Experiences and Challenges of Clinical Research in Traditional Medicines

Thank you for your introduction,thank DIA inviting me to come to this conference.After knowing so many data,I am very happy to learn some details about traditional Chinese medicine (TCM),including China's efforts in TCM,and what has been done in Europe.I would like to tell you about some of the challenges of TCM from the perspective of the European Union (EU).Many of them are mentioned by previous speakers.In fact,there are ways to allow herbs to enter the European market.Traditional herbal products have been established.And there is a full market authorization.Traditionally,it is necessary to ensure their medicinal efficacy and safety.Clinical trials are not necessary for every circumstance,but 10 years of use history within the EU is necessary.This is the process of full marketing.The USA and Europe have a similar situation: 3 of the 4 phases are required before the marketing authorization.These are 3 examples: a newly developed drug in Europe,it is from gentian roots,primrose,sorrel and other drugs,mainly for rhinitis;this is from Switzerland,which is from an extract of coltsfoot flowers;Schwabe's is from lavender,used for anxiety,and this is its name in Australia.

Experiences and Challenges of Clinical Research in Traditional Medicines

Good afternoon,everyone.I'd like to acknowledge DIA for the invitation.I will spend next 25 minutes to briefly talk about the research in Australia and complementary medicine (CM) there.Most importantly,I'd like to introduce a case that I was involved in the last 10 years,which was about developing a new herbal medicine for vascular dementia (VaD).I would actually highlight the issues in it as well as the experience and lessons.

Summary of Zhang Hongxing's Experience in Treating Refractory Angina Pectoris with Traditional Chinese Medicine

As a famous traditional Chinese medicine(TCM)expert in Shandong province and a famous veteran TCM expert in Dezhou city,Zhang Hongxing has been engaged in cardiovascular clinical work for more than 30 years.He has unique experience in the treatment of refractory angina pectoris.This paper comprehensively explains from the aspects of etiology and pathogenesis.His treatment is mostly based on syndrome differentiation,combined with the basic pharmacology of modem Chinese medicine to formulate prescriptions and drugs,and at the same time values the use of insect drugs.We hereby attach the clinical records,hoping to provide reference for clinical workers,which is conducive to the inheritance and development of famous Chinese medical academic experience.

Study on prescription medication mode and mechanism of traditional Chinese medicine in the treatment of noncritical COVID-19 based on data mining

Background:As of 2023,coronavirus disease 2019(COVID-19)is still spreading globally.Therefore,we aim to integrate non-critical COVID-19 high-frequency and high-targeting Chinese medicines to provide a reference for clinical prescriptions to improve COVID-19-related symptoms.Materials and methods:The information on non-critical COVID-19 high-frequency Chinese medicines in the diagnosis and treatment of COVID-19 was obtained by the TCM inheritance support platform.Using network pharmacology and molecular docking technology,high-targeting Chinese medicines with good docking activity with COVID-19 receptors angiotensin-converting enzyme-II(ACE2),3CLpro and tyrosine-protein kinase receptor UFO(AXL)were obtained.A new prescription for non-critical COVID-19 was established by integrating high-frequency and high-targeting Chinese medicines.Rats with acute lung injury induced by lipopolysaccharide were used as the experimental model.The histopathological changes in the lungs of rats in each group were observed by hematoxylin-eosin staining.The lung coefficient of rats was measured.The levels of IL-6,TNF-α,and IL-1βin serum were detected by enzyme-linked immunosorbent assay.The mRNA and protein levels of ACE2 and AXL in lung tissue were detected by real-time quantitative polymerase chain reaction and western blot.Results:Through data mining,it was found that there were 39 high-frequency traditional Chinese medicines for non-critical COVID-19 in the diagnosis and treatment guidelines.According to network pharmacology and molecular docking,30 highly targeted traditional Chinese drugs for COVID-19 were found.The new prescriptions for non-critical COVID-19 were comprehensively obtained,including Glycyrrhizae Radix,Ephedra Herba,Amygdalus Communis Vas,Gypsum Fibrosum,Descurainiae Semen,Atractylodes Lancea,Scutellariae Radix,Amomum Tsao-Ko Crevostet,Forsythiae Fructus,Pogostemon cablin,Magnolia Officinalis.Compared with the LPS-induced lung injury model group,the medium dose of the new prescription group had significantly alleviated pathological changes in lung tissue,decreased lung coefficient,decreased contents of IL-6,TNF-αand IL-1β,and increased mRNA and protein expression of ACE2 and AXL(P<0.05).Conclusion:Based on data mining,network pharmacology and molecular docking technology,the new prescription for non-critical COVID-19 established by this method has an anti-inflammatory effect on rats with acute lung injury induced by lipopolysaccharide and can provide a reference for clinicians to alleviate the symptoms related to non-critical COVID-19.

