Pharmacological intervention for chronic phase of spinal cord injury

Spinal cord injury is an intractable traumatic injury. The most common hurdles faced during spinal cord injury are failure of axonal regrowth and reconnection to target sites. These also tend to be the most challenging issues in spinal cord injury. As spinal cord injury progresses to the chronic phase, lost motor and sensory functions are not recovered. Several reasons may be attributed to the failure of recovery from chronic spinal cord injury. These include factors that inhibit axonal growth such as activated astrocytes, chondroitin sulfate proteoglycan, myelin-associated proteins, inflammatory microglia, and fibroblasts that accumulate at lesion sites. Skeletal muscle atrophy due to denervation is another chronic and detrimental spinal cord injury–specific condition. Although several intervention strategies based on multiple outlooks have been attempted for treating spinal cord injury, few approaches have been successful. To treat chronic spinal cord injury, neural cells or tissue substitutes may need to be supplied in the cavity area to enable possible axonal growth. Additionally, stimulating axonal growth activity by extrinsic factors is extremely important and essential for maintaining the remaining host neurons and transplanted neurons. This review focuses on pharmacotherapeutic approaches using small compounds and proteins to enable axonal growth in chronic spinal cord injury. This review presents some of these candidates that have shown promising outcomes in basic research(in vivo animal studies) and clinical trials: AA-NgR(310)ecto-Fc(AXER-204), fasudil, phosphatase and tensin homolog protein antagonist peptide 4, chondroitinase ABC, intracellular sigma peptide,(-)-epigallocatechin gallate, matrine, acteoside, pyrvate kinase M2, diosgenin, granulocyte-colony stimulating factor, and fampridine-sustained release. Although the current situation suggests that drug-based therapies to recover function in chronic spinal cord injury are limited, potential candidates have been identified through basic research, and these candidates may be subjects of clinical studies in the future. Moreover, cocktail therapy comprising drugs with varied underlying mechanisms may be effective in treating the refractory status of chronic spinal cord injury.

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase evolution.Herein,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation process.The results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial polarization.Moreover,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic diffraction.Specifically,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon matrix.This design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

基于CTA颅内动脉瘤形态联合PHASES评分对破裂出血预测研究

目的:分析头颈部计算机断层扫描血管成像(CTA)联合PHASES评分对颅内动脉瘤(IA)破裂出血的预测价值。方法:回顾性分析2021年10月—2023年9月东莞市长安医院诊治的IA患者临床资料,根据IA破裂出血与否分为IA破裂组(n=46)和IA未破裂组(n=44),收集两组临床资料,对比两组患者CTA影像瘤体特征参数和PHASES评分结果。采用受试者工作特征(ROC)曲线分析两者联合预测动脉瘤破裂的效能。结果:IA破裂组高血压、糖尿病发生率及PHASES评分均高于IA未破裂组,差异有统计学意义(P <0.05)。两组病灶位置以颈内动脉(ICA)和大脑中动脉(MCA)为主,但IA破裂组病灶位置在MCA的占比为41.30%,高于IA未破裂组的20.45%,瘤体>7 mm的最多(瘤体7~9.9 mm占65.22%),瘤体形态不规则占58.7%,未破裂组病灶位置在ICA最多(68.18%),瘤体<7 mm的居多(75.00%),瘤体形态规则囊状动脉瘤占93.18%,差异有统计学意义(P <0.05)。CTA瘤体特征参数比较,IA破裂组患者瘤颈宽度、瘤体高度、瘤体长度、动脉瘤最大直径、入射夹角、动脉瘤体颈比等参数均高于IA未破裂组,差异有统计学意义(P <0.05)。CTA瘤体特征参数+PHASES评分联合预测曲线下面积为0.916,高于CTA瘤体特征参数(0.901)和PHASES评分(0.731)。结论:CTA瘤体特征参数+PHASES评分联合预测IA患者破裂出血效能最佳。

Supersymmetry and Shape Invariance of Hartmann Potential and Ring-Shaped Oscillator Potential in the γ and θ Dimensions of Spherical Polar Coordinates

This article shows that in spherical polar coordinates, some noncentral separable potentials have super-symmetry and shape invariance in the r and θ dimensions, we choose Hartmann potential and ring-shaped oscillator astwo important examples, thus in principle the energy eigenvalues and energy eigenfunctions of such the potentials in ther and θ dimensions can be obtained by the method of supersymmetric quantum mechanics. Here we use an alternativemethod to get the required results.

Buckling-controlled two-way shape memory effect in a ring-shaped bilayer

Shape memory polymers(SMPs)usually have a one-way shape memory effect.In this paper,an easy-operating method to realize a two-way shape memory effect was demonstrated in a ring-shaped bilayer structure where the two layers are SMPs with different thermal transition temperatures.By designing specific thermomechanical processes,the mismatched deformation between the two layers leads to a morphology change of ring-shaped bilayer structures from a smooth ring to a gear-like buckling shape under cooling and a reversible recovery to the smooth shape under heating.Such a morphology change is ascribed to occurrence and recovery of thermoelastic buckling.This method was validated by finite element simulation.We experimentally investigated the influence of pre-strain on buckling,and it was found that both the buckling occurrence and recovery temperature vary with pre-strain.Furthermore,considering a ring-shaped SMP-SMP bilayer structure,finite element analysis was conducted to study the influence of film thickness and modulus ratio of two layers on buckling behavior.The results showed that the critical buckling wavelength was greatly influenced by film thickness and modulus ratio.W e made a theoretical analysis that accorded well with the numerical results.

