Safety of the express freight train running over a long-span bridge

Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains.

Looking ahead to significant improvements in mining safety and health through innovative research and effective diffusion into the industry

Mining safety and health improvements over the past decades are remarkable by many metrics, and yet the expectation of society, and the goal of the mining industry, is zero harm. If we examine the underlying enablers for the significant gains that have been achieved, the key role that research to help understand the causes of problems and to develop lasting solutions is clear. Many of the remaining challenges have been resistant to solutions by various approaches. Some, such as fatalities and injuries from ground control or powered haulage are prominent year after year. Different approaches are indicated and new solutions will be required if we are to achieve a goal of zero harm. These will originate with research, but into which topics, and what are some of these different approaches? This paper examines the current state of mine safety in the United States and highlights areas of significant opportunity for research that will lead to solutions. The likely direction of research that will enable realization of the ‘‘zero harm'' goal is described in terms of evolutionary and revolutionary approaches. Both are important, but the author's view is that some of the largest gains will be made with trans-disciplinary approaches that break from the past. Topical areas of research are suggested and several research questions are given to illustrate the direction of future research in mining safety and health.

Study on Net Hauler Safety Device for Fishing Vessels

[Objective] To design a safety device set for fishing vessel net hauler, in order to reduce the severe potential safety hazards in offshore operation. [Method] In view of the operation and structure of net hauler on the fishing trawler, this paper investigated the existing safety protection devices and designed a new set of purely mechanical structure without changing the original structures of the vessel significantly. [Result] Using the easily-adjustable functions of the main shaft of CNC lathe, and simulating the operation performance of different hauling line speeds and testing the safety device, the results showed that the new device could protect the crew from safety accidents caused by net hauler. [Conclusion] The result provides references for the design and application of mechanical protection devices for net haulers on other fishing trawlers.

To Establish A Body of Evidence on Safety for Postmarketing Chinese Medicine：A New Research Paradigm

The issue of safety evaluation on postmarketing Chinese medicines has become a hot topic in China’s mainland recently. Researchers and decision-makers can obtain a variety of evidence resources about safety in order to evaluate the safety profile for postmarketing Chinese medicines. A registry study on ten Chinese medicine injections for postmarketing surveillance has come to the end. From such a study observing more than 300,000 patients for more than 4 years, a theoretical research question emerges, that is, how to identify and evaluate safety evidence systematically. We put forward a brand new research paradigm on the theory level, which is to establish a body of evidence on safety evaluation for postmarketing Chinese medicine. Therefore, multiple information sources were explored and extracted from preclinical experiments for toxicity, postmarketing clinical trials for efficacy and safety evaluation, registry study for surveillance, retrospective data analysis from hospital information system and spontaneous response system, and case reports and systematic review from literature. Greater efforts for this idea and cooperation with experts in this field both in China and abroad are urgently needed.

Big Data Interprets US Opioid Crisis

Since 2010,there has been a new round of drug crises in the United States.The abuse of opioids has led to a sharp increase in the number of people involved in drug crimes in the United States.There is an urgent need to explore solutions to the drug crisis in the United States.In this paper,the model of in-depth analysis is established under the condition of obtaining the opioid data and the influence factor data of the large sample of five state[1].In the first part,we use the Highway Safety Research Institute model based on the differential equation model to predict the initial value,find the initial position of the drug transfer,and obtain the curve of the number of different groups over time by fitting the data,so that the curves can be predicted the changing trends of the groups in the future.It was found that in Kentucky State,the county's most likely to start using opioids were Pike and Bale.In Ohio,the county's most likely to start using opioids are Jackson and Scioto.In Pennsylvania State,Mercer and Lackawanna are the counties most likely to start using opioids.Martinsville and Galax are the counties where Virginia State is most likely to start using opioids.Logan and Mingo are the counties where West Virginia State is most likely to start using opioids.In the second part,the gray prediction model is used to further analyze the time series of each factor,the maximum likelihood estimation method is used to obtain the weight of each factor,and the weight coefficient matrix is used to simulate the multivariate regression equation,and the factors that have the greatest influence on opioid abuse are educational background and family composition.In the third part,the hypothesis test model of two groups(the data type is proportional)is used to verify the difference between the influence factors(including the predicted values)in the first two parts of the states,thus verifying the feasibility between them.At the same time,we put forward a few suggestions to combine the current situation in the United States with the CDC data.We believe that in order to address the opium crisis,the U.S.government needs to strengthen not only oversight of doctors'prescriptions,but also make joint efforts of all sectors of society to fundamentally reduce the barriers to the use of opioids.

Post-marketing safety monitoring of Shenqifuzheng injection: a solution made of Dangshen(Radix Codonopsis)and Huangqi(Radix Astragali Mongolici)

OBJECTIVE:Toidentify the potential risk factors associated with Shenqifuzheng injection(SFI), a solution made of Dangshen(Radix Codonopsis) and Huangqi(Radix Astragali Mongolici), for the timely provision of information to regulatory authorities.METHODS: A comprehensive analysis of the production process, quality standards, pharmacology,post-marketing clinical studies, and safety evaluation using the primary literature of adverse reactions(ADR), case analyses, and systematic reviews,intensive hospital safety monitoring of post-marketing drugs, and data provided by the hospital in-formationsystem(HIS).RESULTS: Sub-acute toxicity tests suggesting that a dose of 15 mL/kg(concentrated solution) had specific biological effects, whereas a smaller dose engendered no observable effects. Long-term toxicity testing in domestic rabbits showed that after SFI was administered for 90 days, the animals in each dosing group showed no chronic toxic reactions. Among 20 100 cases observed, the incidence of an ADR was 1.85‰. From March to November 2013,of the leading institutions and 22 sub-centers involved in the post-marketing clinical safety intensive hospital monitoring, 21 units completed 8484 cases of monitoring, and reported 23 cases of adverse reactions. No damage to renal function was found using SFI ata dosageanda treatment course larger and longer than that recommended for the adjuvant treatment of tumors. This could reduce the mortality rate of admitted patients based on the analysis of the data provided by the HIS. A total of 16 clinical case reports of adverse reactions related to SFI in 1999-2012 were obtained through literature retrieval. These reports contained information concerning 17 cases, with adverse reaction symptoms including thrombocytopenia, rash,chills,feeling cold,palpitation,dyspnea,edemaofa lower extremity, palpebral edema, and superficial vein in flammation,among others.CONCLUSION: This study introduces "get full access" to the flow of information on medicines regarding their ADR incidence rate and characteristics and factors.It supports the safety of SFI for clinical, research, and production uses based on objec-tive, reliable, and scientific information to provide safe medication.