Bile acids(BAs)are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients.In the intestines,where enteric viruses replicate,BAs also act as ...Bile acids(BAs)are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients.In the intestines,where enteric viruses replicate,BAs also act as signaling molecules that modulate various biological functions via activation of specific receptors and cell signaling pathways.To date,BAs present either pro-viral or anti-viral effects for the replication of enteric viruses in vivo and in vitro.In this review,we summarized current information on biosynthesis,transportation and metabolism of BAs and the role of BAs in replication of enteric caliciviruses,rotaviruses,and coronaviruses.We also discussed the application of BAs for cell culture adaptation of fastidious enteric caliciviruses and control of virus infection,which may provide novel insights into the development of antivirals and/or disinfectants for enteric viruses.展开更多
Porcine sapoviruses (SaVs),which belong to the family Caliciviridae,have been considered potential zoonotic agents for human infection,and several cases have been reported in Asian countries. In this study,a total of ...Porcine sapoviruses (SaVs),which belong to the family Caliciviridae,have been considered potential zoonotic agents for human infection,and several cases have been reported in Asian countries. In this study,a total of 200 porcine fecal samples collected from Lulong county of China were tested. Among 200 samples,porcine sapoviruses were detected by RT-PCR in 17 samples (8.5%) showing their circulation in China. 14 out of 17 positive sapovirus strains were genetically related to the genogroup III (GIII) and were further divided into three different clusters or genotypes according to the phylogenetic analysis. In addition,the remaining three sapovirus strains belonged to GVII (one strain) and a potential novel genogroup (two strains) according to the phylogenetic analysis and the nucleotide identity and amino acid identity. These data suggested the genetic diversity of porcine sapoviruses in China.展开更多
基金supported by state and federal funds appropriated to Ohio Agricultural Research and Development Center(OARDC),College of Food,Agricultural,&Environmental Sciences,The Ohio State Universitysupported by China Scholarship Council(201908230090).
文摘Bile acids(BAs)are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients.In the intestines,where enteric viruses replicate,BAs also act as signaling molecules that modulate various biological functions via activation of specific receptors and cell signaling pathways.To date,BAs present either pro-viral or anti-viral effects for the replication of enteric viruses in vivo and in vitro.In this review,we summarized current information on biosynthesis,transportation and metabolism of BAs and the role of BAs in replication of enteric caliciviruses,rotaviruses,and coronaviruses.We also discussed the application of BAs for cell culture adaptation of fastidious enteric caliciviruses and control of virus infection,which may provide novel insights into the development of antivirals and/or disinfectants for enteric viruses.
文摘Porcine sapoviruses (SaVs),which belong to the family Caliciviridae,have been considered potential zoonotic agents for human infection,and several cases have been reported in Asian countries. In this study,a total of 200 porcine fecal samples collected from Lulong county of China were tested. Among 200 samples,porcine sapoviruses were detected by RT-PCR in 17 samples (8.5%) showing their circulation in China. 14 out of 17 positive sapovirus strains were genetically related to the genogroup III (GIII) and were further divided into three different clusters or genotypes according to the phylogenetic analysis. In addition,the remaining three sapovirus strains belonged to GVII (one strain) and a potential novel genogroup (two strains) according to the phylogenetic analysis and the nucleotide identity and amino acid identity. These data suggested the genetic diversity of porcine sapoviruses in China.
