In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary eq...In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary equilibrium code is developed to investigate such advanced tokamak discharges with current reversal equilibrium configuration. The calculation results show that the reversal current equilibrium can maintain finite pressure and also has considerable effects on the position of the X-point and the magnetic separatrix shape, and hence also on the position of the strike point on the divertor plates, which is extremely useful for magnetic design, MHD stability analysis, and experimental data analysis etc. for the AC plasma current operation on tokamaks.展开更多
We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is know...We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.展开更多
In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in strata.The seabed sediments could be liquefied under storm waves.A laboratory wave flume exper...In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in strata.The seabed sediments could be liquefied under storm waves.A laboratory wave flume experiment demonstrated that storm-induced liquefaction deposits are formed by the oscillations of liquefied sediments.In this paper,the particle size distribution and ^(210)Pb_(ex) specific activity of the sediment samples from the liquefaction disturbed zone and adjacent stable zone of the Yellow River Delta were tested.The stratigraphic divisions based on storm liquefaction deposit sequence can effectively explain the vertical changes in particle size and ^(210)Pb_(ex) specific activity.Due to the differentiation of particles during the storm induced liquefaction,coarse and fine particles regrouped,which could explain the phenomenon of time-reversal in dating data.展开更多
The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic st...The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.展开更多
BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart ...BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular block.This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular block.CASE SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus nephropathy.She developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular block.Then,she underwent parathyroidectomy(PTX)with autotransplantation.Unfortunately,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was reversed.CONCLUSION This case revealed that metastatic cardiac calcification can result in complete atrioventricular blockage.Following parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular block.It is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.展开更多
BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after s...BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma reversal.No studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications separately.AIM To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with RC.METHODS This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September 2022.Continuous variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was used.Univariate and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related complications.RESULTS The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(P<0.01),greater blood loss(P=0.017),and longer operative times(P<0.01)were more likely to experience postoperative complications.The incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(P<0.01),preoperative comorbid hypertension(P=0.049),time from primary surgery to ileostomy reversal(P<0.01)and longer operation time(P=0.010)were more likely to result in stomarelated complications postoperatively.Multivariate logistic regression analysis revealed that a lower preoperative albumin level(P<0.01,OR=0.888,95%CI:0.828-0.958)was an independent risk factor for overall complications.Moreover,multivariate analysis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related complications after stoma reversal.CONCLUSION The preoperative albumin level was a predictor of overall complications.Preoperative BMI and the time from primary surgery to ileostomy reversal were predictors of stoma-related complications.展开更多
BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical...BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.展开更多
Perpendicular synthetic-antiferromagnet(p-SAF) has broad applications in spin-transfer-torque magnetic random access memory and magnetic sensors. In this study, the p-SAF films consisting of (Co/Ni)3]/Ir(tIr)/[(Ni/Co)...Perpendicular synthetic-antiferromagnet(p-SAF) has broad applications in spin-transfer-torque magnetic random access memory and magnetic sensors. In this study, the p-SAF films consisting of (Co/Ni)3]/Ir(tIr)/[(Ni/Co)3are fabricated by magnetron sputtering technology. We study the domain structure and switching field distribution in p-SAF by changing the thickness of the infrared space layer. The strongest exchange coupling field(Hex) is observed when the thickness of Ir layer(tIr) is 0.7 nm and becoming weak according to the Ruderman–Kittel–Kasuya–Yosida-type coupling at 1.05 nm,2.1 nm, 4.55 nm, and 4.9 nm in sequence. Furthermore, the domain switching process between the upper Co/Ni stack and the bottom Co/Ni stack is different because of the antiferromagnet coupling. Compared with ferromagnet coupling films, the antiferromagnet samples possess three irreversible reversal regions in the first-order reversal curve distribution.With tIrincreasing, these irreversible reversal regions become denser and smaller. The results from this study will help us understand the details of the magnetization reversal process in the p-SAF.展开更多
