Objective: There are no detailed reports of three-dimensional measurement of abutment teeth in mastication, because it is knotty to observe the rotation in chewing directly, and inexact to estimate indirectly. This wo...Objective: There are no detailed reports of three-dimensional measurement of abutment teeth in mastication, because it is knotty to observe the rotation in chewing directly, and inexact to estimate indirectly. This work studies the three-dimensional stability of rigidly fixed bridge under the stresses of distributed loads and concentrated loads by optical method that gives the tip angle and rotation angle calculated directly based on measurement data. Methods: The specimen, taken from a 25-year-old male, was a left mandible without the second premolars and the first molars. As abutments, first premolar and second molar have complete periodontium. The specimen was soaked in formaldehyde solution. The bridge was fixed between two abutment teeth (first premolars and second molars), and the mandible was cemented in a steel box. The load was increased from 0 kg to 23 kg. Laser holographic technique was used to measure the three-dimensional bit shift of the dens, both buccolingual bit shift and mesiodistal bit shift, and determine tip angle and rotation angle. Results: The effects of stress distribution on the rigidly fixed bridge were evaluated, and stabilization of the bridge under the stresses of distributed loads and concentrated loads, respectively, were analyzed. The results showed that the tips of two abutments were very similar, and no distinct difference was observed between the distributed load and the concentrated load. However, the maximum rotation angle for the distributed load was two to four times as large as that for the concentrated load. In the experiment, the tip angle of the abutment teeth was no more than 0.65 degree, and the rotation angle was no more than 0.60 degree. All maximum angles occurred in the second molar. Conclusion: The fixed bridge is considered to be safe. In addition, a method for measuring the rotation angle was provided effectively.展开更多
In this paper we compute general-relativistic polytropic models simulating rigidly rotating, pulsating neutron stars. These relativistic compact objects, with a radius of ~10 km and mass between ~1.4 and 3.2 solar mas...In this paper we compute general-relativistic polytropic models simulating rigidly rotating, pulsating neutron stars. These relativistic compact objects, with a radius of ~10 km and mass between ~1.4 and 3.2 solar masses, are closely related to pulsars. We emphasize on computing the change in the pulsation eigenfrequencies owing to a rigid rotation, which, in turn, is a decisive issue for studying stability of such objects. In our computations, we keep rotational perturbation terms of up to second order in the angular velocity.展开更多
Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or a...Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.展开更多
Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of p...Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parkinsonism,including akinesia,bradykinesia,rigidity,and tremor(McGregor and Nelson,2019).展开更多
As drilling wells continue to move into deep ultra-deep layers,the requirements for temperature resistance of drilling fluid treatments are getting higher and higher.Among them,blocking agent,as one of the key treatme...As drilling wells continue to move into deep ultra-deep layers,the requirements for temperature resistance of drilling fluid treatments are getting higher and higher.Among them,blocking agent,as one of the key treatment agents,has also become a hot spot of research.In this study,a high temperature resistant strong adsorption rigid blocking agent(QW-1)was prepared using KH570 modified silica,acrylamide(AM)and allyltrimethylammonium chloride(TMAAC).QW-1 has good thermal stability,average particle size of 1.46μm,water contact angle of 10.5.,has a strong hydrophilicity,can be well dispersed in water.The experimental results showed that when 2 wt%QW-1 was added to recipe A(4 wt%bentonite slurry+0.5 wt%DSP-1(filtration loss depressant)),the API filtration loss decreased from 7.8to 6.4 m L.After aging at 240.C,the API loss of filtration was reduced from 21 to 14 m L,which has certain performance of high temperature loss of filtration.At the same time,it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5μm ceramic sand discs.Under the same conditions,the blocking performance was superior to silica(5μm)and calcium carbonate(2.6μm).In addition,the mechanism of action of QW-1 was further investigated.The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer,thus preventing further intrusion of drilling fluid into the formation.展开更多
Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflector...Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation.To date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention.To investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors.This model was validated using laboratory flume test data from the literature.Then,the model was used to investigate the influence of the deflector angle and multi-barrier arrangements.The optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow mechanisms.The investigation considered the energy dissipation process,retention efficiency,and dead-zone formation.Compared with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris flow.Recommendations for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.展开更多
