Numerical analysis for the free-boundary current reversal equilibrium in the AC plasma current operation in a tokamak

In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary equilibrium code is developed to investigate such advanced tokamak discharges with current reversal equilibrium configuration. The calculation results show that the reversal current equilibrium can maintain finite pressure and also has considerable effects on the position of the X-point and the magnetic separatrix shape, and hence also on the position of the strike point on the divertor plates, which is extremely useful for magnetic design, MHD stability analysis, and experimental data analysis etc. for the AC plasma current operation on tokamaks.

Protected simultaneous quantum remote state preparation scheme by weak and reversal measurements in noisy environments

We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.

Honeymoon phase in type 1 diabetes mellitus: A window of opportunity for diabetes reversal?

The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.

Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular block.This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular block.CASE SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus nephropathy.She developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular block.Then,she underwent parathyroidectomy(PTX)with autotransplantation.Unfortunately,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was reversed.CONCLUSION This case revealed that metastatic cardiac calcification can result in complete atrioventricular blockage.Following parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular block.It is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

Efficacy of cognitive-behavioral therapy combined with habit reversal training on anxiety disorders in children with Tourette’s syndrome

BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.

Investigation of magnetization reversal and domain structures in perpendicular synthetic antiferromagnets by first-order reversal curves and magneto-optical Kerr effect

Perpendicular synthetic-antiferromagnet(p-SAF) has broad applications in spin-transfer-torque magnetic random access memory and magnetic sensors. In this study, the p-SAF films consisting of (Co/Ni)3]/Ir(tIr)/[(Ni/Co)3are fabricated by magnetron sputtering technology. We study the domain structure and switching field distribution in p-SAF by changing the thickness of the infrared space layer. The strongest exchange coupling field(Hex) is observed when the thickness of Ir layer(tIr) is 0.7 nm and becoming weak according to the Ruderman–Kittel–Kasuya–Yosida-type coupling at 1.05 nm,2.1 nm, 4.55 nm, and 4.9 nm in sequence. Furthermore, the domain switching process between the upper Co/Ni stack and the bottom Co/Ni stack is different because of the antiferromagnet coupling. Compared with ferromagnet coupling films, the antiferromagnet samples possess three irreversible reversal regions in the first-order reversal curve distribution.With tIrincreasing, these irreversible reversal regions become denser and smaller. The results from this study will help us understand the details of the magnetization reversal process in the p-SAF.

A novel power-combination method using a time-reversal pulse-compression technique

The electromagnetic time-reversal(TR)technique has the characteristics of spatiotemporal focusing in a time-reversal cavity(TRC),which can be used for pulse compression,thus forming an electromagnetic pulse with high peak power.A time-reversed pulse-compression method in a single channel has high pulse compression gain.However,single channel pulse compression can only generate limited gain.This paper proposes a novel TR power-combination method in a multichannel TRC to obtain higher peak power based on TR pulse-compression theory.First,the TR power-combination model is given,and the crosstalk properties of the associated channel and the influence of the reversal performance are studied.Then,the power-combination performances for the TR pulse compression,such as combined signal to noise ratio(SNR)and combined compression gain,are analyzed by numerical simulation and experimental methods.The results show that the proposed method has obvious advantages over pulse-compression methods using a single channel cavity,and is more convenient for power combination.

Micro-Sized Pinhole Inspection with Segmented Time Reversal and High-Order Modes Cluster Lamb Waves Based on EMATs

Pinhole corrosion is difficult to discover through conventional ultrasonic guided waves inspection,particularly for micro-sized pinholes less than 1 mm in diameter.This study proposes a new micro-sized pinhole inspection method based on segmented time reversal(STR)and high-order modes cluster(HOMC)Lamb waves.First,the principle of defect echo enhancement using STR is introduced.Conventional and STR inspection experiments were conducted on aluminum plates with a thickness of 3 mm and defects with different diameters and depths.The parameters of the segment window are discussed in detail.The results indicate that the proposed method had an amplitude four times larger than of conventional ultrasonic guided waves inspection method for pinhole defect detection and could detect micro-sized pinhole defects as small as 0.5 mm in diameter and 0.5 mm in depth.Moreover,the segment window location and width(5-10 times width of the conventional excitation signal)did not affect the detection sensitivity.The combination of low-power and STR is more conducive to detection in different environments,indicating the robustness of the proposed method.Compared with conventional ultrasonic guided wave inspection methods,the proposed method can detect much smaller defect echoes usually obscured by noise that are difficult to detect with a lower excitation power and thus this study would be a good reference for pinhole defect detection.