Numerical simulation and experimental verification of large-sized Zr-based bulk metallic glass ring-shaped parts in casting process

An outer ring of 29320 self-aliging roller bearing was used in an experimental study on the casting of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) amorphous alloy.Numerical simulations of mold filling and solidification processes were carried out to determine the velocity fields and temperature fields of the alloy melt during mold filling process as well as the temperature fields and temperature gradient fields in the course of the solidification.According to the results,a cast with a complete shape can be obtained at 1200℃under the condition that the cooling rate is greater than the critical cooling rate.The ring-shaped part with a thickness of 25 mm,an equivalent diameter of 22 mm,and a mass of 1.32 kg was prepared by gravity casting in a copper mold.X-ray diffraction and differential scanning calorimetry data revealed that the produced cast had the amorphous structure.

Solution of the Dirac Equation for Ring-Shaped Modified Kratzer Potential

We propose a new exactly solvable potential which is Formed by modified Kratzer potential plus a new ring-shaped potential η cot^2 θ/r^2 The solutions of the Dirac equation with equal scalar and vector ring-shaped modified Kratzer potential are found by using the Nikiforov-Uvarov method. The nonrelativistic limit of the energy spectrum has been discussed.

Solving Dirac Equation with New Ring-Shaped Non-Spherical Harmonic Oscillator Potential

A new ring-shaped non-harmonic oscillator potential is proposed. The precise bound solution of Dirac equation with the potential is gained when the scalar potential is equal to the vector potential. The angular equation and radial equation are obtained through the variable separation method. The results indicate that the normalized angle wave function can be expressed with the generalized associated-Legendre polynomial, and the normalized radial wave function can be expressed with confluent hypergeometric function. And then the precise energy spectrum equations are obtained. The ground state and several low excited states of the system are solved. And those results are compared with the non-relativistic effect energy level in Phys. Lett. A 340 （2005） 94. The positive energy states of system are discussed and the conclusions are made properly.

Generation of ring-shaped human iPSC-derived functional heart microtissues in a M?bius strip configuration

Although human-induced pluripotent stem cell-derived cardiomyocytes(hi PSC-CMs) have been used for disease modeling and drug discovery, clinically relevant three-dimensional(3D) functional myocardial microtissues are lacking. Here, we developed a novel ring-shaped cardiac microtissue comprised of chamber-specific tissues to achieve a geometrically non-orientable ventricular myocardial band, similar to a M?bius loop. The ring-shaped cardiac tissue was constructed of hi PSC-CMs and human cardiac fibroblasts(h CFs) through a facile cellular self-assembly approach. It exhibited basic anatomical structure,positive cardiac troponin T(c Tn T) immunostaining, regular calcium transients, and cardiac-like mechanical strength. The cardiac rings can be self-assembled and scaled up into various sizes with outstanding stability, suggesting their potential for precise therapy, pathophysiological investigation, and large-scale drug screening.

Central corneal epithelium self-healing after ring-shaped glycerin-cryopreserved lamellar keratoplasty in Terrien marginal degeneration

Dear Sir, I am Dr Yan-Long Bi, from the Department of Ophthalmology, Tongji University Affiliated to Tongji University School of Medicine, Shanghai, China. I write to present a case report of total limbal stem cells deficiency after treatment with ring-shaped lamellar keratoplasty secondary to Terrien marginal degeneration. During 3 years

A Longitudinal Zeeman Slower Based on Ring-Shaped Permanent Magnets for a Strontium Optical Lattice Clock

We report a longitudinal Zeeman slower based on ring-shaped permanent magnetic dipoles used for the strontium optical lattice clock. The Zeeman slower is composed of 40 permanent magnets with the same outer diameter but different inner diameters. The maximum variation of the axial field from its target values is less than 2%. In most parts of the Zeeman slower, the intensity variations of the field in radial spatial distribution are less than 0.1 roT. With this Zeeman slower, the strontium atoms are slowed down to 95m/s, and approximately 2% of the total atoms are slowed down to less than 50m/s.

Relativistic Scattering States of Coulomb Potential Plus a New Ring-Shaped Potential

In this paper, exact solutions of scattering states of the Klein-Gordon equation with Coulomb potential plus a new ring-shaped potential are studied under the condition that the scalar potential is equal to the vector potential. The normalized wave functions of scattering states on the “k/27π scale” and the calculation formula of phase shifts are presented. Analytical properties of the scattering amplitude are discussed.

