Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD progression.The diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings.In this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD pathogenesis.Results indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in vitro.Using the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory abilities.Tissue examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse brain.These findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

Effect of compound treatment of rotating magnetic field and Al-5Ti-1B refiner on microstructure and properties of Al-5Cu alloy

The Al-5Cu alloys were prepared by different treatment methods,including adding a refiner Al-5Ti-1B,exerting a rotating magnetic field(RMF),and compound treatment of both refiner and RMF.The effects of treatment methods on the microstructure,properties,and solid solubility of the Al-5Cu alloy were investigated.The optimal magnetic field parameters and addition amount of refiner were confirmed by experiment.Results show that either RMF or adding refiner Al-5Ti-1B alone can refine the grain size,and the refining effect can be further improved by a compound refining treatment with optimized magnetic field parameters(120 A current and 8 Hz frequency) and 1.0wt.% Al-5Ti-1B refiner(RMF*+Al-5Ti-1B*).The average grain size is decreased to 68.1 μm,which is 60.8%,21.1%,and 83.5% lower than that of the alloy treated by the optimized rotating magnetic field,the Al-5Ti-1B refiner,and the alloy without any treatment,respectively.The tensile strength and elongation of the alloy reach 232.5 MPa and 18.6%,respectively,which are obviously higher than those of the alloys treated by rotating magnetic field,Al-5Ti-1B refiner,and the alloy without any treatment,respectively.Additionally,the solid solubility of the alloy is also obviously improved compared to the alloys treated by other methods.

Heisenberg Model in a Rotating Magnetic Field

We study the Hcisenberg moder under the influence of a rotating magnetic field. By using a time- dependent unitary transformation, the time evolution operator for the Schrodinger equation is obtained, which involves no chronological product. The spin vectors (mean values of the spin operators) are obtained as explicit functions of time in the most general case. A series of cyclic solutions are presented. The nonadiabatic geometric phases of these cyclic solutions are caleulated, and are expressed in terms of the solid angle subtended by the closed trace of thc total spin vector, as well as in terms of those of the individual spins.

EFFECT OF ROTATING MAGNETIC FIELD ONMACROSTRUCTURE OF A CENTRIFUGALCASTING Al-1%Cu ALLOY

Rotating electromagnetic field is applied to the centrifugal casting, the macrostructure of centrifugal casting Al-1%Cu alloy stirred with driving or backing magnetic field are both examined. It is shown that both kinds of electromagnetic filed can enforce the columnar-equiaxed transition, the driving one decrease the tendency of porosity occurring due to the increase in the bulk liquid pressure. Stirring with braking electromagnetic field produces the mixture of outer fine grains and inner coarse grains in the casting, this is analyzed to be contributed to the differences both in electric conductivity and density between the crystal and the melt, as well as skin effects.

Determining the sign of g factor via time-resolved Kerr rotation spectroscopy with a rotatable magnetic field

Time-resolved Kerr rotation spectroscopy is used to determine the sign of the g factor of carriers in a semiconductor material, with the help of a rotatable magnetic field in the plane of the sample. The spin precession signal of carriers at a fixed time delay is measured as a function of the orientation of the magnetic field with a fixed strength B. The signal has a sine-like form and its phase determines the sign of the g factor of carriers. As a natural extension of previous methods to measure the （time-resolved） photoluminescence or time-resolved Kerr rotation signal as a function of the magnetic field strength with a fixed orientation, such a method gives the correct sign of the g factor of electrons in GaAs. Furthermore, the sign of carriers in a （Ga, Mn）As magnetic semiconductor is also found to be negative.

The effect of toroidal field on the rotating magnetic field current drive in rotamak plasmas

A rotamak is one kind of compact spherically shaped magnetic-confinement device. In a rotamak the plasma current is driven by means of rotating magnetic field （RMF）. The driven current can reverse the original equilibrium field and generate a field-reversed-configuration. In a conventional rotamak, a toroidal field （TF） is not necessary for the RMF to drive plasma current, but it was found that the present of an additional TF can influence the RMF current drive. In this paper the effect of TF on the RMF current drive in a rotamak are investigated in some detail. The experimental results show that addition of TF increases the RMF driven current greatly and enhances the RMF penetration dramatically. Without TF, the RMF can only penetrate into plasma in the edge region. When a TF is added, the RMF can reach almost the whole plasma region. This is an optimal strength of toroidal magnetic field for getting maximum plasma current when Bv and radio frequency generator power are fixed. Besides driving current, the RMF generates high harmonic fields in rotamak plasma. The effect of TF on the harmonic field spectra are also reported.

