目的 :探讨 s F as与 s F as L和 TNFα在类风湿关节炎 ( RA )发病中的意义。方法 :采用固相酶联免疫分析( EL ISA)法检测 38例 RA患者血清 s Fas,s F as L含量及 TNFα水平。结果 :RA患者血清 s F as,s Fas L ,TNFα水平均高于正常对照...目的 :探讨 s F as与 s F as L和 TNFα在类风湿关节炎 ( RA )发病中的意义。方法 :采用固相酶联免疫分析( EL ISA)法检测 38例 RA患者血清 s Fas,s F as L含量及 TNFα水平。结果 :RA患者血清 s F as,s Fas L ,TNFα水平均高于正常对照组 ,RA患者活动期 s F as L,TNFα显著高于非活动期 ( P<0 .0 1) ,而 s Fas水平未见显著差异。在 38例 RA患者中 ,有 13例 s F as和 s F as L 的水平同时升高 ,RA活动期患者血清 s Fas L 的增高与 TNFα增高呈正相关 ( r=0 .46 9P<0 .0 1) ,而其它组间无相关性 ( P>0 .0 5 )。结论 :s Fas L水平与 RA的炎症程度有关 ,高浓度 s Fas和 s F as L可抑制 Ts细胞对 Th的负向调节。TNFα与 s Fas L具有关联性。血清 s Fas,s Fas L ,TNFα检测有助于对 RA病情进展作出判断 ,并为 RA的免疫生物治疗提供新方法。展开更多
BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis pathway.High expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood co...BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis pathway.High expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was small.AIM To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample size.METHODS Patients underwent LT due to HCC were included in this retrospective study.Serum sFasL levels prior to LT were measured and one-year LT mortality was registered.RESULTS Non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;P<0.001]than surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;P=0.001)independently of age of LT donor in the logistic regression analysis.CONCLUSION We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.展开更多
文摘目的 :探讨 s F as与 s F as L和 TNFα在类风湿关节炎 ( RA )发病中的意义。方法 :采用固相酶联免疫分析( EL ISA)法检测 38例 RA患者血清 s Fas,s F as L含量及 TNFα水平。结果 :RA患者血清 s F as,s Fas L ,TNFα水平均高于正常对照组 ,RA患者活动期 s F as L,TNFα显著高于非活动期 ( P<0 .0 1) ,而 s Fas水平未见显著差异。在 38例 RA患者中 ,有 13例 s F as和 s F as L 的水平同时升高 ,RA活动期患者血清 s Fas L 的增高与 TNFα增高呈正相关 ( r=0 .46 9P<0 .0 1) ,而其它组间无相关性 ( P>0 .0 5 )。结论 :s Fas L水平与 RA的炎症程度有关 ,高浓度 s Fas和 s F as L可抑制 Ts细胞对 Th的负向调节。TNFα与 s Fas L具有关联性。血清 s Fas,s Fas L ,TNFα检测有助于对 RA病情进展作出判断 ,并为 RA的免疫生物治疗提供新方法。
文摘BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis pathway.High expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was small.AIM To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample size.METHODS Patients underwent LT due to HCC were included in this retrospective study.Serum sFasL levels prior to LT were measured and one-year LT mortality was registered.RESULTS Non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;P<0.001]than surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;P=0.001)independently of age of LT donor in the logistic regression analysis.CONCLUSION We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.