The electromagnetic time-reversal(TR)technique has the characteristics of spatiotemporal focusing in a time-reversal cavity(TRC),which can be used for pulse compression,thus forming an electromagnetic pulse with high ...The electromagnetic time-reversal(TR)technique has the characteristics of spatiotemporal focusing in a time-reversal cavity(TRC),which can be used for pulse compression,thus forming an electromagnetic pulse with high peak power.A time-reversed pulse-compression method in a single channel has high pulse compression gain.However,single channel pulse compression can only generate limited gain.This paper proposes a novel TR power-combination method in a multichannel TRC to obtain higher peak power based on TR pulse-compression theory.First,the TR power-combination model is given,and the crosstalk properties of the associated channel and the influence of the reversal performance are studied.Then,the power-combination performances for the TR pulse compression,such as combined signal to noise ratio(SNR)and combined compression gain,are analyzed by numerical simulation and experimental methods.The results show that the proposed method has obvious advantages over pulse-compression methods using a single channel cavity,and is more convenient for power combination.展开更多
In this paper,parameter estimation of linear frequency modulation(LFM)signals containing additive white Gaussian noise is studied.Because the center frequency estimation of an LFM signal is affected by the error propa...In this paper,parameter estimation of linear frequency modulation(LFM)signals containing additive white Gaussian noise is studied.Because the center frequency estimation of an LFM signal is affected by the error propagation effect,resulting in a higher signal to noise ratio(SNR)threshold,a parameter estimation method for LFM signals based on time reversal is proposed.The proposed method avoids SNR loss in the process of estimating the frequency,thus reducing the SNR threshold.The simulation results show that the threshold is reduced by 5 dB compared with the discrete polynomial transform(DPT)method,and the root-mean-square error(RMSE)of the proposed estimator is close to the Cramer-Rao lower bound(CRLB).展开更多
Pinhole corrosion is difficult to discover through conventional ultrasonic guided waves inspection,particularly for micro-sized pinholes less than 1 mm in diameter.This study proposes a new micro-sized pinhole inspect...Pinhole corrosion is difficult to discover through conventional ultrasonic guided waves inspection,particularly for micro-sized pinholes less than 1 mm in diameter.This study proposes a new micro-sized pinhole inspection method based on segmented time reversal(STR)and high-order modes cluster(HOMC)Lamb waves.First,the principle of defect echo enhancement using STR is introduced.Conventional and STR inspection experiments were conducted on aluminum plates with a thickness of 3 mm and defects with different diameters and depths.The parameters of the segment window are discussed in detail.The results indicate that the proposed method had an amplitude four times larger than of conventional ultrasonic guided waves inspection method for pinhole defect detection and could detect micro-sized pinhole defects as small as 0.5 mm in diameter and 0.5 mm in depth.Moreover,the segment window location and width(5-10 times width of the conventional excitation signal)did not affect the detection sensitivity.The combination of low-power and STR is more conducive to detection in different environments,indicating the robustness of the proposed method.Compared with conventional ultrasonic guided wave inspection methods,the proposed method can detect much smaller defect echoes usually obscured by noise that are difficult to detect with a lower excitation power and thus this study would be a good reference for pinhole defect detection.展开更多
We report polarization reversal periodically controlled by the electric field in multiferroic MnWO_(4) with a pulsed field up to 52 T.The electric polarization cannot be reversed by successive opposite electric fields...We report polarization reversal periodically controlled by the electric field in multiferroic MnWO_(4) with a pulsed field up to 52 T.The electric polarization cannot be reversed by successive opposite electric fields in low magnetic fields(<14 T)at 4.2 K,whereas polarization reversal is directly achieved by two opposite electric fields under high magnetic fields(<45 T).Interestingly,the polarization curve of rising and falling fields for H∥u(magnetic easy axis)is irreversible when the magnetic field is close to 52 T.In this case,the rising and falling polarization curves can be individually reversed by the electric field,and thus require five cycles to recover to the initial condition by the order of the applied electric fields(+E,-E,-E,+E,+E).In addition,we find that ferroelectric phaseⅣcan be tuned from parallel to antiparallel in relation to ferroelectric phase AF2 by applying a magnetic field approximated to the c axis.展开更多
Anomalous transports of dipole in alternating electric fields are investigated by means of numerical calculation of its average angular velocity(or current). Our results show that the alternating electric fields can m...Anomalous transports of dipole in alternating electric fields are investigated by means of numerical calculation of its average angular velocity(or current). Our results show that the alternating electric fields can make the dipole exhibit many interesting transport behaviors. There exist current bifurcation and multiple current reversal phenomena about frequency of the alternating electric fields in the system in the absence of constant bias force, while many platforms appear in the curve of its average angular velocity vs. the force, i.e., multiple mobility transitions phenomenon in the presence of the constant force, dependent on frequencies of the alternating electric fields. Further investigation indicates that the multiple mobility transitions are attributed to the traveling forces on the dipole. Intrinsic physical mechanism and conditions for the characteristic dynamical behaviors to occur are also discussed in detail. These findings will possess crucial significance for optimizing heating control in the alternating electric fields.展开更多