The effect of a magnetic field on a 2D problem of fibre-reinforced thermoelasticity rotation under three theories

In the present paper, we introduce the coupled theory （CD）, Lord-Schulman （LS） theory, and Green-Lindsay （GL） theory to study the influences of a magnetic field and rotation on a two-dimensional problem of fibre-reinforced thermoelasticity. The material is a homogeneous isotropic elastic half-space. The method applied here is to use normal mode analysis to solve a thermal shock problem. Some particular cases are also discussed in the context of the problem. Deformation of a body depends on the nature of the force applied as well as the type of boundary conditions. Numerical results for the temperature, displacement, and thermal stress components are given and illustrated graphically in the absence and the presence of the magnetic field and rotation.

Study on Metal Detection with an Electromagnetic Induction Probe Utilizing a Rotating Magnetic Field

The present paper describes an investigation conducted on metal detectors installed with a scanning probe.The authors applied a rotating magnetic field probe to metal detection.The rotating magnetic field probe is comprised of two vertically placed rectangular exciting coils and a circular detecting coil.The experimental results confirmed that the probe can detect metal objects and provide more information about their shape,direction,and electromagnetic characteristics than conventional metal detector probes.A two-dimensional signal display shows a low-resolution image of the metal object and the signal phase indicates the object’s direction and electromagnetic characteristics.The experimental results show that excellent reconstruction of the surface shapes of metal objects can be obtained for both magnetic and nonmagnetic metals under present conditions.There is also the potential for the approximate shape of a metal object to be estimated from the reconstructed image.

Effect of electromagnetic stirring methods on solidification structures of Sn-11% Sb binary alloy

In this paper, a spiral magnetic field electromagnetic stirrer, which can separately induce two different magnetic fields ,is introduced. The corresponding central magnetic flux curves of the stirrer were measured by two different probes of the Tesla meter. Meanwhile, the mentioned spiral magnetic field electromagnetic stirrer was used, the effect of the two different magnetic fields on solidification of Sn-I 1% Sb binary alloy was studied,and the segregations and metallographic structures of the ingot samples were analyzed. The research results show that, with the same electromagnetic stirring parameters,the spiral magnetic field electromagnetic stirring is more effective in reducing the composition difference between the upper and lower parts of the ingot. The microstructure photos show that the grain size was more refined.

Critical state-induced emergence of superior magnetic performances in an iron-based amorphous soft magnetic composite

Soft magnetic composites(SMCs)play a pivotal role in the development of high-frequency,miniaturization and complex forming of modern electronics.However,they usually suffer from a trade-off between high magnetization and good magnetic softness(high permeability and low core loss).In this work,utilizing the order modulation strategy,a critical state in a FeSiBCCr amorphous soft magnetic composite(ASMC),consisting of massive crystal-like orders(CLOs,∼1 nm in size)with the feature ofα-Fe,is designed.This critical-state structure endows the amorphous powder with the enhanced ferromagnetic exchange interactions and the optimized magnetic domains with uniform orientation and fewer micro-vortex dots.Superior comprehensive soft magnetic properties at high frequency emerge in the ASMC,such as a high saturation magnetization(Ms)of 170 emu g^(-1)and effective permeability(µ_(e))of 65 combined with a core loss(Pcv)as low as 70 mW cm^(-3)(0.01 T,1 MHz).This study provides a new strategy for the development of high-frequency ASMCs,possessing suitable comprehensive soft magnetic performance to match the requirements of the modern magnetic devices used in the third-generation semiconductors and new energy fields.

Rotating magnetic field-controlled fabrication of magnetic hydrogel with spatially disk-like microstructures

Composite biomaterials with controllable mi- crostructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructure fabricated by assembly of iron oxide nanopartides during the gelation process in the presence of rotating magnetic field. It should be mentioned that the iron oxide nanoparticles here were synthesized identically following techniques of Fer- umoxytol that is the only inorganic nanodrug approved by FDA for clinical applications. The microstructure of nano- particles inside the hydrogel was ordered three-dimensionally due to the twist of the aligned chains of magnetic nano- particles which leads to the lowest state of systematic energy. The size of microstructure can be tuned from several micro- meters to tens of micrometers by changing the assembly parameters. With the increase of microstructure size, the magnetothermal anisotropy was also augmented. This result confirmed that the assembly-induced anisotropy can occur even for the several micron aggregates of nanopartides. The rotating magnetic field-assisted technique is cost-effective, simple and flexible for the fabrication of composite hydrogel with ordered microstructure. We believe it will be favorable for the quick, green and intelligent fabrication of some com- posite materials.

