The resolutions of both enantiomers of the ornidazole and sec-nidazole were achieved with high enantiomeric excesses (ee > 99%) by acylation of the corresponding racemates with vinylac-etate in the presence of lipa...The resolutions of both enantiomers of the ornidazole and sec-nidazole were achieved with high enantiomeric excesses (ee > 99%) by acylation of the corresponding racemates with vinylac-etate in the presence of lipase Amano AK (from Pseudomonas sp.). The assignments of the absolute configurations of ( + ) or ( - )-ornidazole and secnidazole are described.展开更多
基金Project supported by the National Natural Science Foundation of China(No.297912045)and the Major State Basic Research Development Program(No.G2000 077506).
文摘The resolutions of both enantiomers of the ornidazole and sec-nidazole were achieved with high enantiomeric excesses (ee > 99%) by acylation of the corresponding racemates with vinylac-etate in the presence of lipase Amano AK (from Pseudomonas sp.). The assignments of the absolute configurations of ( + ) or ( - )-ornidazole and secnidazole are described.
