The Disintegration of the Middle East Retreating to the ＂Weak Sovereignty Era＂

The Arab Spring in the spring of 2011 soon brought the Middle East into an abyss of chaos,instability,terrorism and civil war.Over the past six years,the Syria conflict in some areas tended to cool down.President Trump reached an agreement with Russian President Putin on building a new"conflict relegation zone"on July 7,2017.After three years of

Bedrock outcropping in the accumulation zone of the largest glacier in Mexico(Glaciar Norte of Citlaltépetl),as evidence of a possible accelerated extinction

The highest volcano in Mexico,at the same time the third largest mountain in North America(Citlaltépetl,5610 m a.s.l.),is home to the largest glacier in the country.Because of the extinction of the Popocatépetl glacier(5500 m a.s.l.)caused by eruptive activity,and the almost disappearance of the Iztaccíhuatl glaciers(5220 m a.s.l.)due to the lower elevation of the mountain,the Glaciar Norte of Citlatépetl has been the only glacier that has shown a certain degree of stability as a response to the altitude in which it is located.However,as occurs in almost all glaciers on the planet,the retreat of its glacier terminus has been continuous.Furthermore,during the last years the thickness of its upper part began to decrease rapidly until its bedrock was exposed for the first time in 2019.Due to its ecosystem importance and because it is the main glacier in Mexico,as well as the only one in the world located at latitude 19°N,in this work its current dimensions are updated,as well as the local climatology that governs the current state of the glacier is pointed out.The study was based on the analysis of high-resolution Sentinel-2 optical images,as well as through Sentinel-1 SAR images,with the support of climatological information from the study area.Therefore,the outcropping of the bedrock in the accumulation zone and the consequent horizontal retreat of the upper part of the glacier are documented;at the same time,the decrease in the thickness of the ice along it is noted.The rocky outcrop in the accumulation zone suggests that the flow dynamics of the ice towards the ablation zone will be considerably less,accelerating the retreat of the glacier terminus.Finally,the ascent of the glacial front to 5102 m a.s.l.and the modelled altitude of the equilibrium line to 5276 m a.s.l.are reported as a warning signal in terms of snow catchment and mass balance;likewise,the decrease of 23%of its surface is also indicated regarding the surface reduction monitoring that has been done until 2017.These findings may indicate that the future of this glacier is related to its possible extinction sooner than previously thought,with severe environmental consequences,especially in terms of the provision of drinking water for thousands of inhabitants of the slopes of the volcano.This research is expected to help reflect on the impacts of current climate variability and at the same time serve as a reference for the tropical glaciers on the planet.

Recent catastrophic landslides and mitigation in China

Increasing population density and development of mountainous terrain have brought human settlements within reach of landslide hazards.In recent years,due to the shortening of return period for severe natural events such as heavy rainfall,snowline retreating,great earthquake together with human activities,catastrophic landslides happened more frequently than before,resulting in large-scale casualties due to the increasing occurrences of rapid long-runout rock avalanches,especially in China.This paper presents some typical case histories related to the catastrophic landslides,including the Guanling rock avalanche,the Yigong rockslide-debris avalanche,the Wenchuan earthquake-induced landslides and the Danba landslide.They occurred in the last decade.Moreover,taking the Jiweishan catastrophic rockslide-fragment flow and the Yuhuangge landslide located in the new Wushan Town for examples,early-warning system and risk management on landslides are discussed in detail.

