An exploration of the origin and flow of the development of traditional Chinese medicine orthopedic and chiropractic massage

Traditional Chinese medicine(TCM)chiropractic massage is a kind of orthopedic therapy that corrects the abnormal anatomical position of bone or joint and corrects the dislocation of joint by manipulation so that the bone is soft and the Qi and blood are reconciled(Qi:The intangible,high-mobility nutritive substance that maintains vital activities).Manipulation treatment is the first of the four major orthopedic diseases.At the same time,TCM chiropractic massage is also an essential part of TCM.TCM orthopedic chiropractic practice originated from the struggle between humanity and nature,sprouted from the Warring States period to the two Han Dynasty,formed in the Sui,Tang,and Song Dynasties,matured in the Ming and Qing Dynasties,and flourished in the modern era.In more than 2,000 years of development,many practical techniques have been produced,which have profoundly influenced the inheritance and development of modern techniques,making the TCM orthopedic chiropractic massage in the contemporary era form the characteristics of“tendon and bone”and“point-line-face combination”.At present,the development of TCM chiropractic massage is facing the great challenges of modern medicine and modern advanced science and technology such as American chiropractic and the limitations of its development.Therefore,in the future,the development direction of Chinese medicine orthopedic chiropractic massage should be“hybrid to treat”.In the face of modern medicine,we should take its essence to its dross,eclectic,organically integrate its advantages into itself,enrich its theoretical framework,and strengthen the construction of disciplines and departments to enhance its competitiveness.It is believed that Chinese medicine orthopedic chiropractic massage can have better development in the future and can make more contributions to the health of the world’s people.

Influences of Seed Source, Pre-chilling, Light and Temperature on the Germination of South African Pelargonium sidoides

Pelargonium sidoides DC is used in herbal medicine for the treatment of various infections. The roots are being indiscriminately harvested for local and export trade and the collection rate is becoming unsustainable. Seed germination dynamics of this species was studied with the aim to reveal factors that influence its survival in the wild in order to adopt the appropriate germination conditions for use in ex-situ propagation and conservation program. Germination was affected by age of seeds, temperature and pre-chilling conditions. Temperature higher than 25 oC reduced germination by 60%. When seeds of P. sidoides were subjected to pre-chilling treatment for seven days, there was a significant drop in final germination by 29% compared to the other treatments. Although, final germination was not affected by different light treatments, continuous light significantly promoted germination velocity Seeds harvested from the plants grown in the green house performed better in germination than those collected from the field. The ecological implications of these observations on the propagation and conservation ofP. sidoides are discussed.

Total Coumarin Content and Antioxidant Activity in Different Parts of Obazema, a Yi Medicine

[Objectives]This study aimed to determine the total coumarin content and antioxidant activity in vitro of Obazema,a Yi Medicine.[Methods]The extraction process of coumarin from Obazema was optimized by response surface method,and the total contents of coumarin in different sources and different parts of Obazema were compared.With Vc,chlorogenic acid and citric acid as positive controls,the antioxidant activity of the ethanol extracts of different parts of Obazema was determined.[Results]The optimum extraction process for coumarin from Obazema were as follows:80%ethanol,solid to liquid ratio 1∶67,extraction time 120 min and extraction temperature 57℃.The total contents of coumarin in roots,stems,leaves,flowers and fruit of Boenninghausenia sessilicarpa Levl.and B.albiflora(Hook.)Reichb.were 7.75,6.50,33.45 and 44.35,and 8.1,4.6,17.8 and 18.7 mg/g,respectively.The free radicle-scavenging activity of coumarin from Obazema had certain dose-effect relationship,and was slightly stronger than that of the positive drugs.Under the phenanthroline-Fe ^2+method,the free radicle-scavenging activity ranked as B.albiflora(Hook.)Reichb.>B.sessilicarpa Levl.>Vc>citric acid>chlorogenic acid;under the DPPH method,the free radicle-scavenging activity ranked as B.albiflora(Hook.)Reichb.>B.sessilicarpa Levl.>Vc>chlorogenic acid>citric acid;and under the ABSTS+method,the free radicle-scavenging capacity ranked was in the order as B.albiflora(Hook.)Reichb.>B.sessilicarpa Levl.>Vc>chlorogenic acid>citric acid.[Conclusions]There are significant differences in coumarin content between different sources and different parts of Obazema.When coumarin is used as the main active substance,Obazema is better harvested during the flowering period,and the free radicle-scavenging activity of B.sessilicarpa Levl.is higher than that of B.albiflora(Hook.)Reichb.The antioxidant activity of the flower-fruit ethanol extracts of B.sessilicarpa Levl.and B.albiflora(Hook.)Reichb.is stronger than that of the commonly used antioxidants such as Vc,chlorogenic acid and citric acid,which is related to antioxidant components in the ethanol extracts.

