Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

Using Flowable Composite as Gingival Retraction Cord in Prosthodontics Dentistry: Two Case Reports: A Dental Technique

One of the most challenging factors affecting impression quality and good marginal fit is the gingival retraction method, which aims to separate the gingiva from the tooth to expose the finishing line of the prepared tooth. Bleeding and contamination from the crevicular fluid may compete for space with the impression material within the sulcus, leading to indistinct preparations and a lack of detail at the margin. In addition, such procedures might damage the PDL and cause permanent recession. Flowable composite cable, as opposed to traditional retraction cords, offers the proper marginal seal and visibility during the impression record because of its lower viscosity, improved adaptability, and elastic properties. The aim of this report is to present a brand-new, innovative method for controlling gingival hemorrhage in addition to the gingival retraction in restorative and prosthodontic treatment by utilizing a flowable composite during the final impression record procedure. In these case reports, the flowable composite cord technique is used instead of traditional gingival cords to modify and refine the gingival tissue before taking the traditional final impression or digital scan. Two cases were done for patients undergoing fixed prosthodontics and veneer treatment within a 2-year follow-up period. In addition, the flowable composite cord was used as temporary restoration before the final prosthetic cementation or under the provisional crowns. As a result, clean and healthy gingival tissues render cementation of the final prosthesis quicker and easier to perform. The patients in both cases claimed that their prosthodontic treatments, which involved the application of a flowable composite cord to temporarily retraction the gingiva, had produced good outcomes at the yearlong follow-up. In conclusion, the flowable composite cord technique is found to be a useful tool to improve the quality of impressions in fixed prosthodontics by providing excellent access for impression material to record fine details of the finish line of the prepared tooth structure, and to alter the inflamed tissue into a healthy tissue.

Growth Efficiency of Local Chickens Using Sweet Potato Vine with Concentration Feed as a Basal Diet

The experiment was conducted at the animal experimental station of the Faculty of Animal Sciences,Royal University of Agriculture,commenced from 10 January to 14 March,2022.The CRD(Completely Randomized Design)was used with 5 treatments and 4 replications.The 500 chicks at one-day-old,local bread,were purchased from farmers who run their small scale hatchery farm.The chicks were kept together till 21 days old,and then were allocated randomly into in five diets(treatments),25 chicks per replication.The feed formulas for this study were designed and calculated to maintain a protein content of approximately 17%,dividing into 5 feed formulas(Treatments),such as concentrated feed only(control treatment:T0),plus 10%of fresh sweet potato vine(T1),plus 20%of fresh sweet potato vine(T2),plus 30%of fresh sweet potato vine(T3)and plus 20%of sweet potato vine meal(T4).The results showed that the treatment T1,had a similar final weight with the treatment T4,but was slightly lower than the treatment T0 which used concentrated feed alone.Feed intake and FCR(Feed Conversion Ratio)were not significantly different among those treatments.In conclusion,the average daily weight gain of chickens seemed to decrease with increasing the level of fresh sweet potato vine.Thus,the optimum level of fresh sweet potato vine was 10%,which may have little effect on the growth performance of local chickens.In addition,it was not far different from the positive control treatment and the treatment using sweet potato vine meal.However,the producers can increase the amount of sweet potato vine in feed formula by processing it into meal and mixing with concentrated feed or using as feed ingredients.

基于Asaoka法的非等间隔真空预压土体沉降数据处理

工后沉降量是反应地基加固效果的直接技术指标,必须以最终沉降量的计算为依据。为判定某软基施工工程的施工效果和确定停泵时间,以真空预压过程中土体实测沉降量为依据,采用三次样条曲线插值法对非等间隔时距下的实测沉降量进行转化,选用Asaoka法对土体最终沉降量进行预测和软基工后沉降量的计算。结果表明,时间间隔为5 d时对应的最终沉降预测结果较好;抽真空开始后的第120 d,软基土体工后沉降量满足设计要求,可停泵。

基于Asaoka法的软基沉降量预测研究与应用

介绍了Asaoka法的基本理论知识,并以温州某软基加固工程为例,详细分析了取舍初始沉降值、时间间隔(Δt)对Asaoka法预测最终沉降量以及相关指标的影响,确定了以相关系数(R)的大小来判别沉降预测好坏的方法,为类似软土地基沉降预测提供了依据。