Early Paleozoic accretionary orogens along the Western Gondwana margin

Early Paleozoic accretionary orogens dominated the Western Gondwana margin and were characterized by nearly continuous subduction associated with crustal extension and back-arc basin development.The southwestern margin is represented by Famatinian and Pampean basement realms exposed in South America,both related to the protracted Paleozoic evolution of the Terra Australis Orogen,whereas the northwestern margin is mainly recorded in Cadomian domains of Europe and adjacent regions.However,no clear relationships between these regions were so far established.Based on a compilation and reevaluation of geological,paleomagnetic,petrological,geochronological and isotopic evidence,this contribution focuses on crustal-scale tectonic and geodynamic processes occurring in Western Gondwana accretionary orogens,aiming at disentangling their common Early Paleozoic evolution.Data show that accretionary orogens were dominated by high-temperature/lowpressure metamorphism and relatively high geothermal gradients,resulting from the development of extended/hyperextended margins and bulk transtensional deformation.In this sense,retreating-mode accretionary orogens characterized the Early Paleozoic Gondwana margin,though short-lived pulses of compression/transpression also occurred.The existence of retreating subduction zones favoured mantle-derived magmatism and mixing with relatively young(meta)sedimentary sources in a thin continental crust.Crustal reworking of previous forearc sequences due to trenchward arc migration thus took place through assimilation and anatexis in the arc/back-arc regions.Therefore,retreating-mode accretionary orogens were the locus of Early Paleozoic crustal growth in Western Gondwana,intimately associated with major flare-up events,such as those related to the Cadomian and Famatian arcs.Slab roll back,probably resulting from decreasing convergence rates and plate velocities after Gondwana assembly,was a key factor for orogen-scale geodynamic processes.Coupled with synchronous oblique subduction and crustal-scale dextral deformation,slab roll back might trigger toroidal mantle flow,thus accounting for bulk dextral transtension,back-arc extension/transtension and a large-scale anticlockwise rotation of Gondwana mainland.

Geotechnical and Mineralogical Properties of the Recently Exposed Black Mud Deposits along the Northeastern Shore of the Dead Sea

Along the recently evacuated shores of the retreating Dead Sea black mud deposits have been exposed and hence subjected to head ward erosion resulting in landslides and land collapses threatening herewith the infrastructure in the area. The geotechnical and mineralogical characterization of the black mud show the presence of a variety of clays including smectite, kaolinite, illite, montmorollinite and muscovite with a natural water content near the liquid limit. These geotechnical and mineralogical properties indicate that the mud is prone to rapid erosion and sliding, which actually hit the area and have until now caused damages and degrading topography and geology in the area. The study also refers the origin of the black mud and its organic content to the erosion and deposition of Upper Cretaceous-Tertiary oil shale deposits formerly covering the whole surrounding areas of the Dead Sea. The study suggests engineering solutions to the geologic degradation processes in the area, before further damage to the infrastructure takes place.

Changes in soil properties and erodibility of gully heads induced by vegetation restoration on the Loess Plateau, China

Soil erosion on the Loess Plateau of China is effectively controlled due to the implementation of several ecological restoration projects that improve soil properties and reduce soil erodibility. However, few studies have examined the effects of vegetation restoration on soil properties and erodibility of gully head in the gully regions of the Loess Plateau. The objectives of this study were to quantify the effects of vegetation restoration on soil properties and erodibility in this region. Specifically, a control site in a slope cropland and 9 sites in 3 restored land-use types （5 sites in grassland, 3 in woodland and 1 in shrubland） in the Nanxiaohegou watershed of a typical gully region on the Loess Plateau were selected, and soil and root samples were collected to assess soil properties and root characteristics. Soil erodibility factor was calculated by the Erosion Productivity Impact Calculator method. Our results revealed that vegetation restoration increased soil sand content, soil saturated hydraulic conductivity, organic matter content and mean weight diameter of water-stable aggregate but decreased soil silt and clay contents and soil disintegration rate. A significant difference in soil erodibility was observed among different vegetation restoration patterns or land-use types. Compared with cropland, soil erodibility decreased in the restored lands by 3.99% to 21.43%. The restoration patterns of Cleistogenes caespitosa K. and Artemisia sacrorum L. in the grassland showed the lowest soil erodibility and can be considered as the optimal vegetation restoration pattern for improving soil anti-erodibility of the gully heads. Additionally, the negative linear change in soil erodibility for grassland with restoration time was faster than those of woodland and shrubland. Soil erodibility was significantly correlated with soil particle size distribution, soil disintegration rate, soil saturated hydraulic conductivity, water-stable aggregate stability, organic matter content and root characteristics （including root average diameter, root length density, root surface density and root biomass density）, but it showed no association with soil bulk density and soil total porosity. These findings indicate that although vegetation destruction is a short-term process, returning the soil erodibility of cropland to the level of grassland, woodland and shrubland is a long-term process （8-50 years）.

The dominant driving force for supercontinent breakup: Plume push or subduction retreat?