Periodical polarization reversal modulation in multiferroic MnWO_(4) under high magnetic fields

We report polarization reversal periodically controlled by the electric field in multiferroic MnWO_(4) with a pulsed field up to 52 T.The electric polarization cannot be reversed by successive opposite electric fields in low magnetic fields(<14 T)at 4.2 K,whereas polarization reversal is directly achieved by two opposite electric fields under high magnetic fields(<45 T).Interestingly,the polarization curve of rising and falling fields for H∥u(magnetic easy axis)is irreversible when the magnetic field is close to 52 T.In this case,the rising and falling polarization curves can be individually reversed by the electric field,and thus require five cycles to recover to the initial condition by the order of the applied electric fields(+E,-E,-E,+E,+E).In addition,we find that ferroelectric phaseⅣcan be tuned from parallel to antiparallel in relation to ferroelectric phase AF2 by applying a magnetic field approximated to the c axis.

Parameter estimation of LFM signals based on time reversal

In this paper,parameter estimation of linear frequency modulation(LFM)signals containing additive white Gaussian noise is studied.Because the center frequency estimation of an LFM signal is affected by the error propagation effect,resulting in a higher signal to noise ratio(SNR)threshold,a parameter estimation method for LFM signals based on time reversal is proposed.The proposed method avoids SNR loss in the process of estimating the frequency,thus reducing the SNR threshold.The simulation results show that the threshold is reduced by 5 dB compared with the discrete polynomial transform(DPT)method,and the root-mean-square error(RMSE)of the proposed estimator is close to the Cramer-Rao lower bound(CRLB).

Current bifurcation, reversals and multiple mobility transitions of dipole in alternating electric fields

Anomalous transports of dipole in alternating electric fields are investigated by means of numerical calculation of its average angular velocity(or current). Our results show that the alternating electric fields can make the dipole exhibit many interesting transport behaviors. There exist current bifurcation and multiple current reversal phenomena about frequency of the alternating electric fields in the system in the absence of constant bias force, while many platforms appear in the curve of its average angular velocity vs. the force, i.e., multiple mobility transitions phenomenon in the presence of the constant force, dependent on frequencies of the alternating electric fields. Further investigation indicates that the multiple mobility transitions are attributed to the traveling forces on the dipole. Intrinsic physical mechanism and conditions for the characteristic dynamical behaviors to occur are also discussed in detail. These findings will possess crucial significance for optimizing heating control in the alternating electric fields.

Effects of Different Feedback Conditions on Sensorimotor Adaptation Revealed in a Mirror Reversal Paradigm

Humans are able to overcome sensory perturbations imposed on their movements through motor learning. One of the key mechanisms to accomplish this is sensorimotor adaptation, an implicit, error-driven learning mechanism. Past work on sensorimotor adaptation focused mainly on adaptation to rotated visual feedback—A paradigm known as visuomotor rotation. Recent studies have shown that sensorimotor adaptation can also occur under mirror-reversed visual feedback. In visuomotor rotation, sensorimotor adaptation can be driven by both endpoint and online feedback [1] [2]. However, it’s not been clear whether both kinds of feedback can similarly drive adaptation under a mirror reversed perturbation. We performed a study to establish what kinds of feedback can drive adaptation under mirror reversal. In the first two conditions, the participants were asked to ignore visual feedback. In the first condition, we provided mirror reversed online feedback and endpoint feedback. We reproduced previous findings showing that online feedback elicited adaptation under mirror reversal. In a second condition, we provided mirror reversed endpoint feedback. However, in the second condition, we found that endpoint feedback alone failed to elicit adaptation. In a third condition, we provided both types of feedback at the same time, but in a conflicting way: endpoint feedback was non-reversed while online feedback was mirror reversed. The participants were asked to ignore online visual feedback and try to hit the target with help from veridical endpoint feedback. In the third condition, in which veridical endpoint feedback and mirror reversed online feedback were provided, adaptation still occurred. Our results showed that endpoint feedback did not elicit adaptation under mirror reversal but online feedback did. This dissociation between effects of endpoint feedback and online feedback on adaptation under mirror reversal suggests that adaptation under these different kinds of feedback might in fact operate via distinct mechanisms.

