Central European musicians, as a consequence of the efforts of several important figures, have contributed to the development of jazz in the second half of the 20th century. Jazz pianists in Europe were a distinctive ...Central European musicians, as a consequence of the efforts of several important figures, have contributed to the development of jazz in the second half of the 20th century. Jazz pianists in Europe were a distinctive part of the world jazz scene and made significant achievements during the communist era. They were able to master the European classical piano school, becoming virtuoso pianists themselves, as well as acquiring self-taught jazz skills. Semi-isolated from the contemporary music trends abroad, Central European artists nonetheless made remarkable musical accomplishments that deserve to be called the Central European Jazz School. Between 1948 and 1989, the communist ideology controlled every country of Central Europe including East Germany. The careers of jazz pianists in these countries would have developed differently if they had lived under democratic conditions. This is evident in the lives of those who emigrated to Western countries and subsequently found a place in the world jazz scene. Using analysis of the Central European jazz musicians＇ compositions and their professional careers, this paper aims to demonstrate the extent to which the Central European Jazz School has contributed to jazz music in Europe and the wider world.展开更多
In the second half of July in 2008 I was conducting interviews on the housing project beginning in Geren Village of Kyitod Town in Riwoche County(Chamdo Prefecture).By chance Jampel Nyima,the town administrator,
Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquire...Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however,not easily transferrable to human as the pharmacokinetic and pharmacodynamics profiles of the species are quite different.Methods: Using drugs selected for their differential transport across the blood-brain barrier, we here demonstrate the feasibility of brain microdialysis in normal vigil macaque monkey by measuring brain extracellular fluid bioavailability of carbamazepine, digoxin, oxycodone, and quinidine.Results: All drugs, but digoxin, were found in dialysate samples. Drugs that are substrate of P-glycoprotein show a difference of bioavailability or brain pharmacokinetic parameters between rodents and primates.Conclusion: Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain.展开更多
Background Waist circumference （WC）, a proxy measure of central body fat, is a better predictor than overall body fat for cardiovascular risk factors in both adults and children. WC cutoffs have been established in ...Background Waist circumference （WC）, a proxy measure of central body fat, is a better predictor than overall body fat for cardiovascular risk factors in both adults and children. WC cutoffs have been established in many countries, but the national WC reference has not been developed in China. Objective To study the distribution of WC in a representative group of Chinese children for establishing Chinese WC cutoff points. Methods Cross-sectional data obtained from 15 mainland provinces and Hong Kong were collected. There were 160 225 children and adolescents aged 7-18 years old in total. The subjects were divided into five regional groups namely costal city, other city, noah rural, south rural, and Hong Kong, for analyzing the distribution of WC. Results A large variation in WC distribution was found among the five groups for both sexes. Coastal city group had the highest P85 WC values consistently from the early school ages to 18-year-old compared with other groups. In contrast, south rural group had P85 values consistently lagged behind not only the city groups but also the north rural group. Hong Kong group had a high P85 WC at early ages, but because of the smaller increments of WC during adolescence, the P85 curve was gradually exceeded by the north rural groups. Catch-up trend was found in the two rural groups since the peak of puberty. These disparities were caused by not only socioeconomic and urban-rural factors but also north-south differences. Because of the regional variation of WC, a ＂gradient＂ prevalence of central obesity was prospected among these groups. Comparisons of WC distributions between the Chinese and the U.S.A or Netherlands demonstrated the necessary of setting up China＇s own WC cutoffs. Sex and age-specific percentiles were obtained and smoothed by using LMS method. Conclusion The data obtained from this study could be used to develop national WC cutoff points for Chinese children and adolescents.展开更多
