Acupuncture-moxibustion therapy of "banking up original qi and consolidating the foundation" for prevention and treatment of seasonal allergic rhinitis:A randomized controlled trial

Objective： To observe the clinical efficacy of acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ for prevention and treatment of seasonal allergic rhinitis.Methods： Sixty included patients were divided into two groups according to the random number table method with 30 patients in each group. In acupuncture group, warming-needle moxibustion was carried out at Zúsānlǐ（足三里ST 36）, and cone moxibustion on Fùzǐ（附子Radix Aconiti Lateralis Praeparata） cake was conducted at Guānyuán（关元CV 4）, Qìhǎi（气海CV 6） and Dàzhuī（大椎GV 14）. The treatment was conducted in May or June（2 months before the onset of rhinitis in this area）. The treatment was carried out for once every other day and three times per week. Treatment for 24 times was considered as 1 course of treatment. No intervention treatment was conducted in control group. The score of rhinitis symptom, the visual analogue scale（VAS） score changes of total nasal symptom score（TNSS） and total non-nasal symptom score（TNNSS） of patients in 2015 and in 2016 were observed, and the clinical efficacy of the two groups was compared.Results：（1） The score of rhinitis symptom, the VAS score changes of TNSS and TNNSS in acupuncture group in 2016 declined when compared with the results in 2015, which were 4.57 ±0.82 vs 9.40 ± 1.89,13.37 ± 4.01 vs 30.80 ±4.77 and 15.93 ±6.30 vs 46.13 ± 9.79（P〈 0.001）, the results in acupuncture group after treatment were lower than that in control group at same time, which were 4.57 ±0.82 vs 7.53 ±2.06,13.37±4.01 vs 27.17±6.84,15.93±6.30 vs 35.53±11.69（all P〈0.001）. According to comparison, there was no obvious difference in the results in control group at the two time points, which were 8.60 ±2.39 vs7.53 ± 2.06, 29.63 ± 6.30 vs 27.17 ± 6.84 and 40.90 ±12.31 vs 35.53± 11.69（all P〉 0.05）.（2） The total effective rate was 96.7%（29/30） in acupuncture group and 10%（3/30） in control group, and the difference was statistically significant（P〈 0.001）.Conclusion： Acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ was effective on prevention and treatment of seasonal allergic rhinitis.

Clinical Observation of Warm Needling Moxibustion for Seasonal Allergic Rhinitis

Objective： To observe the clinical therapeutic effects of warm needling moxibustion for seasonal allergic rhinitis. Methods： One hundred and eighty cases of the patients with seasonal allergic rhinitis were randomly divided into two groups, 90 cases in the warm needling group, treated by acupuncture plus warm needling moxibustion, and 90 cases in the acupuncture group, treated by acupuncture only, to observe the therapeutic effects after one course of the treatments. Results： The total effective rate was 95.6% in the warm needling group and 85.6% in the acupuncture group, with significant statistical difference in comparison between the two groups. Conclusion： The total effective rate of the warm needling moxibustion is better than that of the acupuncture treatment in the treatment of seasonal allergic rhinitis.

Treatment of 67 Cases of Seasonal Allergic Rhinitis by Acupuncture

Seasonal allergic rhinitis refers to a seasonal and regional allergic disease induced mainly by botanical pollen, also termed ＂Hay Fever＂ and ＂Pollinosis＂, clinically manifested by the main symptoms of itching sensation in the nose, nasal obstruction, sneezing, watery nasal discharge, conjunctival congestion, itching in the eyes, lacrimation, and asthma developed from an incessant cough in some people, or manifested by the gastrointestinal symptoms of nausea, vomiting, abdominal pain, and diarrhea, and skin eczema, urticaria, pruritus vulvae, vaginitis. The author treated 67 cases of seasonal allergic rhinitis by acupuncture from 2002 to 2004. Now, the result is summarized as follows.