Comparative Study of Linear Variable Flux Reluctance Machine with Linear Wound Field Flux Reversal Machine

As members of doubly salient magnetless linear machines,linear variable flux reluctance(LVFR)and wound field flux reversal(LWFFR)machines inherit the merits of conventional magnetless linear machines such as low cost,high flux adjustment capability and high reliability.Furthermore,like linear switched reluctance machine,they have a very simple and compact long secondary,which are very attractive for long stroke applications.However,low force capability is their major defect.To solve this issue,new LVFR and LWFFR machine topologies were proposed in recent work,while lacking studies on their force improvement mechanism and further force evaluation.In this paper,LVFR and LWFFR machines with improved force performance are comparatively studied with the emphasis on their force capabilities.The operation principle of the two machines is analyzed based on magnetic field harmonics produced by flux modulation.Contributions of air-gap flux density harmonic components to no-load back electromagnetic forces of the two machines are analyzed and the average force equation is derived.Moreover,force capabilities of the both machines are investigated by means of the time-stepping finite-element analysis to verify the theoretical analysis.

Expert Consensus on Clinical Management of T2DM Combined with Obesity Reversal Treatment in China(2023 Edition)

With lifestyle changes,the incidence of type 2 diabetes(T2DM)and obesity has significantly increased,becoming major chronic diseases that seriously threaten the health of China’s residents.Both domestic and international guidelines and consensus exist regarding the diagnosis and management of this disease.In recent years,T2DM treatment has focused more on new tactics that lean towards a patient-centered comprehensive management approach,replacing the traditional glucose-centered approach.Additionally,an increasing amount of evidence in medicine suggests that the reversal of diabetes is possible.However,there is currently no expert consensus on the clinical management of T2DM combined with obesity reversal treatment.Therefore,experts and scholars in China with extensive experience in T2DM combined with obesity reversal treatment have been invited to develop this consensus.The content includes early identification and diagnosis of T2DM combined with obesity,definition and mechanisms of diabetes reversal,disease assessment and grading,staging of diabetes and goals of reversal,the 2+N reversal strategy,inpatient system treatment combined with comprehensive outpatient management(including weight control,precise nutrition,scientific exercise,glucose-lowering medication,psychological intervention,rehabilitation therapy,and remote follow-up through online platforms),and evaluation of post-reversal efficacy.The aim is to further improve the level of T2DM combined with obesity reversal diagnosis,treatment,and management in China,and to implement the Healthy China strategy.

Efficient hybrid method for time reversal superresolution imaging

An efficient hybrid time reversal（TR） imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated by the transmitting-mode decomposition of the TR operator（DORT） method employing the signal subspace. Then, the TR multiple signal classification（TR-MUSIC）method employing the noise subspace is used in the estimated target area to get the superresolution imaging of targets. Two examples with homogeneous and inhomogeneous background mediums are considered, respectively. The results show that the proposed hybrid method has advantages in CPU time and memory cost because of the combination of rough and fine imaging.