A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave attenuation.Rigid vegetation canopies with aligned and staggered configurations were tested under the co...A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave attenuation.Rigid vegetation canopies with aligned and staggered configurations were tested under the condition of various regular wave heights and current velocities,with the constant water depth being 0.60 m to create the desired submerged scenarios.Results show that the vegetation-induced wave dissipation is enhanced with the increasing incident wave height.A larger velocity magnititude leads to a greater wave height attenuation for both following and opposing current conditions.Moreover,there is a strong positive linear correlation between the damping coefficientβand the relative wave height H_(0)/h,especially for pure wave conditions.For the velocity profile,the distributions of U_(min)and U_(max)show different patterns under combined wave and current.The time-averaged turbulent kinetic energy(TKE)vary little under pure wave and U_(c)=±0.05 m/s conditions.With the increase of flow velocity amplitude,the time-averaged TKE shows a particularly pronounced increase trend at the top of the canopy.The vegetation drag coefficients are obtained by a calibration approach.The empirical relations of drag coefficient with Reynolds and Keulegane-Carpenter numbers are proposed to further understand the wave-current-vegetation interaction mechanism.展开更多
By introducing the Carathéodory metric,we establish the Schwarz lemma at the boundary for holomorphic self-mappings on the unit p-ball B_(p)^(n) of C^(n).Furthermore,the boundary rigidity theorem for holomorphic ...By introducing the Carathéodory metric,we establish the Schwarz lemma at the boundary for holomorphic self-mappings on the unit p-ball B_(p)^(n) of C^(n).Furthermore,the boundary rigidity theorem for holomorphic self-mappings defined on B_(n)^(p) is obtained.These results cover the boundary Schwarz lemma and rigidity result for holomorphic self-mappings on the unit ball for p=2,and the unit polydisk for p=∞,respectively.展开更多
The objective of this research was to determine the mechanical parameter from EVA foam and also investigate its behavior by using Blatz-Ko,Neo-Hookean,Mooney model and experimental test.The physical characteristic of ...The objective of this research was to determine the mechanical parameter from EVA foam and also investigate its behavior by using Blatz-Ko,Neo-Hookean,Mooney model and experimental test.The physical characteristic of EVA foam was also evaluated by scanning electron microscopy(SEM).The results show that Blatz-Ko and Neo-Hookean model can fit the curve at 5%and 8%strain,respectively.The Mooney model can fit the curve at 50%strain.The modulus of rigidity evaluated from Mooney model is 0.0814±0.0027 MPa.The structure of EVA foam from SEM image shows that EVA structure is a closed cell with homogeneous porous structure.From the result,it is found that Mooney model can adjust the data better than other models.This model can be applied for mechanical response prediction of EVA foam and also for reference value in engineering application.展开更多
Parkinson’s disease(PD)is a complex neurodegenerative disorder characterized by a range of motor symptoms such as bradykinesia,resting tremor,rigidity,and postural instability,as well as non-motor symptoms,such as de...Parkinson’s disease(PD)is a complex neurodegenerative disorder characterized by a range of motor symptoms such as bradykinesia,resting tremor,rigidity,and postural instability,as well as non-motor symptoms,such as depression,anxiety,sleep disturbances,and fatigue(Bloem et al.,2021).展开更多
Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered ...Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic responses.The dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed herein.The simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is conducted.The effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are investigated.The results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind turbine.Considering the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid model.Moreover,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and platform.Thus,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.展开更多
In spacecraft electronic devices,the deformation of solder balls within ball grid array(BGA)packages poses a significant risk of system failure.Therefore,accurately measuring the mechanical behavior of solder balls is...In spacecraft electronic devices,the deformation of solder balls within ball grid array(BGA)packages poses a significant risk of system failure.Therefore,accurately measuring the mechanical behavior of solder balls is crucial for ensuring the safety and reliability of spacecraft.Although finite element simulations have been extensively used to study solder ball deformation,there is a significant lack of experimental validation,particularly under thermal cycling conditions.This is due to the challenges in accurately measuring the internal deformations of solder balls and eliminating the rigid body displacement introduced during ex-situ thermal cycling tests.In this work,an ex-situ three-dimensional deformation measurement method using X-ray computed tomography(CT)and digital volume correlation(DVC)is proposed to overcome these obstacles.By incorporating the layer-wise reliability-guided displacement tracking(LW-RGDT)DVC with a singular value decomposition(SVD)method,this method enables accurate assessment of solder ball mechanical behavior in BGA packages without the influence of rigid body displacement.Experimental results reveal that BGA structures exhibit progressive convex deformation with increased thermal cycling,particularly in peripheral solder balls.This method provides a reliable and effective tool for assessing internal deformations in electronic packages under ex-situ conditions,which is crucial for their design optimization and lifespan predictions.展开更多