《变应性鼻炎及其对哮喘的影响》指南2010年修订版解读

《变应性鼻炎及其对哮喘的影响》(Allergic rhinitis and its impact on asthma,ARIA)指南最新修订版(简称ARIA2010版)最近由《Journal of Allergy and Clinical Immunology》杂志全文发表。与旧版ARIA指南使用循证医学的方法不同,ARIA2010版采用推荐、评估、发展和评价分级(Grading of Recommendations,Assessment,Development and Evaluation,GRADE)工作组提出的透明的、系统化的方法修订了临床建议,以提高其实用价值。

腺样体切除术后圆枕增生与变应性鼻炎的关系

人们已经注意到,变应性鼻炎（allergic rhinitis,AR）患儿腺样体肥大发病率较非AR患儿高,近几年AR患儿发病率逐渐增高,我们考虑,腺样体切除术后圆枕增生可能和AR有密切关系,本文用回顾性分析的方法对此问题进行了探讨。

南昌地区变应性鼻炎患者变应原皮肤点刺试验结果分析

由于生活习惯、地理环境和气候的不同,各地变应性鼻炎（AR）变应原分布特点有很大区别,了解和分析南昌地区常见变应原分布情况,对预防和治疗该地区AR具有重要的指导意义。我科对南昌地区959例AR患者进行变应原皮肤点刺试验（skin prick test,SPT）,现报道如下。

变应性鼻炎患者常见变应原生物共振检测分析

变应性鼻炎（AR）是耳鼻咽喉科常见疾病,可严重影响患者的生活质量。由于各地地理环境和气候不同,变应原具有明显的区域性。为探讨德州市AR常见变应原分布情况,本文回顾性分析2007年1月～2009年12月耳鼻咽喉科门诊及皮肤科变态反应室利用生物共振检测171例拟诊AR患者变应原结果,以了解本地AR常见变应原分布情况,为AR诊断、预防及特异性免疫治疗（specificimmunotherapy,SIT）提供依据。现将检测分析报道如下。

蒿属变应原皮肤点刺试验与血清特异性IgE的相关性研究

蒿属是我国东北地区夏秋季的主要变应原^[1]，其引起疾病者症状严重，季节性明显。本研究旨在通过比较蒿属皮肤点刺实验（skin prick test，SPT）不同皮肤风团直径以及不同皮肤反应指数（skinindex，SI）对应的血清特异性IgE（specificl gE，slgE）阳性率以及SPT级别与血清slgE级别的关系，评估蒿属变应原SPT结果与血清slgE之间的相关性。

正确认识气传变应原及避免措施

避免变应原是预防变应性疾病的根本措施,但现实生活中完全避免变应原是非常难的。本文就室内气传变应原的生物学特征、分子生物学、致敏、环境暴露的评估以及避免措施进行综述。

Hippo通路相关分子在变应性鼻炎中的研究进展

辅助性T细胞1/辅助性T细胞2(T helper 1 cells/T helper 2 cells,Th1/Th2)免疫失衡、调节性T细胞/辅助性T细胞17(regulatory T lymphocytes/T helper 17 cells,Treg/Th17)比例下调以及树突细胞(Dendritic cell,DC)的活化等参与了变应性鼻炎(AR)的发生发展过程。Hippo通路是一种非常保守的信号传导通路,具有调节细胞增殖、凋亡的功能。新近的研究发现,Hippo信号通路中哺乳动物不育系20样激酶1/2、Yes相关蛋白和转录共激活因子PDZ结合基序等主要成员也表达于上述免疫细胞中,并在AR、哮喘等呼吸道变应性炎症的发病中发挥着重要作用。进一步研究Hippo通路有助于深入了解AR的发病机制,本文就Hippo通路的主要成员对Th1/Th2、Treg/Th17和DC的作用进行综述,以期为AR及其他呼吸道变应性疾病的临床治疗提供新的干预靶点和思路。

