subclinic and clinic in Hashimato’s thyroiditis. All patients were evaluated by a single experienced ophthalmologist for the prevalence and characteristics of eye signs.·RESULTS:Theoverallprevalencesofeyechanges were22.7%(25 patients) in patients and 4%(2 persons) in control subjects respectively(P =0.002). In patients the most common symptom was retrobulbar eye pain with or without any eye movement. Thirteen patients had significant upper eyelid retraction(11.8%). Six patients had eye muscle dysfunction as reduced eye movements in up gaze. In control patients one person had proptosis and another had lid retraction. The clinical activity score and classification of the ophthalmopathy did not show any significant differences among subgroups.·CONCLUSION:Theeyesignsweremostlymild(22.7%)and the most common eye sign was the presence of upper eyelid retraction(11.8%). Additionally six patients had eye muscle dysfunction as reduced eye movements in up gaze. Therefore we recommend to make a routine ophthalmic examination in Hashimoto’s thyroiditis patients in order not to omit the associated ophthalmopathy.展开更多
文摘The authors have decided to retract the article published on World J Gastrointest Oncol(2023)for further consideration due to data errors and some misunderstandings in communication.
文摘One of the most challenging factors affecting impression quality and good marginal fit is the gingival retraction method, which aims to separate the gingiva from the tooth to expose the finishing line of the prepared tooth. Bleeding and contamination from the crevicular fluid may compete for space with the impression material within the sulcus, leading to indistinct preparations and a lack of detail at the margin. In addition, such procedures might damage the PDL and cause permanent recession. Flowable composite cable, as opposed to traditional retraction cords, offers the proper marginal seal and visibility during the impression record because of its lower viscosity, improved adaptability, and elastic properties. The aim of this report is to present a brand-new, innovative method for controlling gingival hemorrhage in addition to the gingival retraction in restorative and prosthodontic treatment by utilizing a flowable composite during the final impression record procedure. In these case reports, the flowable composite cord technique is used instead of traditional gingival cords to modify and refine the gingival tissue before taking the traditional final impression or digital scan. Two cases were done for patients undergoing fixed prosthodontics and veneer treatment within a 2-year follow-up period. In addition, the flowable composite cord was used as temporary restoration before the final prosthetic cementation or under the provisional crowns. As a result, clean and healthy gingival tissues render cementation of the final prosthesis quicker and easier to perform. The patients in both cases claimed that their prosthodontic treatments, which involved the application of a flowable composite cord to temporarily retraction the gingiva, had produced good outcomes at the yearlong follow-up. In conclusion, the flowable composite cord technique is found to be a useful tool to improve the quality of impressions in fixed prosthodontics by providing excellent access for impression material to record fine details of the finish line of the prepared tooth structure, and to alter the inflamed tissue into a healthy tissue.
基金Support by National Natural Science Foundation of China(Grant Nos.11731010,12071389)。
文摘In this paper,we show that every super weakly compact convex subset of a Banach space is an absolute uniform retract,and that it also admits the uniform compact approximation property.These can be regarded as extensions of Lindenstrauss and Kalton's corresponding results.
基金This study was reviewed and approved by the Medical Ethics Committee of The Affiliated Hospital of Qingdao University(authorisation number:QYFYWZLL26729).
文摘BACKGROUND Mandibular retraction is the main etiological mechanism of class II malocclusion in China and the subsequent distal molar relationship can cause functional discomfort in mastication,breathing and the temporomandibular joint.The use of mandibular advancement(MA)devices has recently emerged as an adolescent mandibular retraction treatment;however,current studies regarding the effect thereof are relatively few,and there is lack of sufficient clinical support.AIM To investigate the clinical effect of invisalign MA on the treatment of mandibular retraction in adolescents.METHODS This study included 30 adolescent patients who underwent treatment with the MA appliances from December 2017 to June 2021.The lateral cephalometric data before and after treatment were collected and imported into Dolphin Imaging software.The changes were measured by linear measurement superimposed with lateral cephalometric trajectory based on the Pancherz technology.RESULTS There was no significant difference in the length and position of maxilla before and after the treatment.The position of the mandible moved 3.13 mm,the length increased 4.14 mm,the mandibular ramus length increased 4.09 mm,the body length increased 4.25 mm,and the position of the condyle moved 1.03 mm forward after treatment.Additionally,changes in the incisor sagittal position and labial inclination were observed.The position of the upper incisor point moved back 1.33 mm,without statistical difference,the inclination and tooth angle decreased by 3.44°and 4.06°,respectively;the position of the lower incisor point was moved 2.98 mm,and the inclination and tooth angle increased by 2.62°and 1.23°,respectively.Furthermore,changes in the incisor overjet and molar relationship were seen.Overjet decreased by 4.31 mm,of which 1.78 mm was due to dental factors,accounting for 41.3%of the effect as opposed to 58.7%due to skeletal factors.Molar relationship improved 3.87 mm,with 1.34 mm due to dental factors,and dental and skeletal factors were accounted for 34.6%and 65.4%of the effect,respectively.CONCLUSION For adolescent patients with mandible retraction,invisalign MA can effectively promote the mandible growth,and it was proven to be mainly due to skeletal effects.