利用EasyType和Final Cut Pro制作高标清手拍对白字幕

在利用苹果非编软件Final Cut Pro(以下简称为FCP)制作高标清影片时,客户要求制作对白字幕,但利用FCP直接添加对白字幕相当繁琐,而且速度很慢。EasyType高标清手拍字幕对白软件的问世,为FCP制作对白字幕提供了新途径和新方法。本文作者结合自身工作经验,和读者一起分享利用EasyType和Final Cut Pro制作高标清手拍对白字幕的方法和步骤,整理后供大家参考。

最终S-Nekrasov矩阵逆矩阵无穷范数的上界

研究矩阵条件数计算中A的逆矩阵A^(-1)的A|^(-1)|_(∞)的估计问题,利用S-Nekrasov矩阵逆矩阵无穷范数的估计式,结合最终S-Nekrasov矩阵的定义式,得到了该类矩阵的新上界估计式。

基于CLDAS-Prcp多源融合降水产品的WRFHydro模式在綦江流域的水文效用

为了提升对中小尺度流域的径流模拟和洪水预报能力,给防灾减灾和科学研究提供参考依据,本文评估了CLDAS-Prcp多源融合降水产品在中小尺度流域中的水文效用以及WRF-Hydro模式在中小尺度流域中的模拟效果。首先利用CLDAS-Prcp多源融合降水产品和IMERG-Final多源融合降水产品分析了綦江流域7个典型洪水个例中的累计降水量空间分布特征以及小时面雨量时序变化特征,再利用两种多源融合降水产品分别驱动WRF-Hydro模式对綦江流域7个典型的洪水个例进行模拟,并与实测径流量进行对比分析。结果表明:(1)CLDAS-Prcp在累计降水量空间分布上比IMERG-Final刻画出了更多的细节,大值落区和降水总量上也更为准确;两种降水产品都能较好地刻画流域小时面雨量在洪水时段的变化趋势,CLDAS-Prcp在面雨量峰值以及变化趋势上更贴近观测数据。(2)基于CLDAS-Prcp多源融合降水产品的4场径流模拟中,有3场径流模拟的纳什系数高于0.9,表现优异;基于IMERG-Final多源融合降水产品的4场径流模拟中,除20200622号洪水事件外,其余场次模拟的纳什系数皆低于0.7,说明基于CLDAS-Prcp融合降水产品的参数率定以及径流模拟要优于IMERG-Final融合降水产品。(3)WRF-Hydro模式可以很好模拟出洪水个例的洪峰流量,准确地再现了洪峰出现的时间,能够较好地刻画洪水过程的细节。总体而言,CLDAS-Prcp多源融合降水产品和WRF-Hydro模式可以很好地应用在中小尺度流域的水文模拟中。

基于MASTA的断开式中桥主减速器系统变形与强度分析

本文介绍某越野车断开式中桥减速器总成设计过程和基本方法,主要对螺旋锥齿轮副、贯通轴斜圆柱齿轮副以及圆锥滚子轴承进行系统的理论设计计算,计算结果与MASTA软件建立的模型基本系统变形结果进行相互验证。对设计过程进行总结,归纳一套中桥以及同类产品的设计方法;针对理论设计、基本系统变形中无法考虑壳体实际刚度对齿轮、轴承的影响。本文通过MASTA结构柔性模块导入壳体,在柔性系统变形下分析齿轮和轴承,将应力值、错位量、安全系数等结果形成同类产品设计评判的标准。

Extreme brightness laser-based neutron pulses as a pathway for investigating nucleosynthesis in the laboratory

With the much-anticipated multi-petawatt(PW)laser facilities that are coming online,neutron sources with extreme fluxes could soon be in reach.Such sources would rely on spallation by protons accelerated by the high-intensity lasers.These high neutron fluxes would make possible not only direct measurements of neutron capture andβ-decay rates related to the r-process of nucleosynthesis of heavy elements,but also such nuclear measurements in a hot plasma environment,which would be beneficial for s-process investigations in astrophysically relevant conditions.This could,in turn,finally allow possible reconciliation of the observed element abundances in stars and those derived from simulations,which at present show large discrepancies.Here,we review a possible pathway to reach unprecedented neutron fluxes using multi-PW lasers,as well as strategies to perform measurements to investigate the r-and s-processes of nucleosynthesis of heavy elements in cold matter,as well as in a hot plasma environment.