Zhou Lamei's Experience in Treating Gout

Chief physician Zhou Lamei performs diagnosis and treatment according to syndrome differentiation,and proposes the method of combining internal treatment with external treatment of traditional Chinese medicine and paying attention to the adjustment of eating habits and lifestyle,which has certain advantages in relieving acute attack,reducing uric acid,reducing gout complications caused by disease development and reducing adverse reactions of western medicine,and is of great significance to the treatment of gout onset and hyperuricemia control.

Validity and reliability of the evaluation tool of TCM confidence in students with TCM learning experience

Objective:This study aimed to design an evaluation scale of traditional Chinese medicine(TCM)confidence and then evaluate its validity and reliability.Methods:Three parallel samples with TCM learning experience were included in this current study.Randomly selected 500 nursing students were included factor analysis and reliability and validity analyses.After 4 weeks,200 nursing students were recruited to retest the reliability.The evaluation tool of TCM confidence included 6 dimensions and 25 entries.Results:Cronbach's a coefficient of the evaluation scale was 0.95 and that of the 6 observed aspects were higher than 0.90,and splithalf reliability was 0.81.For the retest reliability,Cronbach's a coefficient of the evaluation scale was 0.93 and that of the 6 examined aspects was all over 0.80.The index of content validity Scale Content Validity Index(S-CVI)was 0.92 and Item Content Validity Index(I-CVI)was 0.83–1.00.Conclusions:Observed results may indicate that the designed tool can be used to assess the TCM confidence level of students with TCM studied experience and also can evaluate results of TCM education during studying TCM lectures.

Improvements of Traditional Laser Fraunhofer Diffraction Experiment Using Digital Image Processing Method

We present an improved digital image processing(DIP)method to calculate the widths of single slits.Different from the traditional laser Fraunhofer diffraction experiment in college physical experiments,by performing fast Fourier transform,inverse fast Fourier transform and the nonlinear leastsquare fitting on the diffraction pattern taken by a camera,the DIP method can quickly return an analytic expression,whose period is used to calculate widths of single slits.By comparing the measured results by the DIP method and the successional difference(SD)method,we find that for a single slit whose width is 60372μm,the DIP method is more accurate.Experimental results show that for single slits with widths between 40μm and 160μm,the relative error of the DIP method is less than 2.78%.Also,the DIP method can be used to measure the diameter of filament and fibres online in real time.

East to west:research progress in traditional Chinese medicine for antiaging strategies

Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and traditional Chinese medicine(TCM).In this review,we summarize the current state of antiaging research related to both modern medicine and TCM and provide suggestions for further research.Various theories related to the aging process have been proposed,including the free radical theory,mitochondrial DNA damage theory,telomere theory,cross-linking theory,and intestinal flora theory,and a number of antiaging chemical treatments have been developed using modern medicine.These theories and achievements have resulted in major advancements in antiaging research.TCM is based on practical experience and has a long history with unique advantages in antiaging research.Some antiaging practices such as moderate diet consumption,acupuncture,Tai Chi(a traditional Chinese martial art that can relax the nerves to slow down the aging process),and Wuqin Xi(a traditional Chinese exercise to strengthen the body)have been adopted to maintain health.Several TCMs and prescriptions,particularly those related to medicine food homology,have been used in antiaging treatment,and their antiaging properties have been demonstrated to be effective based on pharmacological experiments and clinical applications.