Basic schools that are located in heavily populated residential and commercial areas in Ghana are exposed to environmental noise that can have detrimental effects on the academic attainments of children. Limited studi...Basic schools that are located in heavily populated residential and commercial areas in Ghana are exposed to environmental noise that can have detrimental effects on the academic attainments of children. Limited studies have been conducted on noise level in basic schools to date in Ghana. The objective of the study was to assess noise levels in and around learning spaces in basic schools in Ghana with </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">a </span></span></span></span></span><span><span><span><span><span style="font-family:""><span style="font-family:Verdana;">focus on Kumasi.</span><i> </i><span style="font-family:Verdana;">A survey employing the use of interviews and an empirical monitoring of noise levels in and around learning spaces in four selected basic schools were adopted. The study revealed that mean outdoor and indoor noise levels exceed the World Health Organisation permissible limits by 30 - 40 percent and 90 - 107 percent respectively for schools in the commercial zones and schools that are located near highways. The school that is sited in an educational environment with a setback from the highway attained mean noise levels ranging from 1.2 percent below to 3.7 percent above the permissible limits for outdoor and between 64 - 105 percent for indoor. The outcome of the study is expected to engender the design of environmental noise resilient buildings to facilitate teaching and learning in basic schools in Ghana</span></span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.展开更多
Purpose: To study and analyze the correlation among corneal biomechanical properties and associated factors including central corneal thickness (CCT), corneal curvature (CT), and intraocular pressure (IOP) in school-a...Purpose: To study and analyze the correlation among corneal biomechanical properties and associated factors including central corneal thickness (CCT), corneal curvature (CT), and intraocular pressure (IOP) in school-age children. Methods:A cross sectional investigation was conducted. An ocular response analyzer was utilized to assess the corneal biomechanical properties,such as corneal hysteresis and corneal resistance factors, in children of school age. Multivariate regression analysis was used to investigate the relationship between corneal biomechanical properties and other ocular parameters including CCT, corneal curvature (k1 and k2), and IOP. The right eyes of all subjects were selected for statistical analysis. Results: A total of 571 children were enrolled: 303 male and 268 female,with an average age of 10.47 ±1.0 years. The mean value of corneal hysteresis was 10.98 ±1.78 mmHg, corneal resistance factor was 11.46±1.69 mmHg,and CCT was 556.01±28.97 μm. Conclusion:The feasibility of corneal biomechanical detection in school age children was validated. This study provides fundamental data on corneal biomechanical properties in school-age children and associated factors. (Eye Science 2013; 28:34-39)展开更多
In July 1994,the CPC Central Committee and the State Council held theThird National Conference on Work in Tibet.During the conference, JiangZemin,General Party Secretary and State President,said that showing carefor,a...In July 1994,the CPC Central Committee and the State Council held theThird National Conference on Work in Tibet.During the conference, JiangZemin,General Party Secretary and State President,said that showing carefor,and providing aid to Tibet constituted the consistent policy of the Partyand the State,and the bounden duty of peoples of all ethnic groups in the country.展开更多
文摘Central European musicians, as a consequence of the efforts of several important figures, have contributed to the development of jazz in the second half of the 20th century. Jazz pianists in Europe were a distinctive part of the world jazz scene and made significant achievements during the communist era. They were able to master the European classical piano school, becoming virtuoso pianists themselves, as well as acquiring self-taught jazz skills. Semi-isolated from the contemporary music trends abroad, Central European artists nonetheless made remarkable musical accomplishments that deserve to be called the Central European Jazz School. Between 1948 and 1989, the communist ideology controlled every country of Central Europe including East Germany. The careers of jazz pianists in these countries would have developed differently if they had lived under democratic conditions. This is evident in the lives of those who emigrated to Western countries and subsequently found a place in the world jazz scene. Using analysis of the Central European jazz musicians＇ compositions and their professional careers, this paper aims to demonstrate the extent to which the Central European Jazz School has contributed to jazz music in Europe and the wider world.
文摘In the second half of July in 2008 I was conducting interviews on the housing project beginning in Geren Village of Kyitod Town in Riwoche County(Chamdo Prefecture).By chance Jampel Nyima,the town administrator,
文摘Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however,not easily transferrable to human as the pharmacokinetic and pharmacodynamics profiles of the species are quite different.Methods: Using drugs selected for their differential transport across the blood-brain barrier, we here demonstrate the feasibility of brain microdialysis in normal vigil macaque monkey by measuring brain extracellular fluid bioavailability of carbamazepine, digoxin, oxycodone, and quinidine.Results: All drugs, but digoxin, were found in dialysate samples. Drugs that are substrate of P-glycoprotein show a difference of bioavailability or brain pharmacokinetic parameters between rodents and primates.Conclusion: Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain.