他汀预防心血管疾病的新阶段—从REVERSAL到PROVE-IT

本期JAMA发表了强化降脂逆转动脉粥样硬化(Reversal of Athrosclerosis with Aggressive Lipid Lowerig，REVERSAL)试验的结果，并同时刊出了Sacks的评论——“高强度他汀治疗冠心病”。

Impacts of the Autumn Arctic Sea Ice on the Intraseasonal Reversal of the Winter Siberian High

During 1979–2015, the intensity of the Siberian high(SH) in November and December–January(DJ) is frequently shown to have an out-of-phase relationship, which is accompanied by opposite surface air temperature and circulation anomalies.Further analyses indicate that the autumn Arctic sea ice is important for the phase reversal of the SH. There is a significantly positive(negative) correlation between the November(DJ) SH and the September sea ice area(SIA) anomalies. It is suggested that the reduction of autumn SIA induces anomalous upward surface turbulent heat flux(SHF), which can persist into November, especially over the Barents Sea. Consequently, the enhanced eddy energy and wave activity flux are transported to mid and high latitudes. This will then benefit the development of the storm track in northeastern Europe. Conversely, when downward SHF anomalies prevail in DJ, the decreased heat flux and suppressed eddy energy hinder the growth of the storm track during DJ over the Barents Sea and Europe. Through the eddy–mean flow interaction, the strengthened(weakened)storm track activities induce decreased(increased) Ural blockings and accelerated(decelerated) westerlies, which makes the cold air from the Arctic inhibited(transported) over the Siberian area. Therefore, a weaker(stronger) SH in November(DJ) occurs downstream. Moreover, anomalously large snowfall may intensify the SH in DJ rather than in November. The ensemble-mean results from the CMIP5 historical simulations further confirm these connections. The different responses to Arctic sea ice anomalies in early and middle winter set this study apart from earlier ones.

Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription

AIM: To interfere with the activation of nuclear factor-κB(NF-κB) with metformin and explore its effect in reversing multidrug resistance(MDR) of hepatocellular carcinoma(HCC) cells.METHODS: Expression of P-glycoprotein(P-gp) and NF-κB in human HepG 2 or HepG 2/adriamycin(ADM) cells treated with pC MV-NF-κB-small interference RNA(siR NA) with or without metformin, was analyzed by Western blot or fluorescence quantitative PCR. Cell viability was tested by CCK-8 assay. Cell cycle and apoptosis were measured by flow cytometry and Annexin-V-PE/7-AnnexinV apoptosis detection double staining assay, respectively. RESULTS: P-gp overexpression in HepG 2 and HepG 2/ADM cells was closely related to mdr1 mR NA(3.310 ± 0.154) and NF-κB mR NA(2.580 ± 0.040) expression. NF-κB gene transcription was inhibited by specific siR NA with significant down-regulation of P-gp and enhanced HCC cell chemosensitivity to doxorubicin. After pretreatment with metformin, Hep G2/ADM cells were sensitized to doxorubicin and P-gp was decreased through the NF-κB signaling pathway. The synergistic effect of metformin and NF-κB siR NA were found in HepG 2/ADM cells with regard to proliferation inhibition, cell cycle arrest and inducing cell apoptosis. CONCLUSION: Metformin via silencing NF-κB signaling could effectively reverse MDR of HCC cells by downregulating MDR1/P-gp expression.

NEAR-FIELD SOURCE LOCALIZATION METHOD AND APPLICATION USING THE TIME REVERSAL MIRROR TECHNIQUE

In order to develop the acoustic keyboard for Personal Computer(PC),it is necessary to seek high-precision near-field source localization algorithm for identifying the keyboard characters.First of all,the focusing property of Time Reversal Mirror(TRM) is introduced,and then a mathe-matical model of microphone array receiving typing sound is established according to the realization of acoustic keyboard from which the TRM localization algorithm is carried out.The results through computer simulation show that the localization Root Mean Square Error(RMSE) performance of the algorithm can reach 10-3,which demonstrates that the algorithm possesses a high accuracy for the actual near-field acoustic source localization,with potential of developing the computer acoustic keyboard.Furthermore,for the purpose of testing its effect on actual near-field source localization,we organize three experiments for acoustic keyboard characters localization.The experiment results show that the positioning error of TRM algorithm is less than 1 cm within a provided acoustic keyboard region.This will provide theoretical guidance for the further research of computer acoustic keyboard.