归来庄金矿矿体和岩体中Au等成分的Runs检验及意义

Runs检验是研究序列分布规律的一种数学方法。用这种方法检验归来庄金矿和铜石杂岩体的某些成分,得出归来庄金矿TC30中Au的高品位值的出现不是随机的,而是具有集中出现的规律性;铜石杂岩体中SiO2和Au都是具有随机变化性,说明杂岩体没有明显的演化关系,不同岩体的形成时间先后对成矿元素Au的富集没有明显影响;杂岩体中Al2O3和TiO2比值在闪长玢岩和二长斑岩中无明显差异,说明二者为同源成因。

Estimation of inbreeding and identification of regions under heavy selection based on runs of homozygosity in a Large White pig population

Background: Runs of homozygosity(ROHs) are homozygous segments of the genome where the two haplotypes inherited from the parents are identical. The current availability of genotypes for a very large number of single nucleotide polymorphisms(SNPs) is leading to more accurate characterization of ROHs in the whole genome. Here,we investigated the occurrence and distribution of ROHs in 3,692 Large White pigs and compared estimates of inbreeding coefficients calculated based on ROHs(FROH), homozygosity(FHOM), genomic relationship matrix(FGRM)and pedigree(FPED). Furthermore, we identified genomic regions with high ROH frequencies and annotated their candidate genes.Results: In total, 176,182 ROHs were identified from 3,569 animals, and all individuals displayed at least one ROH longer than 1 Mb. The ROHs identified were unevenly distributed on the autosomes. The highest and lowest coverages of Sus scrofa chromosomes(SSC) by ROH were on SSC14 and SSC13, respectively. The highest pairwise correlation among the different inbreeding coefficient estimates was 0.95 between FROH_totaland FHOM, while the lowest was-0.083 between FGRMand FPED. The correlations between FPEDand FROHusing four classes of ROH lengths ranged from 0.18 to 0.37 and increased with increasing ROH length, except for ROH > 10 Mb. Twelve ROH islands were located on four chromosomes(SSC1, 4, 6 and 14). These ROH islands harboured genes associated with reproduction, muscular development, fat deposition and adaptation, such as SIRT1, MYPN, SETDB1 and PSMD4.Conclusion: FROHcan be used to accurately assess individual inbreeding levels compared to other inbreeding coefficient estimators. In the absence of pedigree records, FROHcan provide an alternative to inbreeding estimates.Our findings can be used not only to effectively increase the response to selection by appropriately managing the rate of inbreeding and minimizing the negative effects of inbreeding depression but also to help detect genomic regions with an effect on traits under selection.

Genome-wide detection for runs of homozygosity analysis in three pig breeds from Chinese Taihu Basin and Landrace pigs by SLAF-seq data

Erhualian(E),Meishan(MS)and Mi(MI)pigs are excellent indigenous pig breeds in Chinese Taihu Basin,which have made great contributions to the genetic improvement of commercial pigs.Investigation of the genetic structure and inbreeding level of the 3 pig breeds is of great significance for the sustainable breeding of commercial pigs.The length and number of runs of homozygosity(ROH)as well as the frequency of genomes covered by ROH can be used as indicators to evaluate the level of inbreeding and the origin of the population.In this study,the ROH characteristics of E,MS,MI and Landrace(L)pigs were analyzed by SLAF-seq data,and the inbreeding coefficient based on ROH(F_(ROH))was calculated.In addition,we have identified candidate genes in the genomic regions associated with ROH.A total of10568 ROH were detected in 116 individuals of 4 pig breeds.The analysis showed that there were significant differences in genetic structure between 3 Taihu Basin pig breeds and L,and the genetic structure of E and MI was similar.The results of F_(ROH)showed that the inbreeding level of MS was the highest(0.25±0.07),while E and MI were lower than L.Compared with the other 3 pig populations,MS showed a higher frequency of long ROH(>5 Mb),indicating higher inbreeding in MS in recent generations.A large number of candidate genes related to reproductive traits are located in the genomic regions with a high frequency of ROH,and these genes are expected to be used as candidate genes in marker-assisted selection(MAS)breeding programs.Our findings can provide theoretical support for genetic conservation and genetic improvement of 3 pig breeds in Chinese Taihu Basin.

Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese

Runs of homozygosity （ROHs） are a class of important but poorly studied genomic variations and may be in- volved in individual susceptibility to diseases. To better understand ROH and its relationship with lung cancer, we performed a genome-wide ROH analysis of a subset of a previous genome-wide case-control study （1,473 cases and 1,962 controls） in a Han Chinese population. ROHs were classified into two classes, based on lengths, intermedi- ate and long ROils, to evaluate their association with lung cancer risk using existing genome-wide single nucleofide polymorphism （SNP） data. We found that the overall level of intermediate ROHs was significantly associated with a decreased risk of lung cancer （odds ratio = 0.63; 95% confidence interval： 0.51-0.77; P = 4.78 × 10-6 ）, while the long ROHs seemed to be a risk factor of lung cancer. We also identified one ROH region at 14q23A that was con- sistently associated with lung cancer risk in the study. These results indicated that ROHs may be a new class of variation which may be associated with lung cancer risk, and genetic variants at 14q23.1 may be involved in the development of lung cancer.

Still Water Runs Deep:On Practices of Innovative Development in People-to-People Diplomacy of Henan

In recent years,Henan sticks to the points of General Secretary Xi Jinping,makes full use of its rich resources and relations,makes efforts to deepen friendship with people around the world,promotes relations with foreign countries,pushes

Characteristics of non-conveyance ambulance runs: A retrospective study in the Netherlands

Dear editor,Emergency medical services(EMS)have developed from conveyance facilities into providers of advanced pre-hospital care.[1,2]Alongside this development there is a growing demand for EMS care,and the number of ambulance deployments is increasing.[3,4]Suggested reasons for this growing demand are changes in social support of people,accessibility of healthcare and social facilities,and the aging population.

Numerical Procedures for Calculating the Probabilities of Recurrent Runs

Run count statistics serve a central role in tests of non-randomness of stochastic processes of interest to a wide range of disciplines within the physical sciences, social sciences, business and finance, and other endeavors involving intrinsic uncertainty. To carry out such tests, it is often necessary to calculate two kinds of run count probabilities: 1) the probability that a certain number of trials results in a specified multiple occurrence of an event, or 2) the probability that a specified number of occurrences of an event take place within a fixed number of trials. The use of appropriate generating functions provides a systematic procedure for obtaining the distribution functions of these probabilities. This paper examines relationships among the generating functions applicable to recurrent runs and discusses methods, employing symbolic mathematical software, for implementing numerical extraction of probabilities. In addition, the asymptotic form of the cumulative distribution function is derived, which allows accurate runs statistics to be obtained for sequences of trials so large that computation times for extraction of this information from the generating functions could be impractically long.

Counting Types of Runs in Classes of Arborescent Words

An arborescence is a directed rooted tree in which all edges point away from the root. An arborescent word is obtained by replacing each element of the underlying set of an arborescence by an arbitrary letter of a given alphabet (with possible repetitions). We define a run in an arborescent word as a maximal sub-arborescent word whose letters are all identical. Various types of runs (e.g., runs of size ≤ k, linear runs, etc) are studied in the context of R-enriched arborescent words, where R is a given species of structures.

Counting Runs of Ones and Ones in Runs of Ones in Binary Strings

Consider a binary string (a symmetric Bernoulli sequence) of length . For a positive integer , we exactly enumerate, in all? possible binary strings of length , the number of all runs of 1s of length (equal, at least)? and the number of 1s in all runs of 1s of length at least . To solve these counting problems, we use probability theory and we obtain simple and easy to compute explicit formulae as well as recursive schemes, for these potential useful in engineering numbers.

Rural Doctor Runs‘Daddy Daycare’in Southwest China

In the past four years, Lan Chengshan has provided a ＂parents love＂ to more than 200 children. The 34-year-old doctor oper- ates a medical clinic in Lianhua, a remote village in Southwest China＇s Guizhou province. He＇s also the headmaster of a kindergarten, just like Eddie Murphy＇s role in the Hollywood film, Daddy Davcare.

Some Group Runs Based Multivariate Control Charts for Monitoring the Process Mean Vector

In this article, we propose two control charts namely, the “Multivariate Group Runs’ (MV-GR-M)” and the “Multivariate Modified Group Runs’ (MV-MGR-M)” control charts, based on the multivariate normal processes, for monitoring the process mean vector. Methods to obtain the design parameters and operations of these control charts are discussed. Performances of the proposed charts are compared with some existing control charts. It is verified that, the proposed charts give a significant reduction in the out-of-control “Average Time to Signal” (ATS) in the zero state, as well in the steady state compared to the Hotelling’s T2 and the synthetic T2 control charts.