基金supported by grants from Humanity and Social Science Youth Foundation of Ministry of Education of China (21YJC870016).
文摘Purpose: The number of retracted papers from Chinese university-affiliated hospitals is increasing, which has raised much concern. The aim of this study is to analyze the retracted papers from university-affiliated hospitals in China’s mainland from 2000 to 2021. Design/methodology/approach: Data for 1,031 retracted papers were identified from the Web of Science Core collection database. The information of the hospitals involved was obtained from their official websites. We analyzed the chronological changes, journal distribution, discipline distribution and retraction reasons for the retracted papers. The grade and geographic locations of the hospitals involved were explored as well.Findings: We found a rapid increase in the number of retracted papers, while the retraction time interval is decreasing. The main reasons for retraction are plagiarism/self-plagiarism(n=255), invalid data/images/conclusions(n=212), fake peer review(n=175) and honesty error(n=163). The disciplines are mainly distributed in oncology(n=320), pharmacology & pharmacy(n=198) and research & experimental medicine(n=166). About 43.8% of the retracted papers were from hospitals affiliated with prestigious universities. Research limitations: This study fails to differentiate between retractions due to honest error and retractions due to research misconduct. We believe that there is a fundamental difference between honest error retractions and misconduct retractions. Another limitation is that authors of the retracted papers have not been analyzed in this study.Practical implications: This study provides a reference for addressing research misconduct in Chinese university-affiliated hospitals. It is our recommendation that universities and hospitals should educate all their staff about the basic norms of research integrity, punish authors of scientific misconduct retracted papers, and reform the unreasonable evaluation system.Originality/value: Based on the analysis of retracted papers, this study further analyzes the characteristics of institutions of retracted papers, which may deepen the research on retracted papers and provide a new perspective to understand the retraction phenomenon.
文摘Cancer research is occasionally described as being in a reproducibility crisis.The cancer literature has ample papers retracted due to misconduct,including the use of paper mills,invalid authorship,or fake data.The objective of this paper was to gain an appreciation of the balance of retractions and associated retraction notices of 23 retracted Cancer Biotherapy and Radiopharmaceuticals papers associated with paper mills.By 23 March 2023,these retracted papers had already accumulated 287 citations according to Web of Science Core Collection,253 according to Scopus,and 365 according to Google Scholar,i.e.,metrically speaking,they were highly rewarded.All authors had an affiliation(71%being a hospital)in China.Most(12/21;57%)of corresponding authors had emails with a@163.com suffix.Four of the retraction notices(i.e.,17%)explicitly indicated paper mills as a reason for retraction although,in general,the retraction notices lacked details and background that could assist readers’understanding of the retractions.
基金supported by the National Natural Science Foundation of China,Nos.81901267(to YY),82001263(to WXC),81901193(to HLZ)a grant from State Key Laboratory of Trauma,Burn and Combined Injury,No.SKLYQ202002(to YJC)+1 种基金a grant from Wuxi Municipal Health Commission No.2020ZHYB19(to YY)a grant from Wuxi Science and Technology Bureau,No.Y20212045(to LKY)。
文摘The mitochondrial permeability transition pore is a nonspecific transmembrane channel.Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling,calcium overload,and axonal degeneration.Cyclophilin D is an important component of the mitochondrial permeability transition pore.Whether cyclophilin D participates in mitochondrial impairment and axonal injury after intracerebral hemorrhage is not clear.In this study,we established mouse models of intracerebral hemorrhage in vivo by injection of autologous blood and oxyhemoglobin into the striatum in Thy1-YFP mice,in which pyramidal neurons and axons express yellow fluorescent protein.We also simulated intracerebral hemorrhage in vitro in PC12 cells using oxyhemoglobin.We found that axonal degeneration in the early stage of intracerebral hemorrhage depended on mitochondrial swelling induced by cyclophilin D activation and mitochondrial permeability transition pore opening.We further investigated the mechanism underlying the role of cyclophilin D in mouse models and PC12 cell models of intracerebral hemorrhage.We found that both cyclosporin A inhibition and short hairpin RNA interference of cyclophilin D reduced mitochondrial permeability transition pore opening and mitochondrial injury.In addition,inhibition of cyclophilin D and mitochondrial permeability transition pore opening protected corticospinal tract integrity and alleviated motor dysfunction caused by intracerebral hemorrhage.Our findings suggest that cyclophilin D is used as a key mediator of axonal degeneration after intracerebral hemorrhage;inhibition of cyclophilin D expression can protect mitochondrial structure and function and further alleviate corticospinal tract injury and motor dysfunction after intracerebral hemorrhage.Our findings provide a therapeutic target for preventing axonal degeneration of white matter injury and subsequent functional impairment in central nervous diseases.