Humans are able to overcome sensory perturbations imposed on their movements through motor learning. One of the key mechanisms to accomplish this is sensorimotor adaptation, an implicit, error-driven learning mechanis...Humans are able to overcome sensory perturbations imposed on their movements through motor learning. One of the key mechanisms to accomplish this is sensorimotor adaptation, an implicit, error-driven learning mechanism. Past work on sensorimotor adaptation focused mainly on adaptation to rotated visual feedback—A paradigm known as visuomotor rotation. Recent studies have shown that sensorimotor adaptation can also occur under mirror-reversed visual feedback. In visuomotor rotation, sensorimotor adaptation can be driven by both endpoint and online feedback [1] [2]. However, it’s not been clear whether both kinds of feedback can similarly drive adaptation under a mirror reversed perturbation. We performed a study to establish what kinds of feedback can drive adaptation under mirror reversal. In the first two conditions, the participants were asked to ignore visual feedback. In the first condition, we provided mirror reversed online feedback and endpoint feedback. We reproduced previous findings showing that online feedback elicited adaptation under mirror reversal. In a second condition, we provided mirror reversed endpoint feedback. However, in the second condition, we found that endpoint feedback alone failed to elicit adaptation. In a third condition, we provided both types of feedback at the same time, but in a conflicting way: endpoint feedback was non-reversed while online feedback was mirror reversed. The participants were asked to ignore online visual feedback and try to hit the target with help from veridical endpoint feedback. In the third condition, in which veridical endpoint feedback and mirror reversed online feedback were provided, adaptation still occurred. Our results showed that endpoint feedback did not elicit adaptation under mirror reversal but online feedback did. This dissociation between effects of endpoint feedback and online feedback on adaptation under mirror reversal suggests that adaptation under these different kinds of feedback might in fact operate via distinct mechanisms.展开更多
As members of doubly salient magnetless linear machines,linear variable flux reluctance(LVFR)and wound field flux reversal(LWFFR)machines inherit the merits of conventional magnetless linear machines such as low cost,...As members of doubly salient magnetless linear machines,linear variable flux reluctance(LVFR)and wound field flux reversal(LWFFR)machines inherit the merits of conventional magnetless linear machines such as low cost,high flux adjustment capability and high reliability.Furthermore,like linear switched reluctance machine,they have a very simple and compact long secondary,which are very attractive for long stroke applications.However,low force capability is their major defect.To solve this issue,new LVFR and LWFFR machine topologies were proposed in recent work,while lacking studies on their force improvement mechanism and further force evaluation.In this paper,LVFR and LWFFR machines with improved force performance are comparatively studied with the emphasis on their force capabilities.The operation principle of the two machines is analyzed based on magnetic field harmonics produced by flux modulation.Contributions of air-gap flux density harmonic components to no-load back electromagnetic forces of the two machines are analyzed and the average force equation is derived.Moreover,force capabilities of the both machines are investigated by means of the time-stepping finite-element analysis to verify the theoretical analysis.展开更多
With lifestyle changes,the incidence of type 2 diabetes(T2DM)and obesity has significantly increased,becoming major chronic diseases that seriously threaten the health of China’s residents.Both domestic and internati...With lifestyle changes,the incidence of type 2 diabetes(T2DM)and obesity has significantly increased,becoming major chronic diseases that seriously threaten the health of China’s residents.Both domestic and international guidelines and consensus exist regarding the diagnosis and management of this disease.In recent years,T2DM treatment has focused more on new tactics that lean towards a patient-centered comprehensive management approach,replacing the traditional glucose-centered approach.Additionally,an increasing amount of evidence in medicine suggests that the reversal of diabetes is possible.However,there is currently no expert consensus on the clinical management of T2DM combined with obesity reversal treatment.Therefore,experts and scholars in China with extensive experience in T2DM combined with obesity reversal treatment have been invited to develop this consensus.The content includes early identification and diagnosis of T2DM combined with obesity,definition and mechanisms of diabetes reversal,disease assessment and grading,staging of diabetes and goals of reversal,the 2+N reversal strategy,inpatient system treatment combined with comprehensive outpatient management(including weight control,precise nutrition,scientific exercise,glucose-lowering medication,psychological intervention,rehabilitation therapy,and remote follow-up through online platforms),and evaluation of post-reversal efficacy.The aim is to further improve the level of T2DM combined with obesity reversal diagnosis,treatment,and management in China,and to implement the Healthy China strategy.展开更多