To enhance the serviceability of steel bridge deck pavement(SBDP)in high-temperature and rainy regions,a concept of rigid bottom and flexible top was summarized using engineering practices,which led to the proposal of...To enhance the serviceability of steel bridge deck pavement(SBDP)in high-temperature and rainy regions,a concept of rigid bottom and flexible top was summarized using engineering practices,which led to the proposal of a three-layer ultra-high-performance pavement(UHPP).The high-temperature rutting resistance and wet-weather skid resistance of UHPP were evaluated through composite structure tests.The internal temperature distribution within the pavement under typical high-temperature conditions was analyzed using a temperature field model.Additionally,a temperature-stress coupling model was employed to investigate the key load positions and stress response characteristics of the UHPP.The results indicate that compared with the traditional guss asphalt+stone mastic asphalt structure,the dynamic stability of the UHPP composite structure can be improved by up to 20.4%.Even under cyclic loading,UHPP still exhibits superior surface skid resistance compared to two traditional SBDPs.The thickness composition of UHPP significantly impacts its rutting resistance and skid resistance.UHPP exhibits relatively low tensile stress but higher shear stress levels,with the highest shear stress occurring between the UHPP and the steel plate.This suggests that the potential risk of damage for UHPP primarily lies within the interlayer of the pavement.Based on engineering examples,introducing interlayer gravel and optimizing the amount of bonding layer are advised to ensure that UHPP possesses sufficient interlayer shear resistance.展开更多
The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation ...The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.展开更多
Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, thepreservation and maintenance of these roads are critical to attaining a pavement network in good condi...Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, thepreservation and maintenance of these roads are critical to attaining a pavement network in good conditionthroughout its service life. Various performance indicators like the international roughness index (IRI), pavementcondition index (PCI), and present serviceability rating (PSR) have been used by the state department of transportation (DOT) and highway agencies for evaluating pavement surface conditions and planning future maintenance strategies. Limited data availability, multiple distresses depending on region, lack of correlation of thesecondition indices to maintenance strategies, and data collection limitations pose a challenge for applying theseindices to local conditions. This paper compares condition indices of different states for rigid pavements. Further,using a specific condition index for local conditions is also highlighted. For this purpose, five states and theircorresponding condition indices were evaluated and compared to the Michigan DOT distress index (DI). Thesestates include Virginia, Minnesota, North Dakota, Louisiana, and Oregon. The corresponding distresses of eachcondition index were converted to make them compatible with the MDOT DI. This study used the MDOT'spavement management system (PMS) database to evaluate each condition index for 433 rigid pavement sections.Each distress index was plotted against MDOT DI and compared using a paired t-test. Results show that thecondition indices of Virginia and Minnesota are comparable to DI in terms of the Spearman correlation value. Thet-test results show that except for Virgina, condition indices from other states statistically differ from DI.Therefore, one can't use those directly for local conditions in Michigan. This paper presents the evaluation anddata requirements for each condition index and its impact on selecting a maintenance treatment.展开更多
This paper reviews works on the dynamic analysis of flexible and rigid pavements under moving vehicles on the basis of continuum-based plane strain models and linear theories.The purpose of this review is to provide i...This paper reviews works on the dynamic analysis of flexible and rigid pavements under moving vehicles on the basis of continuum-based plane strain models and linear theories.The purpose of this review is to provide in-formation about the existing works on the subject,critically discuss them and make suggestions for further research.The reviewed papers are presented on the basis of the various models for pavement-vehicle systems and the various methods for dynamically analyzing these systems.Flexible pavements are modeled by a homogeneous or layered half-plane with isotropic or anisotropic and linear elastic,viscoelastic or poroelastic material behavior.Rigid pavements are modeled by a beam or plate on a homogeneous or layered half-plane with material properties like the ones for flexible pavements.The vehicles are modeled as concentrated or distributed over a finite area loads moving with constant or time dependent speed.The above pavement-vehicle models are dynamically analyzed by analytical,analytical/numerical or purely numerical methods working in the time or frequency domain.Representative examples are presented to illustrate the models and methods of analysis,demonstrate their merits and assess the effects of the various parameters on pavement response.The paper closes with con-clusions and suggestions for further research in the area.The significance of this research effort has to do with the presentation of the existing literature on the subject in a critical and easy to understand way with the aid of representative examples and the identification of new research areas.展开更多
BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic purposes.Currently,there is an active debate regarding...BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic purposes.Currently,there is an active debate regarding the comparative efficacy and safety of rigid vs flexible bronchoscopy in the treatment of foreign body aspiration.AIM To evaluate our experience with tracheobronchial foreign body extraction using flexible bronchoscopy and provide a literature overview.METHODS This was a single-centre retrospective study.Twenty-four patients were enrolled between January 2017 and January 2023.Medical records of patients aged below 18 years who were admitted to authors’affiliated institution with a suspected diagnosis of foreign body aspiration were collected from hospital’s database to Microsoft Excel 2019.Data were analysed using MedCalc Statistical Software.RESULTS Patient ages varied from 9 months to 11 years.The median age was 23.5 months,95%confidence interval(CI)19.49-44.77.We observed age clustering in children with foreign body aspiration at our institution with three age subgroups:(1)0-25 months;(2)40-60 months;and(3)120-140 months.We expectancy of an organic tracheobronchial foreign body was significantly higher in 0-25 months subgroup than that in older ones when subgroups 40-60 and 120-140 months were combined together(odds ratio=10.0,95%CI:1.44-29.26,P=0.0197).Successful foreign body extraction was performed in all cases.Conversion to a rigid bronchoscope was not required in any of the cases.No major complications(massive bleeding,tracheobronchial tree perforation,or asphyxia)were observed.CONCLUSION Flexible bronchoscopy is an effective and safe method for tracheobronchial foreign body extraction in children.展开更多
Carbon graphite is a crystalline form of carbon consisting of layers of hexagonal carbon atoms arranged in a two-dimensional “graphene” structure. Graphene layers are stacked on top of each other, forming a three-di...Carbon graphite is a crystalline form of carbon consisting of layers of hexagonal carbon atoms arranged in a two-dimensional “graphene” structure. Graphene layers are stacked on top of each other, forming a three-dimensional structure with a high degree of anisotropy. The carbon atoms within each layer are linked together by strong covalent bonds, creating a strong, stable lattice structure. However, the layers themselves are held together by weak van der Waals forces, enabling them to slide easily over each other. The properties of carbon graphite are highly dependent on the orientation and alignment of the graphene layers. When the layers are aligned parallel to each other, the material exhibits high strength and stiffness along the alignment direction, but is weaker and more flexible in other directions. Carbon graphite is used in a variety of applications where high strength, rigidity and electrical conductivity are required. Some common applications include electrical contacts, electric motor brushes, and as a structural material in aerospace and defense applications. The aim of our work is to describe the structure of graphite, its physical and chemical properties and its applications.展开更多
The two kinds of rigid polyurethane (PU) foams were prepared with respectively adding the refined alkali lignin and alkali lignin modified by 3-chloro-1,2-epoxypropane to be instead of 15% of the polyether glycol in...The two kinds of rigid polyurethane (PU) foams were prepared with respectively adding the refined alkali lignin and alkali lignin modified by 3-chloro-1,2-epoxypropane to be instead of 15% of the polyether glycol in weight. The indexes of mechanical performance, apparent density, thermal stability and aging resistance were separately tested for the prepared PU foams. The results show that the mechanical property, thermal insulation and thermal stability for PU foam with modified alkali lignin are excellent among two kinds of PU foams and control samples. The additions of the refined alkali lignin and modified alkali lignin to PU foam have little effect on the natural aging or heat aging resistance except for decreasing hot alkali resistance apparently. Additionally, the thermal conductivity of modified alkali lignin PU foam is lowest among two kinds of PU foams and control samples. The alkali lignin PU foam modified by 3-chloro-1,2-epoxypropane could be applied in the heat preservation field.展开更多
A general analytical method to calculate the passive rigid retaining wall pressure was deduced considering all displacement modes. First, the general displacement mode function was setup, then the hypotheses were made...A general analytical method to calculate the passive rigid retaining wall pressure was deduced considering all displacement modes. First, the general displacement mode function was setup, then the hypotheses were made that the lateral passive pressure is linear to the corresponding horizontal displacement and the soil behind retaining wall is composed of a set of springs and ideal rigid plasticity body, the general analytical method was proposed to calculate the passive rigid retaining wall pressure based on Coulomb theory. The analytical results show that the resultant forces of the passive earth pressure are equal to those of Coulomb's theory, but the distribution of the passive pressure and the position of the resultant force depend on the passive displacement mode parameter, and the former is a parabolic function of the soil depth. The analytical results are also in good agreement with the experimental ones.展开更多