Design and characteristics investigation of a miniature low-temperature plasma spark discharge device

Atmospheric pressure low-temperature plasma is a promising tool in biomedicine applications including blood coagulation,bacterial inactivation,sterilization,and cancer treatment,due to its high chemical activity and limited thermal damage.It is of great importance to develop portable plasma sources that are safe to human touch and suitable for outdoor and household operation.In this work,a portable and rechargeable low-temperature plasma spark discharge device(130 mm×80 mm×35 mm,300 g)was designed.The discharge frequency and plume length were optimized by the selection of resistance,capacitance,electrode gap,and ground electrode aperture.Results show that the spark plasma plume is generated with a length of 12 mm and a frequency of 10 Hz at a capacitance of 0.33μF.resistance of 1 MΩ,electrode gap of 2 mm,and ground electrode aperture of 1.5 mm.Biological tests indicate that the plasma produced by this device contains abundant reactive species,which can be applied in plasma biomedicine,including daily sterilization and wound healing.

A Brief Introduction of Yi Xue Shi (《医学史》 History of Medicine)

The book Yi Xue Shi(《医学史》History of Medicine)was written and edited by Cecilia Mettler and Fred Mettler couple,published in 1947.The book is about the literature research of systematic introduction to the history of medical development worldwide.The book provides a detailed description of the development of various medical disciplines and subjects through various documents and the authors and publication dates.Especially,Prof.Mettler has introduced the Chinese Yin and Yang(阴阳)and the five element theory(五行学说)and Shen Nung’s Materia Medica(神农本草)in this book.

Comparison of Nitric Oxide Concentrations in μs-and ns-Atmospheric Pressure Plasmas by UV Absorption Spectroscopy

In this paper,an absorption spectroscopy measurement method was applied on two atmospheric pressure plasma sources to determine their production of nitric oxide.The concentrations are essential for evaluating the plasma sources based on the principle of the Dielectric Barrier Discharge（DBD）for applications in plasma medicine.The described method is based on a setup with an electrodeless discharge lamp filled with a mixture of oxygen and nitrogen.One of the emitted wavelengths is an important resonance wavelength of nitric oxide（λ = 226.2 nm）.By comparing the absorption behaviour at the minimum and maximum of the spectral absorption cross section of nitric oxide around that wavelength,and measuring the change in intensity by the absorbing plasma,the concentration of nitric oxide inside the plasma can be calculated.The produced nitric oxide concentrations depend on the pulse duration and are in the range of 180 ppm to 1400 ppm,so that a distance of about 10 cm to the respiratory tract is enough to conform to the VDI Guideline 2310.

等离子体医学研究进展

大气压非平衡等离子体(atmospheric pressure nonequilibrium plasma,APNP)能够在产生多种活性成分的同时保持较低甚至常温的气体温度,这使得它在生物医学方面有着巨大的应用前景,因此等离子体医学成为一个备受关注的新兴研究领域。自1996年第一篇等离子体医学研究论文发表以来,等离子体医学领域取得了蓬勃的发展,但也面临着一些核心科学问题亟需解决。文中对等离子体医学的研究进展进行了综述,探讨了该领域面临的核心科学问题和等离子体的生物安全性。此外,还简要介绍了等离子体医学在微生物消杀、伤口愈合、癌症治疗、经皮给药和皮肤病治疗等重要应用方面取得的成果。对于制定等离子体医学的标准和规范、建立第三方检测平台以及共享数据库和标准装置等问题,也进行了初步的讨论。最后,对等离子体医学的未来进行了展望。