Aim To analyze the transient speciality of nonlinear, anisotropic, AC+DC coupling electric field, and to compare the withstand voltage strength of different insulation structures. Methods The transient process o...Aim To analyze the transient speciality of nonlinear, anisotropic, AC+DC coupling electric field, and to compare the withstand voltage strength of different insulation structures. Methods The transient process of polarity reversal is analyzed, considering the anisotropic property of oil immersed press board, a new finite element model based on Galerkin method is presented and verified. The model developed is applied to calculate the electric field distribution in four typical winding end structures of the converter transformer. Results\ The whole ring structure possesses the best insulation characteristics. Conclusion\ By introducing reasonable insulation components, insulation strength with the same surrounding sizes can be improved more than 30%.展开更多
An efficient hybrid time reversal(TR) imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated b...An efficient hybrid time reversal(TR) imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated by the transmitting-mode decomposition of the TR operator(DORT) method employing the signal subspace. Then, the TR multiple signal classification(TR-MUSIC)method employing the noise subspace is used in the estimated target area to get the superresolution imaging of targets. Two examples with homogeneous and inhomogeneous background mediums are considered, respectively. The results show that the proposed hybrid method has advantages in CPU time and memory cost because of the combination of rough and fine imaging.展开更多
In this paper, a new method of time reversal for defect diagnosis of concealed structure has been proposed based on the detecting technique of structure acoustic wave and the theory of time reversal. The time reversal...In this paper, a new method of time reversal for defect diagnosis of concealed structure has been proposed based on the detecting technique of structure acoustic wave and the theory of time reversal. The time reversal recurrence formula for detecting the acoustic wave speed constitution of concealed structures with bilevel asynchronous test has been established. The wave speed constitution can be reconstructed in 2 D graticule form by means of this method. The result of model test shows the method is valid.展开更多
基金supported by National Natural Science Foundation of China (No. 12075276)partly by the Comprehensive Research Facility for Fusion Technology Program of China (No. 2018000052-73-01-001228)。
文摘In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary equilibrium code is developed to investigate such advanced tokamak discharges with current reversal equilibrium configuration. The calculation results show that the reversal current equilibrium can maintain finite pressure and also has considerable effects on the position of the X-point and the magnetic separatrix shape, and hence also on the position of the strike point on the divertor plates, which is extremely useful for magnetic design, MHD stability analysis, and experimental data analysis etc. for the AC plasma current operation on tokamaks.
基金Project supported by Indian Institute of Engineering Science and Technology, Shibpur, India
文摘We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.
基金funding for this project was provided by the National Natural Science Foundation of China (No.41976049)。
文摘In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in strata.The seabed sediments could be liquefied under storm waves.A laboratory wave flume experiment demonstrated that storm-induced liquefaction deposits are formed by the oscillations of liquefied sediments.In this paper,the particle size distribution and ^(210)Pb_(ex) specific activity of the sediment samples from the liquefaction disturbed zone and adjacent stable zone of the Yellow River Delta were tested.The stratigraphic divisions based on storm liquefaction deposit sequence can effectively explain the vertical changes in particle size and ^(210)Pb_(ex) specific activity.Due to the differentiation of particles during the storm induced liquefaction,coarse and fine particles regrouped,which could explain the phenomenon of time-reversal in dating data.
文摘The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.
基金Supported by Weifang Health and Family Planning Commission Research Project,No.WFWSJK-2021-212.
文摘BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular block.This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular block.CASE SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus nephropathy.She developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular block.Then,she underwent parathyroidectomy(PTX)with autotransplantation.Unfortunately,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was reversed.CONCLUSION This case revealed that metastatic cardiac calcification can result in complete atrioventricular blockage.Following parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular block.It is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.
基金Science and Technology Planning Project of Yuzhong District of Chongqing City,No.20210115.