基金the Science Research Foundation of Ministry of Health of China (No. WKJ2006-2-003)the Department of Education of Zhejiang Province (No. 20010505) the Science and Technol-ogy Department of Zhejiang Province (No. 2003C30044), China
文摘Objective: There are no detailed reports of three-dimensional measurement of abutment teeth in mastication, because it is knotty to observe the rotation in chewing directly, and inexact to estimate indirectly. This work studies the three-dimensional stability of rigidly fixed bridge under the stresses of distributed loads and concentrated loads by optical method that gives the tip angle and rotation angle calculated directly based on measurement data. Methods: The specimen, taken from a 25-year-old male, was a left mandible without the second premolars and the first molars. As abutments, first premolar and second molar have complete periodontium. The specimen was soaked in formaldehyde solution. The bridge was fixed between two abutment teeth (first premolars and second molars), and the mandible was cemented in a steel box. The load was increased from 0 kg to 23 kg. Laser holographic technique was used to measure the three-dimensional bit shift of the dens, both buccolingual bit shift and mesiodistal bit shift, and determine tip angle and rotation angle. Results: The effects of stress distribution on the rigidly fixed bridge were evaluated, and stabilization of the bridge under the stresses of distributed loads and concentrated loads, respectively, were analyzed. The results showed that the tips of two abutments were very similar, and no distinct difference was observed between the distributed load and the concentrated load. However, the maximum rotation angle for the distributed load was two to four times as large as that for the concentrated load. In the experiment, the tip angle of the abutment teeth was no more than 0.65 degree, and the rotation angle was no more than 0.60 degree. All maximum angles occurred in the second molar. Conclusion: The fixed bridge is considered to be safe. In addition, a method for measuring the rotation angle was provided effectively.
文摘In this paper we compute general-relativistic polytropic models simulating rigidly rotating, pulsating neutron stars. These relativistic compact objects, with a radius of ~10 km and mass between ~1.4 and 3.2 solar masses, are closely related to pulsars. We emphasize on computing the change in the pulsation eigenfrequencies owing to a rigid rotation, which, in turn, is a decisive issue for studying stability of such objects. In our computations, we keep rotational perturbation terms of up to second order in the angular velocity.
基金partially supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research(KAKENHI,Grant numbers 23H02865[to KK],23K14927[to CA])the Brain/MINDS Beyond program of the Japan Agency for Medical Research and Development(Grant Number JP19dm0307101[to KK])。
文摘Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.
基金supported in part by the research grant from the National Institute of Neurological Disorders and Stroke,No.R01NS 12137 (to HYC)funded in whole or in part by Aligning Science Across Parkinson's (No.ASA P-0205 720) through the Michael J.Fox Foundation for Parkinson's Research (MJFF)。
文摘Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parkinsonism,including akinesia,bradykinesia,rigidity,and tremor(McGregor and Nelson,2019).
基金supported by the National Natural Science Foundation of China (No.52074330,No.52288101)。
文摘As drilling wells continue to move into deep ultra-deep layers,the requirements for temperature resistance of drilling fluid treatments are getting higher and higher.Among them,blocking agent,as one of the key treatment agents,has also become a hot spot of research.In this study,a high temperature resistant strong adsorption rigid blocking agent(QW-1)was prepared using KH570 modified silica,acrylamide(AM)and allyltrimethylammonium chloride(TMAAC).QW-1 has good thermal stability,average particle size of 1.46μm,water contact angle of 10.5.,has a strong hydrophilicity,can be well dispersed in water.The experimental results showed that when 2 wt%QW-1 was added to recipe A(4 wt%bentonite slurry+0.5 wt%DSP-1(filtration loss depressant)),the API filtration loss decreased from 7.8to 6.4 m L.After aging at 240.C,the API loss of filtration was reduced from 21 to 14 m L,which has certain performance of high temperature loss of filtration.At the same time,it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5μm ceramic sand discs.Under the same conditions,the blocking performance was superior to silica(5μm)and calcium carbonate(2.6μm).In addition,the mechanism of action of QW-1 was further investigated.The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer,thus preventing further intrusion of drilling fluid into the formation.
基金supported by the National Natural Science Foundation of China(Grant Nos.42120104008 and 42207198).
文摘Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation.To date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention.To investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors.This model was validated using laboratory flume test data from the literature.Then,the model was used to investigate the influence of the deflector angle and multi-barrier arrangements.The optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow mechanisms.The investigation considered the energy dissipation process,retention efficiency,and dead-zone formation.Compared with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris flow.Recommendations for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.
