Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-V...Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute stroke.However,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after stroke.This double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical University.The subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training.The follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation training.There were no obvious side effects.These findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective.展开更多
Objective To evaluate the efficacy and safety of thalidomide(100 to 200 mg per day)in the treatment of adult refractory Crohn’s disease(CD).Methods From July 2008 to February 2013,29 refractory CD patients were enrol...Objective To evaluate the efficacy and safety of thalidomide(100 to 200 mg per day)in the treatment of adult refractory Crohn’s disease(CD).Methods From July 2008 to February 2013,29 refractory CD patients were enrolled in thalidomide(100 to 200 mg per day)cohort study.The clinical activity was evaluated by展开更多
The role of drug-eluting stent （DES）, which prevents acute or subacute recoil and elutes drugs to prevent smooth muscle cell proliferation, is temporary and limited within a few weeks after its implantation. Beyond ...The role of drug-eluting stent （DES）, which prevents acute or subacute recoil and elutes drugs to prevent smooth muscle cell proliferation, is temporary and limited within a few weeks after its implantation. Beyond that, there is no utility or advantages but only limitations just like foreign materials in patients＇ body. All of these problems can be solved with the use of fully bioabsorbable stent （BAS）,展开更多
Pedestrian signals, particularly at signalized, midblock crossings, delay drivers, which is termed ＂unnecessary delay＂ in this study. A pedestrian hybrid beacon was proven to be effective in decreasing this unnecess...Pedestrian signals, particularly at signalized, midblock crossings, delay drivers, which is termed ＂unnecessary delay＂ in this study. A pedestrian hybrid beacon was proven to be effective in decreasing this unnecessary delay to the drivers at midblock pedestrian crossings when compared to standard signalized midblock crossings. Two pedestrian hybrid beacons were installed at midblock pedestrian crossings in Lawrence, Kansas. A study was conducted at these two locations to determine the effectiveness of the pedestrian hybrid beacon in decreasing the unnecessary delay to drivers by comparing them with a signalized midblock on Massachusetts Street, Lawrence, Kansas. In addition to the delay measurements for drivers at pedestrian hybrid beacon and signalized treatment at midblock pedestrian crossings, other parameters such as driver compliance rate, pedestrian compliance rate, and other driver and pedestrian characteristics were also studied. Video cameras were used at these test locations and the effectiveness of the pedestrian hybrid beacon was analyzed from the video. A more than 90% reduction in delays was observed for the drivers at the pedestrian hybrid beacon at midblock crossings compared to the signalized crossing. Further, a better driver compliance rate was also recorded at the pedestrian hybrid beacon. Information about reductions in unnecessary delay to drivers and improvements to driver and pedestrian compliance rates from the use of pedestrian hybrid beacons would be useful to engineers, decision makers, and researchers to determine an optimum treatment at desired pedestrian crossings.展开更多
基金supported by the Medical Scientific Research Project of Chongqing Municipal Health Commission of China,Nos.2018ZDXM022,2019MSXM017 and 2020MSXM106a grant from Chongqing General Hospital of China,No.2019ZDXM03(all to LCN and JXM).
文摘Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve.There have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute stroke.However,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after stroke.This double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical University.The subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training.The follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation training.There were no obvious side effects.These findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective.
文摘Objective To evaluate the efficacy and safety of thalidomide(100 to 200 mg per day)in the treatment of adult refractory Crohn’s disease(CD).Methods From July 2008 to February 2013,29 refractory CD patients were enrolled in thalidomide(100 to 200 mg per day)cohort study.The clinical activity was evaluated by
文摘The role of drug-eluting stent （DES）, which prevents acute or subacute recoil and elutes drugs to prevent smooth muscle cell proliferation, is temporary and limited within a few weeks after its implantation. Beyond that, there is no utility or advantages but only limitations just like foreign materials in patients＇ body. All of these problems can be solved with the use of fully bioabsorbable stent （BAS）,
基金funded jointly by the Kansas State University Transportation Center with in-kind matching funds from city of Lawrence,Kansas
文摘Pedestrian signals, particularly at signalized, midblock crossings, delay drivers, which is termed ＂unnecessary delay＂ in this study. A pedestrian hybrid beacon was proven to be effective in decreasing this unnecessary delay to the drivers at midblock pedestrian crossings when compared to standard signalized midblock crossings. Two pedestrian hybrid beacons were installed at midblock pedestrian crossings in Lawrence, Kansas. A study was conducted at these two locations to determine the effectiveness of the pedestrian hybrid beacon in decreasing the unnecessary delay to drivers by comparing them with a signalized midblock on Massachusetts Street, Lawrence, Kansas. In addition to the delay measurements for drivers at pedestrian hybrid beacon and signalized treatment at midblock pedestrian crossings, other parameters such as driver compliance rate, pedestrian compliance rate, and other driver and pedestrian characteristics were also studied. Video cameras were used at these test locations and the effectiveness of the pedestrian hybrid beacon was analyzed from the video. A more than 90% reduction in delays was observed for the drivers at the pedestrian hybrid beacon at midblock crossings compared to the signalized crossing. Further, a better driver compliance rate was also recorded at the pedestrian hybrid beacon. Information about reductions in unnecessary delay to drivers and improvements to driver and pedestrian compliance rates from the use of pedestrian hybrid beacons would be useful to engineers, decision makers, and researchers to determine an optimum treatment at desired pedestrian crossings.