多模态影像学方法评估布依药鹿角壮骨煎液的骨折疗效

目的 运用多模态影像学方法评估布依药鹿角壮骨煎液的骨折疗效。方法通过手术方式制作新西兰白兔左下肢胫骨中下段骨折模型30只,随机分成实验组15只给予布依药鹿角壮骨煎液灌胃治疗,对照组15只给予等量0.9%生理盐水灌胃治疗。在造模后当天、第7d、15d、21d、30d、42d随机选择2只模型兔分别行常规DR摄片、常规CT及双能量CT扫描,并对CT扫描数据行冠矢状位及骨髓成像后处理,对比不同影像学方法对实验组及对照组骨折端的对显示情况。结果与对照组比较,实验组在X平片、CT平扫、双能量骨髓成像评估中均有统计学差异(P>0.05),且CT平扫结合双能量骨髓成像对骨折愈合评估更加敏感、准确;对于骨折治愈周期比较,实验组较对照组愈合周期明显缩短,7天时间点骨折的修复评分较对照组提高97.3%。结论布依药鹿角壮骨煎液可促进骨痂生长,缩短骨折病程,且CT平扫结合双能骨髓成像对骨折愈合的评估更加敏感、准确。

现代林产化学加工技术的现状与发展趋势

生物质资源来源广泛,具有可再生性、结构多样性和碳中性等特点。目前,以生物质为原料的林产化工已成为继煤和石油化工之后最重要的化工产业之一。在对中国的林产化学工业发展历史概览的基础上,梳理总结了现代林产化学工业的发展,创新地提出了林产化学加工工程学科发展的能源化、材料化、食药化、饲料化、肥料化和基料化6个方向。其中,能源化中的生物质气/液/固体燃料的有效开发是实现碳达峰和碳中和的重要途径之一,而我国林产化工的传统研究领域制浆造纸、木本油脂、松脂化学等则从材料化找到新的突破和发展,相比前两者,食药化、饲料化、肥料化和基料化还有很大的发展空间。林产化学工业已迈入质量和效益持续提升发展新阶段,今后将在生物质资源高值化利用、全质利用技术创新、精深加工与应用、绿色低碳与生物技术融合、生物基材料与化学品创新应用,以及多学科交叉融合等方面实现突破,推动产业转型升级,构建绿色低碳循环发展新模式。

基于“治虚三本”理论探讨癌因性疲乏的中医辨治

癌因性疲乏属于中医学“虚劳”的范畴,患者受肿瘤侵袭及放化疗、靶向治疗等药毒影响,机体正邪相争,阴阳失调,脏腑气血亏损,最终久虚不复而成劳。“治虚三本”理论来源于明代医家汪琦石所著《理虚元鉴》,强调肺、脾、肾三脏的功能失调是虚劳发生的核心病机。本文以“治虚三本”理论为指导,从肺、脾、肾三脏出发探讨癌因性疲乏的中医辨治。

《黄帝内经》不同语境下“三焦”涵义考

《黄帝内经》中“三焦”一词见于22篇计40处,其中29处意义明确,历代注解无异义;4处有不同观点;另有存在校勘问题者4处;尚有三焦理、三焦下腧、三焦之源3个衍生名词。在不同语境下,29处意义明确的“三焦”分别指三焦腑、手少阳三焦经、上中下三焦,并无争议,只要在阅读过程中仔细分辨,就能够明确其所指。有争议处,为咳论篇之“三焦受之”“三焦咳”、四时气之“三焦约”、经别之“下走三焦”。4处“三焦”存在校勘问题,即“三焦”与“足三焦”、“三焦”与“上焦”(2次)、“三焦”与“三椎”。三焦理、三焦下腧、三焦之源3个衍生名词均与三焦理论有关。

基于多指标结合化学计量学的多基源藏药烈香杜鹃质量评价分析

目的:采用多指标结合化学计量学综合评价烈香杜鹃的质量,为其质量评价提供科学依据。方法:采用2020年版《中国药典》四部通则规定的方法对藏药烈香杜鹃的显微、水分、总灰分等分别进行了鉴别和测定,采用高效液相色谱法(HPLC)测定了金丝桃苷和槲皮苷的含量,并进行聚类分析(HCA)和主成分分析(PCA)。采用中药色谱指纹图谱相似度评价系统(2012)进行了相似度评价。结果:不同基源烈香杜鹃的显微鉴别结果存在细微差别,水分、总灰分、酸不溶性灰分、浸出物含量也显示出一定的差异。指纹图谱的相似度分析显示样品相似度系数为0.705~0.990。金丝桃苷和槲皮苷的含量平均值分别为0.408 2%、0.175 5%、0.583 7%,RSD值分别为62.97%、46.67%和47.89%。化学模式分析结果显示样品间存在一定差异。结论:不同基源的烈香杜鹃质量有一定的差异性,基于多指标结合化学计量法的方法能有效评价藏药烈香杜鹃的质量,为烈香杜鹃的质量评价提供参考。

