Scar-free wound healing is a challenging process due to the excessive deposition of extracellular matrix and collagen.To overcome this issue,hydrogels with superior biochemical and mechanical properties have been used...Scar-free wound healing is a challenging process due to the excessive deposition of extracellular matrix and collagen.To overcome this issue,hydrogels with superior biochemical and mechanical properties have been used in combination with medicinal compounds as wound dressings.In this study,a novel composite hydrogel consisting of double-crosslinked photocurable hyaluronic acid methacrylate(HAMA)and Laponite(Lap)loaded with bioactive bone morphogenetic protein 4(BMP4)was developed and thoroughly characterized for its properties such as degradation,morphology,porosity,compression,skin adhesion and load release.The effect of the HAMA/Lap/BMP4 hydrogel was evaluated through both in vitro and in vivo experiments.In the in vivo rabbit ear-scar model,the HAMA/Lap/BMP4 hydrogel dressing was found to reduce scar-related expressions ofα-SAM and decrease the ratio of collagenΙ/III in wounded tissue.Additionally,histopathological examination indicated that the HAMA/Lap/BMP4 hydrogel-treated groups exhibited enhanced wound repair and increased levels of collagen maintenance compared to other standard groups,ultimately leading to scarless wound healing.Therefore,this sustained-release photocurable HAMA/Lap/BMP4 hydrogel offers a therapeutic approach for scar-free wound healing.展开更多
The swung gel fibers were hea, ted to 400 ℃ at 0. .5 ,1, 1.5,2,2.5,3and4 ℃ min^-1 of heating rate, respectivel, and soaked.for 1 h ; then heated to 600 ℃ at 3 ℃ min ^-1 of.heating rate amt soaked for 1 h at last ...The swung gel fibers were hea, ted to 400 ℃ at 0. .5 ,1, 1.5,2,2.5,3and4 ℃ min^-1 of heating rate, respectivel, and soaked.for 1 h ; then heated to 600 ℃ at 3 ℃ min ^-1 of.heating rate amt soaked for 1 h at last calcined m 1 000, 1 100, 1 200, 1 300, and 1 400 ℃.for 1 h, respectively.展开更多
目的通过Meta分析系统评价改良楔形切除手术方式与单纯切除手术方式治疗小阴唇肥大的效果和安全性。方法采用计算机检索PubMed、Embase、Web of Science、Ovid、Cochrane library英文数据库及万方数据库、中国知网(CNKI)、维普数据库、...目的通过Meta分析系统评价改良楔形切除手术方式与单纯切除手术方式治疗小阴唇肥大的效果和安全性。方法采用计算机检索PubMed、Embase、Web of Science、Ovid、Cochrane library英文数据库及万方数据库、中国知网(CNKI)、维普数据库、中国生物医学文献数据库。通过设定参数及检索词、检索策略,检索自建库以来至2023年10月发表的上述两种手术方式治疗小阴唇肥大的临床随机对照研究,对提取的数据采用Stata 16.0软件进行Meta分析。结果共纳入文献5篇,共计421例患者。Meta分析结果显示,改良楔形切除手术方式在术后Ⅰ期愈合率、满意度、瘢痕发生率、肿胀发生率显著优于单纯手术切除方式。结论改良楔形切除手术方式治疗小阴唇肥大在临床应用中能提高术后愈合率、满意度,降低术后并发症发生率。展开更多
BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of life.The current standard treatment protocols for DFUs have limitations ...BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of life.The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications.A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs.The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing,reduced amputation rates,and improved overall patient outcomes compared to standard treatment protocols.AIM To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.METHODS This retrospective study included 62 patients with DFUs,enrolled between January 2022 and January 2024,randomly assigned to the experimental(n=32)or control(n=30)group.The experimental group received a comprehensive treatment comprising blood circulation improvement,debridement,vacuum sealing drainage,recombinant human epidermal growth factor and anti-inflammatory dressing,and skin grafting.The control group received standard treatment,which included wound cleaning and dressing,antibiotics administration,and surgical debridement or amputation,if necessary.Time taken to reduce the white blood cell count,number of dressing changes,wound healing rate and time,and amputation rate were assessed.RESULTS The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate,wound healing time,and amputation rate.Additionally,the comprehensive treatment protocol was safe and well tolerated by the patients.CONCLUSION Comprehensive treatment for DFUs is more effective than standard treatment,promoting granulation tissue growth,shortening hospitalization time,reducing pain and amputation rate,improving wound healing,and enhancing quality of life.展开更多
基金supported by the Natural Science Foundation of Hubei Province[2022CFB386].
