Relationship between anal cancer recurrence and cigarette smoking

BACKGROUND The incidence of anal cancer has been increasing in the United States.Smoking is a well-established risk factor;however,the impact of smoking on disease recurrence and outcome has not been well studied.The aim of this study was to assess the association between anal cancer recurrence and cigarette smoking.AIM To investigate the relationship between cigarette smoking status and anal cancer treatment outcome.METHODS The cancer registry from a single,community hospital was screened for patients with anal cancer between 2010 and 2021.The following characteristics were gathered from the database:Age;sex;cigarette smoking history;American Joint Committee on Cancer Clinical Stage Group;response to therapy;recurrence;time to recurrence;mortality;time to death;and length of follow-up.Patients were divided into the following groups:Current smokers;former smokers;and never smokers.SPSSv25.0 software(IBM Corp.,Armonk,NY,United States)was used for statistical analysis.RESULTS A total of 95 patients from the database met the screening criteria.There were 37 never smokers,22 former smokers,and 36 current smokers.There was no difference between groups in regards to race or sex.There was no difference in the American Joint Committee on Cancer Clinical Stage Group between groups.The former smokers were significantly older when compared to never smokers and current smokers(66.5±13.17 vs 57.4±7.82 vs 63.7±13.80,P=0.011).Former smokers and current smokers had a higher recurrence rate compared to never smokers(30.8%and 20.8%compared to zero,P=0.009).There was not a significant difference in recurrence between former smokers and current smokers.There was no difference in the mortality,non-response rate,or time to death between the groups.CONCLUSION Our data contributes evidence that cigarette smoking status is associated with increased recurrence for patients with anal cancer.

Safety and efficacy of surgical treatments for axillary osmidrosis: a retrospective cohort study comparing conventional open excision with cartilage-shaver closed curettage

Aim:The aim of this study was to evaluate the usefulness of suction-assisted cartilage shaver(SACS)system closed curettage by comparing it with open excision regarding safety and efficacy.Methods:A retrospective chart review was conducted for patients with axillary osmidrosis(AO)who underwent either open excision or SACS closed curettage between 2006 and 2018.We investigated the demographic data of patients and compared the postoperative complications and outcomes of the patients undergoing the two procedures.Results:A total of 91 patients underwent SACS closed curettage and 188 patients underwent open excision.The complication rate in the SACS group(10.4%)was significantly lower than that in the open excision group(20.7%).Each procedure led to unsuccessful outcomes for two patients.Conclusion:SACS closed curettage was safer than open excision for AO.Both procedures were extremely effective.Although decision-making for surgical treatment options for AO is affected by such other factors as discomfort in dressing,recovery time,scar formation,and cost,our results should be helpful for both surgeons and patients.