Orthogonal transformation operation theorem of a spatial universal uniform rotating magnetic field and its application in capsule endoscopy

According to the anti-phase sine current superposition theorem, the orientation, the magnetic flux density, the angular speed and the rotational direction of the spatial universal rotating magnetic field (SURMF) can be controlled within the tri-axial orthogonal square Helmholtz coils (TOSHC). Nevertheless, three coupling direction angles of the normal vector of the SURMF in the Descartes coordinate system cannot be separately controlled, thus the adjustment of the orientation of the SURMF is difficult and the flexibility of the robotic posture control is restricted. For the dimension reduction and the decoupling of control variables, the orthogonal transformation operation theorem of the SURMF is proposed based on two independent rotation angular variables, which employs azimuth and altitude angles as two variables of the three-phase sine current superposition formula derived by the orthogonal rotation inverse transformation. Then the unique control rules of the orientation and the rotational direction of the SURMF are generalized in each spatial quadrant, thus the scanning of the normal vector of the SURMF along the horizontal or vertical direction can be achieved through changing only one variable, which simplifies the control process of the orientation of the SURMF greatly. To validate its feasibility and maneuverability, experiments were conducted in the animal intestine utilizing the innovative dual hemisphere capsule robot (DHCR) with active and passive modes. It was demonstrated that the posture adjustment and the steering rolling locomotion of the DHCR can be realized through single variable control, thus the orthogonal transformation operation theorem makes the control of the orientation of the SURMF convenient and flexible significantly. This breakthrough will lay a foundation for the human-machine interaction control of the SURMF.

Influence of the Slowly Rotating Transverse Magnetic Fieldon the Solidification of Metallic Alloys

In this work binary alloy of Pb-Sn is directionally solidified under transverse,slowly rotating magnetic field.For some alloys during directional solidification in the transverse magnetic field significant macrosegregation along the diameter of the ingot may appear if the growth velocity and magnetic field strength are chosen appropriately.This occurs as a result of thermoelectric current,driven by the applied temperature gradient at the solidification interface,and magnetic field interaction caused liquid phase forced convection(thermoelectrornagnetic convection). Magnetic field rotation velocity in chosen to be slow enough that induced electric current can be neglected but still fast enough not letting thermoelectromagnetic convection fully develop in the scale of crucible.In this case the effect caused by thermoelectromagnetic convection on the structure is expected to be different from the case with static magnetic field,which is already studied in many works.Newest experimental results as well as theoretical description and interpretation of the obtained results of direction solidification experiments under rotating magnetic field will be presented in this paper.Magnetic field of 0.5 T is created by rotating permanent magnet system driven by electric step motor.

The kinematics of an untwisting solar jet in a polar coronal hole observed by SDO/AIA

Using the multi-wavelength data from the Atmospheric Imaging Assembly （AIA） onboard the Solar Dynamics Observatory （SDO） spacecraft, we study a jet occurring in a coronal hole near the northern pole of the Sun. The jet presented distinct upward helical motion during ejection. By tracking six identified moving features （MFs） in the jet, we found that the plasma moved at an approximately constant speed along the jet＇s axis. Meanwhile, the MFs made a circular motion in the plane transverse to the axis. Inferred from linear and trigonometric fittings to the axial and transverse heights of the six tracks, the mean values of the axial velocities, transverse velocities, angular speeds, rotation periods, and rotation radii of the jet are 114 km s-1, 136 km s-1, 0.81° s-1, 452 s and 9.8 × 10^3 km respectively. As the MFs rose, the jet width at the corresponding height increased. For the first time, we derived the height variation of the longitudinal magnetic field strength in the jet from the assumption of magnetic flux conservation. Our results indicate that at heights of 1 × 10^4 -7 × 10^4 km from the base of the jet, the flux density in the jet decreases from about 15 to 3 G as a function of B = 0.5（R/R） - 1）-0.84 （G）. A comparison was made with other results in previous studies.

