Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention

Psychoactive substance use is characterized by the habitual use of substances that have significant effects in altering the activities of neurotransmitters in certain regions of the brain.Consequently,these alterations manifest as cognitive,emotional,perceptual and behavioural changes in affected individuals[1].

Erratum regarding Declaration of Competing Interest statements in previously published articles

Declaration of Competing Interest statements were incorrectly included in the published version of the following articles that appeared in previous issues of Materials Reports:Energy.The appropriate Declaration of Competing Interest statements,provided by the authors,are included below.

Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity

A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea subsp.hibaria TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which generated a trace of the target products but accumulated a large amount of shunt products.Based on rational analysis of the relevant secondary metabolism,directed engineering of the biosynthetic pathways resulted in the high production of HBM B,as well as new HBM derivates with improved antitumor activity.These results not only establish a biosynthetic system to effectively synthesize HBMs-a class of the largest and most complex Type-Ⅱpolyketides,with a unique pseudo-dimeric structure-but also set the stage for further engineering and deep investigation of this complex biosynthetic pathway toward potent anticancer drugs.

Blockchain-Based Key Management Scheme Using Rational Secret Sharing

Traditional blockchain key management schemes store private keys in the same location,which can easily lead to security issues such as a single point of failure.Therefore,decentralized threshold key management schemes have become a research focus for blockchain private key protection.The security of private keys for blockchain user wallet is highly related to user identity authentication and digital asset security.The threshold blockchain private key management schemes based on verifiable secret sharing have made some progress,but these schemes do not consider participants’self-interested behavior,and require trusted nodes to keep private key fragments,resulting in a narrow application scope and low deployment efficiency,which cannot meet the needs of personal wallet private key escrow and recovery in public blockchains.We design a private key management scheme based on rational secret sharing that considers the self-interest of participants in secret sharing protocols,and constrains the behavior of rational participants through reasonable mechanism design,making it more suitable in distributed scenarios such as the public blockchain.The proposed scheme achieves the escrow and recovery of personal wallet private keys without the participation of trusted nodes,and simulate its implementation on smart contracts.Compared to other existing threshold wallet solutions and keymanagement schemes based on password-protected secret sharing(PPSS),the proposed scheme has a wide range of applications,verifiable private key recovery,low communication overhead,higher computational efficiency when users perform one-time multi-key escrow,no need for trusted nodes,and personal rational constraints and anti-collusion attack capabilities.

Approximate solution of Volterra-Fredholm integral equations using generalized barycentric rational interpolant

It is well-known that interpolation by rational functions results in a more accurate approximation than the polynomials interpolation.However,classical rational interpolation has some deficiencies such as uncontrollable poles and low convergence order.In contrast with the classical rational interpolants,the generalized barycentric rational interpolants which depend linearly on the interpolated values,yield infinite smooth approximation with no poles in real numbers.In this paper,a numerical collocation approach,based on the generalized barycentric rational interpolation and Gaussian quadrature formula,was introduced to approximate the solution of Volterra-Fredholm integral equations.Three types of points in the solution domain are used as interpolation nodes.The obtained numerical results confirm that the barycentric rational interpolants are efficient tools for solving Volterra-Fredholm integral equations.Moreover,integral equations with Runge’s function as an exact solution,no oscillation occurrs in the obtained approximate solutions so that the Runge’s phenomenon is avoided.

Experimental study of core MHD behavior and a novel algorithm for rational surface detection based on profile reflectometry in EAST

Microwave reflectometry is a powerful diagnostic that can measure the density profile and localized turbulence with high spatial and temporal resolution and will be used in ITER,so understanding the influence of plasma perturbations on the reflect signal is important.The characteristics of the reflect signal from profile reflectometry,the time-of-flight(TOF)signal associated with the MHD instabilities,are investigated in EAST.Using a 1D full-wave simulation code by the Finite-DifferenceTime-Domain(FDTD)method,it is well validated that the local density flattening could induce the discontinuity of the simulated TOF signal and an obvious change of reflect amplitude.Experimental TOF signals under different types of MHD instabilities(sawtooth,sawtooth precursors and tearing mode)are studied in detail and show agreement with the simulation.Two new improved algorithms for detecting and localizing the radial positions of the low-order rational surface,the cross-correlation and gradient threshold(CGT)method and the 2D convolutional neural network approach(CNN)are presented for the first time.It is concluded that TOF signal analysis from profile reflectometry can provide a straightforward and localized measurement of the plasma perturbation from the edge to the core simultaneously and may be a complement or correction to the q-profile control,which will be beneficial for the advanced tokamak operation.