2020年版《中华人民共和国药典》(一部)全草类中药来源信息探究

目的:探究2020年版《中华人民共和国药典》(以下简称《中国药典》)(一部)收载全草类中药的来源信息,为后期研究提供参考。方法:制定全草类中药的归类标准,统计2020年版《中国药典》(一部)收载全草类中药的数量、药用部位、采收期、干燥方式、贮藏要求等,建立信息数据库深入分析。结果:2020年版《中国药典》(一部)共收载42科88种全草类中药,占其收载616种药材和饮片的5.03%。药材数量最多的3科是菊科20种、唇形科13种、蔷薇科4种。有71种药材的基原植物数均为1种,有17种药材的基原植物数为2种及以上。全草类中药涉及13种药用部位类型,且分别有42种、34种药材以干燥地上部分、干燥全草为药用部位。全草类中药一般以季节、季节及物候期作为采收期,且有18种药材采收期为“夏、秋二季”。有58种全草类中药的干燥方式是晒干,占比高达65.91%。贮藏要求为置干燥处、置阴凉干燥处、置通风干燥处的全草类中药分别有30种、18种、21种。结论:88种全草类中药的药用部位、采收期、干燥方式、贮藏要求等来源信息存在规律性和多样性,还需分析2020年版《中国药典》的记载内容,进一步发掘全草类中药的鉴别规律和研究开发价值。

叶天士除陈气法述要

[目的]探析叶天士除陈气法及用药特点,以期为脾瘅(代谢综合征)的临床辨治提供新思路。[方法]通过文献综述方法,系统分析陈气概念的起源、发展、历代医家的阐释,考察《黄帝内经》中“兰除陈气”的理论基础及其在明清时期的演变。聚焦叶天士的医理、药理思想,总结其运用除陈气法治疗脾瘅的用药规律,包括药物选择、配伍原则及治疗目标,以此揭示其防治理念的核心。基于现代中医学理论,重新审视陈气概念,分析其与现代代谢性疾病的关联,并评价除陈气法的现代应用状况。[结果]陈气被视为精微物质蓄积异常状态,与代谢失衡紧密相关,为疾病进展的关键环节。除陈气法扎根于《黄帝内经》的“兰除陈气”,叶天士通过精确辨证,以除陈气法为核心,结合人参、黄连等药物,有效干预脾瘅,减少消渴发生,但具体用药策略仍需更多研究支持。除陈气法作为中医药治疗代谢性疾病的关键治疗原则之一,尽管在现代代谢性疾病治疗中显示出潜力,但其具体用法及药物使用目前仍然处于经验积累的阶段,需要进一步深入挖掘和研究。[结论]叶天士的除陈气法为代谢性疾病的中医学理解提供了新的理论视角,强调了早期干预的重要性。研究不仅深化了陈气理论,也为临床实践提供了指导,但仍需更多实验研究和临床数据以精确化其应用。未来工作应侧重于除陈气法的机制研究与临床验证,以期在代谢性疾病的治疗中发挥更大作用。

药用工业大麻茎叶中10种重金属含量测定

建立了药用工业大麻茎叶中10种重金属(Cu、Zn、Mn、Fe、Ni、Cd、Pb、Cr、Hg、As)含量的火焰原子吸收分光光度法和电感耦合等离子体质谱检测方法,并对重金属的可能来源进行分析。结果表明,检测方法准确、可靠,10种重金属元素在各自范围内线性关系良好(R^(2)≥0.999)。药用工业大麻中重金属(Pb、As、Cd、Hg、Cu)质量分数均符合《中国药典》(2020)对药材及饮片(植物类)中重金属限量标准,但Cu、Cr和Hg元素的质量分数超过其他不同国家和组织的最小重金属限量标准,超标率分别为63.64%, 45.45%, 9.09%。药用工业大麻茎叶中重金属主要来源为环境因素,其次为生产种植因素,以及多种残留物产生的多重累积和协同效应。