基于ASYM的激光陀螺捷联惯性系统温度误差模型辨识

为减小温度对导航精度的影响,实现系统级的温度补偿,在实验中采用静态条件下的标定方法;基于激光陀螺捷联惯性系统的误差模型方程,用广义逆算法顺利分离求得陀螺各零偏及标度因数值;根据以往温度误差模型的结构特点,运用渐近辨识方法(ASYM)中的最终输出误差准则(FOE)对温度误差模型中非线性部分的阶次进行准确的计算,确定了合理的温度误差模型结构。为了解决用最小二乘法辨识模型结构的系数时,信息矩阵求逆容易溢出的问题,采用了自适应的岭估计算法确定陀螺零偏温度误差模型的系数,实现了系统级的温度误差建模。所得到的温度误差模型补偿效果比定阶前明显提高。

“Final all possible steps”approach for accelerating stochastic simulation of coupled chemical reactions

In this paper, we develop a modified accelerated stochastic simulation method for chemically reacting systems, called the ＂final all possible steps＂ （FAPS） method, which obtains the reliable statistics of all species in any time during the time course with fewer simulation times. Moreover, the FAPS method can be incorporated into the leap methods, which makes the simulation of larger systems more efficient. Numerical results indicate that the proposed methods can be applied to a wide range of chemically reacting systems with a high-precision level and obtain a significant improvement on efficiency over the existing methods.

利用SLR数据检核GLONASS卫星最终轨道

采用由EDC提供的2015-01-01~2015-12-31的SLR标准点观测数据进行GLONASS卫星最终轨道(CODE提供)检核,分别按照卫星PRN号和不同测站对检核结果进行统计分析。结果表明,不同卫星的检核效果参差不齐,跟卫星的服役年限有关,较新的卫星检核结果较好,第一轨道面的卫星检核结果最好;检核结果中存在一定的系统误差,且大部分的激光测距比最终轨道反算的站星距要短;利用SLR检核2015年全年GLONASS轨道精度总体优于3.3cm,激光观测精度总体优于1.2cm。

ON THE PUNCTURED ELASTIC WELDING PROBLEMS OF DIFFERENT ANISOTROPIC MEDIA

0 IntroductionThe mathematical problems of fracture of compound materials are very important on practical applica-tions. In this paper, we study the plane welding problems of different anisotropic media with holes,theshape of holes and the interface are arbitrary smooth contours. At first, we establish mathematical models,change it into searching complex stress functions, next, we reduce the primitive problems into boundaryvalue problems, and construct the form of solution, under some general restrictions it is reduced to certainsingular integral equations, finally, the existence and the uniqueness of the solution of which are estab-lished.1 The Representation Formula of Complex Stress

Infrared radiation method for measuring ice segregation temperature of artificially frozen soils

In order to study the evolution of the freezing fringe and final lenses of frost susceptible soils and advance the understanding of frost heave and mechanism of frost heave control, we used an open one-dimensional frost heave test system of infrared radiation technology, instead of a traditional thermistor method. Temperatures of the freezing fringe and segregated ice were measured in a non-contact mode. The results show that accurate and precise temperatures of ice segregation can be obtained by infrared thermal imaging systems. A self-developed inversion program inverted the temperature field of frozen soils. Based on our analysis of temperature variation in segregated ice and our study of the relationship between temperature and rate of ice segregation in cooling and warming processes during intermittent freezing, the mechanism of decreasing frost heave of frozen soils by controlling the growth of final lenses with an intermittent freezing mode, can be explained properly.