文摘Scar-free wound healing is a challenging process due to the excessive deposition of extracellular matrix and collagen.To overcome this issue,hydrogels with superior biochemical and mechanical properties have been used in combination with medicinal compounds as wound dressings.In this study,a novel composite hydrogel consisting of double-crosslinked photocurable hyaluronic acid methacrylate(HAMA)and Laponite(Lap)loaded with bioactive bone morphogenetic protein 4(BMP4)was developed and thoroughly characterized for its properties such as degradation,morphology,porosity,compression,skin adhesion and load release.The effect of the HAMA/Lap/BMP4 hydrogel was evaluated through both in vitro and in vivo experiments.In the in vivo rabbit ear-scar model,the HAMA/Lap/BMP4 hydrogel dressing was found to reduce scar-related expressions ofα-SAM and decrease the ratio of collagenΙ/III in wounded tissue.Additionally,histopathological examination indicated that the HAMA/Lap/BMP4 hydrogel-treated groups exhibited enhanced wound repair and increased levels of collagen maintenance compared to other standard groups,ultimately leading to scarless wound healing.Therefore,this sustained-release photocurable HAMA/Lap/BMP4 hydrogel offers a therapeutic approach for scar-free wound healing.
文摘The swung gel fibers were hea, ted to 400 ℃ at 0. .5 ,1, 1.5,2,2.5,3and4 ℃ min^-1 of heating rate, respectivel, and soaked.for 1 h ; then heated to 600 ℃ at 3 ℃ min ^-1 of.heating rate amt soaked for 1 h at last calcined m 1 000, 1 100, 1 200, 1 300, and 1 400 ℃.for 1 h, respectively.
文摘目的通过Meta分析系统评价改良楔形切除手术方式与单纯切除手术方式治疗小阴唇肥大的效果和安全性。方法采用计算机检索PubMed、Embase、Web of Science、Ovid、Cochrane library英文数据库及万方数据库、中国知网(CNKI)、维普数据库、中国生物医学文献数据库。通过设定参数及检索词、检索策略,检索自建库以来至2023年10月发表的上述两种手术方式治疗小阴唇肥大的临床随机对照研究,对提取的数据采用Stata 16.0软件进行Meta分析。结果共纳入文献5篇,共计421例患者。Meta分析结果显示,改良楔形切除手术方式在术后Ⅰ期愈合率、满意度、瘢痕发生率、肿胀发生率显著优于单纯手术切除方式。结论改良楔形切除手术方式治疗小阴唇肥大在临床应用中能提高术后愈合率、满意度,降低术后并发症发生率。
基金Supported by General Medical Research Fund Project,No.TYYLKYJJ-2022-021.
文摘BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of life.The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications.A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs.The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing,reduced amputation rates,and improved overall patient outcomes compared to standard treatment protocols.AIM To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.METHODS This retrospective study included 62 patients with DFUs,enrolled between January 2022 and January 2024,randomly assigned to the experimental(n=32)or control(n=30)group.The experimental group received a comprehensive treatment comprising blood circulation improvement,debridement,vacuum sealing drainage,recombinant human epidermal growth factor and anti-inflammatory dressing,and skin grafting.The control group received standard treatment,which included wound cleaning and dressing,antibiotics administration,and surgical debridement or amputation,if necessary.Time taken to reduce the white blood cell count,number of dressing changes,wound healing rate and time,and amputation rate were assessed.RESULTS The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate,wound healing time,and amputation rate.Additionally,the comprehensive treatment protocol was safe and well tolerated by the patients.CONCLUSION Comprehensive treatment for DFUs is more effective than standard treatment,promoting granulation tissue growth,shortening hospitalization time,reducing pain and amputation rate,improving wound healing,and enhancing quality of life.