基金the National Key Research and Development Program of China(No.2018YFC1505303).
文摘Casing-while-drilling(CWD)with down the hole(DTH)hammer drilling technology has been widely used in unconsolidated formations,due to its advantages in protecting the borehole wall,excellent rock cuttings capacity,and fast penetration rate in hard rock.As an important component of the CWD system,the structure of the retractable drill bit needs not only to ensure to form stronger reverse circulation,but also to be expandable or retractable as needed,otherwise the drill bit cannot be lift and put down smoothly in the casing,and may lead to drilling accidents.This paper developed a new type of reverse circulation DTH hammer drill bit used for CWD drilling technology.The retractable performance of this type of drill bit is studied using ADAMS software.The results show that it is smoothly expandable and retractable as designed under the conditions of the weight of the bit(WOB)of 0.5–2.0 t and the rotation speed of 30–60 r/min.To investigate the reverse circulation effect of the drill bit,Fluent software was used to simulate the flow characteristic inside it.The simulation results indicated that it can form strong reverse circulation,and the entrainment ratio h can reach 9.5%.
文摘Our aim in the present article is to introduce and study new types of retractions of closed flat Robertson-Walker W4 model. Types of the deformation retract of closed flat Robertson-Walker W4 model are obtained. The relations between the retraction and the deformation retract of curves in W4 model are deduced. Types of minimal retractions of curves in W4 model are also presented. Also, the isometric and topological folding in each case and the relation between the deformation retracts after and before folding have been obtained. New types of homotopy maps are deduced. New types of conditional folding are presented. Some commutative diagrams are obtained.
文摘Our aim in the present article is to introduce and study types of retraction of one dimensional manifold. New types of geodesics in one dimensional manifold are presented. The deformation retracts of one dimensional manifold into itself and onto geodesics is deduced. Also, the isometric and topological folding in each case and the relation between the deformations retracts after and before folding has been obtained. New types of conditional folding are described.
文摘The purpose of this paper is to give a combinatorial characterization and also construct representations of the fundamental group of the submanifolds of elastic Klein Bottle by using some geometrical transformations. The homotopy groups of the limit elastic Klein Bottle are presented. The fundamental groups of some types of geodesics in elastic Klein Bottle are discussed. New types of homotopy maps are deduced. Theorems governing this connection are achieved.
文摘We will introduce a new connection between some transformations and some aspects of differential geometry of some curves in Minkowski space. The concept of folding, retractions and contraction on some curves in Minkowski space will be characterized by using some aspects of differential geometry. Types of the deformation retracts of some curves in Minkowski 3-space are obtained. The relations between the foldings and the deformation retracts of some curves are deduced. The connections between some transformations and time like, space like, light like of some curves in Minkowski 3-space are also presented.