文摘BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma reversal.No studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications separately.AIM To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with RC.METHODS This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September 2022.Continuous variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was used.Univariate and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related complications.RESULTS The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(P<0.01),greater blood loss(P=0.017),and longer operative times(P<0.01)were more likely to experience postoperative complications.The incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(P<0.01),preoperative comorbid hypertension(P=0.049),time from primary surgery to ileostomy reversal(P<0.01)and longer operation time(P=0.010)were more likely to result in stomarelated complications postoperatively.Multivariate logistic regression analysis revealed that a lower preoperative albumin level(P<0.01,OR=0.888,95%CI:0.828-0.958)was an independent risk factor for overall complications.Moreover,multivariate analysis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related complications after stoma reversal.CONCLUSION The preoperative albumin level was a predictor of overall complications.Preoperative BMI and the time from primary surgery to ileostomy reversal were predictors of stoma-related complications.
文摘BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.
基金Project supported by the Natural Science Foundation of Gansu Province, China (Grant No. 22JR5RA775)the Science and Technology Program of Lanzhou, China (Grant No. 2021-1-157)+2 种基金the Guangdong Basic and Applied Basic Research Foundation, China (Grant Nos. 2020A1515110998 and 2022A1515012123)the Outstanding Youth Foundation of Gansu Academy of Science, China (Grant No. 2021YQ01)the Innovative Team Construction Project of Gansu Academy of Sciences, China (Grant No. 2020CX005-01)。
文摘Perpendicular synthetic-antiferromagnet(p-SAF) has broad applications in spin-transfer-torque magnetic random access memory and magnetic sensors. In this study, the p-SAF films consisting of (Co/Ni)3]/Ir(tIr)/[(Ni/Co)3are fabricated by magnetron sputtering technology. We study the domain structure and switching field distribution in p-SAF by changing the thickness of the infrared space layer. The strongest exchange coupling field(Hex) is observed when the thickness of Ir layer(tIr) is 0.7 nm and becoming weak according to the Ruderman–Kittel–Kasuya–Yosida-type coupling at 1.05 nm,2.1 nm, 4.55 nm, and 4.9 nm in sequence. Furthermore, the domain switching process between the upper Co/Ni stack and the bottom Co/Ni stack is different because of the antiferromagnet coupling. Compared with ferromagnet coupling films, the antiferromagnet samples possess three irreversible reversal regions in the first-order reversal curve distribution.With tIrincreasing, these irreversible reversal regions become denser and smaller. The results from this study will help us understand the details of the magnetization reversal process in the p-SAF.
基金Project supported by the National Key R&D Program of China(Grant No.2021YFC2203503)。
文摘The electromagnetic time-reversal(TR)technique has the characteristics of spatiotemporal focusing in a time-reversal cavity(TRC),which can be used for pulse compression,thus forming an electromagnetic pulse with high peak power.A time-reversed pulse-compression method in a single channel has high pulse compression gain.However,single channel pulse compression can only generate limited gain.This paper proposes a novel TR power-combination method in a multichannel TRC to obtain higher peak power based on TR pulse-compression theory.First,the TR power-combination model is given,and the crosstalk properties of the associated channel and the influence of the reversal performance are studied.Then,the power-combination performances for the TR pulse compression,such as combined signal to noise ratio(SNR)and combined compression gain,are analyzed by numerical simulation and experimental methods.The results show that the proposed method has obvious advantages over pulse-compression methods using a single channel cavity,and is more convenient for power combination.
基金supported by the Regional Joint Fund for Basic and Applied Basic Research of Guangdong Province(2019B1515120009)the Defense Basic Scientific Research Program(61424132005).
文摘In this paper,parameter estimation of linear frequency modulation(LFM)signals containing additive white Gaussian noise is studied.Because the center frequency estimation of an LFM signal is affected by the error propagation effect,resulting in a higher signal to noise ratio(SNR)threshold,a parameter estimation method for LFM signals based on time reversal is proposed.The proposed method avoids SNR loss in the process of estimating the frequency,thus reducing the SNR threshold.The simulation results show that the threshold is reduced by 5 dB compared with the discrete polynomial transform(DPT)method,and the root-mean-square error(RMSE)of the proposed estimator is close to the Cramer-Rao lower bound(CRLB).