Railway Runs to Lhasa

＂It is a magical road, taking us to paradise on earth; dragon after dragon climb ridges and mountains, bringing prosperity to the snowy plateau……＂ This; is part of a song titled Heavenly Road eulogizing the Qinghai-Tibet Railway.

The Train Runs Faster

Teacher:Why does a train run faster than(比)a car?Pupil:Because it has more wheels(轮子)than a car.

Study on Runs of Knitted Fabrics

The mechanism of runs propagation of plain weft-knit-ted fabric is analyzed theoretically.The relevant physicalmodel,the mathematical equation and the new methodto test the run force are presented accordingly,and themeasured results are described also.The run theory hasbeen proved correct in practice,a means to improve runresist of knit is also recommended.

＇Runs＇ from a run： A case of exercise induced ischemic colitis

Marathon running is a strenuous activity that placesstress on the gastrointestinal system.[1] In fact, 30% to81% of runners report gastrointestinal complaints, whichinclude bloating, abdominal cramps, rectal incontinence,and gastrointestinal bleeding.

Conservation genomics provides insights into genetic resilience and adaptation of the endangered Chinese hazelnut, Corylus chinensis

Global climate change has increased concerns regarding biodiversity loss.However,many key conservation issues still required further research,including demographic history,deleterious mutation load,adaptive evolution,and putative introgression.Here we generated the first chromosome-level genome of the endangered Chinese hazelnut,Corylus chinensis,and compared the genomic signatures with its sympatric widespread C.kwechowensis-C yunnanensis complex.We found large genome rearrangements across all Corylus species and identified species-specific expanded gene families that may be involved in adaptation.Population genomics revealed that both C.chinensis and the C.kwechowensis-C.yunnanensis complex had diverged into two genetic lineages,forming a consistent pattern of southwestern-northern differentiation.Population size of the narrow southwestern lineages of both species have decreased continuously since the late Miocene,whereas the widespread northern lineages have remained stable(C.chinensis) or have even recovered from population bottlenecks(C.kwechowensis-C.yunnanensis complex) during the Quaternary.Compared with C.kwechowensis-C. yunnanensis complex,C.chinensis showed significantly lower genomic diversity and higher inbreeding level.However,C.chinensis carried significantly fewer deleterious mutations than C.kwechowensis-C. yunnanensis complex,as more effective purging selection reduced the accumulation of homozygous variants.We also detected signals of positive selection and adaptive introgression in different lineages,which facilitated the accumulation of favorable variants and formation of local adaptation.Hence,both types of selection and exogenous introgression could have mitigated inbreeding and facilitated survival and persistence of C.chinensis.Overall,our study provides critical insights into lineage differentiation,local adaptation,and the potential for future recovery of endangered trees.

A novel small-animal locomotor activity recording device for biological clock research

The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian rhythm.This study demonstrated how to construct a simple and intelligent running-wheel recording system.The running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's cover.Then,the RJ25 adaptor relayed the running signal to the main control board.Finally,the main control board was connected to the USB port of the computer with the USB connection.Data were collected using the online-accessible,self-created software Magturning.Through Magturning,generated data were saved and exported in real time.Afterward,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light conditions.In conclusion,this new device can record circadian activity of rodents.Our device is appropriate for interdisciplinary investigations related to biological clock research.

Voluntary wheel running ameliorated the deleterious effects of high-fat diet on glucose metabolism,gut microbiota and microbial-associated metabolites

Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus.However,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully elaborated.C57BL/6 male mice were randomly assigned to 4 groups according to diets(fed with normal chow diet or high-fat diet)and running paradigm(housed in static cage or with voluntary running wheel).An integrative 16S rDNA sequencing and metabolites profiling was synchronously performed to characterize the effects of voluntary wheel running on gut microbiota and metabolites.It showed that voluntary wheel running prevented the detrimental effects of high-fat feeding on glucose metabolism 16S rDNA sequencing showed remarkable changes in Rikenella and Marvinbryantia genera.Metabolic profiling indicated multiple altered metabolites,which were enriched in secondary bile acid biosynthesis signaling.In conclusion,our study indicated that voluntary wheel running significantly improved glucose metabolism and counteracted the deleterious effects of high-fat feeding on body weight and glucose intolerance.We further found that voluntary wheel running could integratively program gut microbiota composition and fecal metabolites changes,and may regulate muricholic acid metabolism and secondary bile acid biosynthesis in high-fat fed mice.