基金financially supported by the National Key Research and Development Program of China(2023YFC3208501)the National Natural Science Foundation of China(Grant Nos.U2340225,51979172)+2 种基金the Nanjing Hydraulic Research Institute Special Fund for Basic Scientific Research of Central Public Research Institutes(Y223002,Y220013)the CRSRI Open Research Program(Grant No.CKWV20221007/KY)the Post-Three Gorges Sediment Research Project of MWR(ProjectⅢ:Impact and Countermeasures of the Three Gorges Project on the Stability of the Shoal and Channel and Habitat of Yangtze River Estuary)。
文摘A set of laboratory experiments are carried out to investigate the effect of following/opposing currents on wave attenuation.Rigid vegetation canopies with aligned and staggered configurations were tested under the condition of various regular wave heights and current velocities,with the constant water depth being 0.60 m to create the desired submerged scenarios.Results show that the vegetation-induced wave dissipation is enhanced with the increasing incident wave height.A larger velocity magnititude leads to a greater wave height attenuation for both following and opposing current conditions.Moreover,there is a strong positive linear correlation between the damping coefficientβand the relative wave height H_(0)/h,especially for pure wave conditions.For the velocity profile,the distributions of U_(min)and U_(max)show different patterns under combined wave and current.The time-averaged turbulent kinetic energy(TKE)vary little under pure wave and U_(c)=±0.05 m/s conditions.With the increase of flow velocity amplitude,the time-averaged TKE shows a particularly pronounced increase trend at the top of the canopy.The vegetation drag coefficients are obtained by a calibration approach.The empirical relations of drag coefficient with Reynolds and Keulegane-Carpenter numbers are proposed to further understand the wave-current-vegetation interaction mechanism.
基金supported by the National Natural Science Foundation of China(12071161,11971165)supported by the National Natural Science Foundation of China(11971042)the Natural Science Foundation of Zhejiang Province(Z24A010005)。
文摘By introducing the Carathéodory metric,we establish the Schwarz lemma at the boundary for holomorphic self-mappings on the unit p-ball B_(p)^(n) of C^(n).Furthermore,the boundary rigidity theorem for holomorphic self-mappings defined on B_(n)^(p) is obtained.These results cover the boundary Schwarz lemma and rigidity result for holomorphic self-mappings on the unit ball for p=2,and the unit polydisk for p=∞,respectively.
基金supported by grants funded by Department of Mechanical Engineering,Faculty of Engineering,Chiang Mai University and the Graduate School of Chiang Mai University.
文摘The objective of this research was to determine the mechanical parameter from EVA foam and also investigate its behavior by using Blatz-Ko,Neo-Hookean,Mooney model and experimental test.The physical characteristic of EVA foam was also evaluated by scanning electron microscopy(SEM).The results show that Blatz-Ko and Neo-Hookean model can fit the curve at 5%and 8%strain,respectively.The Mooney model can fit the curve at 50%strain.The modulus of rigidity evaluated from Mooney model is 0.0814±0.0027 MPa.The structure of EVA foam from SEM image shows that EVA structure is a closed cell with homogeneous porous structure.From the result,it is found that Mooney model can adjust the data better than other models.This model can be applied for mechanical response prediction of EVA foam and also for reference value in engineering application.
基金supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),No.424778381-TRR 295(to MM)。
文摘Parkinson’s disease(PD)is a complex neurodegenerative disorder characterized by a range of motor symptoms such as bradykinesia,resting tremor,rigidity,and postural instability,as well as non-motor symptoms,such as depression,anxiety,sleep disturbances,and fatigue(Bloem et al.,2021).
基金funded by the Key Technology Research and Development Program(Nos.2022YFB4201301,and 2022YFB4201304)the National Natural Science Foundation of China(Nos.52101333,52071058,51939002,and 52071301)+2 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LQ21E090009)supported by the Natural Science Foundation of Liaoning Province(No.2022-KF-18-01)the special funds for Promoting High-Quality Development from the Department of Natural Resources of Guangdong Province(No.GDNRC[2020]016).
文摘Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic responses.The dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed herein.The simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is conducted.The effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are investigated.The results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind turbine.Considering the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid model.Moreover,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and platform.Thus,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.