Understanding the dominant force responsible for supercontinent breakup is crucial for establishing Earth＇s geodynamic evolution that includes supercontinent cycles and plate tectonics. Conventionally,two forces have been considered： the push by mantle plumes from the sub-continental mantle which is called the active force for breakup, and the dragging force from oceanic subduction retreat which is called the passive force for breakup. However, the relative importance of these two forces is unclear. Here we model the supercontinent breakup coupled with global mantle convection in order to address this question. Our global model features a spherical harmonic degree-2 structure, which includes a major subduction girdle and two large upwelling（superplume） systems. Based on this global mantle structure,we examine the distribution of extensional stress applied to the supercontinent by both subsupercontinent mantle upwellings and subduction retreat at the supercontinent peripheral. Our results show that：（1） at the center half of the supercontinent, plume push stress is ～3 times larger than the stress induced by subduction retreat;（2） an average hot anomaly of no higher than 50 K beneath the supercontinent can produce a push force strong enough to cause the initialization of supercontinent breakup;（3） the extensional stress induced by subduction retreat concentrates on a ～600 km wide zone on the boundary of the supercontinent, but has far less impact to the interior of the supercontinent. We therefore conclude that although circum-supercontinent subduction retreat assists supercontinent breakup, sub-supercontinent mantle upwelling is the essential force.

The Rapidly Changing Arctic and Its Impact on Global Climate

Arctic sea ice has significant seasonal variability. Prior to the 2000 s, it retreated about 15% in summer and fully recovered in winter. However, by the year 2007, Arctic sea ice extent experienced a catastrophic decline to about 4.28×10^6 km^2, which was 50% lower than conditions in the 1950 s to the 1970 s(Serreze et al., 2008). That was a record low over the course of the modern satellite record, since 1979(note that the year 2012 became the new record low). This astonishing event drew wide-ranging attention in 2007-2009 during the 4 th International Polar Year. The dramatic decline of sea ice attracts many scientists’ interest and has become the focus of intense research since then. Currently, sea ice retreat is not only appearing around the marginal ice zone, but also in the pack ice inside the central Arctic(Zhao et al., 2018). In fact, premonitory signs had already been seen through other evidence. Before the disintegration of the Soviet Union, US naval submarines had been conducting an extensive survey under the sea ice and taking measurements of sea ice thickness. Their measurements revealed a gradual decrease of ice thickness to 1.8 m during winter by the end of the 20 th century, in contrast to the climatological mean of 3.1 m(Rothrock et al., 1999). However, this alarming result did not draw much attention since the Arctic was still severely cold at that time.

Growth of the Sayram Lake and retreat of its water-supplying glaciers in the Tianshan Mountains from 1972 to 2011

Inland lakes and alpine glaciers are important constituents of water resources in arid and semiarid regions. Understanding their variations is critical for both an accurate evaluation of the dynamic changes of water resources and the retrieval of climatic information. On the basis of earlier researches, this study investigated the growth of the Sayram Lake and the retreat of its water-supplying glaciers in the Tianshan Mountains using long-term sequenced remote sensing images. Our results show that over the past 40 years, the surface area and the water level of the lake has increased by 12.0±0.3 km2 and 2.8 m, respectively, and the area of its water-supplying glaciers has decreased continuously since the early 1970s with a total reduction of about–2.13±0.03 km2. Our study has indicative significance to the research of regional climate change.

Preventing roof fall fatalities during pillar recovery:A ground control success story

For decades, pillar recovery accounted for a quarter of all roof fall fatalities in underground coal mines.Studies showed that a miner on a pillar recovery section was at least three times more likely to be killed by a roof fall than other coal miners. Since 2007, however, there has been just one fatal roof fall on a pillar line. This paper describes the process that resulted in this historic achievement. It covers both the key research findings and the ways in which those insights, beginning in the early 2000 s, were implemented in mining practice. One key finding was that safe pillar recovery requires both global and local stability.Global stability is addressed primarily through proper pillar design, and became a major focus after the2007 Crandall Canyon mine disaster. But the most significant improvements resulted from detailed studies that showed that local stability, defined as roof control in the immediate work area, could be achieved with three interventions:(1) leaving an engineered final stump, rather than extracting the entire pillar,(2) enhancing roof bolt support, particularly in intersections, and(3) increasing the use of mobile roof supports(MRS). A final component was an emphasis on better management of pillar recovery operations.This included a focus on worker positioning, as well as on the pillar and lift sequences, MRS operations,and hazard identification. As retreat mines have incorporated these elements into their roof control plans,it has become clear that pillar recovery is not ‘‘inherently unsafe." The paper concludes with a discussion of the challenges that remain, including the problems of rib falls and coal bursts.