基金National Natural Science Foundation of China(Grant No.62071433)National Key R&D Program of China(Grant No.2022YFC3005002)。
文摘Pinhole corrosion is difficult to discover through conventional ultrasonic guided waves inspection,particularly for micro-sized pinholes less than 1 mm in diameter.This study proposes a new micro-sized pinhole inspection method based on segmented time reversal(STR)and high-order modes cluster(HOMC)Lamb waves.First,the principle of defect echo enhancement using STR is introduced.Conventional and STR inspection experiments were conducted on aluminum plates with a thickness of 3 mm and defects with different diameters and depths.The parameters of the segment window are discussed in detail.The results indicate that the proposed method had an amplitude four times larger than of conventional ultrasonic guided waves inspection method for pinhole defect detection and could detect micro-sized pinhole defects as small as 0.5 mm in diameter and 0.5 mm in depth.Moreover,the segment window location and width(5-10 times width of the conventional excitation signal)did not affect the detection sensitivity.The combination of low-power and STR is more conducive to detection in different environments,indicating the robustness of the proposed method.Compared with conventional ultrasonic guided wave inspection methods,the proposed method can detect much smaller defect echoes usually obscured by noise that are difficult to detect with a lower excitation power and thus this study would be a good reference for pinhole defect detection.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12074135,12104388,and 52272219)Nanyang Normal University,the Natural Science Foundation of Henan Province (Grant Nos.222300420255 and 232300421220)the Key Scientific and Technological Projiect of Technology Depeartment of Henan Province of China (Grant Nos.222102230105 and 212102210448)。
文摘We report polarization reversal periodically controlled by the electric field in multiferroic MnWO_(4) with a pulsed field up to 52 T.The electric polarization cannot be reversed by successive opposite electric fields in low magnetic fields(<14 T)at 4.2 K,whereas polarization reversal is directly achieved by two opposite electric fields under high magnetic fields(<45 T).Interestingly,the polarization curve of rising and falling fields for H∥u(magnetic easy axis)is irreversible when the magnetic field is close to 52 T.In this case,the rising and falling polarization curves can be individually reversed by the electric field,and thus require five cycles to recover to the initial condition by the order of the applied electric fields(+E,-E,-E,+E,+E).In addition,we find that ferroelectric phaseⅣcan be tuned from parallel to antiparallel in relation to ferroelectric phase AF2 by applying a magnetic field approximated to the c axis.
基金supported by the Research Group of Nonequilibrium Statistics (Grant No. 14078206)Kunming University of Science and Technology, China。
文摘Anomalous transports of dipole in alternating electric fields are investigated by means of numerical calculation of its average angular velocity(or current). Our results show that the alternating electric fields can make the dipole exhibit many interesting transport behaviors. There exist current bifurcation and multiple current reversal phenomena about frequency of the alternating electric fields in the system in the absence of constant bias force, while many platforms appear in the curve of its average angular velocity vs. the force, i.e., multiple mobility transitions phenomenon in the presence of the constant force, dependent on frequencies of the alternating electric fields. Further investigation indicates that the multiple mobility transitions are attributed to the traveling forces on the dipole. Intrinsic physical mechanism and conditions for the characteristic dynamical behaviors to occur are also discussed in detail. These findings will possess crucial significance for optimizing heating control in the alternating electric fields.
文摘Humans are able to overcome sensory perturbations imposed on their movements through motor learning. One of the key mechanisms to accomplish this is sensorimotor adaptation, an implicit, error-driven learning mechanism. Past work on sensorimotor adaptation focused mainly on adaptation to rotated visual feedback—A paradigm known as visuomotor rotation. Recent studies have shown that sensorimotor adaptation can also occur under mirror-reversed visual feedback. In visuomotor rotation, sensorimotor adaptation can be driven by both endpoint and online feedback [1] [2]. However, it’s not been clear whether both kinds of feedback can similarly drive adaptation under a mirror reversed perturbation. We performed a study to establish what kinds of feedback can drive adaptation under mirror reversal. In the first two conditions, the participants were asked to ignore visual feedback. In the first condition, we provided mirror reversed online feedback and endpoint feedback. We reproduced previous findings showing that online feedback elicited adaptation under mirror reversal. In a second condition, we provided mirror reversed endpoint feedback. However, in the second condition, we found that endpoint feedback alone failed to elicit adaptation. In a third condition, we provided both types of feedback at the same time, but in a conflicting way: endpoint feedback was non-reversed while online feedback was mirror reversed. The participants were asked to ignore online visual feedback and try to hit the target with help from veridical endpoint feedback. In the third condition, in which veridical endpoint feedback and mirror reversed online feedback were provided, adaptation still occurred. Our results showed that endpoint feedback did not elicit adaptation under mirror reversal but online feedback did. This dissociation between effects of endpoint feedback and online feedback on adaptation under mirror reversal suggests that adaptation under these different kinds of feedback might in fact operate via distinct mechanisms.