文摘In spacecraft electronic devices,the deformation of solder balls within ball grid array(BGA)packages poses a significant risk of system failure.Therefore,accurately measuring the mechanical behavior of solder balls is crucial for ensuring the safety and reliability of spacecraft.Although finite element simulations have been extensively used to study solder ball deformation,there is a significant lack of experimental validation,particularly under thermal cycling conditions.This is due to the challenges in accurately measuring the internal deformations of solder balls and eliminating the rigid body displacement introduced during ex-situ thermal cycling tests.In this work,an ex-situ three-dimensional deformation measurement method using X-ray computed tomography(CT)and digital volume correlation(DVC)is proposed to overcome these obstacles.By incorporating the layer-wise reliability-guided displacement tracking(LW-RGDT)DVC with a singular value decomposition(SVD)method,this method enables accurate assessment of solder ball mechanical behavior in BGA packages without the influence of rigid body displacement.Experimental results reveal that BGA structures exhibit progressive convex deformation with increased thermal cycling,particularly in peripheral solder balls.This method provides a reliable and effective tool for assessing internal deformations in electronic packages under ex-situ conditions,which is crucial for their design optimization and lifespan predictions.
基金The National Natural Science Foundation of China(No.51878167)the Postgraduate Research and Practice Innovation Program of Jiangsu Province(No.KYCX23_0300).
文摘To enhance the serviceability of steel bridge deck pavement(SBDP)in high-temperature and rainy regions,a concept of rigid bottom and flexible top was summarized using engineering practices,which led to the proposal of a three-layer ultra-high-performance pavement(UHPP).The high-temperature rutting resistance and wet-weather skid resistance of UHPP were evaluated through composite structure tests.The internal temperature distribution within the pavement under typical high-temperature conditions was analyzed using a temperature field model.Additionally,a temperature-stress coupling model was employed to investigate the key load positions and stress response characteristics of the UHPP.The results indicate that compared with the traditional guss asphalt+stone mastic asphalt structure,the dynamic stability of the UHPP composite structure can be improved by up to 20.4%.Even under cyclic loading,UHPP still exhibits superior surface skid resistance compared to two traditional SBDPs.The thickness composition of UHPP significantly impacts its rutting resistance and skid resistance.UHPP exhibits relatively low tensile stress but higher shear stress levels,with the highest shear stress occurring between the UHPP and the steel plate.This suggests that the potential risk of damage for UHPP primarily lies within the interlayer of the pavement.Based on engineering examples,introducing interlayer gravel and optimizing the amount of bonding layer are advised to ensure that UHPP possesses sufficient interlayer shear resistance.
文摘The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.
文摘Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, thepreservation and maintenance of these roads are critical to attaining a pavement network in good conditionthroughout its service life. Various performance indicators like the international roughness index (IRI), pavementcondition index (PCI), and present serviceability rating (PSR) have been used by the state department of transportation (DOT) and highway agencies for evaluating pavement surface conditions and planning future maintenance strategies. Limited data availability, multiple distresses depending on region, lack of correlation of thesecondition indices to maintenance strategies, and data collection limitations pose a challenge for applying theseindices to local conditions. This paper compares condition indices of different states for rigid pavements. Further,using a specific condition index for local conditions is also highlighted. For this purpose, five states and theircorresponding condition indices were evaluated and compared to the Michigan DOT distress index (DI). Thesestates include Virginia, Minnesota, North Dakota, Louisiana, and Oregon. The corresponding distresses of eachcondition index were converted to make them compatible with the MDOT DI. This study used the MDOT'spavement management system (PMS) database to evaluate each condition index for 433 rigid pavement sections.Each distress index was plotted against MDOT DI and compared using a paired t-test. Results show that thecondition indices of Virginia and Minnesota are comparable to DI in terms of the Spearman correlation value. Thet-test results show that except for Virgina, condition indices from other states statistically differ from DI.Therefore, one can't use those directly for local conditions in Michigan. This paper presents the evaluation anddata requirements for each condition index and its impact on selecting a maintenance treatment.
文摘This paper reviews works on the dynamic analysis of flexible and rigid pavements under moving vehicles on the basis of continuum-based plane strain models and linear theories.The purpose of this review is to provide in-formation about the existing works on the subject,critically discuss them and make suggestions for further research.The reviewed papers are presented on the basis of the various models for pavement-vehicle systems and the various methods for dynamically analyzing these systems.Flexible pavements are modeled by a homogeneous or layered half-plane with isotropic or anisotropic and linear elastic,viscoelastic or poroelastic material behavior.Rigid pavements are modeled by a beam or plate on a homogeneous or layered half-plane with material properties like the ones for flexible pavements.The vehicles are modeled as concentrated or distributed over a finite area loads moving with constant or time dependent speed.The above pavement-vehicle models are dynamically analyzed by analytical,analytical/numerical or purely numerical methods working in the time or frequency domain.Representative examples are presented to illustrate the models and methods of analysis,demonstrate their merits and assess the effects of the various parameters on pavement response.The paper closes with con-clusions and suggestions for further research in the area.The significance of this research effort has to do with the presentation of the existing literature on the subject in a critical and easy to understand way with the aid of representative examples and the identification of new research areas.