Deformation Analysis on Shear-Bending of Ring-Shaped Piezoelectric Actuator

Deformation of a simple single piezoelectric actuator is usually quite small.A ring-shaped piezoelectric actuator with large piezoelectrically generated displacement was proposed.The thickness of the actuator was1 mm,and the inner and outer diameters were 4 mm and 40 mm,respectively.The ring-shaped actuator was made of BiScO_3-PbTiO_3(BS-PT)ceramic and polarized in radial direction.An electric field was applied to thickness direction and a large shear-bending deformation emerged.Then Rayleigh-Ritz method and Bessel functions were adopted to analyze the shear-bending deformation.Results show that under an electric field of 7.5kV/cm,the maximum displacement at the inner edge of the actuator reached 5.07μm,which agreed well with the corresponding experimental results.

Exact solutions of the Klein-Gordon equation with ring-shaped oscillator potential by using the Laplace integral transform

We present exact solutions for the Klein Gordon equation with a ring-shaped oscillator potential. The energy eigenvalues and the normalized wave functions are obtained for a particle in the presence of non-central oscillator potential. The angulm＂ functions are expressed in terms of the hypergeometric functions. The radial eigenfunetions have been obtained by using the Laplace integral transform. By means of the Laplace transform method, which is efficient and simple, the radial Klein-Gordon equation is reduced to a first-order differential equation.

Schrdinger Equation with Hulthen Potential Plus Ring-Shaped Potential

We present the solutions of the Schrodinger equation with the Hulthen potential plus ring-shape potential for l≠ 0 states within the framework of an exponential approximation of the centrifugal potential. Solutions to the corresponding angular and radial equations are obtained in terms of special functions using the conventional NikiforovUvarov method. The normalization constant for the Hulthen potential is also computed.

Adjustable transmission properties through ring-shaped nanotube arrays using finite-difference time-domain method

Metallic ring-shaped nanotube arrays are proposed and its optical transmission properties are studied by using finite-difference time-domain （FDTD） method. Compared with the transmission spectra of conventional circular nanotube arrays, two photonic band gaps are emerged in the transmission spectra offing-shaped nanotube arrays, the two band gaps and transmission spectra are adjusted by the length, inner radius, intertube spacing and the dielectric constants of the core and embedding medium, and magnitude modification, redshift and blueshift of the resonance modes are observed. A metallic ring-shaped nanotube arrays for subwavelength band-stop filter in the range of visible light can be achieved. To understand its physical origin, field-interference mechanism was suggested by the field distributions. The proposed nanostructures and results may have great potential applications in subwavelength near-field optics.

The relativistic bound states for a new ring-shaped harmonic oscillator

In this paper a new ring-shaped harmonic oscillator for spin 1/2 particles is studied, and the corresponding eigenfunctions and eigenenergies are obtained by solving the Dirac equation with equal mixture of vector and scalar potentials. Several particular cases such as the ring-shaped non-spherical harmonic oscillator, the ring-shaped harmonic oscillator, non-spherical harmonic oscillator, and spherical harmonic oscillator are also discussed.

Solution of the Dirac equation with the ring-shaped oscillator potential

The ring-shaped oscillator potential, obtained by replacing the Coulomb part of the Hartmann potential by a harmonic oscillator term, was investigated. Under the equal vector potential and scalar potential, the Dirac equation was solved in spherical coordinate. The exact energy spectrum of the bound states was presented as a solution to the confluent hypergeometric equation by boundary conditions. Furthermore, the normalized angular and radial wave functions were presented.

The spin-one Duffin Kemmer Petiau equation in the presence of pseudo-harmonic oscillatory ring-shaped potential

The Duffin-Kemmer-Petiau equation （DKP） is studied in the presence of a pseudo-harmonic oscillatory ring-shaped potential in （1 ＋ 3）-dimensional space-time for spin-one particles. The exact energy eigenvalues and the eigenfunctions are obtained using the Nikiforov-Uvarov method.

Phase-engineering modulation of Mn-based oxide cathode for constructing super-stable sodium storage

The Mn-based oxide cathode with enriched crystal phase structure and component diversity can provide the excellent chemistry structure for Na-ion batteries.Nevertheless,the broad application prospect is obstructed by the sluggish Na^(+)kinetics and the phase transitions upon cycling.Herein,we establish the thermodynamically stable phase diagram of various Mn-based oxide composites precisely controlled by sodium content tailoring strategy coupling with co-doping and solid-state reaction.The chemical environment of the P2/P'3 and P2/P3 biphasic composites indicate that the charge compensation mechanism stems from the cooperative contribution of anions and cations.Benefiting from the no phase transition to scavenge the structure strain,P2/P'3 electrode can deliver long cycling stability(capacity retention of 73.8%after 1000 cycles at 10 C)and outstanding rate properties(the discharge capacity of 84.08 mA h g^(-1)at 20 C)than P2/P3 electrode.Furthermore,the DFT calculation demonstrates that the introducing novel P'3 phase can significantly regulate the Na^(+)reaction dynamics and modify the local electron configuration of Mn.The effective phase engineering can provide a reference for designing other high-performance electrode materials for Na-ion batteries.