基金supported in part by the National Natural Science Foundation of China under Grant 51977099 and Grant 52177044in part by the Hong Kong Scholars Program under Grant XJ2019031+2 种基金in part by the China Postdoctoral Science Foundation under Grant 2019T120395in part by the Natural Science Foundation of Jiangsu Higher Education Institutions under Grant 21KJA470004in part by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘As members of doubly salient magnetless linear machines,linear variable flux reluctance(LVFR)and wound field flux reversal(LWFFR)machines inherit the merits of conventional magnetless linear machines such as low cost,high flux adjustment capability and high reliability.Furthermore,like linear switched reluctance machine,they have a very simple and compact long secondary,which are very attractive for long stroke applications.However,low force capability is their major defect.To solve this issue,new LVFR and LWFFR machine topologies were proposed in recent work,while lacking studies on their force improvement mechanism and further force evaluation.In this paper,LVFR and LWFFR machines with improved force performance are comparatively studied with the emphasis on their force capabilities.The operation principle of the two machines is analyzed based on magnetic field harmonics produced by flux modulation.Contributions of air-gap flux density harmonic components to no-load back electromagnetic forces of the two machines are analyzed and the average force equation is derived.Moreover,force capabilities of the both machines are investigated by means of the time-stepping finite-element analysis to verify the theoretical analysis.
文摘With lifestyle changes,the incidence of type 2 diabetes(T2DM)and obesity has significantly increased,becoming major chronic diseases that seriously threaten the health of China’s residents.Both domestic and international guidelines and consensus exist regarding the diagnosis and management of this disease.In recent years,T2DM treatment has focused more on new tactics that lean towards a patient-centered comprehensive management approach,replacing the traditional glucose-centered approach.Additionally,an increasing amount of evidence in medicine suggests that the reversal of diabetes is possible.However,there is currently no expert consensus on the clinical management of T2DM combined with obesity reversal treatment.Therefore,experts and scholars in China with extensive experience in T2DM combined with obesity reversal treatment have been invited to develop this consensus.The content includes early identification and diagnosis of T2DM combined with obesity,definition and mechanisms of diabetes reversal,disease assessment and grading,staging of diabetes and goals of reversal,the 2+N reversal strategy,inpatient system treatment combined with comprehensive outpatient management(including weight control,precise nutrition,scientific exercise,glucose-lowering medication,psychological intervention,rehabilitation therapy,and remote follow-up through online platforms),and evaluation of post-reversal efficacy.The aim is to further improve the level of T2DM combined with obesity reversal diagnosis,treatment,and management in China,and to implement the Healthy China strategy.
文摘Aim To analyze the transient speciality of nonlinear, anisotropic, AC+DC coupling electric field, and to compare the withstand voltage strength of different insulation structures. Methods The transient process of polarity reversal is analyzed, considering the anisotropic property of oil immersed press board, a new finite element model based on Galerkin method is presented and verified. The model developed is applied to calculate the electric field distribution in four typical winding end structures of the converter transformer. Results\ The whole ring structure possesses the best insulation characteristics. Conclusion\ By introducing reasonable insulation components, insulation strength with the same surrounding sizes can be improved more than 30%.
基金supported by the National Natural Science Foundation of China(6130127161331007)+2 种基金the Specialized Research Fund for the Doctoral Program of Higher Education of China(2011018512000820120185130001)the Fundamental Research Funds for Central Universities(ZYGX2012J043)
文摘An efficient hybrid time reversal(TR) imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated by the transmitting-mode decomposition of the TR operator(DORT) method employing the signal subspace. Then, the TR multiple signal classification(TR-MUSIC)method employing the noise subspace is used in the estimated target area to get the superresolution imaging of targets. Two examples with homogeneous and inhomogeneous background mediums are considered, respectively. The results show that the proposed hybrid method has advantages in CPU time and memory cost because of the combination of rough and fine imaging.
文摘In this paper, a new method of time reversal for defect diagnosis of concealed structure has been proposed based on the detecting technique of structure acoustic wave and the theory of time reversal. The time reversal recurrence formula for detecting the acoustic wave speed constitution of concealed structures with bilevel asynchronous test has been established. The wave speed constitution can be reconstructed in 2 D graticule form by means of this method. The result of model test shows the method is valid.