Ingenious liquid-observed vapor exchange (LOVE) NMR method revealing how sugars protect dry protein structure

Recently,Gary et al.published an article elucidating how sugars contribute to the protection of dry protein structure.They utilized an ingenious liquid-observed vapor exchange(LOVE)nuclear magnetic resonance(NMR)method,providing valuable insights into the protection mechanism of sugars during the drying process.The details of their study can be found in the article available at https://doi.org/10.1021/acs.biochem.2c00692.

Revealing the Landform Types and Morphologic Features of Lunar Surface

A lunar geologic map at a scale of 1：5000000 was finished in the 1970s by the National Aeronautics and Space Administration, U.S U.S. Geological Survey. Department of the Interior, Till now, the landform classification system and lunar morphologic mapping have not been clarified. The work aims to put forward a new landform classification system and to obtain index and map in the Sheet H010. Some key morphologic features of lunar surface were compared with those of the Earth. This research is very important for whole lunar morphologic mapping and unraveling evolutionary progress.

Revealing the Pressure-Induced Softening/Weakening Mechanism in Representative Covalent Materials

Diamond, cubic boron nitride(c-BN), silicon(Si), and germanium(Ge), as examples of typical strong covalent materials, have been extensively investigated in recent decades, owing to their fundamental importance in material science and industry. However, an in-depth analysis of the character of these materials' mechanical behaviors under harsh service environments, such as high pressure, has yet to be conducted. Based on several mechanical criteria, the effect of pressure on the mechanical properties of these materials is comprehensively investigated.It is demonstrated that, with respect to their intrinsic brittleness/ductile nature, all these materials exhibit ubiquitous pressure-enhanced ductility. By analyzing the strength variation under uniform deformation, together with the corresponding electronic structures, we reveal for the first time that the pressure-induced mechanical softening/weakening exhibits distinct characteristics between diamond and c-BN, owing to the differences in their abnormal charge-depletion evolution under applied strain, whereas a monotonous weakening phenomenon is observed in Si and Ge. Further investigation into dislocation-mediated plastic resistance indicates that the pressure-induced shuffle-set plane softening in diamond(c-BN), and weakening in Si(Ge), can be attributed to the reduction of antibonding states below the Fermi level, and an enhanced metallization, corresponding to the weakening of the bonds around the slipped plane with increasing pressure, respectively. These findings not only reveal the physical mechanism of pressure-induced softening/weakening in covalent materials, but also highlights the necessity of exploring strain-tunable electronic structures to emphasize the mechanical response in such covalent materials.

BiPh-m-BiDPO as a Hole-Blocking Layer for Organic Light-Emitting Diodes： Revealing Molecular Structure-Properties Relationship

We report a simple hole-blocking material （biphenyl-3,3＇-diyl）bis（diphenylphosphine oxide） （BiPh-m-BiDPO） based on our recent advance. The bis（phosphine oxide） compound shows HOMO/LUMO levels of ∽-6.71/- 2.51 eV. Its phosphorescent spectrum in a solid film features two major emission bands peaking at 2.69 and 2.4eV, corresponding to 0-0 and 01 vibronic transitions, respectively. The measurement of the electron-only devices reveals that BiPh-m-BiDPO possesses electron mobility of 2.28 × 10^-9-3.22× 10^-8cm2 V-1s-1 at E = 2- 5 × 10^5 V/cm. The characterization of the sky blue fluorescent and red phosphorescent pin organic light-emitting diodes （OLEDs） utilizing BiPh-m-BiDPO as the hole blocker shows that its shallow LUMO level as well as the low electron mobility affects significantly the power efficiency and hence operational stability, relative to the luminous efficiency, especially at high luminance. In combination with our recent results, the present study provides an indepth insight on the molecular structure-property correlation in the organic phosphinyl-containing hole-blocking materials.

A Blackish Gingiva Revealing a Metastatic Melanoma of the Oral Mucosa

Background and Objective: Malignant melanoma is the most aggressive skin cancer because it has very strong metastatic power. Endobuccal localization is very rare. Its discovery is often made in the late stage, which leads to a consistently pessimistic diagnostic. We report a case of palatal melanoma at the metastatic stage. Case Report: A 43-year-old woman presented left lateral cervical swelling associated with dyspnea for 5 months. She had regularly taken chewing tobacco for 4 years and had developed blackish gums. The endobuccal examination showed a blackish non-haemorrhagic swelling of 5 cm of the long axis, located at the level of the palatal vault, associated with pigmentation in teeth 21, 22, and 23. The anatomopathological examination confirmed the melanoma. The spreading assessment revealed pleural and hepatic metastasis. The proposed treatment was palliative treatment. The patient died 2 months later. Conclusion: Melanoma of the oral mucosa is a very aggressive tumor. The scarcities of dental care among the Malagasy people exacerbate the delay in diagnosis. Its management is still challenging in Madagascar.