Professor Liu Guobin used traditional Chinese medicine to cure a case of primary erythema limb pain

Primary erythema limb pain is a very rare disease,and its pathogenesis is not clear.Usually,the pain symptoms of patients exist for a long time,which seriously affect the daily life of patients and increase the economic burden of patients.Professor Liu Guobin,who has been engaged in the diagnosis and treatment of peripheral vascular diseases for nearly 30 years,believes that heat-toxin and blood stasis collaterals are closely related to the disease,and emphasizes the principle of heat-toxin and evil qi causing the disease.It is emphasized that clearing heat and detoxification,promoting blood circulation and dispersing blood stasis are the main treatment principles.This paper selects a typical case to describe Professor Liu's clinical experience in the treatment of primary erythema limb pain by oral and external use of traditional Chinese medicine,so as to provide an effective method of traditional Chinese medicine for the treatment of primary erythema limb pain.

The Rising,Recession and Revitalization of the Traditional Industrial Base in the Northeastern United States

The distribution of American industries has been unbalanced and most of the early industrial regions were centered in northeastern America.The northeastern traditional industrial base once was called"manufacturing belt".Since the 1950s,old industrial bases in the United States have been under recession.The northeastern region was then even called"rust belt".Some issues and measures of policy were set up by the government to adjust and restructure the old industrial bases,and some are useful experience and inspirations for our country,such as setting up special branches and organizations,establishing and implementing strategic planning for the adjustment and restructure of old industrial bases,adjusting the industrial branch and system,emphasizing on environment control and preservation and so on was achieved.Learning the successful experience from America,effective countermeasures and steps must be taken to accelerate the revival of the old industrial base in Northeastern China.

An introduction of the experience in treating Ventricular premature beat with stasis heat

室性早搏是临床常见的心律失常,不仅大大降低着患者的生活治疗,甚至存在着致死的危险。中医学认为其病机以心肾虚损为本,以痰饮、瘀血等有形实邪的阻滞为标。李远老师在数十年的临床工作中认识瘀血在多种因素影响下从阳化热是室性早搏的重要病机,较为广泛的出现在本病的不同证候、不同治疗阶段中,不应予以忽略。

张婷婷治疗子宫腺肌症痛证经验

子宫腺肌症的发病率逐年上升,其治疗是临床的难点。张婷婷教授治疗子宫腺肌症痛证,根据“瘀阻于内,不通则痛”的基本病机,口服汤剂采用“柴芍方”以疏肝行气、活血止痛;“红藤方”以清热凉血、散瘀止痛;“清瘀温通方”以寒温并用、化瘀止痛;“扶正祛瘀方”以益气扶正、祛瘀止痛。张婷婷临证还结合灌肠、足浴的方法,内外合治,长期管理患者,效果显著。

朱永康治疗分化型甲状腺癌术后并发症的经验

介绍朱永康教授治疗分化型甲状腺癌(DTC)术后并发症的临床经验。认为DTC术后的中医治疗分为早期和远期两个阶段,早期重在治“虚”,远期治疗除缓解其他治疗带来的毒副作用外,将“伏邪”理论引入治疗中,同时注重既病防变、已病防传和病愈防复。并附验案1则。

许铣教授中西医结合治疗玫瑰痤疮的临证经验

许铣教授从事皮肤科临床、科研工作60余年,中西医结合治疗玫瑰痤疮经验丰富。许铣教授认为,肝郁血热、脾胃湿热为玫瑰痤疮的核心病机。治疗应以中药内服为主,结合疾病分型分期辨证论治,红斑与毛细血管扩张期的基本病因病机为肝失疏泄,郁而化热,基本治法为凉血疏肝兼以养阴清热;丘疹脓疱期主要以脾胃运化失司、脾胃湿热为主,治法为清热燥湿、解毒散结。病程日久者往往合并血瘀和湿热。外治中药常选择具有清热凉血、燥湿、解毒之药效及抑菌、控脂之药理作用的中药。同时,可以根据疾病的临床表现选用西药辅助治疗,临床疗效显著,附验案1例加以佐证。

浙派中医治疗痛经经验整理

[目的]总结1911年前浙派中医治疗痛经的经验,探究其特色。[方法]对浙派中医古籍文献中有关痛经的论述、病案等进行摘录整理,总结痛经病机及治疗特色。[结果]浙派中医治疗痛经以“气血失调”为主要病机,提倡以寒热虚实为纲的气血辨证法,从月经有无先后失期、经血色量如何、痛在经行前后三方面进行辨证。文献所记载的痛经证型共8种,分别为血气虚证、血虚有滞证、血虚有寒证、血虚有热证、冲任不足证、肝气郁滞证、气滞血瘀证、寒凝血瘀证,以“温通清化、调和血气”为治则。浙派中医发扬命门学说,擅用温药,记载痛经要药10味,分别为凌霄花、白芍、马鞭草、玄胡、京三棱、鹿角、阳起石、白头翁根、莲房、荷叶。[结论]浙派中医治疗痛经从“气血”立论,“温补”“清化”以治本,“调畅气血”为根本,以辨证论治、治病求本为宗。