ONSET AND RETREAT DATES OF THE SOUTH CHINA SEA SUMMER MONSOON AND THEIR RELATIONSHIPS WITH THE MONSOON INTENSITY IN THE CONTEXT OF CLIMATE WARMING

Global gridded daily mean data from the NCEP/NCAR Reanalysis(1948-2012) are used to obtain the onset date,retreat date and duration time series of the South China Sea summer monsoon(SCSSM) for the past 65 years.The summer monsoon onset(retreat) date is defined as the time when the mean zonal wind at 850 hPa shifts steadily from easterly(westerly) to westerly(easterly) and the pseudo-equivalent potential temperature at the same level remains steady at greater than 335 K(less than 335 K) in the South China Sea area[110-120°E(10-20°N)].The clockwise vortex of the equatorial Indian Ocean region,together with the cross-equatorial flow and the subtropical high,plays a decisive role in the burst of the SCSSM.The onset date of the SCSSM is closely related to its intensity.With late(early) onset of the summer monsoon,its intensity is relatively strong(weak),and the zonal wind undergoes an early(late) abrupt change in the upper troposphere.Climate warming significantly affects the onset and retreat dates of the SCSSM and its intensity.With climate warming,the number of early-onset(-retreat) years of the SCSSM is clearly greater(less),and the SCSSM is clearly weakened.

Subsidence over room and pillar retreat mining in a low coal seam

The objective of this paper is to study the behavior of a low thick and low depth coal seam and the overburden rock mass. The mining method is room and pillar in retreat and partial pillar recovery. The excavation method is conventional drill and blast because of the small production. The partial pillar recovery is about 30% of the previous pillar size, 7 m × 7 m. The roof displacement was monitored during retreat operation; the surface movement was also monitored. The effect of the blasting vibration on the final pillar strength had been considered. Due to blasting, the pillar reduced about 20%. The consequence is more pillar deformation and roof vertical displacement. The pillar retreat and ground movement were simulated in a three-dimensional numerical model. This model was created to predict the surface subsidence and compare to the subsidence measured. This study showed that the remaining pillar and low seam reduce the subsidence that was predicted with conventional methods.

Regional differences in global glacier retreat from 1980 to 2015

Global warming triggers shrinking and thinning of glaciers worldwide,with potentially severe implications for human society.However,regional differences in glacier retreat and its relationship with climatic characteristics have not been conclusively demonstrated.In this study,regional changes in global glaciers based on two primary features,area change and mass balance,were investigated on the basis of data collected from published research on glacier changes.Results show that during the period 1980—2015,the rate of global glacier area shrinkage was 0.18%per year and that of global glacier mass loss was 0.25 m w.e.per year.Retreat of glaciers located at low and middle latitudes was characterized by severe area shrinkage and mass loss.Correspondingly,in the Arctic,deglaciation was characterized by ice thinning due to a low area reduction but relatively high mass loss rate.However,glaciers in high southern latitudes were in a relatively stable status.High Mountain Asia exhibited the lowest rate of area shrinkage and mass loss among glaciers located at low and middle latitudes,and a slower rate of mass loss compared with the global average.Glaciers in the Tropical Andes exhibited the fastest rate of glacier area shrinkage(—1.6%per year),whereas Antarctic and Subantarctic glaciers showed the lowest rate(—0.11%per year).For mass balance,the most negative occurred at Southern Andes(—0.81 m w.e.per year),followed by Alaska(-0.74 m w.e.per year).Only the Antarctic and Subantarctic experienced small mass gain(0.04 m w.e.per year).High levels of correlation are found between the rates of glacier retreat and annual average temperature and annual total precipitation instead of their trends.The variability of the surface climate conditions in the glacier environment plays a key role in driving these regional differences in global glacier retreat.