Facebook——Are You Revealing Too Much?

Most young people know what Facebook is:a free-access Internet social networking website popular among teenagers,and adults,too.It was founded by a Harvard University student named Mark Zuckerberg and launched on February 4,2004.

Evolutionary characteristics of export trade network in the Arctic region

The economic potential induced by environmental changes in the Arctic region garnered substantial interest,which positions Arctic trade as a crucial indicator in forecasting the impacts of climate change on the global economy.Nevertheless,attention devoted to the evolving dynamics of trade in the Arctic region remains scarce.In this study,we constructed export trade network in the Arctic region(including Denmark,Finland,Sweden,Norway,Iceland,the Canadian Arctic,the Russian Arctic,Alaska State of the USA,and Greenland)from 1990 to 2019 and analyzed its topology and evolutionary characteristics through complex network theory.We used a structural entropy index based on the distribution of the number of trading partners and the degree of trade concentration to assess export diversity,while we also utilized a revealed comparative advantage index to evaluate product export competitiveness using the share of trade volume of each type of product.The results indicate that the total export trade in the Arctic region increased by 53.4%during 1990-2019,with the most significant growth observed in the exports of chemical products and mineral fuels.The increasing complexity of trade network in the Arctic region resulted in the region’s export destinations no longer being concentrated on a few major countries and regions.The proportion of exports from the Arctic region to Europe decreased by 13.5%,while the proportion of exports from the Arctic region to Asia and North America increased by 6.8%and 3.1%,respectively.The Arctic region exhibited clear distinctions in the range of flows of different products,and its export trade was becoming increasingly diversified.Although differences in comparative advantages between products within individual countries or regions have narrowed,substantial gaps persist.The findings of this study can enhance the comprehensive understanding of the significance and function of Arctic trade activities within the global economy,providing a scientific basis for addressing the associated challenges and opportunities in the context of climate change.

风雨夜中见温情

1 In the midst of a stormy night in North Carolina,where rain was pouring down on tin roofs and darkness enveloped the world,an inspiring tale unfolded.Despite the tempests rage,a homeless man appeared as an unsung hero,revealing the depth of the human spirit and the profound connection between the man and his furry(毛茸茸的)companions.

Single-cell multi-omics analysis revealing immune features of inactivated COVID-19 vaccination in systemic lupus erythematosus patients

Studies have focused on neutralizing antibody titers and T-cell activation induced by vaccination against different SARS-CoV-2strains[1,2].Advanced single-cell technology has allowed for a comprehensive evaluation of immune responses to diverse vaccines,revealing potential antiviral mechanisms[3-5].Patients with rheumatic diseases(RDs)experience dysregulated cellular and humoral immune responses that affect their disease susceptibility,including COVID-19[6].

Revealed comparative advantage and competitiveness of China’s agricultural products

This paper deals with the competitiveness of Chinese agricultural products, base on the index of revealed comparative advantage (RCA) using lots of data for the period of 1980 to 2003. The index is useful in identifying the demarcation between comparative advantage and comparative disadvantage. The research indicates that some agro-products in China such as edible vegetables and tea have a comparative advantage, but the RCA values have been declining over the 24-year period, which has vast impacts on future reform in China’s agricultural structure.

基于身份的可认证多方密钥协商新方案

认证密钥协商协议允许通信方在公开的网络环境里进行认证,并协商一个安全的共享会话密钥。在M cCu llagh-Barreto方案的基础上,提出了一个基于身份的可认证多方密钥协商新方案。引入密钥种子更新临时公私钥对,实现了认证功能,提高了安全性,成功抵抗了Reveal查询攻击和密钥泄漏扮演攻击,且具有无密钥控制、等献性等特性。

《英美文学选读》辅导(18)

Ⅰ.文学常识1. soliloquy - a speech in which an actor, usually alone onstage, utters his or her thought aloud, revealing personal feelings. Hamlet’s 'To be, or not to be' speech is an example.2. foreshadowing - ominous hints of events to come that help to create an air of suspense in a drama.