基金Supported by the National Natural Science Foundation of China (No.81271043)
文摘AIM: To report the long-term outcomes of a large cohort of upper lid retraction patients treated with subconjunctival triamcinolone acetonide injections.METHODS: This retrospective clinical study was conducted from 2009 to 2016. The documents of 97 patients(126 eyes) were reviewed. The patients were treated with subconjunctival triamcinolone acetonide injections monthly and evaluated pre-and post-treatment by taking measurements of the upper margin reflex distance(MRD1, the distance between the upper-lid margin and the pupil center), lid aperture, lagophthalmos and proptosis. The patients were divided into the cured group, the improved group and the ineffective group based on the final treatment effectiveness. The improved group and the ineffective group were combined into non-cured group.RESULTS: The follow-up time was 23.45±14.86 mo. Of the patients, 63(64.9%) were assigned to the cured group, 22(22.7%) in the improved group, 12(12.4%) in the ineffective group. Injection times for cured group was 4.66±1.74, and for non-cured group was 5.17±2.08(P≤0.05). The MRD1 was significantly reduced between baseline and 1 mo after the initiation of treatment in the cured and improved groups(P〈0.001). The values did not change significantly after 4 mo for the improved group, while they continued to decrease in the cured group. In the ineffective group, the MRD1 did not significantly change after treatment. A statistically significant difference was observed between the baseline and post-treatment values of the mean muscle thickness(2.95±0.99 mm vs 2.04±0.63 mm, P〈0.05) and surface area(27.27±10.5 mm2 vs 18.3±7.04 mm2,P〈0.05) of the levator superioris with magnetic resonance imaging examination. Twelve patients(12.4%) relapsed after treatment and required additional subconjunctival injections. The main side effects included menstrual cycle disturbances(32%) and elevations of intra-ocular pressure(18.6%). CONCLUSION: A repeated subconjunctival injection of triamcinolone is an effective and relatively safe treatment for upper lid retraction due to thyroid-associated ophthalmopathy. This is related to the anti-inflammation effect of the medicine and the levator thickness can become thinner. Patients must be monitored regularly for recurrences and side effects.
基金Supported by Major Science and Technology Innovation Projects of Shandong Province,No.2018CXGC1310Natural Foundation of Shandong Province,No.ZR2019MH134+2 种基金Project of Jinan"20 Universities",No.2019GXRC040Shandong Institute of Advanced Technology,Chinese Academy of Sciences,No.YJZX003Collaborative Innovation Center Project of quality Control of traditional Chinese Medicine and Construction of whole Industry chain in Colleges and Universities of Shandong Province,No.CYLXTCX2020-04.
文摘BACKGROUND Lumbar disc herniation(LDH)has emerged as one of the most common causes of low back pain.The routine treatment approach involves chemonucleolysis therapy,discectomy by percutaneous endoscopy,and percutaneous laser disc decompression.Unfortunately,all of these methods carry inherent risk of causing harm to the patient and,as such,there is an unmet but urgent need for an effective and safe noninvasive treatment for LDH.The purpose of this report is to describe a non-invasive method for re-absorption of LDH.CASE SUMMARY A 34-year-old woman was admitted with a complaint of waist pain that she reported as having become acutely aggravated over the past 3 d and accompanied by discomfort in the right lower limb.Her self-reported medical history included persistent postpartum low back pain from 7 years prior.Physical exam showed positivity for neck flexion test(Lindner sign)and supine abdomen test;the straight leg-raising test showed right 60(+)and left 80(-).Findings from standard imaging(magnetic resonance)and collective physical examinations indicated a L5/S1 herniated lumbar disc.Treatment consisted of three-dimensional(balanced regulating)spinal manipulation and acupuncture,upon which the LDH resolved by retraction.CONCLUSION Following L5/S1 herniated lumbar disc diagnosis,three-dimensional(balanced regulating)spinal manipulation combined with acupuncture therapy is an effective treatment.
文摘·AIM: To determine the prevalence of ophthalmopathy in Hashimoto’s patients and to make a comparison in subgroups of patients·METHODS: The study involved 110 Hashimoto’s thyroiditis patients and 50 control subjects attending to the endocrinology department of the hospital. Subgroup classification of patients was made as euthyroid,subclinic and clinic in Hashimato’s thyroiditis. All patients were evaluated by a single experienced ophthalmologist for the prevalence and characteristics of eye signs.·RESULTS:Theoverallprevalencesofeyechanges were22.7%(25 patients) in patients and 4%(2 persons) in control subjects respectively(P =0.002). In patients the most common symptom was retrobulbar eye pain with or without any eye movement. Thirteen patients had significant upper eyelid retraction(11.8%). Six patients had eye muscle dysfunction as reduced eye movements in up gaze. In control patients one person had proptosis and another had lid retraction. The clinical activity score and classification of the ophthalmopathy did not show any significant differences among subgroups.·CONCLUSION:Theeyesignsweremostlymild(22.7%)and the most common eye sign was the presence of upper eyelid retraction(11.8%). Additionally six patients had eye muscle dysfunction as reduced eye movements in up gaze. Therefore we recommend to make a routine ophthalmic examination in Hashimoto’s thyroiditis patients in order not to omit the associated ophthalmopathy.