Burrow Characteristics and Microhabitat Use of the Turpan Wonder Gecko Teratoscincus roborowskii (Squamata, Gekkonidae)

Burrow structural charactersitcs and microhabitat use of the Turpan wonder gecko Teratoscincus roborowskii （Gekkonidae） were studied between April and September of 2013 in the Turpan Eremophytes Botanic Garden, in the Turpan Depression of Western China. Burrow depth, entrance orientation, entrance height and width were observed. We assessed microhabitat selection and noted differences in microhabitat use among males, females, and juveniles. The magnitude of selection was measured using Jacobs＇ index of selectivity. Entrance height and width of the burrows of adults were significantly larger than those of juveniles, but the difference in burrow depth was not significant. The directional orientation of the burrow entrance showed a preference for the north-northeast and south-southeast, which were likely influenced by local prevailing winds and sunlight. Both the adult and juvenile geckos prefer to construct their burrows in sandy soil within a layer of loose soil whose thickness is greater than 30 cm. A majority of the burrows were located within 20 m of the nearest plant. Nearly half （48%） of the entrances of juveniles were located within 5 m of the nearest vegetation, significantly different from those of the adults. Results showed that the Turpan wonder gecko did not utilize microhabitats according to their availability, but rather that it preferred rnicrohabitats which contained dead wood or the caper bush. Our results suggested that burrow characteristics and microhabitat selection were important factors in T. roborowskii adaptation to harsh and arid desert habitats.

Monitoring glaciers in the Chenab basin with SBAS InSAR technology

The Chenab basin is located in northwest India and eastern Pakistan.Glaciers in Chenab basin,as local freshwater resources,are very important to the regional ecological environment and development.At the same time,SBAS InSAR can monitor the deformation of the ground for a long time,the monitoring accuracy can reach mm level,and can obtain the time series change of deformation,whcih provides a new idea and method for glacier detection.In this study,the deformation from SBAS InSAR was combined with glacial area data to study the glacial changes in Chenab Basin.Sentinel-1 and Landsat series images were used to obtain the deformation and change in the area of glaciers by SBAS InSAR and the semi-automated method.The results showed that glaciers in the Chenab basin retreated rapidly,especially in the past ten years.The glacier area decreased by 88.05 km^(2)in 1990~2000 and 118.86 km^(2) in 2000~2010,and the glacier area decreased by 236.01 km^(2) in 2010~2020,which was the largest rate of change of 9.49%.Moreover,glacial deformation decreased in 2020,and the deformation rate ranged from-146.3mm/a to 119.52 mm/a.Most glaciers had deformation rates between-50 mm/a and 50 mm/a.Influenced by precipitation and temperature,glacial deformation in the Chenab basin started to change in August,the maximum accumulation was 6,828.43mm,and the minimum ablation was-20,656.41 mm.

Response of phytoplankton community to different water types in the western Arctic Ocean surface water based on pigment analysis in summer 2008

Nutrients and photosynthesis pigments were investigated in the western Arctic Ocean during the 3rd Chinese Arctic Research Expedition Cruise in summer 2008. The study area was divided into five provinces using the K- means clustering method based on the physical and chemical characteristics of the sea water, and to discuss the distribution of the phytoplankton community structure in these provinces. CHEMTAX software was performed using HPLC pigments to estimate the contributions of eight algal classes to the total chlorophyll a （TChl a）. The results showed that on the Chukchi Shelf, the Pacific Ocean inflow mainly controlled the Chl a biomass and phytoplankton communities by nutrient concentrations. The high nutrient Anadyr Water and Bering Shelf Water （AnW and BSW） controlled region have high Chl a levels and the diatom dominated community structure. In contrast, in the region occupied by low-nutrient like Alaska Coastal Water （ACW）, the Chl a biomass was low, with pico- and nano-phytoplankton as dominated species, such as prasinophytes, chrysophytes and cryptophytes. However, over the off-shelf, the ice cover condition which would affect the physical and nutrient concentrations of the water masses, in consequence had a greater impact on the phytoplankton community structure. Diatom dominated in ice cover region and its contribution to Chl a biomass was up to 75%. In the region dose to the Mendeleev Abyssal Plain （MAP）, controlled by sea-ice melt water with relatively high salinity （MW-HS）, higher nutrient and Chl a concentrations were found and the phytoplankton was dominated by pico- and nano-algae, while the diatom abundance reduced to 33%. In the southern Canada Basin, an ice-free basin （IfB） with the lowest nutrient concentrations and most freshened surface water, low Chl a biomass was a consequence of low nutrients. The ice retreating and a prolonged period of open ocean may not be beneficial to the carbon export efficiency due to reducing the Chl a biomass or intriguing smaller size algae growth.