Influence fast or later:Two types of influencers in social networks

In real-world networks,there usually exist a small set of nodes that play an important role in the structure and function of networks.Those vital nodes can influence most of other nodes in the network via a spreading process.While most of the existing works focused on vital nodes that can maximize the spreading size in the final stage,which we call final influencers,recent work proposed the idea of fast influencers,which emphasizes nodes’spreading capacity at the early stage.Despite the recent surge of efforts in identifying these two types of influencers in networks,there remained limited research on untangling the differences between the fast influencers and final influencers.In this paper,we firstly distinguish the two types of influencers:fast-only influencers and final-only influencers.The former is defined as individuals who can achieve a high spreading effect at the early stage but lose their superiority in the final stage,and the latter are those individuals that fail to exhibit a prominent spreading performance at the early stage but influence a large fraction of nodes at the final stage.Further experiments are based on eight empirical datasets,and we reveal the key differences between the two types of influencers concerning their spreading capacity and the local structures.We also analyze how network degree assortativity influences the fraction of the proposed two types of influencers.The results demonstrate that with the increase of degree assortativity,the fraction of the fast-only influencers decreases,which indicates that more fast influencers tend to keep their superiority at the final stage.Our study provides insights into the differences and evolution of different types of influencers and has important implications for various empirical applications,such as advertisement marketing and epidemic suppressing.

Study on Forced Straight-Line Guidance for the Final Translation Phase of Spacecraft Rendezvous

Aimed at the problem of final translation of space rendezvous for the applications such as docking,inspection and tracking,optimal straight-line guidance algorithm based on pulse/continuous low-thrust in the context of Clohessy-Wiltshire dynamics is proposed.Two modes of guidance strategy:varying-speed and fixed-speed approaching scheme for V-bar and R-bar approach by using constant/finite low-thrust propulsion respectively are studied,and the corresponding fuel-optimal conditions are obtained.Numerical simulation is conducted to verify and test the proposed algorithms.The results show that there is generally no different between the fuel consumptions by using the two different approaching modes for V-bar case.However,the conclusion for Rbar case is different that the using of continuous low-thrust cost more fuel and transfer time.

Settlement behavior of coal mine waste in different surrounding rock conditions

In order to investigate the influence of complex conditions of in-situ surrounding rocks on the settlement behavior of nubbly coal mine waste subjected to high gravity pressure,four kinds of loading chambers made of different similar materials with different elastic moduli in experiments were used to simulate the deformation features of in-site rocks,including soft,moderate hardness,hard and extra-hard rocks. The results show that all the settlement-axial load (or axial strain-stress) curves obtained under four different surrounding rock conditions present power-exponential function feature. The final settlement of coal mine waste under the same axial load is closely related to the lumpiness gradations and the deformation behavior of chamber materials used to simulate behaviors of different in-situ surrounding rocks. In the same surrounding rock condition,the final settlement under the same maximum axial load decreases with the decrease of the proportion of larger gradation of coal mine waste. While for the same lumpiness gradation case,the settlement increases with the decrease of elastic modulus of simulated surrounding rocks and the lateral pressure induced by axial load increases with the increase of elastic modulus of loading chambers that are used to simulate different surrounding rocks. The test results also reveal that both the compaction curve and lateral pressure curve show a three-stage behavior,and the duration of each stage,which is closely related to gradations and the deformation feature of loading chamber materials,decreases with the increase of the proportion of the small size of coal mine waste and elastic modulus of the simulated rock materials.

New Evidence of Detrital Zircon Ages for the Final Closure Time of the Paleo-Asian Ocean in the Eastern Central Asian Orogenic Belt(NE China)

Objective The NE China is located in the eastern segment of the Central Asian Orogenic Belt（CAOB）,which is a large accretionary orogen between the Siberian Craton and the North China Craton（NCC）.Many researches have discussed about the evolution of the Paleo-Asian Ocean（PAO）in the eastern CAOB.However,

On the Tone of Finality in Famous Successful Speeches

The public speech skill consists of cultural virtue,knowledge accumulation,psychological quality,logical thinking,thinking capacity and language expression.It is a kind of art that speakers achieve the success through their own sound.In dealing with various English speeches,Chinese students are always influenced by the Chinese way of speech delivery,adopting the style of it,especially its tone of finality.After collecting,arranging and learning relevant material,I attaches great importance to the tone of finality in famous English speeches.They show some rules and regulations,such as the return to the middle pitch,the unstable change of stress and the final rising and falling tone.This paper begins with a brief introduction to what the tone of finality is and three famous English speeches in different areas are provided as study cases with the PRAAT pictures and their relevant analysis.And then the comparison will be made among these three speeches from aspects of pitch,length and weight,in the hope of concluding similarities in the tone of finality of these three cases.