合肥地区变应性鼻炎患者变应原皮肤点刺试验

变应性鼻炎（AR）是耳鼻咽喉头颈外科常见病、多发病,是一个全球关注的健康问题。AR严重影响患者生活质量和工作效率,尤其对儿童学习能力、注意力、性情等均可造成不利影响,如合并哮喘则病情更加难以控制。在临床实践中,变应原皮肤点刺试验（skin prick test,SPT）对于特异性变应性疾病的诊断能提供有用的诊断信息。

变应性鼻炎治疗前后生活质量评估

变应性鼻炎（AR）是特应性个体接触变应原后由IgE介导的介质释放、并有多种免疫活性细胞和细胞因子等参与的鼻黏膜慢性炎症反应性疾病。近年来,随着国家工业化程度的提高,患病率呈上升趋势[1,2],其病情反复发作可引起支气管哮喘、变应性鼻窦炎等一系列严重并发症。

中西医结合治疗变应性鼻炎的疗效观察

变应性鼻炎（AR）分为常年性AR和季节性AR,是耳鼻咽喉科临床常见病和多发病。AR属非感染性疾病,经常反复发,难以治愈。根据2008年版《变应性鼻炎及其对哮喘的影响》（allergic rhinitis and its impact on asthma,

2型固有淋巴细胞调控因素的研究进展

2型固有淋巴细胞(group 2 innate lymphoid cells,ILC2s)是一群不表达谱系发育因子Lineage,不具有抗原特异性的特殊免疫细胞,能够在IL-33和IL-25的刺激下产生大量IL-5和IL-13,介导2型先天性免疫应答,在变应性和炎症性疾病中发挥重要作用。近年来ILC2s不同细胞亚型以及复杂的调控因子网络逐渐被发现和证实,这些研究结果拓展了对先天性免疫应答的认识,尤其是ILC2s参与变应原或病原体介导的气道炎症反应,为临床治疗提供了新的思路。

变应性鼻炎的流行病学研究现状

变应性鼻炎是一个全球性健康问题，不同程度影响患者的生活质量。本文就变应性鼻炎的定义，调查研究方法，对生活的影响及对社会的经济负担，研究现状及流行病学发病规律做一综述。

变应性鼻炎治疗中口服抗组胺药物的地位

变应性鼻炎（AR）已成为了一个全球性的健康问题,发病率呈逐年增长趋势,其发病时可以影响患者的日常工作、生活及学习效率,WHO组织全球鼻科和变态反应科的学者编写了＂变应性鼻炎及其对哮喘的影响（Allergic rhinitis and its impact on asthma,ARIA）＂指南,

变应性鼻炎的抗组胺药物治疗

变应性鼻炎（AR）是一个全球性健康问题,全球发病率达10%～40%,且患者人数仍在增加,影响日常生活、工作及学习,造成经济上的沉重负担。为此2001年世界卫生组织参与制定了＂变应性鼻炎及其对哮喘的影响（allergic rhinitis and its impact on asthma,ARIA）＂指南,

环境对变应性鼻炎的影响

遗传和环境是变应性鼻炎（allergic rhinitis,AR）发病的两大因素。近20年来,AR发病率在全球范围内呈上升趋势。这种趋势是难以单纯用遗传基因改变来解释,

《变应性鼻炎及其对哮喘的影响》指南2010年修订版解读

《变应性鼻炎及其对哮喘的影响》(Allergicrhinitis and its impact on asthma,ARIA)指南(简称ARIA2010版)于2010年全文发表在《Journal of Allergy and Clinical Immunology》杂志。ARIA2010版共提出10项有关变态反应,AR和哮喘一、二、三级预防的建议,31项AR的治疗建议和7项AR合并哮喘的治疗建议。本栏目特将部分建议摘编如下。

ARIA指南2010版对抗组胺药物评价和使用建议

变应性鼻炎（AR）是耳鼻咽喉科临床常见的疾病,以清涕、喷嚏、鼻痒及鼻塞等作为主要症状,患病率可高达10%～20%。AR几乎均存在于各年龄阶段人群[1],患者深受疾病困扰,承担一定的生活、工作、经济及家庭等生理心理压力,并且有发展成为哮喘的风险。