Mapping of moraine dammed glacial lakes and assessment of their areal changes in the central and eastern Himalayas using satellite data

The relatively rapid recession of glaciers in the Himalayas and formation of moraine dammed glacial lakes(MDGLs) in the recent past have increased the risk of glacier lake outburst floods(GLOF) in the countries of Nepal and Bhutan and in the mountainous territory of Sikkim in India. As a product of climate change and global warming, such a risk has not only raised the level of threats to the habitation and infrastructure of the region, but has also contributed to the worsening of the balance of the unique ecosystem that exists in this domain that sustains several of the highest mountain peaks of the world. This study attempts to present an up to date mapping of the MDGLs in the central and eastern Himalayan regions using remote sensing data, with an objective to analyse their surface area variations with time from 1990 through 2015, disaggregated over six episodes. The study also includes the evaluation for susceptibility of MDGLs to GLOF with the least criteria decision analysis(LCDA). Forty two major MDGLs, each having a lake surface area greater than 0.2 km2, that were identified in the Himalayan ranges of Nepal, Bhutan, and Sikkim, have been categorized according to their surface area expansion rates in space and time. The lakes have been identified as located within the elevation range of 3800 m and6800 m above mean sea level(a msl). With a total surface area of 37.9 km2, these MDGLs as a whole were observed to have expanded by an astonishing 43.6% in area over the 25 year period of this study. A factor is introduced to numerically sort the lakes in terms of their relative yearly expansion rates, based on their interpretation of their surface area extents from satellite imageries. Verification of predicted GLOF events in the past using this factor with the limited field data as reported in literature indicates that the present analysis may be considered a sufficiently reliable and rapid technique for assessing the potential bursting susceptibility of the MDGLs. The analysis also indicates that, as of now, there are eight MDGLs in the region which appear to be in highly vulnerable states and have high chances in causing potential GLOF events anytime in the recent future.

Three-dimensional inlay-guided endodontics applied in variant root canals: A case report and review of literature

BACKGROUND Root canal retreatment is common after root canal therapy in clinical situations.Especially,completing the retreatment of variant root canals can be challenging.This is particularly true for the molars located at the end of the dental arch.However,advancements in digital dental diagnosis and treatment techniques can solve these problems.Here,we describe a case of a maxillary second molar with a variant distobuccal root canal treated via a novel“inlay-guided endodontics”technique based on improved computer-generated programs.CASE SUMMARY A 63-year-old man complained of a defect in the maxillary left second molar.The tooth,diagnosed with post-treatment endodontic disease,was initially treated by conventional methods,which were ineffective.Our“inlay-guided endodontics”technique was subsequently adopted,with the establishment of a precise integrated three-dimensional(3D)plate model of cone-beam computed tomography data and a digital impression of the dentition.An optimal root canal approach was generated for the“virtual file”in the 3D model.The plate data were imported into a 3D printer and printed.With the help of the guide plate,the file was accurately placed into the cervical third of the distal root canal.The root canal and prosthodontic treatments successfully proceeded subsequently.CONCLUSION Our newly developed inlay guide plates may facilitate individualized and minimally invasive root canal treatment.

Follow-up Study of Retreatment TB Patients with Sputum Smear and/or Culture Positive Two Years after They were Declared Cured with First-line Anti-TB Drugs in Shandong Province

This study aimed to learn the recurrence rate in the retreatment TB patients with sputum smear and/or culture positive （ss＋ and/or c＋） two years after they were declared cured, and to explore causes of recurrence in order to improve long-time treatment outcome. 5 cities were selected as research locations. Recurrence of TB was judged by chest X-ray examination together with sputum smear and culture examination.

Heterogeneity of immune control in chronic hepatitis B virus infection:Clinical implications on immunity with interferon-αtreatment and retreatment

Hepatitis B virus(HBV)infection is a global public health issue.Interferon-α(IFN-α)treatment has been used to treat hepatitis B for over 20 years,but fewer than 5%of Asians receiving IFN-αtreatment achieve functional cure.Thus,IFN-αretreatment has been introduced to enhance antiviral function.In recent years,immune-related studies have found that the complex interactions between immune cells and cytokines could modulate immune response networks,including both innate and adaptive immunity,triggering immune responses that control HBV replication.However,heterogeneity of the immune system to control HBV infection,particularly HBV-specific CD8^(+)T cell heterogeneity,has consequential effects on T cell-based immunotherapy for treating HBV infection.Altogether,the host’s genetic variants,negative-feedback regulators and HBV components affecting the immune system's ability to control HBV.In this study,we reviewed the literature on potential immune mechanisms affecting the immune control of HBV and the clinical effects of IFN-αtreatment and retreatment.