马晓燕撷经典方剂治疗内科杂病经验浅谈

郁证的主要临床表现为情绪抑郁不宁、心胸满闷、胸部以及胁肋部胀痛,或有善哭易怒,亦或咽中如有炙脔等不适。相当于现代医学中的神经衰弱、癔症及焦虑症等。常因喜怒忧思,郁滞不舒,而导致肝疏泄功能失职,脾脏失其健运之功,心失其养,脏腑、气血、阴阳功能紊乱;而消渴常因禀赋不足亦或是饮食不节等因素导致阴津亏损,燥热偏盛,而出现“三多一少”的症状,即多饮、多尿、多食以及形体消瘦,相当于现代医学的“糖尿病”。马教授投身于对于郁证和消渴的证候及治疗的研究,熟读经典、精求古训,并且在长期的诊疗疾病过程中,对于使用经典方剂加减化裁辨治郁证和消渴等内科杂病积累了丰富的临床经验。现撷马教授以经典方剂治疗郁证和消渴等内科杂病的经验作总结与探析。其临床疗效确切。

邓强主任医师辨治胸腰椎结核临床疗效回顾性分析与经验总结

目的:回顾性分析、总结邓强主任医师中西医结合辨治胸腰椎结核的临床效果及经验。方法:回顾性分析2016年6月1日至2020年9月31日在甘肃省中医院住院的47例胸腰椎结核患者的病历资料,治疗方案:四联抗结核药物(利福平胶囊、异烟肼片、乙胺丁醇胶囊、吡嗪酰胺胶囊)口服+胸腰椎后路病灶清除椎弓根钉内固定+围术期中医药辨证论治,并配合围手术期功能锻炼。观察术后2周及术后1、3、6、12、18个月患者血沉、Cobb后凸角、脊髓神经功能分级(ASIA分级)、视觉模拟量表(visual analogue scale,VAS)评分、临床疗效及并发症发生情况,并通过验案探讨其辨治该病的经验。结果:术后18个月患者血沉、VAS评分分别为(8.45±2.11)mm/h、(1.55±1.31)分,低于术后2周的(48.55±6.14)mm/h、(6.12±1.23)分(P<0.05);Cobb后凸角、ASIA分级术后18个月高于术后2周;术后18个月总有效率为97.9%(46/47),高于术后2周的66.1%(31/47);术后6个月1例患者重体力劳动后出现手术切口尾端崩裂约2 cm,无脓性分泌物流出,给予清创缝合换药后,正常愈合;术后18个月1例患者出现内固定断裂伴发脊柱变形,进行了再次手术。结论:口服四联抗结核药物+胸腰椎后路病灶清除椎弓根钉内固定+围术期补虚培元兼化痰通络,可改善胸腰椎结核患者临床症状、体征及ASIA分级。

孙克伟教授辨证论治肝病的经验探析

孙克伟教授在长期临床诊治中总结发现,多种肝病殊途同归,提出“补脾土,疏肝解郁”“逐湿邪,热无所依”“补先天,解毒袪邪”“调气血,瘀滞得化”“温脾阳,截断逆挽”的学术经验,临床应用效果显著。该文将从以上五法探析孙克伟教授辨证论治肝病经验,旨在为肝病中医诊疗提供参考和借鉴。

基于“三焦气化”理论探讨谢春光教授治疗痛风经验

痛风是由单钠尿酸盐沉积所致的晶体相关性关节病,现代医学药物治疗主要以碱化尿液、降尿酸和促尿酸排泄等为主,不良反应较多;而中医药治疗痛风颇具特色,谢春光教授总结30余年临床相关经验,注重三焦气化理论,立足于肺、脾、肾,提出通利三焦以促机体脏腑经络功能恢复,用药灵活,为中医药治疗痛风提供了新的思路。