中药源肥料增效剂对甘肃马铃薯产量及品质的影响

为探讨中药源肥料增效剂对甘肃马铃薯产量及品质的影响,以冀张薯12号为研究对象在甘肃省渭源县进行田间小区试验,设置常规肥(CK1)、中药源增效剂配施100%常规肥(T1)、中药源增效剂配施80%常规肥(T2)、80%中药源增效剂配施100%常规肥(T3)和80%中药源增效剂配施80%常规肥(T4)5个处理,确定最佳施肥方案。考虑马铃薯品质及经济性状因素,中药源增效剂配施80%常规肥为最佳施肥方案。之后,以冀张薯12号、陇薯7号和青薯9号为研究对象,在渭源县、通渭县和定西市安定区进行田间小区试验,设置常规肥(CK2)和中药源增效剂配施80%常规肥(A)2个处理,从土壤理化性质、马铃薯产量和品质等方面评价中药源肥料增效剂的效果。结果表明,CK2土壤pH值显著高于处理A,但土壤有机质、全氮、碱解氮、有效磷和速效钾在CK2与处理A间不存在显著差异。烂薯数在3个试验地点均表现为CK2>处理A(P<0.05),冀张薯12号和青薯9号的还原糖含量均表现为CK2>处理A(P<0.05),且冀张薯12号的单株薯块数和折合产量均表现为CK2<处理A(P<0.05)。中药源肥料增效剂配施80%常规肥可以保持原施肥方案的土壤营养水平,降低土壤碱性,减少马铃薯烂薯数和还原糖含量,提升品质,并且可使冀张薯12号增产17.88%。该配方肥较原施肥方案能够降低投入成本,可在马铃薯种植中进行推广和应用。

传统蒙药乌兰-3汤的简述

目的:通过查阅文献对传统蒙药乌兰-3汤的方解、基源考证、化学成分、质量控制、组方药理作用及其临床应用进行简述,为进一步开发利用提供参考依据。方法:通过收集并整理文献材料、蒙医药古籍,结合临床应用现状,采用文献综述方法对传统蒙药乌兰-3汤的方解、化学成分、质量控制、组方药理作用以及临床应用概况进行综述。结果:乌兰-3汤是蒙医传统方剂,来源于蒙医经典著作《诊治明医典》,现已收载于《中国百科全书·蒙医学》(1992年第一版)、《中华人民共和国卫生部药品标准:蒙药》(1998版)、《内蒙古蒙成药标准》(1988补充版)、《传统蒙药与方剂》(2013年第一版)。具有清肺热、肾热等功效,用于肺、肾损伤性热,膀胱热,肾隐伏热,肺热咳嗽,痰中带血,膀胱刺痛,尿频、尿痛。结论:传统蒙药乌兰-3汤的临床应用为进一步研究和开发提供参考。

药物化学教学电子资源库的构建及应用

目的 总结教学实践经验,构建教学电子资源库,为建设药物化学“金课”,培养德才兼备的高素质、专业化新型药学人才奠定基础。方法 集体备课,搜集整理、凝练总结药物结构模型、药物-靶点相互作用模型、思政素材、微课素材、前沿科研成果素材,构建教学电子资源库并应用于教学实践。结果 利用该库资源,显著提升了教学质量和教学效果,多人次获得教学比赛特等奖、一等奖。结论 在大数据时代,一个高质量的教学电子资源库,将极大地缩短教员备课时间,提升教学质量,启迪思维火花,促进以“教”为中心转向以“学”为中心。

新时代医学类研究生招生工作路径探索——以山东某生殖专科医院为例

研究生招生工作是选拔高层次人才的重要途径,不仅要选拔出更多高层次、高水平的医学人才,更要进一步优化高质量发展需求。随着社会经济的发展和人们生活水平的提高,人类的生殖健康问题愈发突出,生殖医学专业也逐渐成为一个备受关注的领域。通过收集近4年山东某生殖专科医院招收的博士研究生和硕士研究生的基本信息,对招生数量、招生生源等进行分析,聚焦当前硕士研究生招生模式存在的问题,探索新时代生殖医学类硕士研究生招生模式,为生殖医学发展输送更多高水平的人才。

中药熏蒸法治疗周围性面瘫源流解析

中药熏蒸作为一种古老的防病治病方法,对治疗周围性面瘫有独特的作用,随着工业科技发展,其器械与技术改进显著。中药熏蒸法治疗周围性面瘫在临床上颇有成效,此文总结牵正散等经方用于中药熏蒸治疗周围性面瘫的临床效果,证实中药熏蒸法在治疗周围性面瘫方面具有不可替代的辅助甚至重要作用,以期为周围性面瘫的临床治疗提供更多指导。