The Global Security Initiative: Its Relevance, Rationale and Delivery

Today,our world is undergoing profound changes unseen in a century.Global security landscape is becoming ever more unstable and uncertain.In the face of growing deficits in security,Chinese President Xi Jinping put forward the Global Security Initiative(GSI),offering a clear answer to the question of the times:what kind of security concept does the world need,and how can we achieve common security?It is of great significance to fully grasp the relevance of and the rationale for the GSI,and push for its strategic delivery,so as to contribute to the long-term peace and stability of the world.

Practice of Perioperative Rational Use of Antibacterial Drugs Based on Drug Pathway

[Objectives]To establish a new management model for rational use of perioperative antibacterial drugs in surgical departments.[Methods]Based on evidence-based medicine,the department s drug pathway was formulated,and the new mode of rational drug use control was established by using fine pharmaceutical technology intervention,and the intervention effect was evaluated by the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs.[Results]After adopting drug pathway in departments,the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs decreased significantly,and the effect of rational drug use control was remarkable.[Conclusions]The drug pathway provides a new management and control mode for the rational use of perioperative antibacterial drugs in surgical departments of hospitals.Thus,it is worthy of popularization and application.

Exact controllability of rational expectations model with multiplicative noise and input delay

This paper considers the rational expectations model with multiplicative noise and input delay,where the system dynamics rely on the conditional expectations of future states.The main contribution is to obtain a sufficient condition for the exact controllability of the rational expectations model.In particular,we derive a sufficient Gramian matrix condition and a rank condition for the delay-free case.The key is the solvability of the backward stochastic difference equations with input delay which is derived from the forward and backward stochastic system.

The Frontiers and Future Landscape of Research and Education on Value Rationality in Contemporary China

The importance of conducting in-depth research and education on value rationality in the new era is increasingly recognized.Therefore,it is essential to systematically grasp the themes,frontiers,and trends of research in this field,organizing the knowledge system to provide references for future studies.This necessitates clarifying the research achievements of scholars from different disciplines and institutions.Using the CiteSpace visualization analysis method,we can analyze,summarize,and synthesize research networks,hotspots,and knowledge structures,thereby forming a direction for advancing research.Through literature review methods and knowledge graph software analysis,it is believed that value rationality and instrumental rationality represent the rational attitudes individuals adopt when contemplating issues and putting them into practice.They are merely methods and should not be subjected to excessive value judgments.The relationship between value rationality and instrumental rationality is a focal point of societal concern,involving complex interdisciplinary issues with significant theoretical value and practical implications.In the future,the academic community needs to strengthen research collaboration,enhance the expansion of value rationality in various social practice fields,and conduct empirical studies to build consensus for the construction of Chinese society.

Evaluation of the Effectiveness of Community Pharmacy Services on Rational Medication Use in Elderly Patients with Hypertension and Diabetes

Objective:To explore the effect of community pharmacy services on rational medication use in elderly patients with hypertension and diabetes.Methods:Between November 2022 and December 2023,80 elderly patients with hypertension and diabetes were selected and randomly divided into a control group(routine medication guidance)and an observation group(community pharmacy services),with 40 subjects each.The medication effect scores,blood pressure,blood sugar levels,and quality of life scores before and after intervention were compared between the two groups.Results:Comparison of pharmaceutical knowledge,medication compliance,and safe medication behavior scores showed that the observation group had higher scores as compared to the control group(P<0.05);blood pressure(systolic blood pressure,diastolic blood pressure,heart rate)and blood sugar(fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin)index levels were compared,and the observation group’s index levels were lower than those of the control group(P<0.05);the scores of physical health,mental health,social relationships,and environment in the observation group were higher than those in the control group(P<0.05).Conclusion:Community pharmacy services improved the rational medication effect of elderly patients with hypertension and diabetes,and improved their blood pressure,blood sugar control levels,and quality of life.