Coupling effects of coal pillars of thick coal seams in large-space stopes and hard stratum on mine pressure

Concerning the issue of mine pressure behaviors occurred in fully mechanized caving mining of thick coal seams beneath hard stratum in Datong Mining Area, combined with thin and thick plate theory, the paper utilizes theoretical analysis, similar experiments, numerical simulations and field tests to study the influence of remaining coal pillars in Jurassic system goaf on hard stratum fractures, as well as mine pressure behaviors under their coupling effects. The paper concludes the solution formula of initial fault displacement in hard stratum caused by remaining coal pillars. Experiments prove that coupling effects can enhance mine pressure behaviors on working faces. When inter-layer inferior key strata fractures, mine pressure phenomenon such as significant roof weighting steps and increasing resistance in support.When inter-layer superior key strata fractures, the scope of overlying strata extends to Jurassic system goaf, dual-system stopes cut through, and remaining coal pillars lose stability. As a result, the bottom inferior key strata also lose stability. It causes huge impacts on working face, and the second mine pressure behaviors. These phenomena provide evidence for research on other similar mine strata pressure behaviors occurred in dual-system mines with remaining coal pillars.

Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 （FNDC5） protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue （WAT） and uncoupling protein I （UCP1） expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal （IP） administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand （RANKL）- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.

Comparative Genomic Analysis of Enterovirus 71 Revealed Six New Potential Neurovirulence-associated Sites

In the present study,the complete genomes of four common（4/EV71/Wenzhou/CHN/2014,15/EV71/Wenzhou/CHN/2014,116/EV71/Wenzhou/CHN/2014,and 120/EV71/Wenzhou/CHN/2014）and two virulent（11/EV71/Wenzhou/CHN/2014and 109/EV71/Wenzhou/CHN/2014）enterovirus 71（EV71）isolates were sequenced and described.They are 7405 bp in length and belong to EV71 sub-genotype C4 （C4a cluster）.

Angiography reveals early hiding iris neovascularization after ischemic CRVO

Dear Sir, I am Dr. Zhi-Qing Li from Tianjin Medical University Eye Hospital, Tianjin City, China. I write to present a case with hiding iris neovascularization (INV) following central retinal vein occlusion (CRVO) can be detected early by iris angiography (IA) and neovascular glaucoma (NVG) was

Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice

Cre/loxP technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmpl- Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmpl gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in 2-month-old mice, Dmpl-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction. In the bone marrow, Cre activity is evident in certain stromal cells adjacent to the blood vessels, but not in adipocytes. Outside the skeleton, Dmpl-Cre marks not only the skeletal muscle fibers, certain cells in the cerebellum and the hindbrain but also gastric and intestinal mesenchymal cells that express Pdgfra. Confirming the utility of Dmpl-Cre in the gastrointestinal mesenchyme, deletion of Bmprla with Dmpl-Cre causes numerous large polyps along the gastrointestinal tract, consistent with prior work involving inhibition of BMP signaling. Thus, caution needs to be exercised when using Dmpl-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types.

The Three Page Guide to the Most Important Results of M. S. El Naschie’s Research in E-Infinity Quantum Physics and Cosmology

In this short survey, we give a complete list of the most important results obtained by El Naschie’s E-infinity Cantorian space-time theory in the realm of quantum physics and cosmology. Special attention is paid to his recent result on dark energy and revising Einstein’s famous formula .

Mutagenesis reveals that the rice OsMPT3 gene is an important osmotic regulatory factor

Plant mitochondrial phosphate transporters regulate phosphate transport and ATP synthesis. Determining whether they function in abiotic stress response process would shed light on their response to salt stress. We used the CRISPR/Cas9 gene-editing system to mutagenize two mitochondrial phosphate transporters, OsMPT3;1 and OsMPT3;2, to investigate their regulatory roles under salt stress. Two cas9(CRISPR-associated protein9)-free homozygous mutants, mpt33 and mpt30, were confirmed to be stable. Both OsMPT3;1 and OsMPT3;2 were markedly induced by salt stress, and their mutagenesis strongly inhibited growth and development, especially under salt stress. Mutagenesis sharply reduced the accumulation of ATP, phosphate, calcium, soluble sugar, and proline and increased osmotic potential, malondialdehyde, and Na^+ /K^+ ratio under salt stress. Both mutants demonstrate normal growth and development in the presence of ATP, revealing high sensitivity to exogenous ATP under salt stress. The mutants showed lowered rates of Na^+ efflux but also of K^+ and Ca^(2+) influx under salt stress. Mutagenesis of OsMPT3;2 altered the enrichment profiles of differentially expressed genes involved mainly in synthesis of secondary metabolites, metabolism of glycolysis, pyruvate, tricarboxylic acid cycle, in response to salt stress. The mutant displayed significant accumulation differences in 14 metabolites involved in 17 metabolic pathways, and strongly up-regulated the accumulation of glutamine, a precursor in proline synthesis, under salt stress. These findings suggest that the OsMPT3 gene modulates phosphate transport and energy supply for ATP synthesis and triggers changes in accumulation of ions and metabolites participating in osmotic regulation in rice under salt stress, thus increasing rice salt tolerance. This study demonstrates the effective application of CRISPR/Cas9 gene-editing to the investigation of plant functional genes.