基金Funded by International Life Sciences Institute,Focal Point in China.
文摘Background Waist circumference （WC）, a proxy measure of central body fat, is a better predictor than overall body fat for cardiovascular risk factors in both adults and children. WC cutoffs have been established in many countries, but the national WC reference has not been developed in China. Objective To study the distribution of WC in a representative group of Chinese children for establishing Chinese WC cutoff points. Methods Cross-sectional data obtained from 15 mainland provinces and Hong Kong were collected. There were 160 225 children and adolescents aged 7-18 years old in total. The subjects were divided into five regional groups namely costal city, other city, noah rural, south rural, and Hong Kong, for analyzing the distribution of WC. Results A large variation in WC distribution was found among the five groups for both sexes. Coastal city group had the highest P85 WC values consistently from the early school ages to 18-year-old compared with other groups. In contrast, south rural group had P85 values consistently lagged behind not only the city groups but also the north rural group. Hong Kong group had a high P85 WC at early ages, but because of the smaller increments of WC during adolescence, the P85 curve was gradually exceeded by the north rural groups. Catch-up trend was found in the two rural groups since the peak of puberty. These disparities were caused by not only socioeconomic and urban-rural factors but also north-south differences. Because of the regional variation of WC, a ＂gradient＂ prevalence of central obesity was prospected among these groups. Comparisons of WC distributions between the Chinese and the U.S.A or Netherlands demonstrated the necessary of setting up China＇s own WC cutoffs. Sex and age-specific percentiles were obtained and smoothed by using LMS method. Conclusion The data obtained from this study could be used to develop national WC cutoff points for Chinese children and adolescents.
文摘Basic schools that are located in heavily populated residential and commercial areas in Ghana are exposed to environmental noise that can have detrimental effects on the academic attainments of children. Limited studies have been conducted on noise level in basic schools to date in Ghana. The objective of the study was to assess noise levels in and around learning spaces in basic schools in Ghana with </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">a </span></span></span></span></span><span><span><span><span><span style="font-family:""><span style="font-family:Verdana;">focus on Kumasi.</span><i> </i><span style="font-family:Verdana;">A survey employing the use of interviews and an empirical monitoring of noise levels in and around learning spaces in four selected basic schools were adopted. The study revealed that mean outdoor and indoor noise levels exceed the World Health Organisation permissible limits by 30 - 40 percent and 90 - 107 percent respectively for schools in the commercial zones and schools that are located near highways. The school that is sited in an educational environment with a setback from the highway attained mean noise levels ranging from 1.2 percent below to 3.7 percent above the permissible limits for outdoor and between 64 - 105 percent for indoor. The outcome of the study is expected to engender the design of environmental noise resilient buildings to facilitate teaching and learning in basic schools in Ghana</span></span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.
基金supported by Fund for Medical Sciences of Guangdong Province (Grant:B2009187)
文摘Purpose: To study and analyze the correlation among corneal biomechanical properties and associated factors including central corneal thickness (CCT), corneal curvature (CT), and intraocular pressure (IOP) in school-age children. Methods:A cross sectional investigation was conducted. An ocular response analyzer was utilized to assess the corneal biomechanical properties,such as corneal hysteresis and corneal resistance factors, in children of school age. Multivariate regression analysis was used to investigate the relationship between corneal biomechanical properties and other ocular parameters including CCT, corneal curvature (k1 and k2), and IOP. The right eyes of all subjects were selected for statistical analysis. Results: A total of 571 children were enrolled: 303 male and 268 female,with an average age of 10.47 ±1.0 years. The mean value of corneal hysteresis was 10.98 ±1.78 mmHg, corneal resistance factor was 11.46±1.69 mmHg,and CCT was 556.01±28.97 μm. Conclusion:The feasibility of corneal biomechanical detection in school age children was validated. This study provides fundamental data on corneal biomechanical properties in school-age children and associated factors. (Eye Science 2013; 28:34-39)
文摘In July 1994,the CPC Central Committee and the State Council held theThird National Conference on Work in Tibet.During the conference, JiangZemin,General Party Secretary and State President,said that showing carefor,and providing aid to Tibet constituted the consistent policy of the Partyand the State,and the bounden duty of peoples of all ethnic groups in the country.