文摘BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic purposes.Currently,there is an active debate regarding the comparative efficacy and safety of rigid vs flexible bronchoscopy in the treatment of foreign body aspiration.AIM To evaluate our experience with tracheobronchial foreign body extraction using flexible bronchoscopy and provide a literature overview.METHODS This was a single-centre retrospective study.Twenty-four patients were enrolled between January 2017 and January 2023.Medical records of patients aged below 18 years who were admitted to authors’affiliated institution with a suspected diagnosis of foreign body aspiration were collected from hospital’s database to Microsoft Excel 2019.Data were analysed using MedCalc Statistical Software.RESULTS Patient ages varied from 9 months to 11 years.The median age was 23.5 months,95%confidence interval(CI)19.49-44.77.We observed age clustering in children with foreign body aspiration at our institution with three age subgroups:(1)0-25 months;(2)40-60 months;and(3)120-140 months.We expectancy of an organic tracheobronchial foreign body was significantly higher in 0-25 months subgroup than that in older ones when subgroups 40-60 and 120-140 months were combined together(odds ratio=10.0,95%CI:1.44-29.26,P=0.0197).Successful foreign body extraction was performed in all cases.Conversion to a rigid bronchoscope was not required in any of the cases.No major complications(massive bleeding,tracheobronchial tree perforation,or asphyxia)were observed.CONCLUSION Flexible bronchoscopy is an effective and safe method for tracheobronchial foreign body extraction in children.
文摘Carbon graphite is a crystalline form of carbon consisting of layers of hexagonal carbon atoms arranged in a two-dimensional “graphene” structure. Graphene layers are stacked on top of each other, forming a three-dimensional structure with a high degree of anisotropy. The carbon atoms within each layer are linked together by strong covalent bonds, creating a strong, stable lattice structure. However, the layers themselves are held together by weak van der Waals forces, enabling them to slide easily over each other. The properties of carbon graphite are highly dependent on the orientation and alignment of the graphene layers. When the layers are aligned parallel to each other, the material exhibits high strength and stiffness along the alignment direction, but is weaker and more flexible in other directions. Carbon graphite is used in a variety of applications where high strength, rigidity and electrical conductivity are required. Some common applications include electrical contacts, electric motor brushes, and as a structural material in aerospace and defense applications. The aim of our work is to describe the structure of graphite, its physical and chemical properties and its applications.
文摘The two kinds of rigid polyurethane (PU) foams were prepared with respectively adding the refined alkali lignin and alkali lignin modified by 3-chloro-1,2-epoxypropane to be instead of 15% of the polyether glycol in weight. The indexes of mechanical performance, apparent density, thermal stability and aging resistance were separately tested for the prepared PU foams. The results show that the mechanical property, thermal insulation and thermal stability for PU foam with modified alkali lignin are excellent among two kinds of PU foams and control samples. The additions of the refined alkali lignin and modified alkali lignin to PU foam have little effect on the natural aging or heat aging resistance except for decreasing hot alkali resistance apparently. Additionally, the thermal conductivity of modified alkali lignin PU foam is lowest among two kinds of PU foams and control samples. The alkali lignin PU foam modified by 3-chloro-1,2-epoxypropane could be applied in the heat preservation field.
基金Project (201012200094) supported by the Freedom Exploration Program of Central South University of ChinaProject (20090461022) supported by the China Postdoctoral Science FoundationProject (2010ZJ05) supported by the Science and Technology supporting Program of Xinjiang Production and Construction Corps in China
文摘A general analytical method to calculate the passive rigid retaining wall pressure was deduced considering all displacement modes. First, the general displacement mode function was setup, then the hypotheses were made that the lateral passive pressure is linear to the corresponding horizontal displacement and the soil behind retaining wall is composed of a set of springs and ideal rigid plasticity body, the general analytical method was proposed to calculate the passive rigid retaining wall pressure based on Coulomb theory. The analytical results show that the resultant forces of the passive earth pressure are equal to those of Coulomb's theory, but the distribution of the passive pressure and the position of the resultant force depend on the passive displacement mode parameter, and the former is a parabolic function of the soil depth. The analytical results are also in good agreement with the experimental ones.