Flow Control During Solidification of AlSi-Alloys by Means of Tailored AC Magnetic Fields

This paper presents an experimental study which in a first stage is focused on obtaining quantitative information about the isothermal flow field exposed to various magnetic field configurations.Melt stirring has been realized by utilizing time-modulated AC magnetic fields in different variants.We consider time-modulated fields or combinations of traveling magnetic fields(TMF)and rotating magnetic fields(RMF).In a second step solidification experiments are carried out to verify the effect of a certain flow field on the solidification process.Our results demonstrate that the melt agitation using modulated magnetic fields offers a considerable potential for a well-aimed modification of casting properties by an effective control of the flow field.

Modeling and Measurements of Heat Transfer Phenomena in Two-Phase PbSn Alloy Solidification in an External Magnetic Field

The main aim of this work is to study numerically the influence of an external magnetic field on the solidification processes of two-component materials. Based on the continuum model of two-phase flow a mathematical model for the directional solidification of a binary alloy in a magnetic field is presented. The model includes mass, momentum, energy and species mass conservation equations written in compressible form and additional relationships describing the temperature-solute coupling. The geometry under study is a cylindrical mold with adiabatic walls and cooled bottom. The macroscale transport in the solidification of alloys is governed by the progress of the two-phase mushy zone, which is treated by means of a porous medium approach. The volume fraction of liquid and solid phases, respectively, is calculated from a 2D approximation of the phase diagram. The results of calculation are compared with experimental data.

An Experimental Study of a Bubble-Driven Liquid Metal Flow Under the Influence of a Rotating Magnetic Field

In this study we investigate the flow structure in a liquid metal cylinder while a bubble-driven flow is superposed with a rotating magnetic field(RMF).Argon gas is injected through a nozzle into a column of the eutectic alloy GalnSn. Without electromagnetic stirring the bubble plume in the centre region of the cylindrical vessel produces a recirculation with high velocities near the free surface while the fluid velocities in the bottom region remain rather low.The measurements revealed the potential of the RMF to control both the amplitude of the meridional flow and the bubble distribution and to provide an effective mixing in the whole fluid volume.Various periodic flow patterns were observed in a certain parameter range with respect to variations of the magnetic field strength and the gas flow rate.

The Impact of an Oxidised Surface on the Melt Flow Driven by a Rotating Magnetic Field in a Cylindrical Column

This paper considers the situation where the liquid metal flow with a free surface covered by an oxide layer is driven by a rotating magnetic field.The cylindrical configuration was investigated in an experiment accompanied by numerical simulations.The oxide layer feels the effect of the viscous force arising from the moving liquid beneath and the friction force from the side walls.A complex interaction occurs if both forces are in the same order of magnitude.Our measurements demonstrate that the occurrence of the oxide layer may lead to an unexpected oscillating behaviour of the bulk flow.Our numerical model was shown to be able to reproduce essential features of the phenomenon in a qualitative way.

Inertial Waves Occurring in a Liquid Metal Column due to Pulsed Excitation by a Rotating Magnetic Field

We present an experimental study concerning the flow inside a liquid metal column exposed to a pulsed rotating magnetic field.This paper is aimed at highly resolved,quantitative velocity measurements in the eutectic GalnSn alloy.A novel ultrasound Doppler system was used two measure two-dimensional velocity fields of the secondary flow in the radial-meridional plane.It employs an array of 25 transducer elements allowing a fast electronic traversing with concurrently high spatial and temporal resolution.The measurements revealed transient flow regimes showing distinct inertial oscillations and coherent vortex structures.The results demonstrate that the arising flow structure depends sensitively on the frequency of the RMF pulses.A maximum intensity of a periodic meridional flow can be observed,if the corresponding pulse frequency fp relates to the eigenperiod of the respective inertial mode in a developed regime.The electromagnetic stirring method that uses a modulated RMF offers considerable potential to enhance the stirring efficiency and to optimize the properties of castings by a well-aimed flow control during solidification.

Influence of Bipartite Qubit Coupling on Geometric Phase

The geometric phase of the bipartite Heisenberg spin-1/2 system with one spin driven by rotating magnetic field is investigated. It is found that in the one-site drive case, the intersubsystem coupling can be equivalent to a static quasi-magnetic field in the parameter space. This perspective has satisfactorily explained the irregular asymptote effect of geometric phase. We discuss the property of the two-site magnetic drive spin system and discover that a stationary state with no geometric phase shift is generated.