用Rational Rose实现连锁企业网上采购系统的建模设计

探讨了在RationalUnifiedProcess(RUP)指导下 ,用RationalRose实现连锁企业网上采购系统的面向对象建模与设计的过程 ;并结合采购的通用流程 ,建立了几种通用的网上采购模型。

基于UML和Rational Rose的计算机远程教学系统的设计

系统描述了一个用UML和RationalRose实现计算机远程教学系统的设计过程,探讨了面向对象思想在远程教学系统中应用的必要性和科学性。

基于Rational统一过程的物业管理信息系统开发

Rational统一过程是一个先进的通用软件开发过程框架 ,遵循它的开发方法可以在进度和成本的范围内开发出高质量的软件产品。首先介绍统一过程的主要特征 ;然后以一个物业管理信息系统的开发为例 。

基于Rational Rose的数据建模

文章从面向对象角度阐述如何应用Rational Rose进行数据库建模,将数据模型与对象模型相互转换以及由数据模型生成相应的数据库,在此基础上给出了具体的方法和步骤。其目的是将抽象的数据库设计理论变成具体的数据库建模方法,使数据模型与面向对象的开发更好地结合在一起,有效地缩短软件的开发周期,从而满足多种数据库应用的需求。

Rational Rose及用Rose建模火电厂设备状态检修管理信息系统

Rose是一种标准建模语言 (即UML) ,它利用用例图、静态图、行为图、交互图及实现图来表达建模思想 .文章简单介绍了UML及Rose的特点 ,并以设备台帐管理子系统为例 ,通过用Rose捕获用户需求、表达系统的对象和类之间的交互、描述系统的类及关联、添加系统中类的属性和操作以及用Rose生成类代码 ,阐述了用Rose建模火电厂设备状态检修管理信息系统的过程 .实践表明 ,Rose不失为一种强有力的建模工具 .

Rational统一过程中的Use Case业务建模

在利用统一建模语言UML和Rational统一过程建立软件系统模型和开发软件系统时 ,首要的任务就是建立系统的业务模型。本文通过实例详细论述了UseCase以及利用UseCase建立系统业务模型的方法。

ADAPTIVE BACKSTEPPING FLIGHT CONTROL WITH ACTUATOR SATURATION

Because actuator satu ration can become a problem or even a disaster in flight control system, the con sideration of actuator saturation in the design phase may indeed reduce the degr ee of conservativeness of an flight control system (FCS) and thus noticeably enh ance the performance of the FCS. Deflection limits and rate limits are both cons idered in a new adaptive backstepping FCS design process. The key of the method is that a new control Lyapunov function (CLF) and a control law are chosen when the actuator saturation occurs. This idea results from that there must be a vari ation in the pseudo-control at saturation. The whole progress is a modification of an early presented method: adaptive backstepping control scheme. The stabili ty is proved and verified successfully. The conclusion and some comments about t his method are given in the end.

Rational统一过程的可视化建模的应用

为了提高开发软件的效率和软件的质量,采用新一代软件开发过程Rational统一过程,以及功能强大的可视化建模语言UML,二者在软件开发过程中得到了广泛的应用。简要介绍RUP技术和UML语言的基本内容,并在RUP的指导下,运用UML建模技术,对设备缺陷管理及分析系统进行设计,对系统开发的各个阶段进行建模,该过程不但优化了系统的各阶段的迭代与建模过程,而且可以较容易应对需求变更,提前降低开发系统的风险,降低系统的复杂度,提高了软件开发的质量、效率和维护性。

Study on Rational Breeding of High-Yield Avermectin Industrial Strain

[Objective] Strain Biok Av-023 used as the control was employed on screening of high-avermectin yield mutants by rational screening.[Method] With Biok Av-023 as the original strain,the positive mutation strain was firstly screened by routine UV mutagenesis,and then the high-yield avermectin producing strain was selected by the breeding way inferred by L-Ile induction.[Result] UV mutation and L-Ile directional screening had showed that the best L-Ile screening concentration was 0.5%,and the high-yield mutation strain AV60s-32 after re-screening reached the highest titer of 4520 IU/ml,which increased by 23.4% compared with the original strain.[Conclusion] The production of avermectin can be effectively enhanced by the combined way of UV mutation and L-Ile rational breeding.